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Molecular Cancer
Published in: Molecular Cancer 1/2013

Open Access 01-12-2013 | Review

The MicroRNA-148/152 Family: Multi-faceted Players

Authors: Yue Chen, Yong-Xi Song, Zhen-Ning Wang

Published in: Molecular Cancer | Issue 1/2013

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Abstract

MicroRNAs(miRNA) are noncoding RNAs of about 19–23 nucleotides that are crucial for many biological processes. Members of the microRNA-148/152(miR-148/152) family, which include microRNA-148a(miR-148a), microRNA-148b(miR-148b), and microRNA-152(miR-152), are expressed differently in tumor and nontumor tissues and are involved in the genesis and development of disease. Furthermore, members of the miR-148/152 family are important in the growth and development of normal tissues. Members of the miR-148/152 family regulate target genes and are regulated by methylation of CPG islands. In this review, we report recent studies on the expression of members of the miR-148/152 family, methylation of CPG islands, and their target genes in different diseases, as well as in normal tissues.
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Metadata
Title
The MicroRNA-148/152 Family: Multi-faceted Players
Authors
Yue Chen
Yong-Xi Song
Zhen-Ning Wang
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2013
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-12-43

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