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Published in: Malaria Journal 1/2009

Open Access 01-12-2009 | Research

Use and limitations of malaria rapid diagnostic testing by community health workers in war-torn Democratic Republic of Congo

Authors: Michael Hawkes, Jean Paul Katsuva, Claude K Masumbuko

Published in: Malaria Journal | Issue 1/2009

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Abstract

Background

Accurate and practical malaria diagnostics, such as immunochromatographic rapid diagnostic tests (RDTs), have the potential to avert unnecessary treatments and save lives. Volunteer community health workers (CHWs) represent a potentially valuable human resource for expanding this technology to where it is most needed, remote rural communities in sub-Saharan Africa with limited health facilities and personnel. This study reports on a training programme for CHWs to incorporate RDTs into their management strategy for febrile children in the Democratic Republic of Congo, a tropical African setting ravaged by human conflict.

Methods

Prospective cohort study, satisfaction questionnaire and decision analysis.

Results

Twelve CHWs were trained to safely and accurately perform and interpret RDTs, then successfully implemented rapid diagnostic testing in their remote community in a cohort of 357 febrile children. CHWs were uniformly positive in evaluating RDTs for their utility and ease of use. However, high malaria prevalence in this cohort (93% by RDTs, 88% by light microscopy) limited the cost-effectiveness of RDTs compared to presumptive treatment of all febrile children, as evidenced by findings from a simplified decision analysis.

