Published in:
Open Access
01-08-2013 | Poster presentation
Exploring the role of SYK in respiratory in vivo models
Authors:
Michael Caniga, Janice D Woodhouse, Alan Wilhelm, Malgorzata A Gil, Yanlin Jia, Hongshi Yu, Stella Vincent, Richard Miller, Gissela Lieber, Xiomara Fernandez, Richard Chapman, Robbie McLeod, Lily Y Moy, Nancy Kelly, Emily Hickey, Michael A Crackower, Thomas Miller, William M Abraham, Milenko Cicmil
Published in:
Journal of Inflammation
|
Special Issue 1/2013
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Excerpt
Spleen Tyrosine Kinase (SYK) is a key activator of signaling pathways downstream of multiple surface receptors implicated in asthma. SYK function has been extensively studied in Last cells downstream of the high-affinity IgE receptor (FcεR1). Most studies evaluating SYK function in preclinical models have relied on poorly selective compounds, anti-sense oligonucleotides, or SYK knockout mice. Here we describe the characterization of SYK mechanism in multiple in vivo model settings. …
