Published in:
Open Access
01-12-2015 | Poster presentation
Characterisation of the murine C-type lectin receptor CLECSF8 (MCL) reveals its expression on cells of the monocyte/neutrophil lineages and an inter-dependence with Mincle, but not Dectin-2
Authors:
Bernhard Kerscher, Gillian J Wilson, Delyth M Reid, Sho Yamasaki, Janet A Willment, Gordon D Brown
Published in:
Journal of Inflammation
|
Special Issue 1/2015
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Excerpt
C-type lectin-like receptors (CTLRs) play critical roles in immunity and homeostasis by recognising a great variety of microbial or endogenous ligands [
1]. CLECSF8 is a member of the Dectin–2 family of CTLRs. Previous research indicates that CLECSF8 associates with the FcRγ adaptor, which is essential for surface expression and signalling through the SYK/CARD9 pathway. Recently, the mycobacterial cord factor (TDM, trehalose-6,6’-dimycolate) was identified as the ligand of CLECSF8, as shown previously for the closely related CTLR Mincle [
2]. Indeed, we recently showed that CLECSF8 plays a critical role in human and murine anti-mycobacterial immunity [
3]. In this study, we characterised CLECSF8 expression in the mouse under naïve and inflammatory conditions. …