Conclusions

CHWs can safely and effectively use RDTs in their management of febrile children; however, cost-effectiveness of RDTs is limited in zones of high malaria prevalence.
Appendix
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Literature
1.
go back to reference Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI: The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature. 2005, 434: 214-217. 10.1038/nature03342.PubMedCentralCrossRefPubMed Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI: The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature. 2005, 434: 214-217. 10.1038/nature03342.PubMedCentralCrossRefPubMed
3.
go back to reference Coghlan B, Ngoy P, Mulumba F, Hardy C, Bemo VN, Stewart T, Lewis J, Brennan RJ: Update on mortality in the Democratic Republic of Congo: results from a third nationwide survey. Disaster Med Public Health Prep. 2009, 3: 88-96. 10.1097/DMP.0b013e3181a6e952.CrossRefPubMed Coghlan B, Ngoy P, Mulumba F, Hardy C, Bemo VN, Stewart T, Lewis J, Brennan RJ: Update on mortality in the Democratic Republic of Congo: results from a third nationwide survey. Disaster Med Public Health Prep. 2009, 3: 88-96. 10.1097/DMP.0b013e3181a6e952.CrossRefPubMed
4.
go back to reference Coghlan B, Brennan RJ, Ngoy P, Dofara D, Otto B, Clements M, Stewart T: Mortality in the Democratic Republic of Congo: a nationwide survey. Lancet. 2006, 367: 44-51. 10.1016/S0140-6736(06)67923-3.CrossRefPubMed Coghlan B, Brennan RJ, Ngoy P, Dofara D, Otto B, Clements M, Stewart T: Mortality in the Democratic Republic of Congo: a nationwide survey. Lancet. 2006, 367: 44-51. 10.1016/S0140-6736(06)67923-3.CrossRefPubMed
5.
go back to reference Amexo M, Tolhurst R, Barnish G, Bates I: Malaria misdiagnosis: effects on the poor and vulnerable. Lancet. 2004, 364: 1896-1898. 10.1016/S0140-6736(04)17446-1.CrossRefPubMed Amexo M, Tolhurst R, Barnish G, Bates I: Malaria misdiagnosis: effects on the poor and vulnerable. Lancet. 2004, 364: 1896-1898. 10.1016/S0140-6736(04)17446-1.CrossRefPubMed
6.
go back to reference Rafael ME, Taylor T, Magill A, Lim YW, Girosi F, Allan R: Reducing the burden of childhood malaria in Africa: the role of improved diagnostics. Nature. 2006, 444 (Suppl 1): 39-48. 10.1038/nature05445.CrossRefPubMed Rafael ME, Taylor T, Magill A, Lim YW, Girosi F, Allan R: Reducing the burden of childhood malaria in Africa: the role of improved diagnostics. Nature. 2006, 444 (Suppl 1): 39-48. 10.1038/nature05445.CrossRefPubMed
7.
go back to reference Hawkes M, Kain KC: Advances in malaria diagnosis. Expert Rev Anti Infect Ther. 2007, 5: 485-495. 10.1586/14787210.5.3.485.CrossRefPubMed Hawkes M, Kain KC: Advances in malaria diagnosis. Expert Rev Anti Infect Ther. 2007, 5: 485-495. 10.1586/14787210.5.3.485.CrossRefPubMed
8.
go back to reference Ochola LB, Vounatsou P, Smith T, Mabaso ML, Newton CR: The reliability of diagnostic techniques in the diagnosis and management of malaria in the absence of a gold standard. Lancet Infect Dis. 2006, 6: 582-588. 10.1016/S1473-3099(06)70579-5.CrossRefPubMed Ochola LB, Vounatsou P, Smith T, Mabaso ML, Newton CR: The reliability of diagnostic techniques in the diagnosis and management of malaria in the absence of a gold standard. Lancet Infect Dis. 2006, 6: 582-588. 10.1016/S1473-3099(06)70579-5.CrossRefPubMed
9.
go back to reference Cunha ML, Piovesan-Alves F, Pang LW: Community-based program for malaria case management in the Brazilian Amazon. Am J Trop Med Hyg. 2001, 65: 872-876.PubMed Cunha ML, Piovesan-Alves F, Pang LW: Community-based program for malaria case management in the Brazilian Amazon. Am J Trop Med Hyg. 2001, 65: 872-876.PubMed
10.
go back to reference Pang LW, Piovesan-Alves F: Economic advantage of a community-based malaria management program in the Brazilian Amazon. Am J Trop Med Hyg. 2001, 65: 883-886.PubMed Pang LW, Piovesan-Alves F: Economic advantage of a community-based malaria management program in the Brazilian Amazon. Am J Trop Med Hyg. 2001, 65: 883-886.PubMed
11.
go back to reference Yeung S, Van Damme W, Socheat D, White NJ, Mills A: Access to artemisinin combination therapy for malaria in remote areas of Cambodia. Malar J. 2008, 7: 96-10.1186/1475-2875-7-96.PubMedCentralCrossRefPubMed Yeung S, Van Damme W, Socheat D, White NJ, Mills A: Access to artemisinin combination therapy for malaria in remote areas of Cambodia. Malar J. 2008, 7: 96-10.1186/1475-2875-7-96.PubMedCentralCrossRefPubMed
