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Molecular Cancer
Published in: Molecular Cancer 1/2013

Open Access 01-12-2013 | Review

Molecular features in arsenic-induced lung tumors

Authors: Roland Hubaux, Daiana D Becker-Santos, Katey SS Enfield, David Rowbotham, Stephen Lam, Wan L Lam, Victor D Martinez

Published in: Molecular Cancer | Issue 1/2013

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Abstract

Arsenic is a well-known human carcinogen, which potentially affects ~160 million people worldwide via exposure to unsafe levels in drinking water. Lungs are one of the main target organs for arsenic-related carcinogenesis. These tumors exhibit particular features, such as squamous cell-type specificity and high incidence among never smokers. Arsenic-induced malignant transformation is mainly related to the biotransformation process intended for the metabolic clearing of the carcinogen, which results in specific genetic and epigenetic alterations that ultimately affect key pathways in lung carcinogenesis. Based on this, lung tumors induced by arsenic exposure could be considered an additional subtype of lung cancer, especially in the case of never-smokers, where arsenic is a known etiological agent. In this article, we review the current knowledge on the various mechanisms of arsenic carcinogenicity and the specific roles of this metalloid in signaling pathways leading to lung cancer.
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Metadata
Title
Molecular features in arsenic-induced lung tumors
Authors
Roland Hubaux
Daiana D Becker-Santos
Katey SS Enfield
David Rowbotham
Stephen Lam
Wan L Lam
Victor D Martinez
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2013
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-12-20

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