Skip to main content
Top
Published in: World Journal of Surgical Oncology 1/2012

Open Access 01-12-2012 | Case report

Rectosigmoid adenocarcinoma revealed by metastatic anal fistula. The visible part of the iceberg: a report of two cases with literature review

Authors: El Bachir Benjelloun, Said Aitalalim, Leila Chbani, Ihsan Mellouki, Khalid Mazaz, Kahlid Aittaleb

Published in: World Journal of Surgical Oncology | Issue 1/2012

Login to get access

Abstract

Colonic adenocarcinoma revealed by metastatic anorectal fistula is rare, with few cases in the literature. Such lesions can be taken for the more common manifestation of a benign perianal abscess or fistula. Once diagnosed, the management of such conditions remains controversial. We herein report two cases with perianal fistula that were subsequently found to have developed perianal adenocarcinoma on biopsy. Further colonic investigation revealed a rectosigmoid adenocarcinoma. Histology and immunohistochemical staining was identical in both primary and metastatic tumors. Preoperative chemoradiation with further rectal low anterior resection and local excision of metastatic anal fistula was performed. There is no recurrence after 3 years of follow-up.
Appendix
Available only for authorised users
Literature
1.
go back to reference Gertsch P, Baer HU, Kraft R, Maddern GJ, Altermatt HJ: Malignant cells are collected on circular staplers. Dis Colon Rectum. 1992, 35: 238-241. 10.1007/BF02051014.CrossRefPubMed Gertsch P, Baer HU, Kraft R, Maddern GJ, Altermatt HJ: Malignant cells are collected on circular staplers. Dis Colon Rectum. 1992, 35: 238-241. 10.1007/BF02051014.CrossRefPubMed
2.
go back to reference Hsu T-C, I-Lin L: Implantation of adenocarcinoma on hemorrhoidectomy wound. Int J Colorectal Dis. 2007, 22: 1407-1408. 10.1007/s00384-006-0179-5.CrossRefPubMed Hsu T-C, I-Lin L: Implantation of adenocarcinoma on hemorrhoidectomy wound. Int J Colorectal Dis. 2007, 22: 1407-1408. 10.1007/s00384-006-0179-5.CrossRefPubMed
3.
go back to reference Kluger Y, Galili Y, Yossiphov J, Shnaper A, Goldman G, Rabau M: Model of implantation of tumor cells simulating recurrence in colonic anastomosis in mice. Dis Colon Rectum. 1998, 41: 1506-15104. 10.1007/BF02237297.CrossRefPubMed Kluger Y, Galili Y, Yossiphov J, Shnaper A, Goldman G, Rabau M: Model of implantation of tumor cells simulating recurrence in colonic anastomosis in mice. Dis Colon Rectum. 1998, 41: 1506-15104. 10.1007/BF02237297.CrossRefPubMed
4.
go back to reference Guiss RL: The implantation of cancer cells within a fistula in ano. Surgery. 1954, 36: 136-139.PubMed Guiss RL: The implantation of cancer cells within a fistula in ano. Surgery. 1954, 36: 136-139.PubMed
5.
go back to reference Killingback M, Wilson E, Hughes ESR: Anal metastases from carcinoma of the rectum and colon. Aust NZ J Surg. 1965, 34: 178-187. 10.1111/j.1445-2197.1965.tb04353.x.CrossRef Killingback M, Wilson E, Hughes ESR: Anal metastases from carcinoma of the rectum and colon. Aust NZ J Surg. 1965, 34: 178-187. 10.1111/j.1445-2197.1965.tb04353.x.CrossRef
6.
