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Open Access 01-12-2009 | Research

Perioperative immune responses in cancer patients undergoing digestive surgeries

Authors: Masashi Ishikawa, Masanori Nishioka, Norikazu Hanaki, Takayuki Miyauchi, Yutaka Kashiwagi, Hiromi Ioki, Akihiro Kagawa, Yoichi Nakamura

Published in: World Journal of Surgical Oncology | Issue 1/2009

Abstract

Background

Th1/Th2 cell balance is thought to be shifted toward a Th2-type immune response not only by malignancy but also by surgical stress. The aim of this study was to estimate perioperative immune responses with respect to the Th1/Th2 balance in patients with gastrointestinal cancer.

Methods

Ninety-four patients who underwent abdominal surgeries were divided into three groups: gastric resection (n = 40), colorectal resection (n = 34) and hepatic resection (n = 20). Twelve patients undergoing laparoscopic cholecystectomy and 20 healthy subjects were served as control groups. Intracellular cytokine staining in CD4+ T lymphocytes was identified to characterize Th1/Th2 balance. Th1/Th2 balance was evaluated before operation and until postoperative days (POD) 14.

Results

The preoperative Th1/Th2 ratio was significantly lower in patients with malignancy compared with control. The Th1/Th2 ratio of patients in all groups decreased significantly postoperatively. Th1/Th2 balance on POD 2 in patients with malignancy was significantly decreased compared to patients with laparoscopic cholecystectomy, but there were no significant differences among the four groups on POD 14.

Conclusion

Patients with malignancy showed an abnormal perioperative Th1/Th2 balance suggesting predominance of a type-2 immune response. Major abdominal surgeries induce a marked shift in Th1/Th2 balance toward Th2 in the early postoperative stage.

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Title: Perioperative immune responses in cancer patients undergoing digestive surgeries
Authors: Masashi Ishikawa
Masanori Nishioka
Norikazu Hanaki
Takayuki Miyauchi
Yutaka Kashiwagi
Hiromi Ioki
Akihiro Kagawa
Yoichi Nakamura
Publication date: 01-12-2009
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2009
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-7-7

At a glance: The STEP trials

Springer Medicine

Perioperative immune responses in cancer patients undergoing digestive surgeries

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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