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Published in: World Journal of Surgical Oncology 1/2014

Open Access 01-12-2014 | Research

Does a continuous local anaesthetic pain treatment after immediate tissue expander reconstruction in breast carcinoma patients more efficiently reduce acute postoperative pain - a prospective randomised study

Authors: Branka Strazisar, Nikola Besic, Uros Ahcan

Published in: World Journal of Surgical Oncology | Issue 1/2014

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Abstract

Background

Immediate breast reconstruction with an expander is a reasonable option for properly selected patients. After reconstruction, patients have severe postoperative pain, which responds poorly to opioids. Our aim was to evaluate if continuous wound infusion of a local anaesthetic into the surgical wound reduces postoperative pain, consumption of opioids and incidence of chronic pain compared to standard intravenous piritramide after primary breast reconstruction in breast carcinoma patients.

Methods

Altogether, 60 patients were enrolled in our study; one half in the group with wound infusion of a local anaesthetic, and the other half in the standard (piritramide) group. Parameters measured included: pain intensity (visual analogue scale), drug requirements, alertness, hospitalisation, side-effects and late complications. A p-value of < 0.05 was considered statistically significant.

Results

In the recovery room, the test group reported less acute pain at rest (P = 0.03) and at activity (P = 0.01), and on the day of the surgical procedure they reported less pain at activity (P = 0.003). Consumption of piritramide and metoclopramide was lower in this group (P < 0.0001), but their alertness after the surgical procedure was higher compared to the standard group (P < 0.001). After three months, the test group reported less chronic pain (P = 0.01).