go back to reference Parnes IH: An interesting case of cancer of the sigmoid with concomitant cancer in anal fistula. Mt Sinai J Med. 1976, 43: 476-479.PubMed Parnes IH: An interesting case of cancer of the sigmoid with concomitant cancer in anal fistula. Mt Sinai J Med. 1976, 43: 476-479.PubMed
7.
go back to reference Rollinson PD, Dundas SAC: Adenocarcinoma of sigmoid colon seeding into pre-existing fistula-in-ano. Br J Surg. 1984, 71: 664-665.CrossRefPubMed Rollinson PD, Dundas SAC: Adenocarcinoma of sigmoid colon seeding into pre-existing fistula-in-ano. Br J Surg. 1984, 71: 664-665.CrossRefPubMed
8.
go back to reference Ueta K, Umekita N, Matsumine T: A case of metastatic carcinoma found at an anal fistula (in Japanese). J Jpn Surg Assoc. 1991, 52: 1323-1326. Ueta K, Umekita N, Matsumine T: A case of metastatic carcinoma found at an anal fistula (in Japanese). J Jpn Surg Assoc. 1991, 52: 1323-1326.
9.
go back to reference Thomas DJ, Thompson MR: Implantation of metastasis from adenocarcinoma of sigmoid colon into fistula in ano. J R Sci Med. 1992, 85: 361- Thomas DJ, Thompson MR: Implantation of metastasis from adenocarcinoma of sigmoid colon into fistula in ano. J R Sci Med. 1992, 85: 361-
10.
go back to reference Tohira H, Imai N, Tateyama K, Ozeki Y, Yamamoto S: A case of rectal cancer seeding to anal fistula. (In Japanese). Geka. 1998, 60: 853-856. Tohira H, Imai N, Tateyama K, Ozeki Y, Yamamoto S: A case of rectal cancer seeding to anal fistula. (In Japanese). Geka. 1998, 60: 853-856.
11.
go back to reference Tokuhara K, Yamanaka H, Ito D, Koshiba T, Sato M, Kogire M: A case of metastatic carcinoma at an anal fistula (in Japanese). Jpn J Gastroenterol Surg. 2001, 34: 1690-1694. 10.5833/jjgs.34.1690.CrossRef Tokuhara K, Yamanaka H, Ito D, Koshiba T, Sato M, Kogire M: A case of metastatic carcinoma at an anal fistula (in Japanese). Jpn J Gastroenterol Surg. 2001, 34: 1690-1694. 10.5833/jjgs.34.1690.CrossRef
12.
go back to reference Yoshimura H, Ienaga T, Ueda S, Ota T: A case of metastatic carcinoma of anal fistula caused implantation from rectal cancer (in Japanese). Jpn J Gastroenterol Surg. 2001, 34: 1363-1366. 10.5833/jjgs.34.1363.CrossRef Yoshimura H, Ienaga T, Ueda S, Ota T: A case of metastatic carcinoma of anal fistula caused implantation from rectal cancer (in Japanese). Jpn J Gastroenterol Surg. 2001, 34: 1363-1366. 10.5833/jjgs.34.1363.CrossRef
13.
go back to reference Kouraklis G, Glinavou A, Kouvaraki M, Raftopoulos J, Karatzas G: Anal lesion resulting from implantation of viable tumor cells in a pre-existing anal fistula. A case report. Acta Chir Belg. 2002, 102: 212-213.PubMed Kouraklis G, Glinavou A, Kouvaraki M, Raftopoulos J, Karatzas G: Anal lesion resulting from implantation of viable tumor cells in a pre-existing anal fistula. A case report. Acta Chir Belg. 2002, 102: 212-213.PubMed
14.
go back to reference Yagihashi N, Ohsawa T, Narita J, Iwabuchi T, Tsuge T: A case of carcinoma metastatic to an anal fistula treated by pelvic exenteration (in Japanese). J Jpn Surg Assoc. 2002, 63: 2224-2228. 10.3919/jjsa.63.2224.CrossRef Yagihashi N, Ohsawa T, Narita J, Iwabuchi T, Tsuge T: A case of carcinoma metastatic to an anal fistula treated by pelvic exenteration (in Japanese). J Jpn Surg Assoc. 2002, 63: 2224-2228. 10.3919/jjsa.63.2224.CrossRef
