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World Journal of Surgical Oncology

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Open Access 01-12-2012 | Research

Suboptimal chemotherapy is an adverse prognostic factor in osteosarcoma

Published in: World Journal of Surgical Oncology | Issue 1/2012

Abstract

Background

We sought to determine whether suboptimal chemotherapy compromised the prognosis of osteosarcoma patients.

Methods

A total of 132 eligible patients who underwent chemotherapy between 1998 and 2008 were identified in our database. Information regarding patient demographics, clinical characteristics, and survival status were extracted for analysis. Optimal chemotherapy was defined as receipt of ≥80% of the planned dose intensity of prescribed agents within the planned durations.

Results

The use of optimal chemotherapy resulted in an overall survival benefit with P = 0.006. Patients who failed to complete the optimal chemotherapy protocol had a dismal prognosis of 30.8% overall survival over five years, whereas those who completed the optimal chemotherapy had an overall survival rate over five years of 65.3%. Based on multivariate analysis, patients who were treated with a suboptimal protocol had a higher risk of relapse, metastasis and mortality. The hazard ratio (HR) of recurrence or death for the suboptimal chemotherapy group was as high as 2.512 over that of the optimal chemotherapy group (HR = 2.512, 95% confidence interval = 1.242 to 3.729).

Conclusions

Chemotherapy is a significant independent prognostic variable, and suboptimal chemotherapy was found to have a detrimental effect on the outcome of patients with osteosarcoma.

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Title: Suboptimal chemotherapy is an adverse prognostic factor in osteosarcoma
Publication date: 01-12-2012
Published in: World Journal of Surgical Oncology / Issue 1/2012
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-10-191

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Suboptimal chemotherapy is an adverse prognostic factor in osteosarcoma

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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