Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2005

Open Access 01-12-2005 | Research

The effect of patient characteristics on variability in pain and function over two years in early knee osteoarthritis

Authors: Przemyslaw T Paradowski, Martin Englund, L Stefan Lohmander, Ewa M Roos

Published in: Health and Quality of Life Outcomes | Issue 1/2005

Login to get access

Abstract

Background

Large variations in pain and function are seen over time in subjects at risk for and with radiographic knee osteoarthritis (OA). We hypothesized that this variation may be related not only to knee OA but also to patient characteristics. The objective of this study was to investigate the influence of age, gender, and body mass index (BMI) on clinically relevant change in pain and function over two years in subjects at high risk for or with knee OA.

Methods

We assessed 143 individuals (16% women, mean age 50 years [range 27–83]) twice; 14 and 16 years after isolated meniscectomy. Subjects completed one disease-specific questionnaire, the Knee injury and Osteoarthritis Outcome Score (KOOS) and one generic measure, the SF-36. Individuals with a BMI between 25 and 29.9 were considered overweight, while individuals with a BMI of 30 or more were considered obese.

Results

Subjects aged 46–56 (the middle tertile) were more likely to change (≥10 points on a 0–100 scale) in the KOOS subscale Activities of Daily Living (ADL) than younger subjects (odds ratio [OR] 4.5, 95% confidence interval [95% CI] 1.5–13.0). Essentially the same result was obtained after adjusting for baseline values. Overweight or obesity was a risk factor for clinically relevant change for knee pain (OR 2.4, 95% CI 1.0 – 5.8, OR 4.0, 95% CI 1.2 – 13.6) and obesity for change in ADL (OR 4.3, 95% CI 1.2 – 15.4). The results did not remain significant when adjusted for the respective baseline value. Being symptomatic was strongly associated with increased variation in pain and function while presence or absence of radiographic changes did not influence change over two years in this cohort.

