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Cardiovascular Ultrasound

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Open Access 01-12-2014 | Research

Time-course changes in left ventricular myocardial deformation in STZ-induced rabbits on velocity vector imaging

Authors: Shi Zeng, Tao Jiang, Qi-chang Zhou, Lianghui Yuan, Jia-wei Zhou, Dan-min Cao

Published in: Cardiovascular Ultrasound | Issue 1/2014

Abstract

Objectives

To clarify the time-course changes in left ventricular myocardial deformation using velocity vector imaging and to provide insights into our understanding of the cardiac pathophysiology in diabetes mellitus.

Methods

Thirty New Zealand white rabbits were randomly divided into either the control group (n = 10) or the diabetes mellitus (DM) group (induced with STZ, n = 20). For the myocardial deformation studies, echocardiography and syngo-vector velocity imaging (VVI) were performed at baseline and after 2, 4, 8, and 12 weeks in all of the rabbits. The left ventricular (LV) global longitudinal and circumferential strain and strain rate were measured. For histomorphological study of the heart structure, 2 of the STZ-induced rabbits were killed at 2, 4, 8, and 12 weeks. Routine hematoxylin and eosin staining was performed.

Results

At 2 weeks, the global longitudinal strain (GLS), systolic strain rate (GLSRs), and diastolic strain rate (GLSRd) were significantly lower in the DM group compared with the control group (-18.16% versus -24.00%, -1.86 s^-1 versus -2.49 s^-1, 1.93 s^-1 versus 2.42 s^-1, respectively, P < 0.05), while, compared with the control group, the global circumferential strain (GCS), systolic strain rate (GCSRs), and diastolic strain rate (GCSRd) in the DM group were significantly decreased (-12.77% versus -23.31%, -1.31 s^-1 versus -2.20 s^-1, 1.41 s^-1 versus 2.15 s^-1, respectively, P < 0.05) at 8 weeks. With the progression of untreated diabetes, the histoanatomical alterations intensified gradually beginning at 2 weeks.

Conclusions

The progressive impairments in LV myocardial deformation and structure occurred early in diabetic rabbits with normal LV ejection fraction (EF), FS, and E/A. VVI could be used to evaluate subtle cardiac dysfunction in the early phase of DM.

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Title: Time-course changes in left ventricular myocardial deformation in STZ-induced rabbits on velocity vector imaging
Authors: Shi Zeng
Tao Jiang
Qi-chang Zhou
Lianghui Yuan
Jia-wei Zhou
Dan-min Cao
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Cardiovascular Ultrasound / Issue 1/2014
Electronic ISSN: 1476-7120
DOI: https://doi.org/10.1186/1476-7120-12-17

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