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Nutrition Journal
Published in: Nutrition Journal 1/2011

Open Access 01-12-2011 | Research

The older people, omega-3, and cognitive health (EPOCH) trial design and methodology: A randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults

Authors: Vanessa Danthiir, Nicholas R Burns, Ted Nettelbeck, Carlene Wilson, Gary Wittert

Published in: Nutrition Journal | Issue 1/2011

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Abstract

Background

Some studies have suggested an association between omega-3 long-chain polyunsaturated fatty acids (n-3 LC PUFAs) and better cognitive outcomes in older adults. To date, only two randomised, controlled trials have assessed the effect of n-3 LC PUFA supplementation on cognitive function in older cognitively healthy populations. Of these trials only one found a benefit, in the subgroup carrying the ApoE-ε4 allele. The benefits of n-3 LC PUFA supplementation on cognitive function in older normal populations thus still remain unclear. The main objective of the current study was to provide a comprehensive assessment of the potential of n-3 LC PUFAs to slow cognitive decline in normal elderly people, and included ApoE-ε4 allele carriage as a potential moderating factor. The detailed methodology of the trial is reported herein.

Methods

The study was a parallel, 18-month, randomised, double-blind, placebo-controlled intervention with assessment at baseline and repeated 6-monthly. Participants (N = 391, 53.7% female) aged 65-90 years, English-speaking and with normal cognitive function, were recruited from metropolitan Adelaide, South Australia. Participants in the intervention arm received capsules containing fish-oil at a daily dosage of 1720 mg of docosahexaenoic acid and 600 mg of eicosapentaenoic acid while the placebo arm received the equivalent amount of olive oil in their capsules. The primary outcome is rate of change in cognitive performance, as measured by latent variables for the cognitive constructs (encompassing Reasoning, Working Memory, Short-term Memory, Retrieval Fluency, Inhibition, Simple and Choice-Reaction Time, Perceptual Speed, Odd-man-out Reaction Time, Speed of Memory Scanning, and Psychomotor Speed) and assessed by latent growth curve modeling. Secondary outcomes are change in the Mini-mental State Examination, functional capacity and well-being (including health status, depression, mood, and self-report cognitive functioning), blood pressure, and biomarkers of n-3 LC PUFA status, glucose, lipid metabolism, inflammation, oxidative stress, and DNA damage.

