Top

Published in:

Open Access 01-12-2014 | Case report

A case report on efficacy of Abound™ for anti-EGFR antibody-associated skin disorder in metastatic colon cancer

Authors: Nobuhisa Matsuhashi, Takao Takahashi, Kenichi Nonaka, Kengo Ichikawa, Kazunori Yawata, Toshiyuki Tanahashi, Hisashi Imai, Yoshiyuki Sasaki, Yoshihiro Tanaka, Naoki Okumura, Kazuya Yamaguchi, Shinji Osada, Kazuhiro Yoshida

Published in: World Journal of Surgical Oncology | Issue 1/2014

Abstract

Background

Panitumumab is a full human epidermal growth factor receptor (EGFR) monoclonal antibody, an agent for metastatic colorectal cancer therapy. One of the most general adverse events of anti-EGFR monoclonal antibody therapy is skin disorder. At the present time, although prophylaxis of skin disorder is important for continuation of cancer therapy, there are no effective precautionary treatments.

Case presentation

A 73-year-old male with sigmoid colon cancer and synchronous lung metastasis was treated with panitumumab, an alone anti-EGFR monoclonal antibody as the third-line therapy.

During the nine courses of the therapy, the response was stable disease (SD), but skin disorder gradually appeared obviously (CTCAE version 4.0: Grade 2). After 1 month of administration of Abound™, symptoms of the skin disorder improved (CTCAE version 4.0: Grade 1), thus the antibody therapy could be continued.

Conclusion

We report that Abound™ was apparently effective in the treatment for anti-EGFR antibody-associated skin disorder. In the future, Abound™ could be expected as an agent for skin disorder as one of the side effects of colorectal cancer therapy.

Available only for authorised users

Berk L, James J, Schwartz A, Hug E, Mahadevan A, Samuels M, Kachnic L, RTOG: A randomized, double-blind, placebo-controlled trial of a β-hydroxyl β-methyl butyrate, glutamine, and argininemixture for the treatment of cancer cachexia (RTOG 0122). Support Care Cancer. 2008, 16: 1179-1188. 10.1007/s00520-008-0403-7.CrossRefPubMed

Marcoraa S, Lemmeya A, Maddisona P: Dietary treatment of rheumatoid cachexia with b-hydroxy-b-methylbutyrate, glutamine andarginine: a randomised controlled trial. Clin Nutr. 2005, 24: 442-454. 10.1016/j.clnu.2005.01.006.CrossRef

Douillard JY, Siena S, Cassidy J, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, Rivera F, Kocákova I, Ruff P, Błasińska-Morawiec M, Šmakal M, Canon JL, Rother M, Oliner KS, Wolf M, Gansert J: Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol. 2010, 28 (31): 4697-4705. 10.1200/JCO.2009.27.4860.CrossRefPubMed

Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, Juan T, Sikorski R, Suggs S, Radinsky R, Patterson SD, Chang DD: Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol. 2008, 26 (10): 1626-1634. 10.1200/JCO.2007.14.7116.CrossRefPubMed

Peeters M, Price TJ, Cervantes A, Sobrero AF, Ducreux M, Hotko Y, André T, Chan E, Lordick F, Punt CJ, Strickland AH, Wilson G, Ciuleanu TE, Roman L, Van Cutsem E, Tzekova V, Collins S, Oliner KS, Rong A, Gansert J: Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. J Clin Oncol. 2010, 28 (31): 4706-4713. 10.1200/JCO.2009.27.6055.CrossRefPubMed

Moroni M, Veronese S, Benvenuti S, Marrapese G, Sartore-Bianchi A, Di Nicolantonio F, Gambacorta M, Siena S, Bardelli A: Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol. 2005, 6 (5): 279-286. 10.1016/S1470-2045(05)70102-9.CrossRefPubMed

Folprecht G, Lutz MP, Schöffski P, Seufferlein T, Nolting A, Pollert P, Köhne CH: Cetuximab and irinotecan/5-fluorouracil/folinic acid is a safe combination for the first-line treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma. Ann Oncol. 2006, 17 (3): 450-456. 10.1093/annonc/mdj084.CrossRefPubMed

Personeni N, Hendlisz A, Gallez J, Galdon MG, Larsimont D, Van Laethem JL, Nagy N, Barette M, Paesmans M, Cardoso F, Bleiberg H: Correlation between the response to cetuximab alone or in combination with irinotecan and the activated/phosphorylated epidermal growth factor receptor in metastatic colorectal cancer. Semin Oncol. 2005, 32 (6 Suppl 9): S59-S62.CrossRefPubMed

Lièvre A, Bachet JB, Le Corre D, Boige V, Landi B, Emile JF, Côté JF, Tomasic G, Penna C, Ducreux M, Rougier P, Penault-Llorca F, Laurent-Puig P: KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 2006, 66 (8): 3992-3995. 10.1158/0008-5472.CAN-06-0191.CrossRefPubMed

10.

