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Journal of Inflammation
Published in: Journal of Inflammation 1/2013

Open Access 01-08-2013 | Poster presentation

Time-course of inflammation and allergic bronchoconstrictor response in a model of ovalbumin-induced rapid pulmonary inflammation in Brown Norway rats

Authors: Sorif Uddin, Sara Hughes, Edith Hessel

Published in: Journal of Inflammation | Special Issue 1/2013

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Excerpt

Most animal models that elicit pulmonary allergic inflammation require a protracted sensitisation period that can last for weeks. We describe here further characterisation of a model developed by Werner-Klein and colleagues [1] that exhibits rapid and long lasting pulmonary eosinophilic infiltration requiring only a short sensitisation period. In addition, this modified rat model also exhibits a bronchoconstrictor response to allergen after a single rechallenge two weeks after the initial challenge period. …
Literature
1.
Werner-Klein M, Göggel R, Westhof A, Erb KJ: Pulm Pharmacol Ther. 2008, 21 (4): 648-56. 10.1016/j.pupt.2008.03.002.CrossRefPubMed
Metadata
Title
Time-course of inflammation and allergic bronchoconstrictor response in a model of ovalbumin-induced rapid pulmonary inflammation in Brown Norway rats
Authors
Sorif Uddin
Sara Hughes
Edith Hessel
Publication date
01-08-2013
Publisher
BioMed Central
Published in
Journal of Inflammation / Issue Special Issue 1/2013
Electronic ISSN: 1476-9255
DOI
https://doi.org/10.1186/1476-9255-10-S1-P12

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