15.
go back to reference Shimoyama M, Suda T, Iiai T, Okamoto H, Hatakeyama K: A case of metastatic carcinoma of an anal fistula caused by implantaion of rectal cancer (in Japanese). J Jpn Surg Assoc. 2003, 64: 1434-1438. 10.3919/jjsa.64.1434.CrossRef Shimoyama M, Suda T, Iiai T, Okamoto H, Hatakeyama K: A case of metastatic carcinoma of an anal fistula caused by implantaion of rectal cancer (in Japanese). J Jpn Surg Assoc. 2003, 64: 1434-1438. 10.3919/jjsa.64.1434.CrossRef
16.
go back to reference Hyman N, Kida M: Adenocarcinoma of the sigmoid colon seeding a chronic anal fistula. Dis Colon Rectum. 2003, 46: 835-836. 10.1007/s10350-004-6665-3.CrossRefPubMed Hyman N, Kida M: Adenocarcinoma of the sigmoid colon seeding a chronic anal fistula. Dis Colon Rectum. 2003, 46: 835-836. 10.1007/s10350-004-6665-3.CrossRefPubMed
17.
go back to reference Gravante G, Delogu D, Venditti D: Colosigmoid adenocarcinoma anastomotic recurrence seeding into a transsphincteric fistula-in-ano: a clinical report and literature review. Surg Laparosc Endosc Percutan Tech. 2008, 18: 407-408. 10.1097/SLE.0b013e3181693346.CrossRefPubMed Gravante G, Delogu D, Venditti D: Colosigmoid adenocarcinoma anastomotic recurrence seeding into a transsphincteric fistula-in-ano: a clinical report and literature review. Surg Laparosc Endosc Percutan Tech. 2008, 18: 407-408. 10.1097/SLE.0b013e3181693346.CrossRefPubMed
18.
go back to reference Isbister WH: Unusual ‘recurrence’ sites for colorectal cancer. Dig Surg. 2000, 17: 81-83. 10.1159/000018805.CrossRefPubMed Isbister WH: Unusual ‘recurrence’ sites for colorectal cancer. Dig Surg. 2000, 17: 81-83. 10.1159/000018805.CrossRefPubMed
19.
go back to reference Shinohara T, Hara H, Kato Y, Asano M, Nakazawa Y, Kato T, Nogaki T, Yamashita Y: Implantation of rectal cancer cells in a fistula in ano: report of a case. Surg Today. 2001, 31: 1094-1096. 10.1007/s595-001-8065-9.CrossRefPubMed Shinohara T, Hara H, Kato Y, Asano M, Nakazawa Y, Kato T, Nogaki T, Yamashita Y: Implantation of rectal cancer cells in a fistula in ano: report of a case. Surg Today. 2001, 31: 1094-1096. 10.1007/s595-001-8065-9.CrossRefPubMed
20.
go back to reference Zbar AP, Shenoy RK: Synchronous carcinoma of the sigmoid colon and a perianal fistula. Dis Colon Rectum. 2004, 47: 544-545. 10.1007/s10350-003-0069-7.CrossRefPubMed Zbar AP, Shenoy RK: Synchronous carcinoma of the sigmoid colon and a perianal fistula. Dis Colon Rectum. 2004, 47: 544-545. 10.1007/s10350-003-0069-7.CrossRefPubMed
21.
go back to reference Gupta R, Kay M, Birch DW: Implantation metastasis from adenocarcinoma of the colon into a fistula-in-ano: a case report. Can J Surg. 2005, 48: 162-163.PubMedCentralPubMed Gupta R, Kay M, Birch DW: Implantation metastasis from adenocarcinoma of the colon into a fistula-in-ano: a case report. Can J Surg. 2005, 48: 162-163.PubMedCentralPubMed
22.
