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Journal of Inflammation
Published in: Journal of Inflammation 1/2013

Open Access 01-08-2013 | Meeting report

Models of respiratory disease symposium

Authors: Kathy H Abbott-Banner, Anthony Holmes, Ian Adcock, Navin L Rao, Edward Barrett, Richard Knowles

Published in: Journal of Inflammation | Special Issue 1/2013

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Excerpt

The symposium brought together representatives from the pharmaceutical industry and academia who are actively involved with establishing animal models and also in vitro translational assays of respiratory disease. It was the second of its kind, (the first one was held at the Glaxo SmithKline (GSK) Stevenage, UK site in April 2009) exchanging information on the difficult challenge of establishing predictive animal models of respiratory diseases. The organising group, which was led by Dr Kathy Abbott Banner and Prof. Richard Knowles, were originally drawn from the respiratory representatives of the European Federation of Pharmaceutical Industries and Associations (EFPIA) group of companies involved in a bid for EU funds to support work on severe asthma, but have spread the network to include many companies outside this group. …
Literature
1.
Holmes AM, Solari R, Holgate ST: Animal models of asthma: value, limitations and opportunities for alternative approaches. Drug Discov Today. 2011, 16 (15-16): 659-70. 10.1016/j.drudis.2011.05.014.CrossRefPubMed
2.
3.
4.
5.
Barnes PJ: Immunology of asthma and chronic obstructive pulmonary disease. Nat.Rev.Immunol. 2008, 8: 183-192. 10.1038/nri2254.CrossRefPubMed
6.
Holgate ST, Arshad HS, Roberts GC, Howarth PH, Thurner P, Davies DE: A new look at the pathogenesis of asthma. Clin.Sci.(Lond). 2010, 118: 439-450.CrossRef
7.
8.
Kumar RK, Foster PS: Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?. Front Physiol. 2012, 3: 312-PubMedCentralPubMed
9.
Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV: T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am.J.Respir.Crit Care Med. 2009, 180: 388-395. 10.1164/rccm.200903-0392OC.PubMedCentralCrossRefPubMed
10.
Choy DF, Modrek B, Abbas AR, Kummerfeld S, Clark HF, Wu LC, Fedorowicz G, Modrusan Z, Fahy JV, Woodruff PG: Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways. J.Immunol. 2011, 186: 1861-1869. 10.4049/jimmunol.1002568.PubMedCentralCrossRefPubMed
11.
Corren J, Lemanske RF, Hanania NA, Korenblat PE, Parsey MV, Arron JR, Harris JM, Scheerens H, Wu LC, Su Z: Lebrikizumab treatment in adults with asthma. N.Engl.J.Med. 2011, 365: 1088-1098. 10.1056/NEJMoa1106469.CrossRefPubMed
12.
McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A: TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J.Immunol. 2008, 181: 4089-4097.PubMedCentralCrossRefPubMed
13.
Jan ZG, ten Hacken NH, Hoffmann RF, Van Oosterhout AJ, Heijink IH: IL-17A induces glucocorticoid insensitivity in human bronchial epithelial cells. Eur.Respir.J. 2011
14.
Wenzel SE: Asthma phenotypes: the evolution from clinical to molecular approaches. Nat.Med. 2012, 18: 716-725. 10.1038/nm.2678.CrossRefPubMed
15.
Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, Wardlaw AJ, Green RH: Cluster Analysis and Clinical Asthma Phenotypes. Am J Respir Crit Care Med. 2008
16.
Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R, Castro M, Curran-Everett D, Fitzpatrick AM: Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am.J.Respir.Crit Care Med. 2010, 181: 315-323. 10.1164/rccm.200906-0896OC.PubMedCentralCrossRefPubMed
17.
Bel EH, Sousa A, Fleming L, Bush A, Chung KF, Versnel J, Wagener AH, Wagers SS, Sterk PJ, Compton CH: Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI). Thorax. 2011, 66: 910-917. 10.1136/thx.2010.153643.CrossRefPubMed
18.
Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, Ortega H, Chanez P: Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012, 380: 651-659. 10.1016/S0140-6736(12)60988-X.CrossRefPubMed
19.
Fleischmann R, Kremer J, Cush J, Schulze-Koops H, Connell CA, Bradley JD, Gruben D, Wallenstein GV, Zwillich SH, Kanik KS: Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. N.Engl.J.Med. 2012, 367: 495-507. 10.1056/NEJMoa1109071.CrossRefPubMed
20.
Adcock IM, Caramori G, Chung KF: New targets for drug development in asthma. Lancet. 2008, 372: 1073-1087. 10.1016/S0140-6736(08)61449-X.CrossRefPubMed
21.
Jackson DJ, Sykes A, Mallia P, Johnston SL: Asthma exacerbations: origin, effect, and prevention. J.Allergy Clin.Immunol. 2011, 128: 1165-1174. 10.1016/j.jaci.2011.10.024.CrossRefPubMed
Metadata
Title
Models of respiratory disease symposium
Authors
Kathy H Abbott-Banner
Anthony Holmes
Ian Adcock
Navin L Rao
Edward Barrett
Richard Knowles
Publication date
01-08-2013
Publisher
BioMed Central
Published in
Journal of Inflammation / Issue Special Issue 1/2013
Electronic ISSN: 1476-9255
DOI
https://doi.org/10.1186/1476-9255-10-S1-I1

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