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Published in: Molecular Cancer 1/2006

Open Access 01-12-2006 | Review

Epigenetic aberrations and cancer

Authors: Miryam Ducasse, Mark A Brown

Published in: Molecular Cancer | Issue 1/2006

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Abstract

The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms. Here, we review recent findings regarding chromatin modifications and their relevance to cancer.
Literature
1.
go back to reference Sims RJ, Reinberg D: From chromatin to cancer: a new histone lysine methyltransferase enters the mix. Nat Cell Biol. 2004, 6 (8): 685-687. 10.1038/ncb0804-685PubMed Sims RJ, Reinberg D: From chromatin to cancer: a new histone lysine methyltransferase enters the mix. Nat Cell Biol. 2004, 6 (8): 685-687. 10.1038/ncb0804-685PubMed
2.
go back to reference Cavalli G: Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity. Development. 2006, 133 (11): 2089-2094. 10.1242/dev.02402PubMed Cavalli G: Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity. Development. 2006, 133 (11): 2089-2094. 10.1242/dev.02402PubMed
3.
go back to reference Brown MA, Sims RJ, Gottlieb PD, Tucker PW: Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Mol Cancer. 2006, 5: 26- 10.1186/1476-4598-5-26PubMedCentralPubMed Brown MA, Sims RJ, Gottlieb PD, Tucker PW: Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Mol Cancer. 2006, 5: 26- 10.1186/1476-4598-5-26PubMedCentralPubMed
4.
go back to reference Jenuwein T, Allis CD: Translating the histone code. Science. 2001, 293 (5532): 1074-1080. 10.1126/science.1063127PubMed Jenuwein T, Allis CD: Translating the histone code. Science. 2001, 293 (5532): 1074-1080. 10.1126/science.1063127PubMed
5.
go back to reference Jenuwein T: The epigenetic magic of histone lysine methylation. Febs J. 2006, 273 (14): 3121-3135. 10.1111/j.1742-4658.2006.05343.xPubMed Jenuwein T: The epigenetic magic of histone lysine methylation. Febs J. 2006, 273 (14): 3121-3135. 10.1111/j.1742-4658.2006.05343.xPubMed
6.
go back to reference Festenstein R, Aragon L: Decoding the epigenetic effects of chromatin. Genome Biol. 2003, 4 (10): 342- 10.1186/gb-2003-4-10-342PubMedCentralPubMed Festenstein R, Aragon L: Decoding the epigenetic effects of chromatin. Genome Biol. 2003, 4 (10): 342- 10.1186/gb-2003-4-10-342PubMedCentralPubMed
7.
go back to reference Mito Y, Henikoff JG, Henikoff S: Genome-scale profiling of histone H3.3 replacement patterns. Nat Genet. 2005, 37 (10): 1090-1097. 10.1038/ng1637PubMed Mito Y, Henikoff JG, Henikoff S: Genome-scale profiling of histone H3.3 replacement patterns. Nat Genet. 2005, 37 (10): 1090-1097. 10.1038/ng1637PubMed
9.
go back to reference Staub E, Grone J, Mennerich D, Ropcke S, Klamann I, Hinzmann B, Castanos-Velez E, Mann B, Pilarsky C, Brummendorf T, Weber B, Buhr HJ, Rosenthal A: A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer. Mol Cancer. 2006, 5: 37- 10.1186/1476-4598-5-37PubMedCentralPubMed Staub E, Grone J, Mennerich D, Ropcke S, Klamann I, Hinzmann B, Castanos-Velez E, Mann B, Pilarsky C, Brummendorf T, Weber B, Buhr HJ, Rosenthal A: A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer. Mol Cancer. 2006, 5: 37- 10.1186/1476-4598-5-37PubMedCentralPubMed
10.
go back to reference Baylin SB, Ohm JE: Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?. Nat Rev Cancer. 2006, 6 (2): 107-116. 10.1038/nrc1799PubMed Baylin SB, Ohm JE: Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?. Nat Rev Cancer. 2006, 6 (2): 107-116. 10.1038/nrc1799PubMed
11.
go back to reference Turner BM: Cellular memory and the histone code. Cell. 2002, 111 (3): 285-291. 10.1016/S0092-8674(02)01080-2PubMed Turner BM: Cellular memory and the histone code. Cell. 2002, 111 (3): 285-291. 10.1016/S0092-8674(02)01080-2PubMed
12.
go back to reference Richmond TJ: Genomics: predictable packaging. Nature. 2006, 442 (7104): 750-752. 10.1038/442750aPubMed Richmond TJ: Genomics: predictable packaging. Nature. 2006, 442 (7104): 750-752. 10.1038/442750aPubMed
13.
go back to reference Kornberg RD, Lorch Y: Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell. 1999, 98 (3): 285-294. 10.1016/S0092-8674(00)81958-3PubMed Kornberg RD, Lorch Y: Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell. 1999, 98 (3): 285-294. 10.1016/S0092-8674(00)81958-3PubMed
14.
go back to reference Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ: Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature. 1997, 389 (6648): 251-260. 10.1038/38444PubMed Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ: Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature. 1997, 389 (6648): 251-260. 10.1038/38444PubMed
15.
go back to reference Yap KL, Zhou MM: Structure and function of protein modules in chromatin biology. Results Probl Cell Differ. 2006, 41: 1-23.PubMed Yap KL, Zhou MM: Structure and function of protein modules in chromatin biology. Results Probl Cell Differ. 2006, 41: 1-23.PubMed
16.
go back to reference Khorasanizadeh S: The nucleosome: from genomic organization to genomic regulation. Cell. 2004, 116 (2): 259-272. 10.1016/S0092-8674(04)00044-3PubMed Khorasanizadeh S: The nucleosome: from genomic organization to genomic regulation. Cell. 2004, 116 (2): 259-272. 10.1016/S0092-8674(04)00044-3PubMed
17.
go back to reference Hayes JJ, Clark DJ, Wolffe AP: Histone contributions to the structure of DNA in the nucleosome. Proc Natl Acad Sci U S A. 1991, 88 (15): 6829-6833. 10.1073/pnas.88.15.6829PubMedCentralPubMed Hayes JJ, Clark DJ, Wolffe AP: Histone contributions to the structure of DNA in the nucleosome. Proc Natl Acad Sci U S A. 1991, 88 (15): 6829-6833. 10.1073/pnas.88.15.6829PubMedCentralPubMed
18.
go back to reference Vitolo JM, Thiriet C, Hayes JJ: The H3-H4 N-terminal tail domains are the primary mediators of transcription factor IIIA access to 5S DNA within a nucleosome. Mol Cell Biol. 2000, 20 (6): 2167-2175. 10.1128/MCB.20.6.2167-2175.2000PubMedCentralPubMed Vitolo JM, Thiriet C, Hayes JJ: The H3-H4 N-terminal tail domains are the primary mediators of transcription factor IIIA access to 5S DNA within a nucleosome. Mol Cell Biol. 2000, 20 (6): 2167-2175. 10.1128/MCB.20.6.2167-2175.2000PubMedCentralPubMed
19.
go back to reference Davey CA, Sargent DF, Luger K, Maeder AW, Richmond TJ: Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution. J Mol Biol. 2002, 319 (5): 1097-1113. 10.1016/S0022-2836(02)00386-8PubMed Davey CA, Sargent DF, Luger K, Maeder AW, Richmond TJ: Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution. J Mol Biol. 2002, 319 (5): 1097-1113. 10.1016/S0022-2836(02)00386-8PubMed
20.
go back to reference Segal E, Fondufe-Mittendorf Y, Chen L, Thastrom A, Field Y, Moore IK, Wang JP, Widom J: A genomic code for nucleosome positioning. Nature. 2006, 442 (7104): 772-778. 10.1038/nature04979PubMedCentralPubMed Segal E, Fondufe-Mittendorf Y, Chen L, Thastrom A, Field Y, Moore IK, Wang JP, Widom J: A genomic code for nucleosome positioning. Nature. 2006, 442 (7104): 772-778. 10.1038/nature04979PubMedCentralPubMed
21.
go back to reference Vicent GP, Nacht AS, Smith CL, Peterson CL, Dimitrov S, Beato M: DNA instructed displacement of histones H2A and H2B at an inducible promoter. Mol Cell. 2004, 16 (3): 439-452. 10.1016/j.molcel.2004.10.025PubMed Vicent GP, Nacht AS, Smith CL, Peterson CL, Dimitrov S, Beato M: DNA instructed displacement of histones H2A and H2B at an inducible promoter. Mol Cell. 2004, 16 (3): 439-452. 10.1016/j.molcel.2004.10.025PubMed
22.