Conclusion

In a population highly enriched in early-stage and established knee OA, symptomatic, middle-aged, and overweight or obese subjects were more likely to vary in their knee function and pain over two years. The natural course of knee pain and function may be associated with subject characteristics such as age and BMI.
Appendix
Available only for authorised users
Literature
1.
Roos H, Lauren M, Adalberth T, Roos EM, Jonsson K, Lohmander LS: Knee osteoarthritis after meniscectomy: prevalence of radiographic changes after twenty-one years, compared with matched controls. Arthritis Rheum 1998, 41: 687–693. Publisher Full Text 10.1002/1529-0131(199804)41:4<687::AID-ART16>3.0.CO;2-2PubMedCrossRef
2.
Englund M, Roos EM, Lohmander LS: Impact of type of meniscal tear on radiographic and symptomatic knee osteoarthritis: a sixteen-year followup of meniscectomy with matched controls. Arthritis Rheum 2003, 48: 2178–2187. 10.1002/art.11088PubMedCrossRef
3.
Englund M, Lohmander LS: Risk factors for symptomatic knee osteoarthritis fifteen to twenty-two years after meniscectomy. Arthritis Rheum 2004, 50: 2811–2819. 10.1002/art.20489PubMedCrossRef
4.
Paradowski PT, Englund M, Roos EM, Lohmander LS: Similar group mean scores, but large individual variations, in patient-relevant outcomes over 2 years in meniscectomized subjects with and without radiographic knee osteoarthritis. Health Qual Life Outcomes 2004, 2: 38. 10.1186/1477-7525-2-38PubMedCentralPubMedCrossRef
5.
Roos EM, Roos HP, Ekdahl C, Lohmander LS: Knee injury and Osteoarthritis Outcome Score (KOOS)--validation of a Swedish version. Scand J Med Sci Sports 1998, 8: 439–448.PubMedCrossRef
6.
Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW: Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 1988, 15: 1833–1840.PubMed
7.
Roos EM, Roos HP, Lohmander LS, Ekdahl C, Beynnon BD: Knee Injury and Osteoarthritis Outcome Score (KOOS)--development of a self-administered outcome measure. J Orthop Sports Phys Ther 1998, 28: 88–96.PubMedCrossRef
8.
Roos EM, Toksvig-Larsen S: Knee injury and Osteoarthritis Outcome Score (KOOS) - validation and comparison to the WOMAC in total knee replacement. Health Qual Life Outcomes 2003, 1: 17. 10.1186/1477-7525-1-17PubMedCentralPubMedCrossRef
9.
Sullivan M, Karlsson J, Ware JEJ: The Swedish SF-36 Health Survey--I. Evaluation of data quality, scaling assumptions, reliability and construct validity across general populations in Sweden. Soc Sci Med 1995, 41: 1349–1358. 10.1016/0277-9536(95)00125-QPubMedCrossRef
10.
Ware JEJ, Sherbourne CD: The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992, 30: 473–483.PubMedCrossRef
11.
Hawker G, Melfi C, Paul J, Green R, Bombardier C: Comparison of a generic (SF-36) and a disease specific (WOMAC) (Western Ontario and McMaster Universities Osteoarthritis Index) instrument in the measurement of outcomes after knee replacement surgery. J Rheumatol 1995, 22: 1193–1196.PubMed
12.
Ehrich EW, Davies GM, Watson DJ, Bolognese JA, Seidenberg BC, Bellamy N: Minimal perceptible clinical improvement with the Western Ontario and McMaster Universities osteoarthritis index questionnaire and global assessments in patients with osteoarthritis. J Rheumatol 2000, 27: 2635–2641.PubMed
13.
14.
Dieppe P, Cushnaghan J, Tucker M, Browning S, Shepstone L: The Bristol 'OA500 study': progression and impact of the disease after 8 years. Osteoarthritis Cartilage 2000, 8: 63–68. 10.1053/joca.1999.0272PubMedCrossRef
15.
Petersson IF, Boegard T, Saxne T, Silman AJ, Svensson B: Radiographic osteoarthritis of the knee classified by the Ahlback and Kellgren & Lawrence systems for the tibiofemoral joint in people aged 35–54 years with chronic knee pain. Ann Rheum Dis 1997, 56: 493–496.PubMedCentralPubMedCrossRef
16.
Hart DJ, Doyle DV, Spector TD: Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study. Arthritis Rheum 1999, 42: 17–24. Publisher Full Text 10.1002/1529-0131(199901)42:1<17::AID-ANR2>3.0.CO;2-EPubMedCrossRef
17.
Roos EM, Paradowski PT, Bergman S, Lundius A, Lohmander LS: Knee specific outcomes related to age and gender in a population-based cohort. Arthritis Rheum 2004, 50: S666.
18.
Lethbridge-Cejku M, Scott WWJ, Reichle R, Ettinger WH, Zonderman A, Costa P, Plato CC, Tobin JD, Hochberg MC: Association of radiographic features of osteoarthritis of the knee with knee pain: data from the Baltimore Longitudinal Study of Aging. Arthritis Care Res 1995, 8: 182–188.PubMedCrossRef
19.
Hannan MT, Felson DT, Pincus T: Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. J Rheumatol 2000, 27: 1513–1517.PubMed
20.
Chatain F, Robinson AH, Adeleine P, Chambat P, Neyret P: The natural history of the knee following arthroscopic medial meniscectomy. Knee Surg Sports Traumatol Arthrosc 2001, 9: 15–18. 10.1007/s001670000146PubMedCrossRef
21.
Englund M, Roos EM, Roos HP, Lohmander LS: Patient-relevant outcomes fourteen years after meniscectomy: influence of type of meniscal tear and size of resection. Rheumatology (Oxford) 2001, 40: 631–639. 10.1093/rheumatology/40.6.631CrossRef
Metadata
Title
The effect of patient characteristics on variability in pain and function over two years in early knee osteoarthritis
Authors
Przemyslaw T Paradowski
Martin Englund
L Stefan Lohmander
Ewa M Roos
Publication date
01-12-2005
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2005
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-3-59

Other articles of this Issue 1/2005

Health and Quality of Life Outcomes 1/2005 Go to the issue

Research

Quality of life after acute myocardial infarction: A comparison of diabetic versus non-diabetic acute myocardial infarction patients in Quebec acute care hospitals

Research

Effects of psycho-educational intervention on health-related quality of life (QOL) of patients with chronic liver disease referring to Shiraz University of Medical Sciences

Research

Responsiveness: a reinvention of the wheel?

Research

Health-related quality of life is related to COPD disease severity

Research

Effects of a self-care program on quality of life of cirrhotic patients referring to Tehran Hepatitis Center

Research

Internal consistency reliability is a poor predictor of responsiveness