Top

World Journal of Surgical Oncology

Published in:

Open Access 01-12-2012 | Research

Pattern of distant recurrence according to the molecular subtypes in Korean women with breast cancer

Authors: Hyung Seok Park, Shinhyuk Kim, Kiho Kim, Ho Yoo, Byung Joo Chae, Ja Seong Bae, Byung Joo Song, Sang Seol Jung

Published in: World Journal of Surgical Oncology | Issue 1/2012

Abstract

Background

Distant recurrence is one of the most important risk factors in overall survival, and distant recurrence is related to a complex biologic interaction of seed and soil factors. The aim of the study was to investigate the association between the molecular subtypes and patterns of distant recurrence in patients with breast cancer.

Methods

In an investigation of 313 women with breast cancer who underwent surgery from 1994 and 2000, the expressions of estrogen and progestrone receptor (ER/PR), and human epithelial receptor-2 (HER2) were evaluated. The subtypes were defined as luminal-A, luminal-HER2, HER2-enriched, and triple negative breast cancer (TNBC) according to ER, PR, and HER2 status.

Results

Bone was the most common site of distant recurrence. The incidence of first distant recurrence site was significantly different among the subtypes. Brain metastasis was more frequent in the luminal-HER2 and TNBC subtypes. In subgroup analysis, overall survival in patients with distant recurrence after 24 months after surgery was significantly different among the subtypes.

Conclusions

Organ-specific metastasis may depend on the molecular subtype of breast cancer. Tailored strategies against distant metastasis concerning the molecular subtypes in breast cancer may be considered.

Available only for authorised users

Solomayer EF, Diel IJ, Meyberg GC, Gollan C, Bastert G: Metastatic breast cancer: clinical course, prognosis and therapy related to the first site of metastasis. Breast Cancer Res Treat. 2000, 59: 271-278. 10.1023/A:1006308619659.CrossRefPubMed

Norton L, Massague J: Is cancer a disease of self-seeding?. Nat Med. 2006, 12: 875-878. 10.1038/nm0806-875.CrossRefPubMed

Paget S: The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev. 1989, 8: 98-101.PubMed

Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA: Molecular portraits of human breast tumours. Nature. 2000, 406: 747-752. 10.1038/35021093.CrossRefPubMed

Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 2001, 98: 10869-10874. 10.1073/pnas.191367098.PubMedCentralCrossRefPubMed

Spitale A, Mazzola P, Soldini D, Mazzucchelli L, Bordoni A: Breast cancer classification according to immunohistochemical markers: clinicopathologic features and short-term survival analysis in a population-based study from the South of Switzerland. Ann Oncol. 2009, 20: 628-635. 10.1093/annonc/mdn675.CrossRefPubMed

Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, Nielsen TO, Gelmon K: Metastatic behavior of breast cancer subtypes. J Clin Oncol. 2010, 28: 3271-3277. 10.1200/JCO.2009.25.9820.CrossRefPubMed

Meyers MO, Klauber-Demore N, Ollila DW, Amos KD, Moore DT, Drobish AA, Burrows EM, Dees EC, Carey LA: Impact of Breast Cancer Molecular Subtypes on Locoregional Recurrence in Patients Treated with Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer. Ann Surg Oncol. 2011, 18 (10): 2851-7. 10.1245/s10434-011-1665-8.CrossRefPubMed

Kim SI, Sohn J, Koo JS, Park SH, Park HS, Park BW: Molecular Subtypes and Tumor Response to Neoadjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer. Oncology. 2011, 79: 324-330.CrossRef

10.

Voduc KD, Cheang MC, Tyldesley S, Gelmon K, Nielsen TO, Kennecke H: Breast cancer subtypes and the risk of local and regional relapse. J Clin Oncol. 2010, 28: 1684-1691. 10.1200/JCO.2009.24.9284.CrossRefPubMed

11.

Zaha DC, Lazar E, Lazureanu C: Clinicopathologic features and five years survival analysis in molecular subtypes of breast cancer. Rom J Morphol Embryol. 2010, 51: 85-89.PubMed

12.

Smid M, Wang Y, Zhang Y, Sieuwerts AM, Yu J, Klijn JG, Foekens JA, Martens JW: Subtypes of breast cancer show preferential site of relapse. Cancer Res. 2008, 68: 3108-3114. 10.1158/0008-5472.CAN-07-5644.CrossRefPubMed

13.

Kuru B, Camlibel M, Dinc S, Gulcelik MA, Gonullu D, Alagol H: Prognostic factors for survival in breast cancer patients who developed distant metastasis subsequent to definitive surgery. Singapore Med J. 2008, 49: 904-911.PubMed

14.

