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World Journal of Surgical Oncology

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Open Access 01-12-2014 | Research

Marginal resection for osteosarcoma with effective neoadjuvant chemotherapy: long-term outcomes

Authors: Ming Xu, SongFeng Xu, XiuChun Yu

Published in: World Journal of Surgical Oncology | Issue 1/2014

Abstract

Background

We report the long-term outcomes of patients with osteosarcoma who underwent effective preoperative chemotherapy and subsequently underwent marginal resection.

Methods

We reviewed the records of 50 patients with osteosarcoma who underwent marginal resection following effective preoperative chemotherapy; 18 were treated with the MMIA (high-dose methotrexate (HD-MTX), adriamycin (ADR), ifosfamide (IFO)) and cisplatin (DDP), and 32 patients were treated with the DIA (DDP, ADR and IFO). protocol. The functions of the affected limb were evaluated using the revised MSTS93 system. The Kaplan-Meier method was used for survival analysis.

Results

After a median follow-up of 5.5 years, the rates were: overall 5-year cumulative survival 61.7%, event-free survival 57.7%, recurrence 8.5%, pulmonary metastases 42.6%, and excellent to good function of the affected limb 57.7%.

Conclusions

Our results showed that marginal resection can be performed in patients with osteosarcoma who obtain clinically favorable responses to chemotherapy. Patients had a good clinical course and there was no negative effect on rates of survival or local recurrence.

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Title: Marginal resection for osteosarcoma with effective neoadjuvant chemotherapy: long-term outcomes
Authors: Ming Xu
SongFeng Xu
XiuChun Yu
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2014
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-12-341

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Marginal resection for osteosarcoma with effective neoadjuvant chemotherapy: long-term outcomes

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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