Trial registration

Australia and New Zealand Clinical Trials Register (ANZCTR): ACTRN12607000278​437
Appendix
Available only for authorised users
Literature
1.
Neuringer M, Anderson GJ, Connor WE: The essentiality of n-3 fatty acids for the development and function of the retina and brain. Annu Rev Nutr. 1988, 8: 517-541. 10.1146/annurev.nu.08.070188.002505.PubMed
2.
Uauy R, Dangour AD: Nutrition in brain development and aging: Role of essential fatty acids. Nutrition Reviews. 2006, 64 (5): S24-S33. 10.1301/nr.2006.may.S24-S33.PubMed
3.
Soderberg M, Edlund C, Kristensson K, Dallner G: Fatty-Acid Composition of Brain Phospholipids in Aging and in Alzheimers-Disease. Lipids. 1991, 26 (6): 421-425. 10.1007/BF02536067.PubMed
4.
Suzuki H, Park SJ, Tamura M, Ando S: Effect of the long-term feeding of dietary lipids on the learning ability, fatty acid composition of brain stem phospholipids and synaptic membrane fluidity in adult mice: a comparison of sardine oil diet with palm oil diet. Mech Ageing Dev. 1998, 101 (1-2): 119-128. 10.1016/S0047-6374(97)00169-3.PubMed
5.
Xiao YWL, Xu RJ, Chen ZY: DHA depletion in rat brain is associated with impairment on spatial learning and memory. Biomedical and Environmental Science. 2006, 19 (6): 474-480.
6.
Moriguchi T, Salem N: Recovery of brain docosahexaenoate leads to recovery of spatial task performance. J Neurochem. 2003, 87 (2): 297-309. 10.1046/j.1471-4159.2003.01966.x.PubMed
7.
Chung W-L, Chen J-J, Su H-M: Fish Oil Supplementation of Control and (n-3) Fatty Acid-Deficient Male Rats Enhances Reference and Working Memory Performance and Increases Brain Regional Docosahexaenoic Acid Levels. 2008, 138: 1165-1171.
8.
Sugimoto Y, Taga C, Nishiga M, Fujiwara M, Konishi F, Tanaka K, Kamei C: Effect of docosahexaenoic acid-fortified Chlorella vulgaris strain CK22 on the radial maze performance in aged mice. Biol Pharm Bull. 2002, 25 (8): 1090-1092. 10.1248/bpb.25.1090.PubMed
9.
van Gelder BM, Tijhuis M, Kalmijn S, Kromhout D: Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study. 2007, 85: 1142-1147.
10.
Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM: Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol. 1997, 42 (5): 776-782. 10.1002/ana.410420514.PubMed
11.
Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS: Fish consumption and cognitive decline with age in a large community study. Archives of neurology. 2005, 62 (12): 1849-1853. 10.1001/archneur.62.12.noc50161.PubMed
12.
Kalmijn S, Feskens EJM, Launer LJ, Kromhout D: Polyunsaturated Fatty Acids, Antioxidants, and Cognitive Function in Very Old Men. Am J Epidemiol. 1997, 145 (1): 33-41.PubMed
13.
Barberger-Gateau P, Letenneur L, Deschamps V, Peres K, Dartigues J-F, Renaud S: Fish, meat, and risk of dementia: cohort study. BMJ. 2002, 325 (7370): 932-933. 10.1136/bmj.325.7370.932.PubMedPubMedCentral
14.
Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Wilson RS, Aggarwal N, Schneider JA: Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease. Archives of neurology. 2003, 60 (7): 940-946. 10.1001/archneur.60.7.940.PubMed
15.
Kalmijn S, van Boxtel MPJ, Ocke M, Verschuren WMM, Kromhout D, Launer LJ: Dietary intake of fatty acids and fish in relation to cognitive performance at middle age. Neurology. 2004, 62 (2): 275-280.PubMed
16.
Nurk E, Drevon CA, Refsum H, Solvoll K, Vollset SE, Nygard O, Nygaard HA, Engedal K, Tell GS, Smith AD: Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study. Am J Clin Nutr. 2007, 86 (5): 1470-1478.PubMed
17.
Dangour A, Allen E, Elbourne D, Fletcher A, Richards M, Uauy R: Fish consumption and cognitive function among older people in the UK: Baseline data from the OPAL study. The Journal of Nutrition, Health and Aging. 2009, 13 (3): 198-202. 10.1007/s12603-009-0057-2.PubMed