go back to reference Oudet P, Gross-Bellard M, Chambon P: Electron microscopic and biochemical evidence that chromatin structure is a repeating unit. Cell. 1975, 4 (4): 281-300. 10.1016/0092-8674(75)90149-XPubMed Oudet P, Gross-Bellard M, Chambon P: Electron microscopic and biochemical evidence that chromatin structure is a repeating unit. Cell. 1975, 4 (4): 281-300. 10.1016/0092-8674(75)90149-XPubMed
23.
go back to reference Schalch T, Duda S, Sargent DF, Richmond TJ: X-ray structure of a tetranucleosome and its implications for the chromatin fibre. Nature. 2005, 436 (7047): 138-141. 10.1038/nature03686PubMed Schalch T, Duda S, Sargent DF, Richmond TJ: X-ray structure of a tetranucleosome and its implications for the chromatin fibre. Nature. 2005, 436 (7047): 138-141. 10.1038/nature03686PubMed
24.
go back to reference Bharath MM, Chandra NR, Rao MR: Molecular modeling of the chromatosome particle. Nucleic Acids Res. 2003, 31 (14): 4264-4274. 10.1093/nar/gkg481PubMedCentralPubMed Bharath MM, Chandra NR, Rao MR: Molecular modeling of the chromatosome particle. Nucleic Acids Res. 2003, 31 (14): 4264-4274. 10.1093/nar/gkg481PubMedCentralPubMed
25.
go back to reference Bednar J, Horowitz RA, Grigoryev SA, Carruthers LM, Hansen JC, Koster AJ, Woodcock CL: Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin. Proc Natl Acad Sci U S A. 1998, 95 (24): 14173-14178. 10.1073/pnas.95.24.14173PubMedCentralPubMed Bednar J, Horowitz RA, Grigoryev SA, Carruthers LM, Hansen JC, Koster AJ, Woodcock CL: Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin. Proc Natl Acad Sci U S A. 1998, 95 (24): 14173-14178. 10.1073/pnas.95.24.14173PubMedCentralPubMed
26.
go back to reference Cui Y, Bustamante C: Pulling a single chromatin fiber reveals the forces that maintain its higher-order structure. Proc Natl Acad Sci U S A. 2000, 97 (1): 127-132. 10.1073/pnas.97.1.127PubMedCentralPubMed Cui Y, Bustamante C: Pulling a single chromatin fiber reveals the forces that maintain its higher-order structure. Proc Natl Acad Sci U S A. 2000, 97 (1): 127-132. 10.1073/pnas.97.1.127PubMedCentralPubMed
27.
go back to reference Robinson PJ, Rhodes D: Structure of the '30 nm' chromatin fibre: a key role for the linker histone. Curr Opin Struct Biol. 2006, 16 (3): 336-343. 10.1016/j.sbi.2006.05.007PubMed Robinson PJ, Rhodes D: Structure of the '30 nm' chromatin fibre: a key role for the linker histone. Curr Opin Struct Biol. 2006, 16 (3): 336-343. 10.1016/j.sbi.2006.05.007PubMed
28.
go back to reference Adkins NL, Watts M, Georgel PT: To the 30-nm chromatin fiber and beyond. Biochim Biophys Acta. 2004, 1677 (1-3): 12-23.PubMed Adkins NL, Watts M, Georgel PT: To the 30-nm chromatin fiber and beyond. Biochim Biophys Acta. 2004, 1677 (1-3): 12-23.PubMed
29.
go back to reference McBryant SJ, Adams VH, Hansen JC: Chromatin architectural proteins. Chromosome Res. 2006, 14 (1): 39-51. 10.1007/s10577-006-1025-xPubMed McBryant SJ, Adams VH, Hansen JC: Chromatin architectural proteins. Chromosome Res. 2006, 14 (1): 39-51. 10.1007/s10577-006-1025-xPubMed
30.
go back to reference Reiner SL: Epigenetic control in the immune response. Hum Mol Genet. 2005, 14 Spec No 1: R41-6. 10.1093/hmg/ddi115PubMed Reiner SL: Epigenetic control in the immune response. Hum Mol Genet. 2005, 14 Spec No 1: R41-6. 10.1093/hmg/ddi115PubMed
31.
go back to reference Margueron R, Trojer P, Reinberg D: The key to development: interpreting the histone code?. Curr Opin Genet Dev. 2005, 15 (2): 163-176. 10.1016/j.gde.2005.01.005PubMed Margueron R, Trojer P, Reinberg D: The key to development: interpreting the histone code?. Curr Opin Genet Dev. 2005, 15 (2): 163-176. 10.1016/j.gde.2005.01.005PubMed
32.
go back to reference Lin W, Dent SY: Functions of histone-modifying enzymes in development. Curr Opin Genet Dev. 2006, 16 (2): 137-142. 10.1016/j.gde.2006.02.002PubMed Lin W, Dent SY: Functions of histone-modifying enzymes in development. Curr Opin Genet Dev. 2006, 16 (2): 137-142. 10.1016/j.gde.2006.02.002PubMed
33.
go back to reference Dannenberg JH, David G, Zhong S, van der Torre J, Wong WH, Depinho RA: mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes Dev. 2005, 19 (13): 1581-1595. 10.1101/gad.1286905PubMedCentralPubMed Dannenberg JH, David G, Zhong S, van der Torre J, Wong WH, Depinho RA: mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes Dev. 2005, 19 (13): 1581-1595. 10.1101/gad.1286905PubMedCentralPubMed
34.
go back to reference Zhang Y, Reinberg D: Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev. 2001, 15 (18): 2343-2360. 10.1101/gad.927301PubMed Zhang Y, Reinberg D: Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev. 2001, 15 (18): 2343-2360. 10.1101/gad.927301PubMed
35.
go back to reference Lachner M, Jenuwein T: The many faces of histone lysine methylation. Curr Opin Cell Biol. 2002, 14 (3): 286-298. 10.1016/S0955-0674(02)00335-6PubMed Lachner M, Jenuwein T: The many faces of histone lysine methylation. Curr Opin Cell Biol. 2002, 14 (3): 286-298. 10.1016/S0955-0674(02)00335-6PubMed
36.
go back to reference Kouzarides T: Histone methylation in transcriptional control. Curr Opin Genet Dev. 2002, 12 (2): 198-209. 10.1016/S0959-437X(02)00287-3PubMed Kouzarides T: Histone methylation in transcriptional control. Curr Opin Genet Dev. 2002, 12 (2): 198-209. 10.1016/S0959-437X(02)00287-3PubMed
37.
go back to reference Bernstein E, Hake SB: The nucleosome: a little variation goes a long way. Biochem Cell Biol. 2006, 84 (4): 505-517. 10.1139/O06-085PubMed Bernstein E, Hake SB: The nucleosome: a little variation goes a long way. Biochem Cell Biol. 2006, 84 (4): 505-517. 10.1139/O06-085PubMed
38.
go back to reference Lund AH, van Lohuizen M: Epigenetics and cancer. Genes Dev. 2004, 18 (19): 2315-2335. 10.1101/gad.1232504PubMed Lund AH, van Lohuizen M: Epigenetics and cancer. Genes Dev. 2004, 18 (19): 2315-2335. 10.1101/gad.1232504PubMed
39.
go back to reference Fraga MF, Esteller M: Towards the human cancer epigenome: a first draft of histone modifications. Cell Cycle. 2005, 4 (10): 1377-1381.PubMed Fraga MF, Esteller M: Towards the human cancer epigenome: a first draft of histone modifications. Cell Cycle. 2005, 4 (10): 1377-1381.PubMed
40.
go back to reference Agrelo R, Cheng WH, Setien F, Ropero S, Espada J, Fraga MF, Herranz M, Paz MF, Sanchez-Cespedes M, Artiga MJ, Guerrero D, Castells A, von Kobbe C, Bohr VA, Esteller M: Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci U S A. 2006, 103 (23): 8822-8827. 10.1073/pnas.0600645103PubMedCentralPubMed Agrelo R, Cheng WH, Setien F, Ropero S, Espada J, Fraga MF, Herranz M, Paz MF, Sanchez-Cespedes M, Artiga MJ, Guerrero D, Castells A, von Kobbe C, Bohr VA, Esteller M: Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci U S A. 2006, 103 (23): 8822-8827. 10.1073/pnas.0600645103PubMedCentralPubMed
41.
