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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2010

Open Access 01-12-2010 | Research

The relationship among acute-phase response proteins, cytokines and hormones in cachectic patients with colon cancer

Authors: Ozgur Kemik, Aziz Sumer, Ahu Sarbay Kemik, Ismail Hasirci, Sevim Purisa, Ahmet Cumhur Dulger, Baris Demiriz, Sefa Tuzun

Published in: World Journal of Surgical Oncology | Issue 1/2010

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Abstract

Backgraund

Acute-phase response proteins (APRP), cytokines and hormones have been claimed to be an independent prognostic factor of malignancies, however the basis for their association with prognosis remains unexplained. We suggest that in colon malignancies, as similar to pancreatic and lung cancers, changes in APRP are associated with angiogenesis.

Methods

C-reactive protein (CRP), albumin, IL-1α, IL-1β, IL-6, IL-8, IL-10, TNF-α, midkine, VEGF-A, VEGF-C, leptin, adiponectin, and ghrelin serum levels are studied in 126 colon cancer patients and 36 healthy subjects.

Results

We found statistically significant difference and correlations between two groups. We found significantly higher serum CRP, IL-1α, IL-1β, IL-6, IL-8, IL-10, TNF-α, VEGF-A, VEGF-C and leptin concentrations in patients relative to controls (p < 0.001). We found lower levels of the serum albumin, midkine, adiponectin and ghrelin in patients compared to control subjects (p < 0.001).

Conclusions

Cachexia in patients with colon cancers is associated with changes in APRP, cytokines and hormone concentrations. These biomarkers and cachexia together have a direct relationship with accelerated angiogenesis. This may lead to a connection between the outcomes in malignancies and the biomarkers.
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Metadata
Title
The relationship among acute-phase response proteins, cytokines and hormones in cachectic patients with colon cancer
Authors
Ozgur Kemik
Aziz Sumer
Ahu Sarbay Kemik
Ismail Hasirci
Sevim Purisa
Ahmet Cumhur Dulger
Baris Demiriz
Sefa Tuzun
Publication date
01-12-2010
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2010
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-8-85

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