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Open Access 01-12-2012 | Review

Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens

Authors: Ricarda Cortés-Vieyra, Alejandro Bravo-Patiño, Juan J Valdez-Alarcón, Marcos Cajero Juárez, B Brett Finlay, Víctor M Baizabal-Aguirre

Published in: Journal of Inflammation | Issue 1/2012

Abstract

Glycogen synthase kinase 3β (GSK3β) plays a fundamental role during the inflammatory response induced by bacteria. Depending on the pathogen and its virulence factors, the type of cell and probably the context in which the interaction between host cells and bacteria takes place, GSK3β may promote or inhibit inflammation. The goal of this review is to discuss recent findings on the role of the inhibition or activation of GSK3β and its modulation of the inflammatory signaling in monocytes/macrophages and epithelial cells at the transcriptional level, mainly through the regulation of nuclear factor-kappaB (NF-κB) activity. Also included is a brief overview on the importance of GSK3 in non-inflammatory processes during bacterial infection.

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Title: Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens
Authors: Ricarda Cortés-Vieyra
Alejandro Bravo-Patiño
Juan J Valdez-Alarcón
Marcos Cajero Juárez
B Brett Finlay
Víctor M Baizabal-Aguirre
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Journal of Inflammation / Issue 1/2012
Electronic ISSN: 1476-9255
DOI: https://doi.org/10.1186/1476-9255-9-23

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