go back to reference Egger G, Liang G, Aparicio A, Jones PA: Epigenetics in human disease and prospects for epigenetic therapy. Nature. 2004, 429 (6990): 457-463. 10.1038/nature02625PubMed Egger G, Liang G, Aparicio A, Jones PA: Epigenetics in human disease and prospects for epigenetic therapy. Nature. 2004, 429 (6990): 457-463. 10.1038/nature02625PubMed
42.
go back to reference Dhillon N, Kamakaka RT: Breaking through to the other side: silencers and barriers. Curr Opin Genet Dev. 2002, 12 (2): 188-192. 10.1016/S0959-437X(02)00285-XPubMed Dhillon N, Kamakaka RT: Breaking through to the other side: silencers and barriers. Curr Opin Genet Dev. 2002, 12 (2): 188-192. 10.1016/S0959-437X(02)00285-XPubMed
43.
go back to reference Wittenberg C, Reed SI: Cell cycle-dependent transcription in yeast: promoters, transcription factors, and transcriptomes. Oncogene. 2005, 24 (17): 2746-2755. 10.1038/sj.onc.1208606PubMed Wittenberg C, Reed SI: Cell cycle-dependent transcription in yeast: promoters, transcription factors, and transcriptomes. Oncogene. 2005, 24 (17): 2746-2755. 10.1038/sj.onc.1208606PubMed
44.
go back to reference Ney PA: Gene expression during terminal erythroid differentiation. Curr Opin Hematol. 2006, 13 (4): 203-208. 10.1097/01.moh.0000231415.18333.2cPubMed Ney PA: Gene expression during terminal erythroid differentiation. Curr Opin Hematol. 2006, 13 (4): 203-208. 10.1097/01.moh.0000231415.18333.2cPubMed
45.
go back to reference Teng CT: Factors regulating lactoferrin gene expression. Biochem Cell Biol. 2006, 84 (3): 263-267. 10.1139/O06-034PubMed Teng CT: Factors regulating lactoferrin gene expression. Biochem Cell Biol. 2006, 84 (3): 263-267. 10.1139/O06-034PubMed
46.
go back to reference Olson EN: Gene regulatory networks in the evolution and development of the heart. Science. 2006, 313 (5795): 1922-1927. 10.1126/science.1132292PubMedCentralPubMed Olson EN: Gene regulatory networks in the evolution and development of the heart. Science. 2006, 313 (5795): 1922-1927. 10.1126/science.1132292PubMedCentralPubMed
47.
go back to reference Thomas MC, Chiang CM: The general transcription machinery and general cofactors. Crit Rev Biochem Mol Biol. 2006, 41 (3): 105-178. 10.1080/10409230600648736PubMed Thomas MC, Chiang CM: The general transcription machinery and general cofactors. Crit Rev Biochem Mol Biol. 2006, 41 (3): 105-178. 10.1080/10409230600648736PubMed
48.
go back to reference Hebbar PB, Archer TK: Chromatin remodeling by nuclear receptors. Chromosoma. 2003, 111 (8): 495-504.PubMed Hebbar PB, Archer TK: Chromatin remodeling by nuclear receptors. Chromosoma. 2003, 111 (8): 495-504.PubMed
49.
go back to reference Kumar R, Johnson BH, Thompson EB: Overview of the structural basis for transcription regulation by nuclear hormone receptors. Essays Biochem. 2004, 40: 27-39.PubMed Kumar R, Johnson BH, Thompson EB: Overview of the structural basis for transcription regulation by nuclear hormone receptors. Essays Biochem. 2004, 40: 27-39.PubMed
50.
go back to reference Hawkins RD, Ren B: Genome-wide location analysis: insights on transcriptional regulation. Hum Mol Genet. 2006, 15 Spec No 1: R1-7. 10.1093/hmg/ddl043PubMed Hawkins RD, Ren B: Genome-wide location analysis: insights on transcriptional regulation. Hum Mol Genet. 2006, 15 Spec No 1: R1-7. 10.1093/hmg/ddl043PubMed
51.
go back to reference Johnson CN, Adkins NL, Georgel P: Chromatin remodeling complexes: ATP-dependent machines in action. Biochem Cell Biol. 2005, 83 (4): 405-417. 10.1139/o05-115PubMed Johnson CN, Adkins NL, Georgel P: Chromatin remodeling complexes: ATP-dependent machines in action. Biochem Cell Biol. 2005, 83 (4): 405-417. 10.1139/o05-115PubMed
52.
go back to reference Becker PB, Hörz W: ATP-dependent nucleosome remodeling. Annu Rev Biochem. 2002, 71: 247-273. 10.1146/annurev.biochem.71.110601.135400PubMed Becker PB, Hörz W: ATP-dependent nucleosome remodeling. Annu Rev Biochem. 2002, 71: 247-273. 10.1146/annurev.biochem.71.110601.135400PubMed
53.
go back to reference Horn PJ, Peterson CL: The bromodomain: a regulator of ATP-dependent chromatin remodeling?. Front Biosci. 2001, 6: D1019-23.PubMed Horn PJ, Peterson CL: The bromodomain: a regulator of ATP-dependent chromatin remodeling?. Front Biosci. 2001, 6: D1019-23.PubMed
54.
go back to reference Dirscherl SS, Krebs JE: Functional diversity of ISWI complexes. Biochem Cell Biol. 2004, 82 (4): 482-489. 10.1139/o04-044PubMed Dirscherl SS, Krebs JE: Functional diversity of ISWI complexes. Biochem Cell Biol. 2004, 82 (4): 482-489. 10.1139/o04-044PubMed
55.
go back to reference Bouazoune K, Mitterweger A, Langst G, Imhof A, Akhtar A, Becker PB, Brehm A: The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization. Embo J. 2002, 21 (10): 2430-2440. 10.1093/emboj/21.10.2430PubMedCentralPubMed Bouazoune K, Mitterweger A, Langst G, Imhof A, Akhtar A, Becker PB, Brehm A: The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization. Embo J. 2002, 21 (10): 2430-2440. 10.1093/emboj/21.10.2430PubMedCentralPubMed
56.
go back to reference Nagaich AK, Walker DA, Wolford R, Hager GL: Rapid periodic binding and displacement of the glucocorticoid receptor during chromatin remodeling. Mol Cell. 2004, 14 (2): 163-174. 10.1016/S1097-2765(04)00178-9PubMed Nagaich AK, Walker DA, Wolford R, Hager GL: Rapid periodic binding and displacement of the glucocorticoid receptor during chromatin remodeling. Mol Cell. 2004, 14 (2): 163-174. 10.1016/S1097-2765(04)00178-9PubMed
57.
go back to reference Mellor J: The dynamics of chromatin remodeling at promoters. Mol Cell. 2005, 19 (2): 147-157. 10.1016/j.molcel.2005.06.023PubMed Mellor J: The dynamics of chromatin remodeling at promoters. Mol Cell. 2005, 19 (2): 147-157. 10.1016/j.molcel.2005.06.023PubMed
58.
go back to reference Chen T, Li E: Establishment and maintenance of DNA methylation patterns in mammals. Curr Top Microbiol Immunol. 2006, 301: 179-201.PubMed Chen T, Li E: Establishment and maintenance of DNA methylation patterns in mammals. Curr Top Microbiol Immunol. 2006, 301: 179-201.PubMed
59.
go back to reference Wade PA: Methyl CpG binding proteins: coupling chromatin architecture to gene regulation. Oncogene. 2001, 20 (24): 3166-3173. 10.1038/sj.onc.1204340PubMed Wade PA: Methyl CpG binding proteins: coupling chromatin architecture to gene regulation. Oncogene. 2001, 20 (24): 3166-3173. 10.1038/sj.onc.1204340PubMed
60.
go back to reference Villagra A, Gutierrez J, Paredes R, Sierra J, Puchi M, Imschenetzky M, Wijnen Av A, Lian J, Stein G, Stein J, Montecino M: Reduced CpG methylation is associated with transcriptional activation of the bone-specific rat osteocalcin gene in osteoblasts. J Cell Biochem. 2002, 85 (1): 112-122. 10.1002/jcb.10113PubMed Villagra A, Gutierrez J, Paredes R, Sierra J, Puchi M, Imschenetzky M, Wijnen Av A, Lian J, Stein G, Stein J, Montecino M: Reduced CpG methylation is associated with transcriptional activation of the bone-specific rat osteocalcin gene in osteoblasts. J Cell Biochem. 2002, 85 (1): 112-122. 10.1002/jcb.10113PubMed
61.
go back to reference Monk M: Epigenetic programming of differential gene expression in development and evolution. Dev Genet. 1995, 17 (3): 188-197. 10.1002/dvg.1020170303PubMed Monk M: Epigenetic programming of differential gene expression in development and evolution. Dev Genet. 1995, 17 (3): 188-197. 10.1002/dvg.1020170303PubMed
62.