Kennecke H, McArthur H, Olivotto IA, Speers C, Bajdik C, Chia SK, Ellard S, Norris B, Hayes M, Barnett J, Gelmon KA: Risk of early recurrence among postmenopausal women with estrogen receptor-positive early breast cancer treated with adjuvant tamoxifen. Cancer. 2008, 112: 1437-1444. 10.1002/cncr.23320.CrossRefPubMed

15.

Saphner T, Tormey DC, Gray R: Annual hazard rates of recurrence for breast cancer after primary therapy. J Clin Oncol. 1996, 14: 2738-2746.PubMed

16.

Kennecke HF, Olivotto IA, Speers C, Norris B, Chia SK, Bryce C, Gelmon KA: Late risk of relapse and mortality among postmenopausal women with estrogen responsive early breast cancer after 5 years of tamoxifen. Ann Oncol. 2007, 18: 45-51. 10.1093/annonc/mdl450.CrossRefPubMed

17.

Park YH, Lee S, Cho EY, Choi YL, Lee JE, Nam SJ, Yang JH, Ahn JS, Im YH: Patterns of relapse and metastatic spread in HER2-overexpressing breast cancer according to estrogen receptor status. Cancer Chemother Pharmacol. 2010, 66: 507-516. 10.1007/s00280-009-1190-7.CrossRefPubMed

18.

DeSantis C, Jemal A, Ward E: Disparities in breast cancer prognostic factors by race, insurance status, and education. Cancer Causes Control. 2010, 21: 1445-1450. 10.1007/s10552-010-9572-z.CrossRefPubMed

19.

Yao-Lung K, Dar-Ren C, Tsai-Wang C: Clinicopathological features of triple-negative breast cancer in Taiwanese women. Int J Clin Oncol. 2011, 16: 500-505. 10.1007/s10147-011-0211-9.CrossRefPubMed

20.

Martin DN, Boersma BJ, Yi M, Reimers M, Howe TM, Yfantis HG, Tsai YC, Williams EH, Lee DH, Stephens RM: Differences in the tumor microenvironment between African-American and European-American breast cancer patients. PLoS One. 2009, 4: e4531-10.1371/journal.pone.0004531.PubMedCentralCrossRefPubMed

21.

Yuan ZY, Wang SS, Gao Y, Su ZY, Luo WB, Guan ZZ: [Clinical characteristics and prognosis of triple-negative breast cancer: a report of 305 cases]. Ai Zheng. 2008, 27: 561-565.PubMed

22.

Fulford LG, Reis-Filho JS, Ryder K, Jones C, Gillett CE, Hanby A, Easton D, Lakhani SR: Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival. Breast Cancer Res. 2007, 9: R4-10.1186/bcr1636.PubMedCentralCrossRefPubMed

23.

Lin NU, Claus E, Sohl J, Razzak AR, Arnaout A, Winer EP: Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: high incidence of central nervous system metastases. Cancer. 2008, 113: 2638-2645. 10.1002/cncr.23930.PubMedCentralCrossRefPubMed

24.

Dawood S, Broglio K, Esteva FJ, Yang W, Kau SW, Islam R, Albarracin C, Yu TK, Green M, Hortobagyi GN, Gonzalez-Angulo AM: Survival among women with triple receptor-negative breast cancer and brain metastases. Ann Oncol. 2009, 20: 621-627. 10.1093/annonc/mdn682.PubMedCentralCrossRefPubMed

25.

Clayton AJ, Danson S, Jolly S, Ryder WD, Burt PA, Stewart AL, Wilkinson PM, Welch RS, Magee B, Wilson G: Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer. Br J Cancer. 2004, 91: 639-643.PubMedCentralPubMed

26.

Bendell JC, Domchek SM, Burstein HJ, Harris L, Younger J, Kuter I, Bunnell C, Rue M, Gelman R, Winer E: Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer. 2003, 97: 2972-2977. 10.1002/cncr.11436.CrossRefPubMed

Title: Pattern of distant recurrence according to the molecular subtypes in Korean women with breast cancer
Authors: Hyung Seok Park
Shinhyuk Kim
Kiho Kim
Ho Yoo
Byung Joo Chae
Ja Seong Bae
Byung Joo Song
Sang Seol Jung
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2012
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-10-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Pattern of distant recurrence according to the molecular subtypes in Korean women with breast cancer

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2012

Problems of primary T-cell lymphoma of the thyroid gland -A case report

Nasolabial flap reconstruction in oral cancer

CT-guided percutaneous microwave ablation of pulmonary malignancies: Results in 69 cases

Experience and analysis of Delphian lymph node metastasis in patients with papillary thyroid carcinoma

Skin-sparing mastectomy and immediate latissimus dorsi flap reconstruction: a retrospective analysis of the surgical and patient-reported outcomes

Neoadjuvant versus adjuvant treatment: which one is better for resectable esophageal squamous cell carcinoma?