18.
Whalley LJ, Fox HC, Wahle KW, Starr JM, Deary IJ: Cognitive aging, childhood intelligence, and the use of food supplements: possible involvement of n-3 fatty acids. American Journal of Clinical Nutrition. 2004, 80 (6): 1650-1657.PubMed
19.
Whalley LJ, Deary IJ, Starr JM, Wahle KW, Rance KA, Bourne VJ, Fox HC: n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: an observational follow-up study in late adulthood. Am J Clin Nutr. 2008, 87 (2): 449-454.PubMed
20.
Heude B, Ducimetiere P, Berr C: Cognitive decline and fatty acid composition of erythrocyte membranes--The EVA Study. Am J Clin Nutr. 2003, 77 (4): 803-808.PubMed
21.
Schaefer EJ, Bongard V, Beiser AS, Lamon-Fava S, Robins SJ, Au R, Tucker KL, Kyle DJ, Wilson PWF, Wolf PA: Plasma Phosphatidylcholine Docosahexaenoic Acid Content and Risk of Dementia and Alzheimer Disease: The Framingham Heart Study. Archives of neurology. 2006, 63 (11): 1545-1550. 10.1001/archneur.63.11.1545.PubMed
22.
Laurin D, Verreaulta R, Lindsay J, Dewailly E, Holube B: Omega-3 fatty acids and risk of cognitive impairment and dementia. Journal of Alzheimer's Disease. 2003, 5: 315-322.PubMed
23.
Chiu CC, Su KP, Cheng TC, Liu HC, Chang CJ, Dewey ME, Stewart R, Huang SY: The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study. Progress in neuro-psychopharmacology & biological psychiatry. 2008, 32 (6): 1538-1544. 10.1016/j.pnpbp.2008.05.015.
24.
Dangour AD, Allen E, Elbourne D, Fasey N, Fletcher AE, Hardy P, Holder GE, Knight R, Letley L, Richards M, et al: Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial. American Journal of Clinical Nutrition. 2010, 91: 1725-1732. 10.3945/ajcn.2009.29121.PubMed
25.
Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T, Basun H, Faxen-Irving G, Garlind A, Vedin I, Vessby B, Wahlund L-O, Palmblad J: Omega-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study: A Randomized Double-blind Trial. Archives of neurology. 2006, 63 (10): 1402-1408. 10.1001/archneur.63.10.1402.PubMed
26.
Quinn JF, Raman R, Thomas RG, Yurko-Mauro K, Nelson EB, Van Dyck C, Galvin JE, Emond J, Jack CR, Weiner M, et al: Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease A Randomized Trial. Jama-J Am Med Assoc. 2010, 304 (17): 1903-1911. 10.1001/jama.2010.1510.
27.
van de Rest O, Geleijnse J, Kok F, van Staveren W, Dullemeijer C, OldeRikkert M, Beekman A, de Groot C: Effect of fish oil on cognitive performance in older subjects: A randomized, controlled trial. Neurology. 2008, 71: 430-438. 10.1212/01.wnl.0000324268.45138.86.PubMed
28.
Yurko-Mauro K, McCarthy D, Rom D, Nelson EB, Ryan AS, Blackwell A, Salem N, Stedman M: Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement. 2010, 6 (6): 456-464. 10.1016/j.jalz.2010.01.013.PubMed
29.
Barberger-Gateau P, Raffaitin C, Letenneur L, Berr C, Tzourio C, Dartigues JF, Alperovitch A: Dietary patterns and risk of dementia: the three city cohort study. Neurology. 2007, 69 (20): 1921-1930. 10.1212/01.wnl.0000278116.37320.52.PubMed
30.
Minihane AM, Khan S, Leigh-Firbank EC, Talmud P, Wright JW, Murphy MC, Griffin BA, Williams CM: ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype. Arteriosclerosis, thrombosis, and vascular biology. 2000, 20 (8): 1990-1997. 10.1161/01.ATV.20.8.1990.PubMed
31.
Plourde M, Vohla M, Vandal M, Couture P, Lemieuxa S, Cunnanea S: Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE 4 but not by the common PPAR-α L162V polymorphism in men. British Journal of Nutrition. 2009, 102: 1121-1124. 10.1017/S000711450938215X.PubMed
32.