go back to reference Bird A: DNA methylation patterns and epigenetic memory. Genes Dev. 2002, 16 (1): 6-21. 10.1101/gad.947102PubMed Bird A: DNA methylation patterns and epigenetic memory. Genes Dev. 2002, 16 (1): 6-21. 10.1101/gad.947102PubMed
63.
go back to reference Hendrich B, Tweedie S: The methyl-CpG binding domain and the evolving role of DNA methylation in animals. Trends Genet. 2003, 19 (5): 269-277. 10.1016/S0168-9525(03)00080-5PubMed Hendrich B, Tweedie S: The methyl-CpG binding domain and the evolving role of DNA methylation in animals. Trends Genet. 2003, 19 (5): 269-277. 10.1016/S0168-9525(03)00080-5PubMed
64.
go back to reference Li E: Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet. 2002, 3 (9): 662-673. 10.1038/nrg887PubMed Li E: Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet. 2002, 3 (9): 662-673. 10.1038/nrg887PubMed
65.
go back to reference Holmes R, Soloway PD: Regulation of imprinted DNA methylation. Cytogenet Genome Res. 2006, 113 (1-4): 122-129. 10.1159/000090823PubMed Holmes R, Soloway PD: Regulation of imprinted DNA methylation. Cytogenet Genome Res. 2006, 113 (1-4): 122-129. 10.1159/000090823PubMed
66.
go back to reference Strahl BD, Allis CD: The language of covalent histone modifications. Nature. 2000, 403 (6765): 41-45. 10.1038/47412PubMed Strahl BD, Allis CD: The language of covalent histone modifications. Nature. 2000, 403 (6765): 41-45. 10.1038/47412PubMed
67.
go back to reference Dutnall RN, Denu JM: Methyl magic and HAT tricks. Nat Struct Biol. 2002, 9 (12): 888-891. 10.1038/nsb1202-888PubMed Dutnall RN, Denu JM: Methyl magic and HAT tricks. Nat Struct Biol. 2002, 9 (12): 888-891. 10.1038/nsb1202-888PubMed
68.
go back to reference McManus KJ, Hendzel MJ: The relationship between histone H3 phosphorylation and acetylation throughout the mammalian cell cycle. Biochem Cell Biol. 2006, 84 (4): 640-657. 10.1139/O06-086PubMed McManus KJ, Hendzel MJ: The relationship between histone H3 phosphorylation and acetylation throughout the mammalian cell cycle. Biochem Cell Biol. 2006, 84 (4): 640-657. 10.1139/O06-086PubMed
69.
go back to reference Daujat S, Bauer UM, Shah V, Turner B, Berger S, Kouzarides T: Crosstalk between CARM1 methylation and CBP acetylation on histone H3. Curr Biol. 2002, 12 (24): 2090-2097. 10.1016/S0960-9822(02)01387-8PubMed Daujat S, Bauer UM, Shah V, Turner B, Berger S, Kouzarides T: Crosstalk between CARM1 methylation and CBP acetylation on histone H3. Curr Biol. 2002, 12 (24): 2090-2097. 10.1016/S0960-9822(02)01387-8PubMed
70.
go back to reference Dillon N, Festenstein R: Unravelling heterochromatin: competition between positive and negative factors regulates accessibility. Trends Genet. 2002, 18 (5): 252-258. 10.1016/S0168-9525(02)02648-3PubMed Dillon N, Festenstein R: Unravelling heterochromatin: competition between positive and negative factors regulates accessibility. Trends Genet. 2002, 18 (5): 252-258. 10.1016/S0168-9525(02)02648-3PubMed
71.
go back to reference Allfrey VG, Faulkner R, Mirsky AE: Acetylation and Methylation of Histones and Their Possible Role in the Regulation of Rna Synthesis. Proc Natl Acad Sci U S A. 1964, 51: 786-794. 10.1073/pnas.51.5.786PubMedCentralPubMed Allfrey VG, Faulkner R, Mirsky AE: Acetylation and Methylation of Histones and Their Possible Role in the Regulation of Rna Synthesis. Proc Natl Acad Sci U S A. 1964, 51: 786-794. 10.1073/pnas.51.5.786PubMedCentralPubMed
72.
go back to reference Kimura A, Matsubara K, Horikoshi M: A decade of histone acetylation: marking eukaryotic chromosomes with specific codes. J Biochem (Tokyo). 2005, 138 (6): 647-662. Kimura A, Matsubara K, Horikoshi M: A decade of histone acetylation: marking eukaryotic chromosomes with specific codes. J Biochem (Tokyo). 2005, 138 (6): 647-662.
73.
go back to reference Verdone L, Caserta M, Di Mauro E: Role of histone acetylation in the control of gene expression. Biochem Cell Biol. 2005, 83 (3): 344-353. 10.1139/o05-041PubMed Verdone L, Caserta M, Di Mauro E: Role of histone acetylation in the control of gene expression. Biochem Cell Biol. 2005, 83 (3): 344-353. 10.1139/o05-041PubMed
74.
go back to reference Verdone L, Agricola E, Caserta M, Di Mauro E: Histone acetylation in gene regulation. Brief Funct Genomic Proteomic. 2006, 5 (3): 209-221. 10.1093/bfgp/ell028PubMed Verdone L, Agricola E, Caserta M, Di Mauro E: Histone acetylation in gene regulation. Brief Funct Genomic Proteomic. 2006, 5 (3): 209-221. 10.1093/bfgp/ell028PubMed
75.
go back to reference Umlauf D, Goto Y, Feil R: Site-specific analysis of histone methylation and acetylation. Methods Mol Biol. 2004, 287: 99-120.PubMed Umlauf D, Goto Y, Feil R: Site-specific analysis of histone methylation and acetylation. Methods Mol Biol. 2004, 287: 99-120.PubMed
76.
go back to reference de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB: Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J. 2003, 370 (Pt 3): 737-749. 10.1042/BJ20021321PubMedCentralPubMed de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB: Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J. 2003, 370 (Pt 3): 737-749. 10.1042/BJ20021321PubMedCentralPubMed
77.
go back to reference Agalioti T, Chen G, Thanos D: Deciphering the transcriptional histone acetylation code for a human gene. Cell. 2002, 111 (3): 381-392. 10.1016/S0092-8674(02)01077-2PubMed Agalioti T, Chen G, Thanos D: Deciphering the transcriptional histone acetylation code for a human gene. Cell. 2002, 111 (3): 381-392. 10.1016/S0092-8674(02)01077-2PubMed
78.
go back to reference Xu F, Zhang K, Grunstein M: Acetylation in histone H3 globular domain regulates gene expression in yeast. Cell. 2005, 121 (3): 375-385. 10.1016/j.cell.2005.03.011PubMed Xu F, Zhang K, Grunstein M: Acetylation in histone H3 globular domain regulates gene expression in yeast. Cell. 2005, 121 (3): 375-385. 10.1016/j.cell.2005.03.011PubMed
79.
go back to reference Brownell JE, Zhou J, Ranalli T, Kobayashi R, Edmondson DG, Roth SY, Allis CD: Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell. 1996, 84 (6): 843-851. 10.1016/S0092-8674(00)81063-6PubMed Brownell JE, Zhou J, Ranalli T, Kobayashi R, Edmondson DG, Roth SY, Allis CD: Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell. 1996, 84 (6): 843-851. 10.1016/S0092-8674(00)81063-6PubMed
80.
go back to reference Yang XJ: The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res. 2004, 32 (3): 959-976. 10.1093/nar/gkh252PubMedCentralPubMed Yang XJ: The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res. 2004, 32 (3): 959-976. 10.1093/nar/gkh252PubMedCentralPubMed
81.
go back to reference Gregoretti IV, Lee YM, Goodson HV: Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol. 2004, 338 (1): 17-31. 10.1016/j.jmb.2004.02.006PubMed Gregoretti IV, Lee YM, Goodson HV: Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol. 2004, 338 (1): 17-31. 10.1016/j.jmb.2004.02.006PubMed
82.
go back to reference Marmorstein R, Roth SY: Histone acetyltransferases: function, structure, and catalysis. Curr Opin Genet Dev. 2001, 11 (2): 155-161. 10.1016/S0959-437X(00)00173-8PubMed Marmorstein R, Roth SY: Histone acetyltransferases: function, structure, and catalysis. Curr Opin Genet Dev. 2001, 11 (2): 155-161. 10.1016/S0959-437X(00)00173-8PubMed
83.
