Skip to main content
Top
Published in: World Journal of Surgical Oncology 1/2014

Open Access 01-12-2014 | Case report

Carcinosarcoma of native renal pelvis in recipient after a renal transplant: a case report

Authors: Jitao Wu, Xuyun Wang, Chunhua Lin, Shengqiang Yu, Li Cai, Zhenli Gao

Published in: World Journal of Surgical Oncology | Issue 1/2014

Login to get access

Abstract

Background

Carcinosarcoma is a malignancy that rarely occurs in the renal pelvis.

Materials and methods

We present a case of histologically proven, native renal pelvis carcinosarcoma in a 65-year-old woman who had accepted a renal transplant. We performed a laparoscopic ureterectomy, combined with lymph node dissection and immunosuppression with sirolimus (SRL), which was alternated with the conventional immunosuppressant - cyclosporine.

Results

This patient was still alive 34 months after renal transplantation.

Conclusions

Operation is still the best choice, and the SRL may be beneficial for preventing the progression of a tumor.
Appendix
Available only for authorised users
Literature
1.
go back to reference Penn I: Occurrence of cancers in immunosuppressed organ transplant recipients. Clin Transpl. 1994, 1994: 99-109. Penn I: Occurrence of cancers in immunosuppressed organ transplant recipients. Clin Transpl. 1994, 1994: 99-109.
2.
3.
go back to reference Navarro MD, Lopez-Andreu M, Rodriguez-Benot A, Aguera ML, Del Castillo D, Aljama P: Cancer incidence and survival in kidney transplant patients. Transplant Proc. 2008, 40: 2936-2940. 10.1016/j.transproceed.2008.09.025.CrossRefPubMed Navarro MD, Lopez-Andreu M, Rodriguez-Benot A, Aguera ML, Del Castillo D, Aljama P: Cancer incidence and survival in kidney transplant patients. Transplant Proc. 2008, 40: 2936-2940. 10.1016/j.transproceed.2008.09.025.CrossRefPubMed
4.
go back to reference Morath C, Mueller M, Goldschmidt H, Schwenger V, Opelz G, Zeier M: Malignancy in renal transplantation. J Am Soc Nephrol. 2004, 15: 1582-1588. 10.1097/01.ASN.0000126194.77004.9B.CrossRefPubMed Morath C, Mueller M, Goldschmidt H, Schwenger V, Opelz G, Zeier M: Malignancy in renal transplantation. J Am Soc Nephrol. 2004, 15: 1582-1588. 10.1097/01.ASN.0000126194.77004.9B.CrossRefPubMed
5.
go back to reference Melchior S, Franzaring L, Shardan A, Schwenke C, Plümpe A, Schnell R, Dreikorn K: Urological de novo malignancy after kidney transplantation: a case for the urologist. J Urol. 2011, 185: 428-432. 10.1016/j.juro.2010.09.091.CrossRefPubMed Melchior S, Franzaring L, Shardan A, Schwenke C, Plümpe A, Schnell R, Dreikorn K: Urological de novo malignancy after kidney transplantation: a case for the urologist. J Urol. 2011, 185: 428-432. 10.1016/j.juro.2010.09.091.CrossRefPubMed
6.
go back to reference Qu X, Wang X, Huang X, Li X, Li J, Zhang X: Clinical analysis of urothelial cancer after renal transplantation. Beijing Da Xue Xue Bao. 2011, 43: 579-581.PubMed Qu X, Wang X, Huang X, Li X, Li J, Zhang X: Clinical analysis of urothelial cancer after renal transplantation. Beijing Da Xue Xue Bao. 2011, 43: 579-581.PubMed
7.
go back to reference Wang J, Wang FW, Kessinger A: The natural history and outcomes of the patients with carcinosarcoma involving kidney and renal pelvis. Adv Urol. 2011, 2011: 693964-PubMedCentralCrossRefPubMed Wang J, Wang FW, Kessinger A: The natural history and outcomes of the patients with carcinosarcoma involving kidney and renal pelvis. Adv Urol. 2011, 2011: 693964-PubMedCentralCrossRefPubMed