Conclusions

After primary tissue expander breast reconstruction, wound infusion of a local anaesthetic significantly reduces acute pain and enables reduced opioid consumption, resulting in less postoperative sedation and reduced need for antiemetic drugs. Wound infusion of a local anaesthetic reduces chronic pain.
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Literature
2.
go back to reference Yip CH, Smith RA, Anderson BO, Miller AB, Thomas DB, Ang ES, Caffarella RS, Corbex M, Kreps GL, McTiernan A: Guideline implementation for breast healthcare in low-income and middle-income countries: overview of the Breast Health Global Initiative Global Summit 2007. Cancer. 2008, 113 (8 suppl): 2221-2243.PubMed Yip CH, Smith RA, Anderson BO, Miller AB, Thomas DB, Ang ES, Caffarella RS, Corbex M, Kreps GL, McTiernan A: Guideline implementation for breast healthcare in low-income and middle-income countries: overview of the Breast Health Global Initiative Global Summit 2007. Cancer. 2008, 113 (8 suppl): 2221-2243.PubMed
3.
go back to reference Cordeiro PG: Breast Reconstruction after Surgery for Breast Cancer. N Engl J Med. 2008, 359: 1590-1601. 10.1056/NEJMct0802899.CrossRefPubMed Cordeiro PG: Breast Reconstruction after Surgery for Breast Cancer. N Engl J Med. 2008, 359: 1590-1601. 10.1056/NEJMct0802899.CrossRefPubMed
4.
go back to reference Garcia-Etienne CA, Forcellini D, Sagona A, Caviggioli F, Barbieri E, Cornegliani G, Giannasi S, Tinterri C: Breast reconstruction: a quality measure for breast cancer care?. Breast. 2012, 21: 105-106. 10.1016/j.breast.2011.08.133.CrossRefPubMed Garcia-Etienne CA, Forcellini D, Sagona A, Caviggioli F, Barbieri E, Cornegliani G, Giannasi S, Tinterri C: Breast reconstruction: a quality measure for breast cancer care?. Breast. 2012, 21: 105-106. 10.1016/j.breast.2011.08.133.CrossRefPubMed
5.
go back to reference Spear SL, Spittler CJ: Breast reconstruction with implants and expanders. Plast Reconstr Surg. 2001, 107: 177-187. 10.1097/00006534-200101000-00029.CrossRefPubMed Spear SL, Spittler CJ: Breast reconstruction with implants and expanders. Plast Reconstr Surg. 2001, 107: 177-187. 10.1097/00006534-200101000-00029.CrossRefPubMed
6.
go back to reference Legeby M, Segerdahl M, Sandelin K, Wickman M, Ostman K, Olofsson C: Immediate reconstruction in breast cancer surgery requires intensive post-operative pain treatment but the effects of axillary dissection may be more predictive of chronic pain. Breast. 2002, 11: 156-162. 10.1054/brst.2001.0386.CrossRefPubMed Legeby M, Segerdahl M, Sandelin K, Wickman M, Ostman K, Olofsson C: Immediate reconstruction in breast cancer surgery requires intensive post-operative pain treatment but the effects of axillary dissection may be more predictive of chronic pain. Breast. 2002, 11: 156-162. 10.1054/brst.2001.0386.CrossRefPubMed
7.
go back to reference Rawal N, Gupta A, Helsing M, Grell K, Allvin R: Pain relief following breast augmentation surgery: a comparison between incisional patient-controlled regional analgesia and traditional oral analgesia. Eur J Anaesthesiol. 2006, 23: 1010-1017. 10.1017/S0265021506000883.CrossRefPubMed Rawal N, Gupta A, Helsing M, Grell K, Allvin R: Pain relief following breast augmentation surgery: a comparison between incisional patient-controlled regional analgesia and traditional oral analgesia. Eur J Anaesthesiol. 2006, 23: 1010-1017. 10.1017/S0265021506000883.CrossRefPubMed
8.
go back to reference Legeby M, Jurell G, Beausang-Linder M, Olofsson C: Placebo-controlled trial of local anaesthesia for treatment of pain after breast reconstruction. Scand J Plast Reconstr Surg Hand Surg. 2009, 43: 315-319. 10.1080/02844310903259108.CrossRefPubMed Legeby M, Jurell G, Beausang-Linder M, Olofsson C: Placebo-controlled trial of local anaesthesia for treatment of pain after breast reconstruction. Scand J Plast Reconstr Surg Hand Surg. 2009, 43: 315-319. 10.1080/02844310903259108.CrossRefPubMed
9.