go back to reference Taunton J, Hassig CA, Schreiber SL: A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science. 1996, 272 (5260): 408-411. 10.1126/science.272.5260.408PubMed Taunton J, Hassig CA, Schreiber SL: A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science. 1996, 272 (5260): 408-411. 10.1126/science.272.5260.408PubMed
84.
go back to reference Blander G, Guarente L: The Sir2 family of protein deacetylases. Annu Rev Biochem. 2004, 73: 417-435. 10.1146/annurev.biochem.73.011303.073651PubMed Blander G, Guarente L: The Sir2 family of protein deacetylases. Annu Rev Biochem. 2004, 73: 417-435. 10.1146/annurev.biochem.73.011303.073651PubMed
85.
go back to reference Nusinzon I, Horvath CM: Histone deacetylases as transcriptional activators? Role reversal in inducible gene regulation. Sci STKE. 2005, 2005 (296): re11- 10.1126/stke.2962005re11PubMed Nusinzon I, Horvath CM: Histone deacetylases as transcriptional activators? Role reversal in inducible gene regulation. Sci STKE. 2005, 2005 (296): re11- 10.1126/stke.2962005re11PubMed
86.
go back to reference Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y: Histone demethylation by a family of JmjC domain-containing proteins. Nature. 2006, 439 (7078): 811-816. 10.1038/nature04433PubMed Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y: Histone demethylation by a family of JmjC domain-containing proteins. Nature. 2006, 439 (7078): 811-816. 10.1038/nature04433PubMed
87.
go back to reference Wang H, An W, Cao R, Xia L, Erdjument-Bromage H, Chatton B, Tempst P, Roeder RG, Zhang Y: mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol Cell. 2003, 12 (2): 475-487. 10.1016/j.molcel.2003.08.007PubMed Wang H, An W, Cao R, Xia L, Erdjument-Bromage H, Chatton B, Tempst P, Roeder RG, Zhang Y: mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol Cell. 2003, 12 (2): 475-487. 10.1016/j.molcel.2003.08.007PubMed
88.
go back to reference Santos-Rosa H, Schneider R, Bannister AJ, Sherriff J, Bernstein BE, Emre NC, Schreiber SL, Mellor J, Kouzarides T: Active genes are tri-methylated at K4 of histone H3. Nature. 2002, 419 (6905): 407-411. 10.1038/nature01080PubMed Santos-Rosa H, Schneider R, Bannister AJ, Sherriff J, Bernstein BE, Emre NC, Schreiber SL, Mellor J, Kouzarides T: Active genes are tri-methylated at K4 of histone H3. Nature. 2002, 419 (6905): 407-411. 10.1038/nature01080PubMed
89.
go back to reference O'Carroll D, Erhardt S, Pagani M, Barton SC, Surani MA, Jenuwein T: The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol. 2001, 21 (13): 4330-4336. 10.1128/MCB.21.13.4330-4336.2001PubMedCentralPubMed O'Carroll D, Erhardt S, Pagani M, Barton SC, Surani MA, Jenuwein T: The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol. 2001, 21 (13): 4330-4336. 10.1128/MCB.21.13.4330-4336.2001PubMedCentralPubMed
90.
go back to reference Sims RJ, Nishioka K, Reinberg D: Histone lysine methylation: a signature for chromatin function. Trends Genet. 2003, 19 (11): 629-639. 10.1016/j.tig.2003.09.007PubMed Sims RJ, Nishioka K, Reinberg D: Histone lysine methylation: a signature for chromatin function. Trends Genet. 2003, 19 (11): 629-639. 10.1016/j.tig.2003.09.007PubMed
91.
go back to reference Sims RJ, Chen CF, Santos-Rosa H, Kouzarides T, Patel SS, Reinberg D: Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem. 2005, 280 (51): 41789-41792. 10.1074/jbc.C500395200PubMedCentralPubMed Sims RJ, Chen CF, Santos-Rosa H, Kouzarides T, Patel SS, Reinberg D: Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem. 2005, 280 (51): 41789-41792. 10.1074/jbc.C500395200PubMedCentralPubMed
92.
go back to reference Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y: Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004, 119 (7): 941-953. 10.1016/j.cell.2004.12.012PubMed Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y: Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004, 119 (7): 941-953. 10.1016/j.cell.2004.12.012PubMed
93.
go back to reference Ahmad K, Henikoff S: The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly. Mol Cell. 2002, 9 (6): 1191-1200. 10.1016/S1097-2765(02)00542-7PubMed Ahmad K, Henikoff S: The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly. Mol Cell. 2002, 9 (6): 1191-1200. 10.1016/S1097-2765(02)00542-7PubMed
94.
go back to reference Meneghini MD, Wu M, Madhani HD: Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin. Cell. 2003, 112 (5): 725-736. 10.1016/S0092-8674(03)00123-5PubMed Meneghini MD, Wu M, Madhani HD: Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin. Cell. 2003, 112 (5): 725-736. 10.1016/S0092-8674(03)00123-5PubMed
95.
go back to reference Chakravarthy S, Gundimella SK, Caron C, Perche PY, Pehrson JR, Khochbin S, Luger K: Structural characterization of the histone variant macroH2A. Mol Cell Biol. 2005, 25 (17): 7616-7624. 10.1128/MCB.25.17.7616-7624.2005PubMedCentralPubMed Chakravarthy S, Gundimella SK, Caron C, Perche PY, Pehrson JR, Khochbin S, Luger K: Structural characterization of the histone variant macroH2A. Mol Cell Biol. 2005, 25 (17): 7616-7624. 10.1128/MCB.25.17.7616-7624.2005PubMedCentralPubMed
96.
go back to reference Regnier V, Vagnarelli P, Fukagawa T, Zerjal T, Burns E, Trouche D, Earnshaw W, Brown W: CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1. Mol Cell Biol. 2005, 25 (10): 3967-3981. 10.1128/MCB.25.10.3967-3981.2005PubMedCentralPubMed Regnier V, Vagnarelli P, Fukagawa T, Zerjal T, Burns E, Trouche D, Earnshaw W, Brown W: CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1. Mol Cell Biol. 2005, 25 (10): 3967-3981. 10.1128/MCB.25.10.3967-3981.2005PubMedCentralPubMed
97.
go back to reference Mattick JS, Makunin IV: Non-coding RNA. Hum Mol Genet. 2006, 15 Spec No 1: R17-29. 10.1093/hmg/ddl046PubMed Mattick JS, Makunin IV: Non-coding RNA. Hum Mol Genet. 2006, 15 Spec No 1: R17-29. 10.1093/hmg/ddl046PubMed
98.
go back to reference Kawasaki H, Taira K: Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature. 2004, 431 (7005): 211-217. 10.1038/nature02889PubMed Kawasaki H, Taira K: Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature. 2004, 431 (7005): 211-217. 10.1038/nature02889PubMed
99.
go back to reference Morris KV, Chan SW, Jacobsen SE, Looney DJ: Small interfering RNA-induced transcriptional gene silencing in human cells. Science. 2004, 305 (5688): 1289-1292. 10.1126/science.1101372PubMed Morris KV, Chan SW, Jacobsen SE, Looney DJ: Small interfering RNA-induced transcriptional gene silencing in human cells. Science. 2004, 305 (5688): 1289-1292. 10.1126/science.1101372PubMed
100.
go back to reference Singh U, Fohn LE, Wakayama T, Ohgane J, Steinhoff C, Lipkowitz B, Schulz R, Orth A, Ropers HH, Behringer RR, Tanaka S, Shiota K, Yanagimachi R, Nuber UA, Fundele R: Different molecular mechanisms underlie placental overgrowth phenotypes caused by interspecies hybridization, cloning, and Esx1 mutation. Dev Dyn. 2004, 230 (1): 149-164. 10.1002/dvdy.20024PubMed Singh U, Fohn LE, Wakayama T, Ohgane J, Steinhoff C, Lipkowitz B, Schulz R, Orth A, Ropers HH, Behringer RR, Tanaka S, Shiota K, Yanagimachi R, Nuber UA, Fundele R: Different molecular mechanisms underlie placental overgrowth phenotypes caused by interspecies hybridization, cloning, and Esx1 mutation. Dev Dyn. 2004, 230 (1): 149-164. 10.1002/dvdy.20024PubMed
101.
go back to reference Kavi HH, Fernandez HR, Xie W, Birchler JA: RNA silencing in Drosophila. FEBS Lett. 2005, 579 (26): 5940-5949. 10.1016/j.febslet.2005.08.069PubMed Kavi HH, Fernandez HR, Xie W, Birchler JA: RNA silencing in Drosophila. FEBS Lett. 2005, 579 (26): 5940-5949. 10.1016/j.febslet.2005.08.069PubMed
102.
go back to reference Bernstein E, Allis CD: RNA meets chromatin. Genes Dev. 2005, 19 (14): 1635-1655. 10.1101/gad.1324305PubMed Bernstein E, Allis CD: RNA meets chromatin. Genes Dev. 2005, 19 (14): 1635-1655. 10.1101/gad.1324305PubMed
103.
go back to reference Santos-Reboucas CB, Pimentel MM: Implication of abnormal epigenetic patterns for human diseases. Eur J Hum Genet. 2006. Santos-Reboucas CB, Pimentel MM: Implication of abnormal epigenetic patterns for human diseases. Eur J Hum Genet. 2006.
