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World Journal of Surgical Oncology

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Open Access 01-12-2014 | Research

Prediction of tumor recurrence after curative resection in gastric carcinoma based on bcl-2 expression

Authors: Jianghong Wu, Xiaowen Liu, Hong Cai, Yanong Wang

Published in: World Journal of Surgical Oncology | Issue 1/2014

Abstract

Background

There are currently no reliable predictive factors for gastric cancer recurrence. The aim of this study was to evaluate the relationship between bcl-2 expression and risk of gastric cancer recurrence.

Methods

From January 1996 to December 2007, 449 gastric cancer patients who underwent curative resection were retrospectively studied. The expression levels of bcl-2 were examined by immunohistochemistry. Logistic regression was performed to identify independent risk factors for overall recurrence of gastric cancer.

Results

151 patients (33.6%) experienced recurrences. The median time to recurrence was 17.0 months, 113 (74.8%) patients had recurrences within 2 years. Peritoneal recurrence was the most prevalent pattern, followed by hematogenous metastasis in which the liver was the most common site. Depth of invasion, lymph node metastases, and negative expression of bcl-2 were independent risk factors for overall recurrence. The overall survival time of recurrent patients was 22.7 months. The median survival time after recurrence was 6.7 months.

Conclusion

The depth of invasion, lymph node metastases and expression of bcl-2 are independent factors for predicting gastric cancer recurrence.

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Title: Prediction of tumor recurrence after curative resection in gastric carcinoma based on bcl-2 expression
Authors: Jianghong Wu
Xiaowen Liu
Hong Cai
Yanong Wang
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2014
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-12-40

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prediction of tumor recurrence after curative resection in gastric carcinoma based on bcl-2 expression

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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