8.
9.
go back to reference Yilmaz E, Birlik B, Arican Z, Guney S: Carcinosarcoma of the renal pelvis and urinary bladder: a case report. Korean J Radiol. 2003, 4: 255-259. 10.3348/kjr.2003.4.4.255.PubMedCentralCrossRefPubMed Yilmaz E, Birlik B, Arican Z, Guney S: Carcinosarcoma of the renal pelvis and urinary bladder: a case report. Korean J Radiol. 2003, 4: 255-259. 10.3348/kjr.2003.4.4.255.PubMedCentralCrossRefPubMed
10.
go back to reference Deshmukh SD, Gaopande VL, Pande DP, Pathak GS, Kulkarni BK: Carcinosarcoma of renal pelvis with immunohistochemical correlation. Gulf J Oncol. 2012, 12: 65-69. Deshmukh SD, Gaopande VL, Pande DP, Pathak GS, Kulkarni BK: Carcinosarcoma of renal pelvis with immunohistochemical correlation. Gulf J Oncol. 2012, 12: 65-69.
11.
go back to reference Chiu KC, Lin MC, Liang YC, Chen CY: Renal carcinosarcoma: case report and review of literature. Ren Fail. 2008, 30: 1034-1039. 10.1080/08860220802403192.CrossRefPubMed Chiu KC, Lin MC, Liang YC, Chen CY: Renal carcinosarcoma: case report and review of literature. Ren Fail. 2008, 30: 1034-1039. 10.1080/08860220802403192.CrossRefPubMed
12.
go back to reference Hisataki T, Takahashi A, Taguchi K, Shimizu T, Suzuki K, Takatsuka K, Iwaki H: Sarcomatoid transitional cell carcinoma originating from a duplicated renal pelvis. Int J Urol. 2001, 8: 704-706. 10.1046/j.1442-2042.2001.00396.x.CrossRefPubMed Hisataki T, Takahashi A, Taguchi K, Shimizu T, Suzuki K, Takatsuka K, Iwaki H: Sarcomatoid transitional cell carcinoma originating from a duplicated renal pelvis. Int J Urol. 2001, 8: 704-706. 10.1046/j.1442-2042.2001.00396.x.CrossRefPubMed
13.
go back to reference Hojo M, Morimoto T, Maluccio M, Asano T, Morimoto K, Lagman M, Shimbo T, Suthanthiran M: Cyclosporine induces cancer progression by a cell-autonomous mechanism. Nature. 1999, 397: 530-534. 10.1038/17401.CrossRefPubMed Hojo M, Morimoto T, Maluccio M, Asano T, Morimoto K, Lagman M, Shimbo T, Suthanthiran M: Cyclosporine induces cancer progression by a cell-autonomous mechanism. Nature. 1999, 397: 530-534. 10.1038/17401.CrossRefPubMed
14.
go back to reference Lebranchu Y, Snanoudj R, Toupance O, Weestel PF, De Ligny BH, Buchler M, Rerolle JP, Thierry A, Moulin B, Subra JF: Five‒year results of a randomized trial comparing de novo sirolimus and cyclosporine in renal transplantation: the spiesser study. Am J Transplant. 2012, 12: 1801-1810. 10.1111/j.1600-6143.2012.04036.x.CrossRefPubMed Lebranchu Y, Snanoudj R, Toupance O, Weestel PF, De Ligny BH, Buchler M, Rerolle JP, Thierry A, Moulin B, Subra JF: Five‒year results of a randomized trial comparing de novo sirolimus and cyclosporine in renal transplantation: the spiesser study. Am J Transplant. 2012, 12: 1801-1810. 10.1111/j.1600-6143.2012.04036.x.CrossRefPubMed
15.
go back to reference Garrouste C, Kamar N, Guilbeau-Frugier C, Guitard J, Esposito L, Lavayssiere L, Nogier M-B, Cointault O, Ribes D, Rostaing L: Long-term results of conversion from calcineurin inhibitors to sirolimus in 150 maintenance kidney transplant patients. Exp Clin Transplant. 2012, 10: 110-118. 10.6002/ect.2011.0116.CrossRefPubMed Garrouste C, Kamar N, Guilbeau-Frugier C, Guitard J, Esposito L, Lavayssiere L, Nogier M-B, Cointault O, Ribes D, Rostaing L: Long-term results of conversion from calcineurin inhibitors to sirolimus in 150 maintenance kidney transplant patients. Exp Clin Transplant. 2012, 10: 110-118. 10.6002/ect.2011.0116.CrossRefPubMed