104.
go back to reference Sansam CG, Roberts CW: Epigenetics and cancer: altered chromatin remodeling via Snf5 loss leads to aberrant cell cycle regulation. Cell Cycle. 2006, 5 (6): 621-624.PubMed Sansam CG, Roberts CW: Epigenetics and cancer: altered chromatin remodeling via Snf5 loss leads to aberrant cell cycle regulation. Cell Cycle. 2006, 5 (6): 621-624.PubMed
105.
go back to reference Dennis K, Fan T, Geiman T, Yan Q, Muegge K: Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev. 2001, 15 (22): 2940-2944. 10.1101/gad.929101PubMedCentralPubMed Dennis K, Fan T, Geiman T, Yan Q, Muegge K: Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev. 2001, 15 (22): 2940-2944. 10.1101/gad.929101PubMedCentralPubMed
106.
go back to reference Santoro R, Li J, Grummt I: The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nat Genet. 2002, 32 (3): 393-396. 10.1038/ng1010PubMed Santoro R, Li J, Grummt I: The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nat Genet. 2002, 32 (3): 393-396. 10.1038/ng1010PubMed
107.
go back to reference Gibbons RJ, McDowell TL, Raman S, O'Rourke DM, Garrick D, Ayyub H, Higgs DR: Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation. Nat Genet. 2000, 24 (4): 368-371. 10.1038/74191PubMed Gibbons RJ, McDowell TL, Raman S, O'Rourke DM, Garrick D, Ayyub H, Higgs DR: Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation. Nat Genet. 2000, 24 (4): 368-371. 10.1038/74191PubMed
108.
go back to reference Yamamichi N, Yamamichi-Nishina M, Mizutani T, Watanabe H, Minoguchi S, Kobayashi N, Kimura S, Ito T, Yahagi N, Ichinose M, Omata M, Iba H: The Brm gene suppressed at the post-transcriptional level in various human cell lines is inducible by transient HDAC inhibitor treatment, which exhibits antioncogenic potential. Oncogene. 2005, 24 (35): 5471-5481. 10.1038/sj.onc.1208716PubMed Yamamichi N, Yamamichi-Nishina M, Mizutani T, Watanabe H, Minoguchi S, Kobayashi N, Kimura S, Ito T, Yahagi N, Ichinose M, Omata M, Iba H: The Brm gene suppressed at the post-transcriptional level in various human cell lines is inducible by transient HDAC inhibitor treatment, which exhibits antioncogenic potential. Oncogene. 2005, 24 (35): 5471-5481. 10.1038/sj.onc.1208716PubMed
109.
go back to reference Debauve G, Nonclercq D, Ribaucour F, Wiedig M, Gerbaux C, Leo O, Laurent G, Journe F, Belayew A, Toubeau G: Early expression of the Helicase-Like Transcription Factor (HLTF/SMARCA3) in an experimental model of estrogen-induced renal carcinogenesis. Mol Cancer. 2006, 5: 23- 10.1186/1476-4598-5-23PubMedCentralPubMed Debauve G, Nonclercq D, Ribaucour F, Wiedig M, Gerbaux C, Leo O, Laurent G, Journe F, Belayew A, Toubeau G: Early expression of the Helicase-Like Transcription Factor (HLTF/SMARCA3) in an experimental model of estrogen-induced renal carcinogenesis. Mol Cancer. 2006, 5: 23- 10.1186/1476-4598-5-23PubMedCentralPubMed
110.
go back to reference Bultman S, Gebuhr T, Yee D, La Mantia C, Nicholson J, Gilliam A, Randazzo F, Metzger D, Chambon P, Crabtree G, Magnuson T: A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Mol Cell. 2000, 6 (6): 1287-1295. 10.1016/S1097-2765(00)00127-1PubMed Bultman S, Gebuhr T, Yee D, La Mantia C, Nicholson J, Gilliam A, Randazzo F, Metzger D, Chambon P, Crabtree G, Magnuson T: A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. Mol Cell. 2000, 6 (6): 1287-1295. 10.1016/S1097-2765(00)00127-1PubMed
111.
go back to reference Roberts CW, Orkin SH: The SWI/SNF complex--chromatin and cancer. Nat Rev Cancer. 2004, 4 (2): 133-142.PubMed Roberts CW, Orkin SH: The SWI/SNF complex--chromatin and cancer. Nat Rev Cancer. 2004, 4 (2): 133-142.PubMed
112.
go back to reference Gibbons RJ: Histone modifying and chromatin remodelling enzymes in cancer and dysplastic syndromes. Hum Mol Genet. 2005, 14 Spec No 1: R85-92. 10.1093/hmg/ddi106PubMed Gibbons RJ: Histone modifying and chromatin remodelling enzymes in cancer and dysplastic syndromes. Hum Mol Genet. 2005, 14 Spec No 1: R85-92. 10.1093/hmg/ddi106PubMed
113.
go back to reference Kouzarides T: Histone acetylases and deacetylases in cell proliferation. Curr Opin Genet Dev. 1999, 9 (1): 40-48. 10.1016/S0959-437X(99)80006-9PubMed Kouzarides T: Histone acetylases and deacetylases in cell proliferation. Curr Opin Genet Dev. 1999, 9 (1): 40-48. 10.1016/S0959-437X(99)80006-9PubMed
114.
go back to reference Lehrmann H, Pritchard LL, Harel-Bellan A: Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation. Adv Cancer Res. 2002, 86: 41-65.PubMed Lehrmann H, Pritchard LL, Harel-Bellan A: Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation. Adv Cancer Res. 2002, 86: 41-65.PubMed
115.
go back to reference Linggi BE, Brandt SJ, Sun ZW, Hiebert SW: Translating the histone code into leukemia. J Cell Biochem. 2005, 96 (5): 938-950. 10.1002/jcb.20604PubMed Linggi BE, Brandt SJ, Sun ZW, Hiebert SW: Translating the histone code into leukemia. J Cell Biochem. 2005, 96 (5): 938-950. 10.1002/jcb.20604PubMed
116.
go back to reference Chavez-Blanco A, Segura-Pacheco B, Perez-Cardenas E, Taja-Chayeb L, Cetina L, Candelaria M, Cantu D, Gonzalez-Fierro A, Garcia-Lopez P, Zambrano P, Perez-Plasencia C, Cabrera G, Trejo-Becerril C, Angeles E, Duenas-Gonzalez A: Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study. Mol Cancer. 2005, 4 (1): 22- 10.1186/1476-4598-4-22PubMedCentralPubMed Chavez-Blanco A, Segura-Pacheco B, Perez-Cardenas E, Taja-Chayeb L, Cetina L, Candelaria M, Cantu D, Gonzalez-Fierro A, Garcia-Lopez P, Zambrano P, Perez-Plasencia C, Cabrera G, Trejo-Becerril C, Angeles E, Duenas-Gonzalez A: Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study. Mol Cancer. 2005, 4 (1): 22- 10.1186/1476-4598-4-22PubMedCentralPubMed
117.
go back to reference Lin RJ, Egan DA, Evans RM: Molecular genetics of acute promyelocytic leukemia. Trends Genet. 1999, 15 (5): 179-184. 10.1016/S0168-9525(99)01710-2PubMed Lin RJ, Egan DA, Evans RM: Molecular genetics of acute promyelocytic leukemia. Trends Genet. 1999, 15 (5): 179-184. 10.1016/S0168-9525(99)01710-2PubMed
118.
go back to reference Hiebert SW, Downing JR, Lenny N, Meyers S: Transcriptional regulation by the t(8;21) fusion protein, AML-1/ETO. Curr Top Microbiol Immunol. 1996, 211: 253-258.PubMed Hiebert SW, Downing JR, Lenny N, Meyers S: Transcriptional regulation by the t(8;21) fusion protein, AML-1/ETO. Curr Top Microbiol Immunol. 1996, 211: 253-258.PubMed
119.
