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World Journal of Surgical Oncology

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Open Access 01-12-2014 | Research

Sublobectomy versus Lobectomy for stage IA (T1a) non-small-cell lung cancer: a meta-analysis study

Authors: Yaxin Liu, Cheng Huang, Hongsheng Liu, Yeye Chen, Shanqing Li

Published in: World Journal of Surgical Oncology | Issue 1/2014

Abstract

Background

Although lobectomy is considered the standard surgical treatment for the majority of patients with non-small-cell lung cancer (NSCLC), the operation project for patients with stage IA NSCLC (T1a, tumor diameter ≤2 cm) remains controversial. Sublobectomy is appropriate only in certain patients as many doctors consider it to be overtreatment. We evaluated the five-year overall survival rate of sublobectomy and lobectomy for stage IA NSCLC (T1a, tumor diameter ≤2 cm) through a meta-analysis.

Methods

The five-year overall survival rate (OS) of stage IA (T1a) NSCLC after sublobectomy (including wedge resection and segmentectomy) and lobectomy were compared. We also compared the OS of stage IA (T1a) NSCLC after segmentectomy and lobectomy. The log (hazard ratio, ln (HR)) and its standard error (SE) were used as the outcome measure for data combining.

Results

There were 12 eligible studies published between 1994 and 2013 in which the total number of participants was 18,720. When compared to lobectomy, there was a statistically significant difference of sublobectomy on OS of stage IA (T1a) NSCLC patients (HR 1.38; 95% confidence interval (95% CI), 1.19 to 1.61; P <0.0001). For the comparison between segmentectomy and lobectomy, there was also a statistically significant difference of segmentectomy alone on OS of stage IA (T1a) NSCLC patients (HR 1.48; 95% CI: 1.27 to 1.73; P <0.00001)

Conclusions

We have concluded that in stage IA (T1a) patients sublobectomy, including segmentectomy and wedge resection, causes a lower survival rate than lobectomy.

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Title: Sublobectomy versus Lobectomy for stage IA (T1a) non-small-cell lung cancer: a meta-analysis study
Authors: Yaxin Liu
Cheng Huang
Hongsheng Liu
Yeye Chen
Shanqing Li
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2014
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-12-138

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Sublobectomy versus Lobectomy for stage IA (T1a) non-small-cell lung cancer: a meta-analysis study

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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