Su X, Lacouture ME, Jia Y, Wu S: Risk of high-grade skin rash in cancer patients treated with cetuximab – an antibody against epidermal growth factor receptor: systemic review and meta-analysis. Oncol. 2009, 77 (2): 124-133. 10.1159/000229752.CrossRef

11.

Gatzemeier U, von Pawel J, Vynnychenko I, Zatloukal P, de Marinis F, Eberhardt WE, Paz-Ares L, Schumacher KM, Goddemeier T, O’Byrne KJ, Pirker R: First-cycle rash and survival in patients with advanced non-small-cell lung cancer receiving cetuximab in combination with first-line chemotherapy: a subgroup analysis of data from the FLEX phase 3 study. Lancet Oncol. 2011, 12 (1): 30-37. 10.1016/S1470-2045(10)70278-3.CrossRefPubMed

12.

Pirker R, Pereira JR, von Pawel J, Krzakowski M, Ramlau R, Park K, de Marinis F, Eberhardt WE, Paz-Ares L, Störkel S, Schumacher KM, von Heydebreck A, Celik I, O'Byrne KJ: EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study. Lancet Oncol. 2012, 13: 33-42. 10.1016/S1470-2045(11)70318-7.CrossRefPubMed

13.

Scope A, Agero AL, Dusza SW, Myskowski PL, Lieb JA, Saltz L, Kemeny NE, Halpern AC: Randomized double-blind trial of prophylactic oral minocycline and topical tazarotene for cetuximab-associated acne-like eruption. J Clin Oncol. 2007, 25 (34): 5390-5396. 10.1200/JCO.2007.12.6987.CrossRefPubMed

14.

May PE, Barber A, D’Olimpio JT, Hourihane A, Abumrad NN: Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine. Am J Sur. 2002, 183 (4): 471-479. 10.1016/S0002-9610(02)00823-1.CrossRef

15.

Williams JZ, Abumrad N, Barbul A: Effect of a specialized amino acid mixture on human collagen deposition. Ann Surg. 2002, 236 (3): 369-375. 10.1097/00000658-200209000-00013.PubMedCentralCrossRefPubMed

16.

Clark RH, Feleke G, Din M, Yasmin T, Singh G, Khan FA, Rathmacher JA: Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. JPEN J Parenter Enteral Nutr. 2000, 24 (3): 133-139. 10.1177/0148607100024003133.CrossRefPubMed

Title: A case report on efficacy of Abound™ for anti-EGFR antibody-associated skin disorder in metastatic colon cancer
Authors: Nobuhisa Matsuhashi
Takao Takahashi
Kenichi Nonaka
Kengo Ichikawa
Kazunori Yawata
Toshiyuki Tanahashi
Hisashi Imai
Yoshiyuki Sasaki
Yoshihiro Tanaka
Naoki Okumura
Kazuya Yamaguchi
Shinji Osada
Kazuhiro Yoshida
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2014
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-12-35

ACC 2024 Congress

Springer Medicine

A case report on efficacy of Abound™ for anti-EGFR antibody-associated skin disorder in metastatic colon cancer

Abstract

Background

Case presentation

Conclusion

ACC 2024 Congress

Springer Medicine

Abstract

Background

Case presentation

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2014

High expression of periostin is dramatically associated with metastatic potential and poor prognosis of patients with osteosarcoma

Expression of the GLI family genes is associated with tumor progression in advanced lung adenocarcinoma

Secondary bile acids: an underrecognized cause of colon cancer

Curative use of forequarter amputation for recurrent breast cancer over an axillary area: a case report and literature review

Sleep disturbances and quality of life in postoperative management after esophagectomy for esophageal cancer

Diffusion weighted magnetic resonance imaging demonstrates tumor response following palliative embolization of a recurrent shoulder plasmacytoma