go back to reference Turan Z, Sandelin K: Local infiltration of anaesthesia with subpectoral indwelling catheters after immediate breast reconstruction with implants: a pilot study. Scand J Plast Reconstr Surg Hand Surg. 2006, 40: 136-139. 10.1080/02844310500475784.CrossRefPubMed Turan Z, Sandelin K: Local infiltration of anaesthesia with subpectoral indwelling catheters after immediate breast reconstruction with implants: a pilot study. Scand J Plast Reconstr Surg Hand Surg. 2006, 40: 136-139. 10.1080/02844310500475784.CrossRefPubMed
10.
go back to reference Lu L, Fine NA: The efficacy of continuous local anesthetic infiltration in breast surgery: reduction mammaplasty and reconstruction. Plast Recronstr Surg. 2005, 115: 1927-1934. 10.1097/01.PRS.0000163332.04220.BD.CrossRef Lu L, Fine NA: The efficacy of continuous local anesthetic infiltration in breast surgery: reduction mammaplasty and reconstruction. Plast Recronstr Surg. 2005, 115: 1927-1934. 10.1097/01.PRS.0000163332.04220.BD.CrossRef
11.
go back to reference Schell SR: Patient outcomes after axillary lymph node dissection for breast cancer: use of postoperative continuous local anesthesia infusion. J Surg Res. 2006, 134: 124-132. 10.1016/j.jss.2005.11.571.CrossRefPubMed Schell SR: Patient outcomes after axillary lymph node dissection for breast cancer: use of postoperative continuous local anesthesia infusion. J Surg Res. 2006, 134: 124-132. 10.1016/j.jss.2005.11.571.CrossRefPubMed
12.
go back to reference Jacobs VR, Morrison JE: Application of a locally placed anesthesia catheter for reduction of postoperative pain after mastectomy for breast cancer. Int J Fertil Womens Med. 2006, 51: 225-229.PubMed Jacobs VR, Morrison JE: Application of a locally placed anesthesia catheter for reduction of postoperative pain after mastectomy for breast cancer. Int J Fertil Womens Med. 2006, 51: 225-229.PubMed
13.
go back to reference Fassoulaki A, Triga A, Melemeni A, Sarantopoulos C: Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer. Anesth Analg. 2005, 101: 1427-1432. 10.1213/01.ANE.0000180200.11626.8E.CrossRefPubMed Fassoulaki A, Triga A, Melemeni A, Sarantopoulos C: Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer. Anesth Analg. 2005, 101: 1427-1432. 10.1213/01.ANE.0000180200.11626.8E.CrossRefPubMed
14.
go back to reference Strazisar B, Besic N: Comparison of continuous local anaesthetic and systemic pain treatment after axillary lymphadenectomy in breast carcinoma patients – a prospective randomized study. Radiol Oncol. 2013, 47: 145-153.PubMedCentralCrossRefPubMed Strazisar B, Besic N: Comparison of continuous local anaesthetic and systemic pain treatment after axillary lymphadenectomy in breast carcinoma patients – a prospective randomized study. Radiol Oncol. 2013, 47: 145-153.PubMedCentralCrossRefPubMed
15.
go back to reference Leone S, Di Cianni S, Casati A, Fanelli G: Pharmacology, toxicology, and clinical use of new long acting local anesthetics, ropivacaine and levobupivacaine. Acta Biomed. 2008, 79: 92-105.PubMed Leone S, Di Cianni S, Casati A, Fanelli G: Pharmacology, toxicology, and clinical use of new long acting local anesthetics, ropivacaine and levobupivacaine. Acta Biomed. 2008, 79: 92-105.PubMed
17.
go back to reference Pacik PT: Pain management in augmentation mammaplasty: a randomized, comparative study of the use of a continuous infusion versus self-administration intermittent bolus of a local anesthetic. Aesthetic Surg J. 2004, 24: 523-530. 10.1016/j.asj.2004.09.003.CrossRef Pacik PT: Pain management in augmentation mammaplasty: a randomized, comparative study of the use of a continuous infusion versus self-administration intermittent bolus of a local anesthetic. Aesthetic Surg J. 2004, 24: 523-530. 10.1016/j.asj.2004.09.003.CrossRef
18.
go back to reference Talbot H, Hutchinson SP, Edbrooke DL, Wrench I, Kohlhardt SR: Evaluation of a local anaesthesia regimen following mastectomy. Anaesthesia. 2004, 59: 664-667. 10.1111/j.1365-2044.2004.03795.x.CrossRefPubMed Talbot H, Hutchinson SP, Edbrooke DL, Wrench I, Kohlhardt SR: Evaluation of a local anaesthesia regimen following mastectomy. Anaesthesia. 2004, 59: 664-667. 10.1111/j.1365-2044.2004.03795.x.CrossRefPubMed
19.
