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Molecular Cancer
Published in: Molecular Cancer 1/2010

Open Access 01-12-2010 | Review

Integrin-mediated function of Rab GTPases in cancer progression

Authors: Dhatchayini Subramani, Suresh K Alahari

Published in: Molecular Cancer | Issue 1/2010

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Abstract

The RAS (rat sarcoma) superfamily of small GTPases is broadly subdivided into five groups: Ras, Rho, Rab, Ran, and Arf. Rab family proteins are important in regulating signal transduction and cellular processes such as differentiation, proliferation, vesicle transport, nuclear assembly, and cytoskeleton formation. However, some Rab proteins have been reported to be necessary for the adhesion and migration of cancer cells. Although Ras and Rho family members have been strongly implicated in cancer progression, knowledge of Rabs action in this regard is limited. Some reports have also linked Rab GTPases with cancer cell migration and invasiveness. This review discusses the implications of the involvement of Rabs in malignant transformation and cancer therapy through integrin-mediated signaling events, with particular emphasis on breast cancer.
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Metadata
Title
Integrin-mediated function of Rab GTPases in cancer progression
Authors
Dhatchayini Subramani
Suresh K Alahari
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2010
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-9-312

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