go back to reference Di Croce L: Chromatin modifying activity of leukaemia associated fusion proteins. Hum Mol Genet. 2005, 14 Spec No 1: R77-84. 10.1093/hmg/ddi109PubMed Di Croce L: Chromatin modifying activity of leukaemia associated fusion proteins. Hum Mol Genet. 2005, 14 Spec No 1: R77-84. 10.1093/hmg/ddi109PubMed
120.
go back to reference Plass C, Soloway PD: DNA methylation, imprinting and cancer. Eur J Hum Genet. 2002, 10 (1): 6-16. 10.1038/sj.ejhg.5200768PubMed Plass C, Soloway PD: DNA methylation, imprinting and cancer. Eur J Hum Genet. 2002, 10 (1): 6-16. 10.1038/sj.ejhg.5200768PubMed
121.
go back to reference Ehrlich M: DNA methylation in cancer: too much, but also too little. Oncogene. 2002, 21 (35): 5400-5413. 10.1038/sj.onc.1205651PubMed Ehrlich M: DNA methylation in cancer: too much, but also too little. Oncogene. 2002, 21 (35): 5400-5413. 10.1038/sj.onc.1205651PubMed
122.
go back to reference Jones PA, Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet. 2002, 3 (6): 415-428.PubMed Jones PA, Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet. 2002, 3 (6): 415-428.PubMed
123.
go back to reference Tryndyak VP, Kovalchuk O, Pogribny IP: Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins. Cancer Biol Ther. 2006, 5 (1): 65-70.PubMed Tryndyak VP, Kovalchuk O, Pogribny IP: Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins. Cancer Biol Ther. 2006, 5 (1): 65-70.PubMed
124.
go back to reference Tryndyak V, Kovalchuk O, Pogribny IP: Identification of differentially methylated sites within unmethylated DNA domains in normal and cancer cells. Anal Biochem. 2006, 356 (2): 202-207. 10.1016/j.ab.2006.05.019PubMed Tryndyak V, Kovalchuk O, Pogribny IP: Identification of differentially methylated sites within unmethylated DNA domains in normal and cancer cells. Anal Biochem. 2006, 356 (2): 202-207. 10.1016/j.ab.2006.05.019PubMed
125.
126.
go back to reference Narayan G, Goparaju C, Arias-Pulido H, Kaufmann AM, Schneider A, Durst M, Mansukhani M, Pothuri B, Murty VV: Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression. Mol Cancer. 2006, 5: 16- 10.1186/1476-4598-5-16PubMedCentralPubMed Narayan G, Goparaju C, Arias-Pulido H, Kaufmann AM, Schneider A, Durst M, Mansukhani M, Pothuri B, Murty VV: Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression. Mol Cancer. 2006, 5: 16- 10.1186/1476-4598-5-16PubMedCentralPubMed
127.
go back to reference Baylin SB, Herman JG: DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet. 2000, 16 (4): 168-174. 10.1016/S0168-9525(99)01971-XPubMed Baylin SB, Herman JG: DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet. 2000, 16 (4): 168-174. 10.1016/S0168-9525(99)01971-XPubMed
128.
go back to reference Wei SH, Chen CM, Strathdee G, Harnsomburana J, Shyu CR, Rahmatpanah F, Shi H, Ng SW, Yan PS, Nephew KP, Brown R, Huang TH: Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers. Clin Cancer Res. 2002, 8 (7): 2246-2252.PubMed Wei SH, Chen CM, Strathdee G, Harnsomburana J, Shyu CR, Rahmatpanah F, Shi H, Ng SW, Yan PS, Nephew KP, Brown R, Huang TH: Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers. Clin Cancer Res. 2002, 8 (7): 2246-2252.PubMed
129.
go back to reference Lyko F, Stach D, Brenner A, Stilgenbauer S, Dohner H, Wirtz M, Wiessler M, Schmitz OJ: Quantitative analysis of DNA methylation in chronic lymphocytic leukemia patients. Electrophoresis. 2004, 25 (10-11): 1530-1535. 10.1002/elps.200305830PubMed Lyko F, Stach D, Brenner A, Stilgenbauer S, Dohner H, Wirtz M, Wiessler M, Schmitz OJ: Quantitative analysis of DNA methylation in chronic lymphocytic leukemia patients. Electrophoresis. 2004, 25 (10-11): 1530-1535. 10.1002/elps.200305830PubMed
130.
go back to reference Teodoridis JM, Strathdee G, Brown R: Epigenetic silencing mediated by CpG island methylation: potential as a therapeutic target and as a biomarker. Drug Resist Updat. 2004, 7 (4-5): 267-278. 10.1016/j.drup.2004.06.005PubMed Teodoridis JM, Strathdee G, Brown R: Epigenetic silencing mediated by CpG island methylation: potential as a therapeutic target and as a biomarker. Drug Resist Updat. 2004, 7 (4-5): 267-278. 10.1016/j.drup.2004.06.005PubMed
131.
go back to reference Omenn GS: Strategies for plasma proteomic profiling of cancers. Proteomics. 2006, 6 (20): 5662-5673. 10.1002/pmic.200600331PubMed Omenn GS: Strategies for plasma proteomic profiling of cancers. Proteomics. 2006, 6 (20): 5662-5673. 10.1002/pmic.200600331PubMed
132.
go back to reference Peters AH, O'Carroll D, Scherthan H, Mechtler K, Sauer S, Schofer C, Weipoltshammer K, Pagani M, Lachner M, Kohlmaier A, Opravil S, Doyle M, Sibilia M, Jenuwein T: Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell. 2001, 107 (3): 323-337. 10.1016/S0092-8674(01)00542-6PubMed Peters AH, O'Carroll D, Scherthan H, Mechtler K, Sauer S, Schofer C, Weipoltshammer K, Pagani M, Lachner M, Kohlmaier A, Opravil S, Doyle M, Sibilia M, Jenuwein T: Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell. 2001, 107 (3): 323-337. 10.1016/S0092-8674(01)00542-6PubMed
133.
go back to reference Hamamoto R, Furukawa Y, Morita M, Iimura Y, Silva FP, Li M, Yagyu R, Nakamura Y: SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol. 2004, 6 (8): 731-740. 10.1038/ncb1151PubMed Hamamoto R, Furukawa Y, Morita M, Iimura Y, Silva FP, Li M, Yagyu R, Nakamura Y: SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol. 2004, 6 (8): 731-740. 10.1038/ncb1151PubMed
134.
go back to reference Tsuge M, Hamamoto R, Silva FP, Ohnishi Y, Chayama K, Kamatani N, Furukawa Y, Nakamura Y: A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers. Nat Genet. 2005, 37 (10): 1104-1107. 10.1038/ng1638PubMed Tsuge M, Hamamoto R, Silva FP, Ohnishi Y, Chayama K, Kamatani N, Furukawa Y, Nakamura Y: A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers. Nat Genet. 2005, 37 (10): 1104-1107. 10.1038/ng1638PubMed
135.
go back to reference Frank B, Hemminki K, Wappenschmidt B, Klaes R, Meindl A, Schmutzler RK, Bugert P, Untch M, Bartram CR, Burwinkel B: Variable number of tandem repeats polymorphism in the SMYD3 promoter region and the risk of familial breast cancer. Int J Cancer. 2006, 118 (11): 2917-2918. 10.1002/ijc.21696PubMed Frank B, Hemminki K, Wappenschmidt B, Klaes R, Meindl A, Schmutzler RK, Bugert P, Untch M, Bartram CR, Burwinkel B: Variable number of tandem repeats polymorphism in the SMYD3 promoter region and the risk of familial breast cancer. Int J Cancer. 2006, 118 (11): 2917-2918. 10.1002/ijc.21696PubMed
136.
go back to reference Xu JY, Chen LB, Xu JY, Yang Z, Xu RH, Wei HY: [Experimental research of therapeutic effect on hepatocellular carcinoma of targeting SMYD3 gene inhibition by RNA interference]. Zhonghua Wai Ke Za Zhi. 2006, 44 (7): 481-484.PubMed Xu JY, Chen LB, Xu JY, Yang Z, Xu RH, Wei HY: [Experimental research of therapeutic effect on hepatocellular carcinoma of targeting SMYD3 gene inhibition by RNA interference]. Zhonghua Wai Ke Za Zhi. 2006, 44 (7): 481-484.PubMed
137.