go back to reference Tomimaru Y, Ohue M, Noura S, Tanida T, Miyashiro I, Yano M, Ohigashi H, Sasaki Y, Ishikawa O, Imaoka S: A case of anal fistula cancer probably developing from intraluminal dissemination of rectal cancer. (in Japanese). Gan To Kagaku Ryoho. 2005, 32: 1776-1778.PubMed Tomimaru Y, Ohue M, Noura S, Tanida T, Miyashiro I, Yano M, Ohigashi H, Sasaki Y, Ishikawa O, Imaoka S: A case of anal fistula cancer probably developing from intraluminal dissemination of rectal cancer. (in Japanese). Gan To Kagaku Ryoho. 2005, 32: 1776-1778.PubMed
23.
go back to reference Hamada M, Ozaki K, Iwata J, Nishioka Y, Horimi T: A case of rectosigmoid cancer metastasizing to a fistula in ano. Jpn J Clin Oncol. 2005, 35: 676-679. 10.1093/jjco/hyi181.CrossRefPubMed Hamada M, Ozaki K, Iwata J, Nishioka Y, Horimi T: A case of rectosigmoid cancer metastasizing to a fistula in ano. Jpn J Clin Oncol. 2005, 35: 676-679. 10.1093/jjco/hyi181.CrossRefPubMed
24.
go back to reference Ishiyama S, Inoue S, Kobayashi K, Sano Y, Kushida N, Yamazaki Y, Yanaga K: Implantation of rectal cancer in an anal fistula: report of a case. Surg Today. 2006, 36 (8): 747-749. 10.1007/s00595-006-3236-3.CrossRefPubMed Ishiyama S, Inoue S, Kobayashi K, Sano Y, Kushida N, Yamazaki Y, Yanaga K: Implantation of rectal cancer in an anal fistula: report of a case. Surg Today. 2006, 36 (8): 747-749. 10.1007/s00595-006-3236-3.CrossRefPubMed
25.
go back to reference Sandiford N, Prussia PR, Chiappa A, Zbar AP: Synchronous mucinous adenocarcinoma of the rectosigmoid seeding onto a pre-existing anal fistula. Int Semin Surg Oncol. 2006, 3: 25-10.1186/1477-7800-3-25.PubMedCentralCrossRefPubMed Sandiford N, Prussia PR, Chiappa A, Zbar AP: Synchronous mucinous adenocarcinoma of the rectosigmoid seeding onto a pre-existing anal fistula. Int Semin Surg Oncol. 2006, 3: 25-10.1186/1477-7800-3-25.PubMedCentralCrossRefPubMed
26.
go back to reference Wakatsuki K, Oeda Y, Isono T, Yoshioka S, Nukui Y, Yamazaki K, Nabeshima S, Miyazaki M: Adenocarcinoma of the rectosigmoid colon seeding into pre-existing anal fistula. Hepatogastroenterology. 2008, 55 (84): 952-955.PubMed Wakatsuki K, Oeda Y, Isono T, Yoshioka S, Nukui Y, Yamazaki K, Nabeshima S, Miyazaki M: Adenocarcinoma of the rectosigmoid colon seeding into pre-existing anal fistula. Hepatogastroenterology. 2008, 55 (84): 952-955.PubMed
27.
go back to reference Ryall C: Cancer infection and cancer recurrence. Lancet. 1907, 2: 1311-1316.CrossRef Ryall C: Cancer infection and cancer recurrence. Lancet. 1907, 2: 1311-1316.CrossRef
28.
go back to reference Ramalingam P, Hart WR, Goldblum JR: Cytokeratin subset immunostaining in rectal adenocarcinoma and normal anal glands. Arch Pathol Lab Med. 2001, 125: 1074-1077.PubMed Ramalingam P, Hart WR, Goldblum JR: Cytokeratin subset immunostaining in rectal adenocarcinoma and normal anal glands. Arch Pathol Lab Med. 2001, 125: 1074-1077.PubMed
Metadata
Title
Rectosigmoid adenocarcinoma revealed by metastatic anal fistula. The visible part of the iceberg: a report of two cases with literature review
Authors
El Bachir Benjelloun
Said Aitalalim
Leila Chbani
Ihsan Mellouki
Khalid Mazaz
Kahlid Aittaleb
Publication date
01-12-2012
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2012
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-10-209

Other articles of this Issue 1/2012

World Journal of Surgical Oncology 1/2012 Go to the issue