Published in:
Open Access 01-12-2013 | Research
The relationship between the BRAFV600E mutation in papillary thyroid microcarcinoma and clinicopathologic factors
Published in: World Journal of Surgical Oncology | Issue 1/2013
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Background
The BRAFV600E mutation, which accounts for about 60–80% papillary thyroid carcinoma(PTC), has been identifiedas a prognostic marker for risk stratification of PTC patients. However, the BRAFV600E mutation as a prognostic marker in papillary thyroid microcarcinoma (PTMC) is unclear.
Methods
We performed a retrospective review of 101 patients who underwent surgery for PTMC. We studied the prevalence of the BRAFV600E mutation. The associations between the BRAFV600E mutation and clinicopathologic characteristics were analyzed.
Results
The BRAFV600E mutation was observed in 72 patients (71.3%). There was no statistically significant correlation in age, gender, multifocality, extrathyroidal extension, presence of Hashimoto thyroiditis, and lymph node metastasis between the BRAFV600E mutant group and wild group.
Conclusions
The BRAFV600E mutation is not significantly associated with prognostic factors in PTMC.