go back to reference Xu JY, Chen LB, Xu JY, Yang Z, Wei HY, Xu RH: [Suppression of SMYD3 expression in HepG2 cell by shRNA interference]. Zhonghua Gan Zang Bing Za Zhi. 2006, 14 (2): 105-108.PubMed Xu JY, Chen LB, Xu JY, Yang Z, Wei HY, Xu RH: [Suppression of SMYD3 expression in HepG2 cell by shRNA interference]. Zhonghua Gan Zang Bing Za Zhi. 2006, 14 (2): 105-108.PubMed
138.
go back to reference Xu JY, Chen LB, Xu JY, Yang Z, Wei HY, Xu RH: [Inhibition of SMYD3 gene expression by RNA interference induces apoptosis in human hepatocellular carcinoma cell line HepG2]. Ai Zheng. 2006, 25 (5): 526-532.PubMed Xu JY, Chen LB, Xu JY, Yang Z, Wei HY, Xu RH: [Inhibition of SMYD3 gene expression by RNA interference induces apoptosis in human hepatocellular carcinoma cell line HepG2]. Ai Zheng. 2006, 25 (5): 526-532.PubMed
139.
go back to reference Wang H, Cao R, Xia L, Erdjument-Bromage H, Borchers C, Tempst P, Zhang Y: Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol Cell. 2001, 8 (6): 1207-1217. 10.1016/S1097-2765(01)00405-1PubMed Wang H, Cao R, Xia L, Erdjument-Bromage H, Borchers C, Tempst P, Zhang Y: Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol Cell. 2001, 8 (6): 1207-1217. 10.1016/S1097-2765(01)00405-1PubMed
140.
go back to reference Nishioka K, Chuikov S, Sarma K, Erdjument-Bromage H, Allis CD, Tempst P, Reinberg D: Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev. 2002, 16 (4): 479-489. 10.1101/gad.967202PubMedCentralPubMed Nishioka K, Chuikov S, Sarma K, Erdjument-Bromage H, Allis CD, Tempst P, Reinberg D: Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev. 2002, 16 (4): 479-489. 10.1101/gad.967202PubMedCentralPubMed
141.
go back to reference Chuikov S, Kurash JK, Wilson JR, Xiao B, Justin N, Ivanov GS, McKinney K, Tempst P, Prives C, Gamblin SJ, Barlev NA, Reinberg D: Regulation of p53 activity through lysine methylation. Nature. 2004, 432 (7015): 353-360. 10.1038/nature03117PubMed Chuikov S, Kurash JK, Wilson JR, Xiao B, Justin N, Ivanov GS, McKinney K, Tempst P, Prives C, Gamblin SJ, Barlev NA, Reinberg D: Regulation of p53 activity through lysine methylation. Nature. 2004, 432 (7015): 353-360. 10.1038/nature03117PubMed
142.
go back to reference Huang J, Perez-Burgos L, Placek BJ, Sengupta R, Richter M, Dorsey JA, Kubicek S, Opravil S, Jenuwein T, Berger SL: Repression of p53 activity by Smyd2-mediated methylation. Nature. 2006, In press: Huang J, Perez-Burgos L, Placek BJ, Sengupta R, Richter M, Dorsey JA, Kubicek S, Opravil S, Jenuwein T, Berger SL: Repression of p53 activity by Smyd2-mediated methylation. Nature. 2006, In press:
143.
go back to reference Mattick JS, Makunin IV: Small regulatory RNAs in mammals. Hum Mol Genet. 2005, 14 Spec No 1: R121-32. 10.1093/hmg/ddi101PubMed Mattick JS, Makunin IV: Small regulatory RNAs in mammals. Hum Mol Genet. 2005, 14 Spec No 1: R121-32. 10.1093/hmg/ddi101PubMed
144.
go back to reference Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR: MicroRNA expression profiles classify human cancers. Nature. 2005, 435 (7043): 834-838. 10.1038/nature03702PubMed Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR: MicroRNA expression profiles classify human cancers. Nature. 2005, 435 (7043): 834-838. 10.1038/nature03702PubMed
145.
go back to reference Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, Menard S, Palazzo JP, Rosenberg A, Musiani P, Volinia S, Nenci I, Calin GA, Querzoli P, Negrini M, Croce CM: MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 2005, 65 (16): 7065-7070. 10.1158/0008-5472.CAN-05-1783PubMed Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, Menard S, Palazzo JP, Rosenberg A, Musiani P, Volinia S, Nenci I, Calin GA, Querzoli P, Negrini M, Croce CM: MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 2005, 65 (16): 7065-7070. 10.1158/0008-5472.CAN-05-1783PubMed
146.
go back to reference Calin GA, Garzon R, Cimmino A, Fabbri M, Croce CM: MicroRNAs and leukemias: how strong is the connection?. Leuk Res. 2006, 30 (6): 653-655. 10.1016/j.leukres.2005.10.017PubMed Calin GA, Garzon R, Cimmino A, Fabbri M, Croce CM: MicroRNAs and leukemias: how strong is the connection?. Leuk Res. 2006, 30 (6): 653-655. 10.1016/j.leukres.2005.10.017PubMed
147.
go back to reference Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, Prueitt RL, Yanaihara N, Lanza G, Scarpa A, Vecchione A, Negrini M, Harris CC, Croce CM: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A. 2006, 103 (7): 2257-2261. 10.1073/pnas.0510565103PubMedCentralPubMed Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, Prueitt RL, Yanaihara N, Lanza G, Scarpa A, Vecchione A, Negrini M, Harris CC, Croce CM: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A. 2006, 103 (7): 2257-2261. 10.1073/pnas.0510565103PubMedCentralPubMed
148.
go back to reference Horsthemke B: Epimutations in human disease. Curr Top Microbiol Immunol. 2006, 310: 45-59.PubMed Horsthemke B: Epimutations in human disease. Curr Top Microbiol Immunol. 2006, 310: 45-59.PubMed
149.
go back to reference Brown R, Strathdee G: Epigenomics and epigenetic therapy of cancer. Trends Mol Med. 2002, 8 (4 Suppl): S43-8. 10.1016/S1471-4914(02)02314-6PubMed Brown R, Strathdee G: Epigenomics and epigenetic therapy of cancer. Trends Mol Med. 2002, 8 (4 Suppl): S43-8. 10.1016/S1471-4914(02)02314-6PubMed
150.
go back to reference Lyko F, Brown R: DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J Natl Cancer Inst. 2005, 97 (20): 1498-1506.PubMed Lyko F, Brown R: DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J Natl Cancer Inst. 2005, 97 (20): 1498-1506.PubMed
151.
go back to reference Minucci S, Pelicci PG: Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer. 2006, 6 (1): 38-51. 10.1038/nrc1779PubMed Minucci S, Pelicci PG: Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer. 2006, 6 (1): 38-51. 10.1038/nrc1779PubMed
152.
go back to reference Lind GE, Thorstensen L, Lovig T, Meling GI, Hamelin R, Rognum TO, Esteller M, Lothe RA: A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. Mol Cancer. 2004, 3: 28- 10.1186/1476-4598-3-28PubMedCentralPubMed Lind GE, Thorstensen L, Lovig T, Meling GI, Hamelin R, Rognum TO, Esteller M, Lothe RA: A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. Mol Cancer. 2004, 3: 28- 10.1186/1476-4598-3-28PubMedCentralPubMed
153.
go back to reference Claus R, Fliegauf M, Stock M, Duque J, Kolanczyk M, Lubbert M: Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression. J Leukoc Biol. 2006. Claus R, Fliegauf M, Stock M, Duque J, Kolanczyk M, Lubbert M: Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression. J Leukoc Biol. 2006.
154.
go back to reference Claus R, Almstedt M, Lubbert M: Epigenetic treatment of hematopoietic malignancies: in vivo targets of demethylating agents. Semin Oncol. 2005, 32 (5): 511-520. 10.1053/j.seminoncol.2005.07.024PubMed Claus R, Almstedt M, Lubbert M: Epigenetic treatment of hematopoietic malignancies: in vivo targets of demethylating agents. Semin Oncol. 2005, 32 (5): 511-520. 10.1053/j.seminoncol.2005.07.024PubMed
155.
go back to reference Alao JP, Stavropoulou AV, Lam EW, Coombes RC, Vigushin DM: Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. Mol Cancer. 2006, 5: 8- 10.1186/1476-4598-5-8PubMedCentralPubMed Alao JP, Stavropoulou AV, Lam EW, Coombes RC, Vigushin DM: Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. Mol Cancer. 2006, 5: 8- 10.1186/1476-4598-5-8PubMedCentralPubMed
Metadata
Title
Epigenetic aberrations and cancer
Authors
Miryam Ducasse
Mark A Brown
Publication date
01-12-2006
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2006
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-5-60

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