Deary IJ, Whiteman MC, Pattie A, Starr JM, Hayward C, Wright AF, Carothers A, Whalley LJ: Ageing: Cognitive change and the APOE-ε4 allele. Nature. 2002, 418 (6901): 932-932. 10.1038/418932a.PubMed
33.
Panza F, D'Introno A, Colacicco AM, Capurso C, Pichichero G, Capurso SA, Capurso A, Solfrizzi V: Lipid metabolism in cognitive decline and dementia. Brain Research Reviews. 2006, 51 (2): 275-292. 10.1016/j.brainresrev.2005.11.007.PubMed
34.
Christensen H: What cognitive changes can be expected with normal ageing?. Australian and New Zealand Journal of Psychiatry. 2001, 35 (6): 768-775. 10.1046/j.1440-1614.2001.00966.x.PubMed
35.
Kotani S, Sakaguchi E, Warashina S, Matsukawa N, Ishikura Y, Kiso Y, Sakakibara M, Yoshimoto T, Guo J, Yamashima T: Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. Neuroscience Research. 2006, 56 (2): 159-164. 10.1016/j.neures.2006.06.010.PubMed
36.
Sinn N, Bryan J, Wilson C: Cognitive effects of polyunsaturated fatty acids in children with attention deficit hyperactivity disorder symptoms: a randomised controlled trial. Prostaglandins, leukotrienes, and essential fatty acids. 2008, 78 (4-5): 311-326. 10.1016/j.plefa.2008.04.004.PubMed
37.
Newkirk LA, Kim JM, Thompson JM, Tinklenberg JR, Yesavage JA, Taylor JL: Validation of a 26-point telephone version of the Mini-Mental State Examination. Journal of geriatric psychiatry and neurology. 2004, 17 (2): 81-87. 10.1177/0891988704264534.PubMed
38.
Brown AJ, Roberts DC, Pritchard JE, Truswell AS: A mixed Australian fish diet and fish-oil supplementation: impact on the plasma lipid profile of healthy men. Am J Clin Nutr. 1990, 52 (5): 825-833.PubMed
39.
Solfrizzi V, Colacicco AM, D'Introno A, Capurso C, Torres F, Rizzo C, Capurso A, Panza F: Dietary intake of unsaturated fatty acids and age-related cognitive decline: A 8.5-year follow-up of the Italian Longitudinal Study on Aging. Neurobiology of Aging. 2006, 27 (11): 1694-1704. 10.1016/j.neurobiolaging.2005.09.026.PubMed
40.
Foster TC: Bological markers of age-related memory deficits: Treatments of senescent physiology. CNS Drugs. 2006, 20: 153-166. 10.2165/00023210-200620020-00006.PubMed
41.
Dziedzic T: Systemic Inflammatory Markers and Risk of Dementia. American Journal of Alzheimer's Disease and Other Dementias. 2006, 21 (4): 258-262. 10.1177/1533317506289260.PubMed
42.
Katan MB, Deslypere JP, van Birgelen AP, Penders M, Zegwaard M: Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. 1997, 38: 2012-2022.
43.
Danthiir V, Wilhelm O, Schulze R, Roberts RD: Factor structure and validity of paper-and-pencil measures of mental speed: Evidence for a higher-order structure?. Intelligence. 2005, 33: 491-514. 10.1016/j.intell.2005.03.003.
44.
Stankov L, Danthiir V, Williams LM, Pallier G, Roberts RD, Gordon E: Intelligence and the tuning-in of brain networks. Learning and Individual Differences. 2006, 16 (3): 217-233. 10.1016/j.lindif.2004.12.003.
45.
Gregory T, Nettelbeck T, Wilson C: Inspection time and everyday functioning: A longitudinal study. Personality and Individual Differences. 2009, 47 (8): 999-1002. 10.1016/j.paid.2009.07.009.
46.
Salthouse TA: The processing-speed theory of adult age differences in cognition. Psychological Review. 1996, 103 (3): 403-428.PubMed
47.
Jette AM, Haley SM, Coster WJ, Kooyoomjian JT, Levenson S, Heeren T, Ashba J: Late Life Function and Disability Instrument: I. Development and evaluation of the Disability component. Journal of Gerontology: Medical Sciences. 2002, 57A (4): M209-M216.
48.
Haley SM, Jette AM, Coster WJ, Kooyoomjian JT, Levenson S, Heeren T, Ashba J: Late Life Function and Disability Instrument: II. Development and Evaluation of the Function component. Journal of Gerontoly: Medical Sciences. 2002, 57A (4): M217-M222.
49.
