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Open Access 01-12-2014 | Review

Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis

Authors: Birgit Schittek, Tobias Sinnberg

Published in: Molecular Cancer | Issue 1/2014

Abstract

Isoforms of the casein kinase 1 (CK1) family have been shown to phosphorylate key regulatory molecules involved in cell cycle, transcription and translation, the structure of the cytoskeleton, cell-cell adhesion and receptor-coupled signal transduction. They regulate key signaling pathways known to be critically involved in tumor progression. Recent results point to an altered expression or activity of different CK1 isoforms in tumor cells. This review summarizes the expression and biological function of CK1 family members in normal and malignant cells and the evidence obtained so far about their role in tumorigenesis.

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Title: Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis
Authors: Birgit Schittek
Tobias Sinnberg
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Molecular Cancer / Issue 1/2014
Electronic ISSN: 1476-4598
DOI: https://doi.org/10.1186/1476-4598-13-231

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