Top

Published in:

Open Access 01-12-2012 | Research

Parathyroid involvement in thyroid cancer: an unforeseen event

Authors: Alexandra Chrisoulidou, Stylianos Mandanas, Periklis Mitsakis, Paschalia K Iliadou, Kosmas Manafis, Nikolaos Flaris, Maria Boudina, Lemonia Mathiopoulou, Kalliopi Pazaitou-Panayiotou

Published in: World Journal of Surgical Oncology | Issue 1/2012

Abstract

Background

Parathyroid metastatic disease from thyroid cancer has not been studied extensively, mainly due to the need for parathyroid preservation during thyroid surgery.

Methods

We reviewed files from 1,770 patients with thyroid cancer followed up in our department and 10 patients with parathyroid metastases (0.5%) were identified. Patient and tumor characteristics were recorded.

Results

Six out of ten patients had metastases from papillary thyroid cancer, three from follicular thyroid cancer and one from anaplastic thyroid cancer. In nine patients parathyroid infiltration from thyroid cancer was found in direct contact with the thyroid cancer, and in one patient metastatic foci were observed not in continuity with the thyroid cancer.

Conclusions

Parathyroid involvement, although infrequent, may occur in thyroid cancer independently of patient age and tumor size. The clinical significance of such event is not clear. The influence on disease outcome remains to be elucidated.

Available only for authorised users

Gattuso P, Khan NA, Jablokow VR, Kathuria S: Neoplasms metastatic to parathyroid glands. South Med J. 1988, 81: 1467-10.1097/00007611-198811000-00039.CrossRefPubMed

de la Monte SM, Hutchins GM, Moore GW: Endocrine organ metastases from breast carcinoma. Am J Pathol. 1984, 114: 131-136.PubMedCentralPubMed

Tang W, Kakudo K, Nakamura MY, Nakamura M, Mori I, Morita S, Miyauchi A: Parathyroid gland involvement by papillary carcinoma of the thyroid gland. Arch Pathol Lab Med. 2002, 126: 1511-1514.PubMed

Ito Y, Kakudo K, Hirokawa M, Fukushima M, Tomoda C, Inoue H, Kihara M, Higashiyama T, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Miyauchi A: Clinical significance of extrathyroid extension to the parathyroid gland of papillary thyroid carcinoma. Endocr J. 2009, 56: 251-255. 10.1507/endocrj.K08E-297.CrossRefPubMed

Kakudo K, Tang W, Ito Y, Nakamura Y, Yasuoka H, Morita S, Miyauchi A: Parathyroid invasion, nodal recurrence, and lung metastasis by papillary carcinoma of the thyroid. J Clin Pathol. 2004, 57: 245-249. 10.1136/jcp.2003.012070.PubMedCentralCrossRefPubMed

Pazaitou-Panayiotou K, Kaprara A, Boudina M, Georgiou E, Drimonitis A, Vainas I, Raptou E, Galaktidou G: Thyroid carcinoma in children and adolescents: presentation, clinical course, and outcome of therapy in 23 children and adolescents in Northern Greece. Hormones (Athens). 2005, 4: 213-220.CrossRef

Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM: Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009, 19: 1167-1214. 10.1089/thy.2009.0110.CrossRefPubMed

Nishida T, Nakao K, Hashimoto T: Local control in differentiated thyroid carcinoma with extrathyroidal invasion. Am J Surg. 2000, 179: 86-91. 10.1016/S0002-9610(00)00275-0.CrossRefPubMed

Kowalski LP, Filho JG: Results of the treatment of locally invasive thyroid carcinoma. Head Neck. 2002, 24: 340-344. 10.1002/hed.10058.CrossRefPubMed

10.

Asari R, Koperek O, Scheuba C, Riss P, Kaserer K, Hoffmann M, Niederle B: Follicular thyroid carcinoma in an iodine-replete endemic goiter region: a prospectively collected, retrospectively analyzed clinical trial. Ann Surg. 2009, 249: 1023-1031. 10.1097/SLA.0b013e3181a77b7b.CrossRefPubMed

11.

Miller FR: Surgical anatomy of the thyroid and parathyroid glands. Otolaryngol Clin North Am. 2003, 36: 1-7. 10.1016/S0030-6665(02)00132-9. viiCrossRefPubMed

12.

Lane MJ, Desser TS, Weigel RJ, Jeffrey RB: Use of color and power Doppler sonography to identify feeding arteries associated with parathyroid adenomas. AJR Am J Roentgenol. 1998, 171: 819-823.CrossRefPubMed

Title: Parathyroid involvement in thyroid cancer: an unforeseen event
Authors: Alexandra Chrisoulidou
Stylianos Mandanas
Periklis Mitsakis
Paschalia K Iliadou
Kosmas Manafis
Nikolaos Flaris
Maria Boudina
Lemonia Mathiopoulou
Kalliopi Pazaitou-Panayiotou
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2012
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-10-121

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Parathyroid involvement in thyroid cancer: an unforeseen event

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2012

The utility of hyperthermia for local recurrence of breast cancer

A case of metastatic leptomeningeal carcinomatosis from early gastric carcinoma

Osteosarcoma of the jaws: a review of literature and a case report on synchronous multicentric osteosarcomas

18 F-fluoro-deoxy-glucose focal uptake in very small pulmonary nodules: fact or artifact? Case reports

Long-term survival from adenocarcinoma of the esophagus after transthoracic and transhiatal esophagectomy

Sorafenib for hepatocellular carcinoma patients beyond Milan criteria after orthotopic liver transplantation: a case control study