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World Journal of Surgical Oncology

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Open Access 01-12-2013 | Case report

Bronchioloalveolar carcinoma as a second malignancy in a pediatric osteosarcoma survivor: case report

Authors: Masayuki Okui, Taichiro Goto, Yuichiro Hayashi, Robert Nakayama, Mitsutomo Kohno

Published in: World Journal of Surgical Oncology | Issue 1/2013

Abstract

Background

Primary lung cancer is extremely rare in children, while secondary malignancies reportedly develop in 2% to 3% of pediatric osteosarcoma survivors.

Case presentation

A 14-year-old girl was found to have two pulmonary lesions on computed tomography. These tumors had developed 1 year after osteosarcoma surgery. Segmentectomy of right segment 1 and wedge resection of right segment 9 were performed. Both lesions were completely resected and postoperative histopathological examination revealed metastasis of osteosarcoma and bronchioloalveolar carcinoma, respectively.

Conclusion

Bronchioloalveolar carcinoma may present as a solitary pulmonary lesion indistinguishable from a metastatic lesion and should be included in the differential diagnosis of pulmonary lesions in survivors of pediatric cancer. Thus, pulmonary lesions identified in these patients should be biopsied or resected to establish a histological diagnosis.

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Meyers PA, Schwartz CL, Krailo MD, Healey JH, Bernstein ML, Betcher D, Ferguson WS, Gebhardt MC, Goorin AM, Harris M: Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival–a report from the Children's Oncology Group. J Clin Oncol. 2008, 26: 633-638. 10.1200/JCO.2008.14.0095.CrossRefPubMed

Briccoli A, Rocca M, Salone M, Bacci G, Ferrari S, Balladelli A, Mercuri M: Resection of recurrent pulmonary metastases in patients with osteosarcoma. Cancer. 2005, 104: 1721-1725. 10.1002/cncr.21369.CrossRefPubMed

McCarville MB, Kaste SC, Cain AM, Goloubeva O, Rao BN, Pratt CB: Prognostic factors and imaging patterns of recurrent pulmonary nodules after thoracotomy in children with osteosarcoma. Cancer. 2001, 91: 1170-1176. 10.1002/1097-0142(20010315)91:6<1170::AID-CNCR1114>3.0.CO;2-B.CrossRefPubMed

Weldon CB, Shamberger RC: Pediatric pulmonary tumors: primary and metastatic. Semin Pediatr Surg. 2008, 17: 17-29. 10.1053/j.sempedsurg.2007.10.004.CrossRefPubMed

Ohye RG, Cohen DM, Caldwell S, Qualman SJ: Pediatric bronchioloalveolar carcinoma: a favorable pediatric malignancy?. J Pediatr Surg. 1998, 33: 730-732. 10.1016/S0022-3468(98)90200-7.CrossRefPubMed

Granata C, Gambini C, Balducci T, Toma P, Michelazzi A, Conte M, Jasonni V: Bronchioloalveolar carcinoma arising in congenital cystic adenomatoid malformation in a child: a case report and review on malignancies originating in congenital cystic adenomatoid malformation. Pediatr Pulmonol. 1998, 25: 62-66. 10.1002/(SICI)1099-0496(199801)25:1<62::AID-PPUL8>3.0.CO;2-Q.CrossRefPubMed

Kaslovsky RA, Purdy S, Dangman BC, McKenna BJ, Brien T, Ilves R: Bronchioloalveolar carcinoma in a child with congenital cystic adenomatoid malformation. Chest. 1997, 112: 548-551. 10.1378/chest.112.2.548.CrossRefPubMed

Kowalski P, Rodziewicz B, Pejcz J: Bilateral bronchioloalveolar carcinoma of the lungs in a 7 year old girl treated for Hodgkin’s disease. Tumori. 1989, 75: 449-451.PubMed

Kuttesch JF, Wexler LH, Marcus RB, Fairclough D, Weaver-McClure L, White M, Mao L, Delaney TF, Pratt CB, Horowitz ME, Kun LE: Second malignancies after Ewing’s sarcoma: radiation dose-dependency of secondary sarcomas. J Clin Oncol. 1996, 14: 2818-2825.PubMed

10.