go back to reference Chernik DA, Gillings D, Laine H, Hendler J, Silver JM, Davidson AB, Schwam EM, Siegel JL: Validity and reliability of the Observer's Assessment of Alertness/Sedation Scale: study with intravenous midazolam. J Clin Psychopharmacol. 1990, 10: 244-251.CrossRefPubMed Chernik DA, Gillings D, Laine H, Hendler J, Silver JM, Davidson AB, Schwam EM, Siegel JL: Validity and reliability of the Observer's Assessment of Alertness/Sedation Scale: study with intravenous midazolam. J Clin Psychopharmacol. 1990, 10: 244-251.CrossRefPubMed
20.
go back to reference McCarthy CM, Pusic AL, Hidalgo DA: Efficacy of pocket irrigation with bupivacaine and ketorolac in breast augmentation: a randomized controlled trial. Ann Plast Surg. 2009, 62: 15-17. 10.1097/SAP.0b013e31817e9c5b.CrossRefPubMed McCarthy CM, Pusic AL, Hidalgo DA: Efficacy of pocket irrigation with bupivacaine and ketorolac in breast augmentation: a randomized controlled trial. Ann Plast Surg. 2009, 62: 15-17. 10.1097/SAP.0b013e31817e9c5b.CrossRefPubMed
21.
go back to reference Rawal N, Axelsson K, Hylander J, Allvin R, Amilon A, Lidegran G, Hallén J: Postoperative patient-controlled local anesthetic administration at home. Anesth Analg. 1998, 86: 86-89.PubMed Rawal N, Axelsson K, Hylander J, Allvin R, Amilon A, Lidegran G, Hallén J: Postoperative patient-controlled local anesthetic administration at home. Anesth Analg. 1998, 86: 86-89.PubMed
22.
go back to reference Pacik PT, Nelson CE, Werner C: Pain control in augmentation mammaplasty using indwelling catheters in 687 consecutive patients: data analysis. Aesthetic Surg J. 2008, 28: 631-641. 10.1016/j.asj.2008.09.001.CrossRef Pacik PT, Nelson CE, Werner C: Pain control in augmentation mammaplasty using indwelling catheters in 687 consecutive patients: data analysis. Aesthetic Surg J. 2008, 28: 631-641. 10.1016/j.asj.2008.09.001.CrossRef
23.
go back to reference Mahabir RC, Peterson BD, Williamson JS, Valnicek SM, Williamson DG, East WE: Locally administered ketorolac and bupivacaine for control of postoperative pain in breast augmentation patients. Plast Reconstr Surg. 2004, 114: 1910-1916. 10.1097/01.PRS.0000142996.50331.2C.CrossRefPubMed Mahabir RC, Peterson BD, Williamson JS, Valnicek SM, Williamson DG, East WE: Locally administered ketorolac and bupivacaine for control of postoperative pain in breast augmentation patients. Plast Reconstr Surg. 2004, 114: 1910-1916. 10.1097/01.PRS.0000142996.50331.2C.CrossRefPubMed
24.
go back to reference Mahabir RC, Peterson BD, Williamson JS, Valnicek SM, Williamson DG, East WE: Locally administered ketorolac and bupivacaine for control of postoperative pain in breast augmentation patients: part II. 10-day follow-up. Plast Reconstr Surg. 2008, 121: 638-643. 10.1097/01.prs.0000298112.52389.e1.CrossRefPubMed Mahabir RC, Peterson BD, Williamson JS, Valnicek SM, Williamson DG, East WE: Locally administered ketorolac and bupivacaine for control of postoperative pain in breast augmentation patients: part II. 10-day follow-up. Plast Reconstr Surg. 2008, 121: 638-643. 10.1097/01.prs.0000298112.52389.e1.CrossRefPubMed
25.
go back to reference Gottschalk A, Burmeister MA, Radtke P, Krieg M, Farokhzad F, Kreissl S, Strauss M, Standl T: Continuous wound infiltration with ropivacaine reduces pain and analgesic requirement after shoulder surgery. Anesth Analg. 2003, 97: 1086-1091.CrossRefPubMed Gottschalk A, Burmeister MA, Radtke P, Krieg M, Farokhzad F, Kreissl S, Strauss M, Standl T: Continuous wound infiltration with ropivacaine reduces pain and analgesic requirement after shoulder surgery. Anesth Analg. 2003, 97: 1086-1091.CrossRefPubMed
26.
go back to reference Vintar N, Rawal N, Veselko M: Intraarticular patient-controlled regional anesthesia after arthroscopically assisted anterior cruciate ligament reconstruction: ropivacaine/morphine/ketorolac versus ropivacaine/morphine. Anesth Analg. 2005, 101: 573-578. 10.1213/01.ANE.0000158608.27411.A9.CrossRefPubMed Vintar N, Rawal N, Veselko M: Intraarticular patient-controlled regional anesthesia after arthroscopically assisted anterior cruciate ligament reconstruction: ropivacaine/morphine/ketorolac versus ropivacaine/morphine. Anesth Analg. 2005, 101: 573-578. 10.1213/01.ANE.0000158608.27411.A9.CrossRefPubMed
27.
