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World Journal of Surgical Oncology

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Open Access 01-12-2010 | Case report

A colliding maxillary sinus cancer of adenosquamous carcinoma and small cell neuroendocrine carcinoma - a case report with EGFR copy number analysis

Authors: Shiang-Fu Huang, Wen-Yu Chuang, Sou-De Cheng, Li-Jen Hsin, Li-Yu Lee, Huang-Kai Kao

Published in: World Journal of Surgical Oncology | Issue 1/2010

Abstract

Background

Small cell neuroendocrine carcinoma (SNEC) of maxillary sinus is a rare and aggressive malignancy. A tumor with squamous cell carcinoma, adenocarcinoma and SNEC co-existence is extremely rare.

Case presentation

We present a colliding tumor of squamous cell, adenocarcinoma and SNEC in maxillary sinus. The clinical features, diagnosis and EGFR flourescence in situ hybridization (FISH) study are presented. A 52-year-old female had a 1-month history of progressing left cheek swelling and purulent rhinorrhea. Magnetic resonance imaging showed a tumor involving left maxilla and orbital floor. Excision of tumor was done and the defect was reconstructed with free flap. The pathology revealed a malignant tumor composed of squamous cell carcinoma, adenocarcinoma and SNEC components. EGFR FISH study showed no gene amplification in 3 components of this tumor. The tumor progressed rapidly and the patient expired at 8 months after surgery.

Conclusion

A colliding tumor of squamous cell, adenocarcinoma and neuroendocrine carcinoma in maxillary sinus was aggressive in behavior and the treatment response was poor due to the complexity of tumor.

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Title: A colliding maxillary sinus cancer of adenosquamous carcinoma and small cell neuroendocrine carcinoma - a case report with EGFR copy number analysis
Authors: Shiang-Fu Huang
Wen-Yu Chuang
Sou-De Cheng
Li-Jen Hsin
Li-Yu Lee
Huang-Kai Kao
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2010
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-8-92

At a glance: The STEP trials

Springer Medicine

A colliding maxillary sinus cancer of adenosquamous carcinoma and small cell neuroendocrine carcinoma - a case report with EGFR copy number analysis

Abstract

Background

Case presentation

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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