Spaner SJ, Raymond G, Puttagunta L, Bhargava R: Bronchioloalveolar cell carcinoma in a child with hepatoblastoma: case report. Can Assoc Radiol J. 1999, 50: 343-345.PubMed

11.

Travis WD, Linnoila RI, Horowitz M, Becker RL, Pass H, Ozols R, Gazdar A: Pulmonary nodules resembling bronchioloalveolar carcinoma in adolescent cancer patients. Mod Pathol. 1988, 1: 372-377.PubMed

12.

Bacci G, Ferrari C, Longhi A, Ferrari S, Forni C, Bacchini P, Palmerini E, Briccoli A, Pignotti E, Balladelli A, Picci P: Second malignant neoplasm in patients with osteosarcoma of the extremities treated with adjuvant and neoadjuvant chemotherapy. J Pediatr Hematol Oncol. 2006, 28: 774-780. 10.1097/01.mph.0000243664.02174.73.CrossRefPubMed

13.

Aung L, Gorlick RG, Shi W, Thaler H, Shorter NA, Healey JH, Huvos AG, Meyers PA: Second malignant neoplasms in long-term survivors of osteosarcoma: memorial sloan-kettering cancer center experience. Cancer. 2002, 95: 1728-1734. 10.1002/cncr.10861.CrossRefPubMed

14.

Pratt CB, Meyer WH, Luo X, Cain AM, Kaste SC, Pappo AS, Rao BN, Fleming ID, Jenkins JJ: Second malignant neoplasms occuring in survivors of osteosarcoma. Cancer. 1997, 80: 960-965. 10.1002/(SICI)1097-0142(19970901)80:5<960::AID-CNCR19>3.0.CO;2-U.CrossRefPubMed

15.

Knowling MA, Basco VE: Breast cancer after treatment for osteosarcoma. Med Pediatr Oncol. 1986, 14: 51-53. 10.1002/mpo.2950140112.CrossRefPubMed

16.

Kobayashi H, Mori T, Yoshioka M, Tanaka M, Okuma T, Iida SI, Isogai M, Tabira Y, Kitamura N: A 14-year-old boy with small primary lung cancer. J Jpn Assoc Chest Surg. 1999, 13: 144-147. 10.2995/jacsurg.13.144.CrossRef

17.

Lebensburger J, Katzenstein H, Jenkins JJ, Rodriguez-Galindo C: Bronchioloalveolar carcinoma as a second malignancy in osteosarcoma survivors. Pediatr Blood Cancer. 2009, 53: 499-501. 10.1002/pbc.22005.CrossRefPubMed

18.

Longhi A, Bertoni F, Bacchini P, Albisinni U, Mercati U, Bacci G: Simultaneous osteosarcoma lung metastasis and second primary lung cancer. J Pediatr Hematol Oncol. 2004, 26: 457-461. 10.1097/00043426-200407000-00013.CrossRefPubMed

19.

Nonomura A, Mizukami Y, Shimizu J, Watanabe Y, Kamimura R, Takashima T, Tsuchiya H, Tomita K: Simultaneous occurrence of lung adenocarcinoma and fibular osteosarcoma in a 13-year-old girl. Thorac Cardiovasc Surg. 1994, 42: 61-63. 10.1055/s-2007-1016458.CrossRefPubMed

20.

Shiraishi K, Mori T, Ohba Y, Iwatani K, Yoshimoto K, Iyama K: Three young osteosarcoma patients with small adenocarcinoma or atypical adenomatous hyperplasia of the lung. Ann Thorac Cardiovasc Surg. 2010, 16: 358-361.PubMed

21.

Icard P, Regnard JF, de Napoli S, Rojas-Miranda A, Dartevelle P, Levasseur P: Primary lung cancer in young patients: a study of 82 surgically treated patients. Ann Thorac Surg. 1992, 54: 99-103. 10.1016/0003-4975(92)91150-8.CrossRefPubMed

Title: Bronchioloalveolar carcinoma as a second malignancy in a pediatric osteosarcoma survivor: case report
Authors: Masayuki Okui
Taichiro Goto
Yuichiro Hayashi
Robert Nakayama
Mitsutomo Kohno
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2013
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-11-135

At a glance: The STEP trials

Springer Medicine

Bronchioloalveolar carcinoma as a second malignancy in a pediatric osteosarcoma survivor: case report

Abstract

Background

Case presentation

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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