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Journal of Inflammation
Published in: Journal of Inflammation 1/2013

Open Access 01-08-2013 | Poster presentation

Brown Norway ovalbumin model: temporal profile of cytokines

Authors: Janice D Woodhouse, Alan Wilhelm, Michael Caniga, Malgorzata Gil, Jie Zhang-Hoover, Robbie McLeod, Lily Y Moy, Milenko Cicmil

Published in: Journal of Inflammation | Special Issue 1/2013

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Excerpt

The ovalbumin (OVA) sensitized and challenged Brown Norway (BN) rat model is a practical PD model often used to determine the impact of drug treatment on late phase lung inflammation. However, the sole measurement of bronchoalveolar lavage fluid (BALF) inflammatory cells does not always correlate into human efficacy for respiratory diseases such as asthma. Added value to this rodent model may be derived by a deeper understanding of the relationship between disease-related cytokine secretion and inflammation. …
Literature
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Chapman RW, Curran AK, House A, Richard J, Salisbury B, Hunter JC, Anthes JC, Phillips JE: Effect of mometasone furoate (MF)/formoterol fumarate (F) combination (MF/F) on late-phase responses in allergen-challenged Brown Norway rats. Pulm Pharmacol Ther. 2011, 24 (1): 67-73. 10.1016/j.pupt.2010.10.002.CrossRefPubMed
Metadata
Title
Brown Norway ovalbumin model: temporal profile of cytokines
Authors
Janice D Woodhouse
Alan Wilhelm
Michael Caniga
Malgorzata Gil
Jie Zhang-Hoover
Robbie McLeod
Lily Y Moy
Milenko Cicmil
Publication date
01-08-2013
Publisher
BioMed Central
Published in
Journal of Inflammation / Issue Special Issue 1/2013
Electronic ISSN: 1476-9255
DOI
https://doi.org/10.1186/1476-9255-10-S1-P9

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