Radloff LS: The CES-D scale: A self report depression scale for research in the general population. Applied Psychological Measurement. 1977, 1: 385-401. 10.1177/014662167700100306.
50.
Broadbent DE, Cooper PF, FitzGerald P, Parkes KR: The Cognitive Failures Questionnaire (CFQ) and its correlates. The British journal of clinical psychology/the British Psychological Society. 1982, 21 (Pt 1): 1-16.PubMed
51.
Smith G, Della Sala S, Logie RH, Maylor EA: Prospective and retrospective memory in normal ageing and dementia: A questionnaire study. Memory. 2000, 8 (5): 311-321. 10.1080/09658210050117735.PubMed
52.
Watson D, Clark LA: Manual for the Positive and Negative Affect Schedule - Expanded Form. 1994, The University of Iowa
53.
Diener E, Emmons RA, Larsen RJ, Griffin S: The Satisfaction with Life Scale. Journal of Personality Assessment. 1985, 49 (1): 71-75. 10.1207/s15327752jpa4901_13.PubMed
54.
International Wellbeing Group: Personal Wellbeing Index. 2006, Melbourne: Australian Centre on Quality of Life, Deakin University
55.
Ware JE, Kosinski MA, Dewey JE: How to score version 2 of the Sf-36 health survey. 2000, Lincoln: Quality Metric Inc.
56.
Hunt SM, Mcewen J, Mckenna SP: Measuring Health-Status - a New Tool for Clinicians and Epidemiologists. Journal of the Royal College of General Practitioners. 1985, 35 (273): 185-188.PubMedPubMedCentral
57.
Dipietro L, Caspersen CJ, Ostfeld AM, Nadel ER: A Survey for Assessing Physical-Activity among Older Adults. Medicine and Science in Sports and Exercise. 1993, 25 (5): 628-642.PubMed
58.
Giles GG, Ireland PD: Dietary Questionnaire for Epidemiological Studies (Version 2). 1996, Melbourne: Cancer Council Victoria
59.
Hodge A, Patterson AJ, Brown WJ, Ireland P, Giles GG: The Anti Cancer Council of Victoria FFQ: relative validity of nutrient intakes compared with weighed food records in young to middle-aged women in a study of iron supplementation. Aust N Z J Public Health. 2000, 24 (6): 576-583. 10.1111/j.1467-842X.2000.tb00520.x.PubMed
60.
Swierk M, Williams PG, Wilcox J, Russell KG, Meyer BJ: Validation of an Australian electronic food frequency questionnaire to measure polyunsaturated fatty acid intake. Nutrition. 2011, 27 (6): 641-646. 10.1016/j.nut.2010.06.011.PubMed
61.
Hosking D, Danthiir V, Nettelbeck T, Wilson C: Assessing lifetime diet: reproducibility of a self-administered, non-quantitative FFQ. Public health nutrition. 2011, 14 (5): 801-808. 10.1017/S1368980010003174.PubMed
62.
Friedewa Wt, Fredrick Ds, Levy RI: Estimation of Concentration of Low-Density Lipoprotein Cholesterol in Plasma, without Use of Preparative Ultracentrifuge. Clinical chemistry. 1972, 18 (6): 499-
63.
Belobrajdic DP, Lam YY, Mano M, Wittert GA, Bird AR: Cereal based diets modulate some markers of oxidative stress and inflammation in lean and obese Zucker rats. Nutrition and Metabolism. 2011, 8: 27-10.1186/1743-7075-8-27.PubMedPubMedCentral
64.
Yang CS, Lee M-J: Methodology of Plasma Retinol, Tocopherol and Carotenoid Assays in Cancer Prevention Studies. Journal of Nutrition, Growth and Cancer. 1987, 4: 19-27.
65.
Ridges L, Sunderland R, Moerman K, Meyer B, Astheimer L, Howe P: Cholesterol lowering benefits of soy and linseed enriched foods. Asia Pac J Clin Nutr. 2001, 10 (3): 204-211. 10.1046/j.1440-6047.2001.00253.x.PubMed
66.
Lepage G, Roy CC: Direct Transesterification of All Classes of Lipids in a One-Step Reaction. J Lipid Res. 1986, 27 (1): 114-120.PubMed
67.
Hixson JE, Vernier DT: Restriction Isotyping of Human Apolipoprotein-E by Gene Amplification and Cleavage with Hhai. J Lipid Res. 1990, 31 (3): 545-548.PubMed
68.
