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Journal of Inflammation
Published in: Journal of Inflammation 1/2013

Open Access 01-08-2013 | Poster presentation

Poly I:C causes exacerbation in a murine allergic inflammation model driven by house dust mite in Freund's complete adjuvant

Authors: Jorge De Alba, Raquel Otal, Elena Calama, Félix Gil, Neil Gozzard, Montserrat Miralpeix

Published in: Journal of Inflammation | Special Issue 1/2013

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Excerpt

RNA viruses are major causes of respiratory infections and known to exacerbate asthma and other respiratory diseases. The objective of the study was to use poly I:C, a synthetic analogue dsRNA, to elicit exacerbation in a model of allergic inflammation driven by house dust mite (HDM) in Freund's Complete Adjuvant (FCA). This model is characterized by airway hyperresponsiveness (AHR) and a mixed T-helper phenotype [1]. …
Literature
1.
Nasra J, Tomlinson K, Catley M, Palframan R, Watt G, Shaw S, Gozzard : Development Of a Murine Model Of Lung Inflammation And Airway Hyperresponsiveness Driven By House Dust Mite In Complete Freund’s Adjuvant. Am J Respir Crit Care Med. 2010, 181: A2842-
Metadata
Title
Poly I:C causes exacerbation in a murine allergic inflammation model driven by house dust mite in Freund's complete adjuvant
Authors
Jorge De Alba
Raquel Otal
Elena Calama
Félix Gil
Neil Gozzard
Montserrat Miralpeix
Publication date
01-08-2013
Publisher
BioMed Central
Published in
Journal of Inflammation / Issue Special Issue 1/2013
Electronic ISSN: 1476-9255
DOI
https://doi.org/10.1186/1476-9255-10-S1-P21

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