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Molecular Cancer
Published in: Molecular Cancer 1/2010

Open Access 01-12-2010 | Review

Personalized therapies in the cancer "omics" era

Authors: Alberto Ocaña, Atanasio Pandiella

Published in: Molecular Cancer | Issue 1/2010

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Abstract

A molecular hallmark of cancer is the presence of genetic alterations in the tumoral DNA. Understanding how these alterations translate into the malignant phenotype is critical for the adequate treatment of oncologic diseases. Several cancer genome sequencing reports have uncovered the number and identity of proteins and pathways frequently altered in cancer. In this article we discuss how integration of these genomic data with other biological and proteomic studies may help in designing anticancer therapies "a la carte". An important conclusion is that next generation treatment of neoplasias must be based on rational drug combinations that target various pathways and cellular entities that sustain the survival of cancer cells.
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Metadata
Title
Personalized therapies in the cancer "omics" era
Authors
Alberto Ocaña
Atanasio Pandiella
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2010
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-9-202

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