16.
go back to reference Guba M, Yezhelyev M, Eichhorn ME, Schmid G, Ischenko I, Papyan A, Graeb C, Seeliger H, Geissler EK, Jauch K-W: Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF. Blood. 2005, 105: 4463-4469. 10.1182/blood-2004-09-3540.CrossRefPubMed Guba M, Yezhelyev M, Eichhorn ME, Schmid G, Ischenko I, Papyan A, Graeb C, Seeliger H, Geissler EK, Jauch K-W: Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF. Blood. 2005, 105: 4463-4469. 10.1182/blood-2004-09-3540.CrossRefPubMed
17.
go back to reference Lopez-Beltran A, Escudero AL, Cavazzana AO, Spagnoli LG, Vicioso-Recio L: Sarcomatoid transitional cell carcinoma of the renal pelvis. A report of five cases with clinical, pathological, immunohistochemical and DNA ploidy analysis. Pathol Res Pract. 1996, 192: 1218-1224. 10.1016/S0344-0338(96)80154-3.CrossRefPubMed Lopez-Beltran A, Escudero AL, Cavazzana AO, Spagnoli LG, Vicioso-Recio L: Sarcomatoid transitional cell carcinoma of the renal pelvis. A report of five cases with clinical, pathological, immunohistochemical and DNA ploidy analysis. Pathol Res Pract. 1996, 192: 1218-1224. 10.1016/S0344-0338(96)80154-3.CrossRefPubMed
18.
go back to reference Acikalin MF, Kabukcuoglu S, Can C: Sarcomatoid carcinoma of the renal pelvis with giant cell tumor‒like features: case report with immunohistochemical findings. Int J Urol. 2005, 12: 199-203. 10.1111/j.1442-2042.2005.01002.x.CrossRefPubMed Acikalin MF, Kabukcuoglu S, Can C: Sarcomatoid carcinoma of the renal pelvis with giant cell tumor‒like features: case report with immunohistochemical findings. Int J Urol. 2005, 12: 199-203. 10.1111/j.1442-2042.2005.01002.x.CrossRefPubMed
19.
go back to reference Petsch M, Planz B, Tschahargane C, Caspers H: Primary sarcomatoid carcinoma of the ureter. Aktuelle Urol. 2004, 35: 137-139. 10.1055/s-2004-818363.CrossRefPubMed Petsch M, Planz B, Tschahargane C, Caspers H: Primary sarcomatoid carcinoma of the ureter. Aktuelle Urol. 2004, 35: 137-139. 10.1055/s-2004-818363.CrossRefPubMed
20.
go back to reference Thiel DD, Igel TC, Wu KJ: Sarcomatoid carcinoma of transitional cell origin confined to renal pelvis. Urology. 2006, 67: 622-e629-622. e611CrossRefPubMed Thiel DD, Igel TC, Wu KJ: Sarcomatoid carcinoma of transitional cell origin confined to renal pelvis. Urology. 2006, 67: 622-e629-622. e611CrossRefPubMed
21.
go back to reference Kälble T, Lucan M, Nicita G, Sells R, Revilla F, Wiesel M: EAU guidelines on renal transplantation. Eur Urol. 2005, 47: 156-166. 10.1016/j.eururo.2004.02.009.CrossRefPubMed Kälble T, Lucan M, Nicita G, Sells R, Revilla F, Wiesel M: EAU guidelines on renal transplantation. Eur Urol. 2005, 47: 156-166. 10.1016/j.eururo.2004.02.009.CrossRefPubMed
Metadata
Title
Carcinosarcoma of native renal pelvis in recipient after a renal transplant: a case report
Authors
Jitao Wu
Xuyun Wang
Chunhua Lin
Shengqiang Yu
Li Cai
Zhenli Gao
Publication date
01-12-2014
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2014
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-12-407

Other articles of this Issue 1/2014

World Journal of Surgical Oncology 1/2014 Go to the issue