go back to reference Beaussier M, El'Ayoubi H, Schiffer E, Rollin M, Parc Y, Mazoit JX, Azizi L, Gervaz P, Rohr S, Biermann C, Lienhart A, Eledjam JJ: Continuous preperitoneal infusion of ropivacaine provides effective analgesia and accelerates recovery after colorectal surgery: a randomized, double-blind, placebo-controlled study. Anesthesiology. 2007, 107: 461-468. 10.1097/01.anes.0000278903.91986.19.CrossRefPubMed Beaussier M, El'Ayoubi H, Schiffer E, Rollin M, Parc Y, Mazoit JX, Azizi L, Gervaz P, Rohr S, Biermann C, Lienhart A, Eledjam JJ: Continuous preperitoneal infusion of ropivacaine provides effective analgesia and accelerates recovery after colorectal surgery: a randomized, double-blind, placebo-controlled study. Anesthesiology. 2007, 107: 461-468. 10.1097/01.anes.0000278903.91986.19.CrossRefPubMed
28.
go back to reference Fredman B, Shapiro A, Zohar E, Feldman E, Shorer S, Rawal N, Jedeikin R: The analgesic efficacy of patient-controlled ropivacaine instillation after cesarean delivery. Anesth Analg. 2000, 91: 1436-1440. 10.1097/00000539-200012000-00025.CrossRefPubMed Fredman B, Shapiro A, Zohar E, Feldman E, Shorer S, Rawal N, Jedeikin R: The analgesic efficacy of patient-controlled ropivacaine instillation after cesarean delivery. Anesth Analg. 2000, 91: 1436-1440. 10.1097/00000539-200012000-00025.CrossRefPubMed
29.
go back to reference White PF, Rawal S, Latham P, Markowitz S, Issioui T, Chi L, Dellaria S, Shi C, Morse L, Ing C: Use of a continuous local anesthetic infusion for pain management after median sternotomy. Anesthesiology. 2003, 99: 918-923. 10.1097/00000542-200310000-00026.CrossRefPubMed White PF, Rawal S, Latham P, Markowitz S, Issioui T, Chi L, Dellaria S, Shi C, Morse L, Ing C: Use of a continuous local anesthetic infusion for pain management after median sternotomy. Anesthesiology. 2003, 99: 918-923. 10.1097/00000542-200310000-00026.CrossRefPubMed
30.
go back to reference Fisher A, Meller Y: Continuous postoperative regional analgesia by nerve sheath block for amputation surgery: a pilot study. Anesth Analg. 1991, 72: 300-303.CrossRefPubMed Fisher A, Meller Y: Continuous postoperative regional analgesia by nerve sheath block for amputation surgery: a pilot study. Anesth Analg. 1991, 72: 300-303.CrossRefPubMed
31.
go back to reference Sakuragi T, Ishino H, Dan K: Bactericidal activity of clinically used local anesthetics on Staphylococcus aureus. Reg Anesth. 1996, 21: 239-242.PubMed Sakuragi T, Ishino H, Dan K: Bactericidal activity of clinically used local anesthetics on Staphylococcus aureus. Reg Anesth. 1996, 21: 239-242.PubMed
32.
go back to reference Stratford AF, Zoutman DE, Davidson JSD: Effect of lidocaine and epinephrine on Staphylococcus aureus in a guinea pig model of surgical wound infection. Plast Reconstr Surg. 2002, 110: 1275-1279. 10.1097/00006534-200210000-00010.CrossRefPubMed Stratford AF, Zoutman DE, Davidson JSD: Effect of lidocaine and epinephrine on Staphylococcus aureus in a guinea pig model of surgical wound infection. Plast Reconstr Surg. 2002, 110: 1275-1279. 10.1097/00006534-200210000-00010.CrossRefPubMed
33.
go back to reference Parr AM, Zoutman DE, Davidson JSD: Antimicrobial activity of lidocaine against bacteria associated with nosocomial wound infection. Ann Plast Surg. 1999, 43: 239-245. 10.1097/00000637-199909000-00003.CrossRefPubMed Parr AM, Zoutman DE, Davidson JSD: Antimicrobial activity of lidocaine against bacteria associated with nosocomial wound infection. Ann Plast Surg. 1999, 43: 239-245. 10.1097/00000637-199909000-00003.CrossRefPubMed
34.
go back to reference Tasmuth T, Von Smitten K, Hietanen P, Kataja M, Kalso E: Pain and other symptoms after different treatment modalities of breast cancer. Ann Oncol. 1995, 6: 453-459.PubMed Tasmuth T, Von Smitten K, Hietanen P, Kataja M, Kalso E: Pain and other symptoms after different treatment modalities of breast cancer. Ann Oncol. 1995, 6: 453-459.PubMed
Metadata
Title
Does a continuous local anaesthetic pain treatment after immediate tissue expander reconstruction in breast carcinoma patients more efficiently reduce acute postoperative pain - a prospective randomised study
Authors
Branka Strazisar
Nikola Besic
Uros Ahcan
Publication date
01-12-2014
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2014
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-12-16

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