O'Callaghan NJ, Dhillon VS, Thomas P, Fenech M: A quantitative real-time PCR method for absolute telomere length. Biotechniques. 2008, 44 (6): 807-809. 10.2144/000112761.PubMed
69.
Muthén BO, Curran PJ: General longitudinal modeling of individual differences in experimental designs: A latent variable framework for analysis and power estimation. Psychological Methods. 1997, 2: 371-402.
70.
Greaud VA, Green BF: Equivalence of conventional and computer presentation of speed tests. Applied Psychological Measurement. 1986, 10: 23-34. 10.1177/014662168601000102.
71.
Ekstrom R, French J, Harman H, D D: Kit of factor-referenced cognitive tests. 1976, Princeton, NJ: Educational Testing Service
72.
Raven J, Raven JC, Court JH: Section 3: The Standard Progressive Matrices. Manual for Raven's Progressive Matrices and Vocabulary Scales. 2000, San Antonio, TX: Harcourt Assessment
73.
Willis SL, Marsiske M: Manual for the Everyday Problems Test. 1993, University Park: Pennsylvania State University
74.
Lawton MP, Brody EM: Assessment of older people: self-maintaining and instrumental activities of daily living. The Gerontologist. 1969, 9 (3): 179-186. 10.1093/geront/9.3_Part_1.179.PubMed
75.
Woodcock RW, McGrew KS, Mather N: Woodcock-Johnson III Tests of Cognitive Ability. 2001, Itasca, IL: Riverside
76.
Herzmann G, Danthiir V, Schacht A, Sommer W, Wilhelm O: Towards a Comprehensive Test Battery for Face Processing: Assessment of the Tasks. Behavior Research Methods. 2008, 40 (3): 840-857. 10.3758/BRM.40.3.840.PubMed
77.
Rey A: L'examen clinique en psychologie. 1964, Paris: Presses Universitaires de France
78.
Wechsler D: Manual for the Wechsler Adult Intelligence Scale - Revised. 1981, New York: The Psychological Corporation
79.
Engle RW, Tuholski SW, Laughlin JE, Conway ARA: Working memory, short-term memory and general fluid intelligence: A latent variable approach. Journal of Experimental Psychology: General. 1999, 128: 309-331.
80.
Kane MJ, Hambrick DZ, Tuholski SW, Wilhelm O, Payne TW, Engle RW: The generality of working-memory capacity: A latent-variable approach to verbal and visuo-spatial memory span and reasoning. Journal of Experimental Psychology: General. 2004, 133: 189-217.
81.
Burns NR, Nettelbeck T: Inspection time and speed of processing: Sex differences on perceptual speed but not IT. Personality and Individual Differences. 2005, 39: 439-446. 10.1016/j.paid.2005.01.022.
82.
Wetherill GB, Levitt H: Sequential Estimation of Points on a Psychometric Function. British Journal of Mathematical & Statistical Psychology. 1965, 18 (1): 1-10. 10.1111/j.2044-8317.1965.tb00689.x.
83.
Sternberg S: High-Speed Scanning in Human Memory. Science. 1966, 153 (3736): 652-654. 10.1126/science.153.3736.652.PubMed
84.
Simon JR: Reactions toward Source of Stimulation. J Exp Psychol. 1969, 81 (1): 174-PubMed
85.
Stroop JR: Studies of interference in serial verbal reactions. J Exp Psychol. 1935, 18: 643-662.
86.
Macleod CM: Half a Century of Research on the Stroop Effect - an Integrative Review. Psychological Bulletin. 1991, 109 (2): 163-203.PubMed
87.
Eriksen B, Eriksen C: Effects of noise letters upon the identification of a target letter in a nonsearch task. Perception and psychophysics. 1974, 16 (1): 143-149. 10.3758/BF03203267.
88.
Research HH, (ed.): Findings from Autumn 2004 Health Omnibus Survey. 2004, Adelaide: Harrison Health Research
89.
Hawthorne G, Osborne R, Taylor A, Sansoni J: The SF36 Version 2: critical analyses of population weights, scoring algorithms and population norms. Quality of Life Research. 2007, 16 (4): 661-673. 10.1007/s11136-006-9154-4.PubMed
90.
Harada ND, Chiu V, King AC, Stewart AL: An evaluation of three self-report physical activity instruments for older adults. Medicine and Science in Sports and Exercise. 2001, 33 (6): 962-970. 10.1097/00005768-200106000-00016.PubMed
