Top

World Journal of Surgical Oncology

Published in:

Open Access 01-12-2009 | Case report

Synchronous association of rectal adenocarcinoma and three ileal carcinoids: a case report

Authors: Seamus M McHugh, Jill O'Donnell, Peter Gillen

Published in: World Journal of Surgical Oncology | Issue 1/2009

Abstract

Background

Synchronous midgut carcinoids with gastrointestinal adenocarcinoma are a rare but recognised association.

Case presentation

The patient, a 74 year old woman, underwent anterior resection for a low rectal adenocarcinoma. Intra-operatively 3 serosal deposits of tumour were noted in the distal ileum. Histology revealed these to be ileal carcinoids.

Conclusion

During resection of a gastrointestinal tumour, a thorough inspection of the abdominal cavity should be undertaken to investigate the possibility of metastatic secondaries or a synchronous tumour as is reported in this case.

Available only for authorised users

Jenson RT: Carcinoid and pancreatic endocrine tumors: recent advances in molecular pathogenesis, localization, and treatment. Curr Opin Oncol. 2000, 12: 368-77. 10.1097/00001622-200007000-00015.CrossRef

Maggard M, O'Connell JB, Ko CY: Updated population-based review of carcinoid tumors. Ann Surg. 2004, 240 (1): 117-22. 10.1097/01.sla.0000129342.67174.67.PubMedCentralCrossRefPubMed

Pearson CM, Fitzgerald PJ: Carcinoid tumours: A re-emphasis of their malignant nature: Review of 140 cases. Cancer. 1949, 2: 1005-26. 10.1002/1097-0142(194911)2:6<1005::AID-CNCR2820020608>3.0.CO;2-1.CrossRefPubMed

Lotliker U, Fogler R, Novetsky AD, Yoon NY: Concurrent colonic carcinoma and small bowel carcinoid tumour: Case reports and review of the literature. Dis Colon Rectum. 1982, 25: 375-82. 10.1007/BF02553621.CrossRef

Brown NK, Smith MP: Neoplastic diathesis of patients with carcinoid: Report of a case with four other neoplasms. Cancer. 1973, 32: 216-22. 10.1002/1097-0142(197307)32:1<216::AID-CNCR2820320132>3.0.CO;2-5.CrossRefPubMed

Khubchandani M, Alford JE: Primary carcinoid and carcinoma of the rectum occurring simultaneously: Report of a case. Dis Colon Rectum. 1974, 17: 117-22. 10.1007/BF02587554.CrossRefPubMed

Sparta D, Massimilliano B, Lleshi A, Rossela F, Santo B, Salvatore B: Right colon cancer and incidental ileal carcinoid: case report. Acta Chirurgica Mediterranea. 2005, 21: 15-

Sweeney JF, Rosemurgy AS: Carcinoid tumors of the gut. Cancer Control. 1997, 4 (1): 18-24.PubMed

Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A, Evans DB: One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008, 26 (18): 3063-72. 10.1200/JCO.2007.15.4377.CrossRefPubMed

10.

Berge T, Linell F: Carcinoid tumours. Frequency in a defined population during a 12-year period. Acta Pathol Mircobio Immunol Scand [A]. 1976, 84 (4): 322-330.

11.

O'Toole D, Hentic O, Corcos O, Ruszniewski P: Chemotherapy for Gastro-Enteropancreatic Tumours. Neuroendocrinology. 2004, 80 Suppl 1: 79-84. 10.1159/000080747.CrossRefPubMed

12.

Sutton R, Doran HE, Williams EM, Vora J, Vinjamuri S, Evans J, Campbell F, Raraty MG, Ghaneh P, Hartley M, Poston GJ, Neoptolemos JP: Surgery for midgut carcinoid. Endocrine-Related Cancer. 2003, 469-481. 10.1677/erc.0.0100469. 10

13.

Eriksson B, Klöppel G, Krenning E, Ahlman H, Plöckinger U, Wiedenmann B, Arnold R, Auernhammer C, Körner M, Rindi G, Wildi S, Frascati Consensus Conference participants: Consensus guidelines for the management of patients with digestive neuroendocrine tumors – Well-differentiated Jejunal-ileal tumor/carcinoma. Neuroendocrinology. 2008, 87: 8-19. 10.1159/000111034.CrossRefPubMed

14.

Gerstle JT, Kauffman GL, Koltun WA: The incidence, management, and outcome of patients with gastrointestinal carcinoids and second primary malignancy. J Am Coll Surg. 1995, 180: 427-32.PubMed

15.

Zucker KA, Longo WE, Modlin IM, Bilchik AJ, Adrian TE: Malignant diathesis from jejuno-ileal carcinoids. Am J Gastroenterol. 1989, 84: 182-186.PubMed

16.

Reubi JC, Schaer JC, Waser B: Cholecystokinin (CCK)-A and CCK-B/gastrin receptors in human tumors. Cancer Res. 1997, 57: 1377-1386.PubMed

17.

Habal N, Sims C, Bilchik AJ: Gastrointestinal carcinoid tumors and second primary malignancies. J Surg Oncol. 2000, 75: 310-316. 10.1002/1096-9098(200012)75:4<306::AID-JSO14>3.0.CO;2-3.CrossRefPubMed

18.

McCabe HL: Adenocarcinoma of the gastro-oesophageal junction with a synchronous carcinoid of the duodenum. Postgrad Medical Journal, BMJ. 2001, 77: 255-256. 10.1136/pmj.77.906.255.CrossRef

Title: Synchronous association of rectal adenocarcinoma and three ileal carcinoids: a case report
Authors: Seamus M McHugh
Jill O'Donnell
Peter Gillen
Publication date: 01-12-2009
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2009
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-7-21

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Synchronous association of rectal adenocarcinoma and three ileal carcinoids: a case report

Abstract

Background

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2009

Three synchronous primary carcinomas in a patient with HNPCC associated with a novel germline mutation in MLH1: Case report

Peritoneal carcinomatosis: patients selection, perioperative complications and quality of life related to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Perioperative immune responses in cancer patients undergoing digestive surgeries

Taurolidine reduces the tumor stimulating cytokine interleukin-1beta in patients with resectable gastrointestinal cancer: a multicentre prospective randomized trial

Paraganglioma of the filum terminale: case report

P38 MAP Kinase inhibition promotes primary tumour growth via VEGF independent mechanism