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World Journal of Surgical Oncology

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Open Access 01-12-2012 | Case report

Simultaneous development of adenocarcinoma and gastrointestinal stromal tumor (GIST) in the stomach: case report

Authors: Daigo Yamamoto, Yoshinori Hamada, Yu Tsubota, Katsuhiro Kawakami, Chizuko Yamamoto, Mitsuo Yamamoto

Published in: World Journal of Surgical Oncology | Issue 1/2012

Abstract

Background

Gastrointestinal stromal tumors (GISTs) and adenocarcinoma are distinct neoplasms originating from different cell layers. Approximately 20% of patients with GIST develop other cancers.

Case presentation

We report a case of the coexistence of adenocarcinoma and gastrointestinal stromal tumor (GIST). Gastric endoscopy showed the ulcerated tumor with bleeding along the lesser curvature of the proximal stomach and a submucosal nodule that measured about 3 cm in diameter in the lower part of the stomach body. Their pathological examination showed gastric cancer (poorly differentiated diffuse adenocarcinoma) and GIST (low-risk category). Further, immunohistochemical staining for C-kit and CD34 was positive, while that for SMA and S-100 was negative.

Conclusion

Although it is not easy to speculate on the coexistence of adenocarcinoma and GIST, pre-and post-operative diagnoses may be essential, and such cancer development is not considered to be unusual.

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Bircan S, Candir O, Aydin S, Baspinar S, Buldul M, Kapucuoglu M, Karahan N, Ciris M: Synchronous primary adenocarcinoma and gastrointestinal stromal tumour in the stomach. a report of two cases. Turk J Gastroenterol. 2004, 15: 187-191.PubMed

Rauf F, Ahmad Z, Muzzafar S, Hussaini AS: Synchronous occurrence of gastrointestinal stromal tumour and gastric adenocarcinoma. a case report. J Pak Med Assoc. 2006, 56: 184-186.PubMed

Liu SW, Chen GH, Hsieh PP: Collision tumour of the Stomach. A case report of Mixed Stromal Tumour and Adenocarcinoma. J Clin Gastroenterol. 2002, 35: 332-334. 10.1097/00004836-200210000-00010.CrossRefPubMed

Maiorana A, Fante R, Maria Cesinaro A, Adriana Fano R: Synchronous occurrence of epithelial and stromal tumors in the stomach. a report of 6 cases. Arch Pathol Lab Med. 2000, 124: 682-686.PubMed

Yamamoto D, Hamada Y, Okazaki S, Kawakami , Kanzaki S, Yamamoto C, Yamamoto M: Metastatic gastric tumor from renal cell carcinoma. Gastric Cancer. 2009, 12: 170-173. 10.1007/s10120-009-0519-6.CrossRefPubMed

Yamamoto D, Yoshida H, Sumida K, Ueyama Y, Kanematsu S, Shoji T, Sueoka N, Tanaka K, Tsubota Y, Kon M: Gastric Tumor from Metastasis of Breast Cancer. Anticancer Res. 2010, 30: 3705-3708.PubMed

Kaffes A, Hughes L, Hollinshead J, Katelaris P: Synchronous primary adenocarcinoma, mucosa-associated lymphoid tissue lymphoma and a stromal tumor in a Helicobacter pylori-infected stomach. J Gastroenterol Hepatol. 2002, 17: 1033-1036. 10.1046/j.1440-1746.2002.02649.x.CrossRefPubMed

Fletcher CD, Berman JJ, Corless C: Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol. 2002, 33: 459-65. 10.1053/hupa.2002.123545.CrossRefPubMed

Pandurengan RK, Dumont AG, Araujo DM, Ludwig JA, Ravi V, Patel S, Garber J, Benjamin RS, Strom SS, Trent JC: Survival of patients with multiple primary malignancies: a study of 783 patients with gastrointestinal stromal tumor. Ann Oncol. 2010, 21: 2107-11. 10.1093/annonc/mdq078.PubMedCentralCrossRefPubMed

10.

Pidhorecky I, Cheney RT, Kraybill WG, Gibbs JF: Gastrointestinal stromal tumors. current diagnosis, biologic behavior, and management. Ann Surg Oncol. 2000, 7: 705-12. 10.1007/s10434-000-0705-6.CrossRefPubMed

11.

Rabin I, Chikman B, Lavy R, Sandbank J, Maklakovsky M, Gold-Deutch R: Gastrointestinal stromal tumors: a 19 year experience. Isr Med Assoc J. 2009, 11: 98-102.PubMed

12.

Liu FY, Qi JP, Xu FL, Wu AP: Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor. World J Gastroenterol. 2006, 12: 4161-5.PubMedCentralPubMed

13.

Kang Na Y, Jung Ra H, Hwang I: Clinicopathological and Immunohistochemical Features of Gastointestinal Stromal Tumors. Cancer Res Treat. 2010, 42: 135-143. 10.4143/crt.2010.42.3.135.CrossRef

14.

Patel S: Navigating risk stratification systems for the management of patients with GIST. Ann Surg Oncol. 2011, 18: 1698-704. 10.1245/s10434-010-1496-z.CrossRefPubMed

Title: Simultaneous development of adenocarcinoma and gastrointestinal stromal tumor (GIST) in the stomach: case report
Authors: Daigo Yamamoto
Yoshinori Hamada
Yu Tsubota
Katsuhiro Kawakami
Chizuko Yamamoto
Mitsuo Yamamoto
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2012
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-10-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Simultaneous development of adenocarcinoma and gastrointestinal stromal tumor (GIST) in the stomach: case report

Abstract

Background

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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