91.
Zich JM, Attkisson CC, Greenfield TK: Screening for depression in primary care clinics: the CES-D and the BDI. International journal of psychiatry in medicine. 1990, 20 (3): 259-277. 10.2190/LYKR-7VHP-YJEM-MKM2.PubMed
92.
Hertzog C, Van Alsline J, Usala PD, Hultsch DP, Dixon R: Measurement properties of the Center for Epidemiological Studies Depression Scale (CES-D) in older populations. Psychological Assessment. 1990, 2: 64-72.
93.
Beekman ATF, Deeg DJH, Van Limbeek J, Braam AW, De Vries MZ, Van Tilburg W: Criterion validity of the Center for Epidemiologic Studies Depression scale (CES-D): results from a community-based sample of older subjects in the Netherlands. Psychological Medicine. 1997, 27 (01): 231-235. 10.1017/S0033291796003510.PubMed
94.
Pavot W, Diener E: Review of the Satisfaction With Life Scale. Psychological Assessment. 1993, 5 (2): 164-172.
95.
Rast P, Van Boxtel M: Factor structure and measurement invariance of the Cognitive Failures Questionnaire across the adult life span. Assessment. 2009, 16 (2): 145-158. 10.1177/1073191108324440.PubMed
96.
Kliegel M, Jager T: Can the Prospective and Retrospective Memory Questionnaire (PRMQ) predict actual prospective memory performance. Current Psychology. 2006, 25 (3): 182-191. 10.1007/s12144-006-1002-8.
97.
Mäntylä T: Remembering To Remember: Adult Age Differences in Prospective Memory. The Journal of Gerontology. 1994, 49 (6): 276-282.
98.
Ronnlund M, Mantyla T, Nilsson LG: The Prospective and Retrospective Memory Questionnaire (PRMQ): factorial structure, relations to global subjective memory ratings, and Swedish norms. Scandinavian journal of psychology. 2008, 49 (1): 11-18. 10.1111/j.1467-9450.2007.00600.x.PubMed
99.
Crawford JR, Smith G, Maylor EA, Della Sala S, Logie RH: The Prospective and Retrospective Memory Questionnaire (PRMQ): Normative data and latent structure in a large non-clinical sample. Memory. 2003, 11 (3): 261-275. 10.1080/09658210244000027.PubMed
100.
Jette AM, Haley SM, Coster WJ, Kooyoomjian JT, Levenson S, Heeren T, Ashba J: Late life function and disability instrument: I. Development and evaluation of the disability component. J Gerontol a-Biol. 2002, 57 (4): M209-M216. 10.1093/gerona/57.4.M209.
101.
Haley SM, Jette AM, Coster WJ, Kooyoomjian JT, Levenson S, Heeren T, Ashba J: Late life function and disability instrument: II. Development and evaluation of the function component. J Gerontol a-Biol. 2002, 57 (4): M217-M222. 10.1093/gerona/57.4.M217.
102.
Sayers SP, Jette AM, Haley SM, Heeren TC, Guralnik JM, Fielding RA: Validation of the Late-Life Function and Disability Instrument. Journal of the American Geriatrics Society. 2004, 52 (9): 1554-1559. 10.1111/j.1532-5415.2004.52422.x.PubMed
Metadata
Title
The older people, omega-3, and cognitive health (EPOCH) trial design and methodology: A randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults
Authors
Vanessa Danthiir
Nicholas R Burns
Ted Nettelbeck
Carlene Wilson
Gary Wittert
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Nutrition Journal / Issue 1/2011
Electronic ISSN: 1475-2891
DOI
https://doi.org/10.1186/1475-2891-10-117

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Comparison of high protein and high fiber weight-loss diets in women with risk factors for the metabolic syndrome: a randomized trial
Obesity Clinical Trial Summary

At a glance: The STEP trials

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

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Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

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