12.
go back to reference Premji Z, Minjas JN, Shiff CJ: Laboratory diagnosis of malaria by village health workers using the rapid manual ParaSight-F test. Trans R Soc Trop Med Hyg. 1994, 88: 418-10.1016/0035-9203(94)90409-X.CrossRefPubMed Premji Z, Minjas JN, Shiff CJ: Laboratory diagnosis of malaria by village health workers using the rapid manual ParaSight-F test. Trans R Soc Trop Med Hyg. 1994, 88: 418-10.1016/0035-9203(94)90409-X.CrossRefPubMed
13.
go back to reference Harvey SA, Jennings L, Chinyama M, Masaninga F, Mulholland K, Bell DR: Improving community health worker use of malaria rapid diagnostic tests in Zambia: package instructions, job aid and job aid-plus-training. Malar J. 2008, 7: 160-10.1186/1475-2875-7-160.PubMedCentralCrossRefPubMed Harvey SA, Jennings L, Chinyama M, Masaninga F, Mulholland K, Bell DR: Improving community health worker use of malaria rapid diagnostic tests in Zambia: package instructions, job aid and job aid-plus-training. Malar J. 2008, 7: 160-10.1186/1475-2875-7-160.PubMedCentralCrossRefPubMed
14.
go back to reference Elmardi KA, Malik EM, Abdelgadir T, Ali SH, Elsyed AH, Mudather MA, Elhassan AH, Adam I: Feasibility and acceptability of home-based management of malaria strategy adapted to Sudan's conditions using artemisinin-based combination therapy and rapid diagnostic test. Malar J. 2009, 8: 39-10.1186/1475-2875-8-39.PubMedCentralCrossRefPubMed Elmardi KA, Malik EM, Abdelgadir T, Ali SH, Elsyed AH, Mudather MA, Elhassan AH, Adam I: Feasibility and acceptability of home-based management of malaria strategy adapted to Sudan's conditions using artemisinin-based combination therapy and rapid diagnostic test. Malar J. 2009, 8: 39-10.1186/1475-2875-8-39.PubMedCentralCrossRefPubMed
17.
go back to reference Shillcutt S, Morel C, Goodman C, Coleman P, Bell D, Whitty CJ, Mills A: Cost-effectiveness of malaria diagnostic methods in sub-Saharan Africa in an era of combination therapy. Bull World Health Organ. 2008, 86: 101-110. 10.2471/BLT.07.042259.PubMedCentralCrossRefPubMed Shillcutt S, Morel C, Goodman C, Coleman P, Bell D, Whitty CJ, Mills A: Cost-effectiveness of malaria diagnostic methods in sub-Saharan Africa in an era of combination therapy. Bull World Health Organ. 2008, 86: 101-110. 10.2471/BLT.07.042259.PubMedCentralCrossRefPubMed
18.
go back to reference Zikusooka CM, McIntyre D, Barnes KI: Should countries implementing an artemisinin-based combination malaria treatment policy also introduce rapid diagnostic tests?. Malar J. 2008, 7: 176-10.1186/1475-2875-7-176.PubMedCentralCrossRefPubMed Zikusooka CM, McIntyre D, Barnes KI: Should countries implementing an artemisinin-based combination malaria treatment policy also introduce rapid diagnostic tests?. Malar J. 2008, 7: 176-10.1186/1475-2875-7-176.PubMedCentralCrossRefPubMed
20.
go back to reference Rolland E, Checchi F, Pinoges L, Balkan S, Guthmann JP, Guerin PJ: Operational response to malaria epidemics: are rapid diagnostic tests cost-effective?. Trop Med Int Health. 2006, 11: 398-408. 10.1111/j.1365-3156.2006.01580.x.CrossRefPubMed Rolland E, Checchi F, Pinoges L, Balkan S, Guthmann JP, Guerin PJ: Operational response to malaria epidemics: are rapid diagnostic tests cost-effective?. Trop Med Int Health. 2006, 11: 398-408. 10.1111/j.1365-3156.2006.01580.x.CrossRefPubMed
21.
go back to reference Hashizume M, Kondo H, Murakami T, Kodama M, Nakahara S, Lucas ME, Wakai S: Use of rapid diagnostic tests for malaria in an emergency situation after the flood disaster in Mozambique. Public Health. 2006, 120: 444-447. 10.1016/j.puhe.2005.11.007.CrossRefPubMed Hashizume M, Kondo H, Murakami T, Kodama M, Nakahara S, Lucas ME, Wakai S: Use of rapid diagnostic tests for malaria in an emergency situation after the flood disaster in Mozambique. Public Health. 2006, 120: 444-447. 10.1016/j.puhe.2005.11.007.CrossRefPubMed
22.
go back to reference Swarthout TD, Counihan H, Senga RK, Broek van den I: Paracheck-Pf accuracy and recently treated Plasmodium falciparum infections: is there a risk of over-diagnosis?. Malar J. 2007, 6: 58-10.1186/1475-2875-6-58.PubMedCentralCrossRefPubMed Swarthout TD, Counihan H, Senga RK, Broek van den I: Paracheck-Pf accuracy and recently treated Plasmodium falciparum infections: is there a risk of over-diagnosis?. Malar J. 2007, 6: 58-10.1186/1475-2875-6-58.PubMedCentralCrossRefPubMed
23.
go back to reference Humar A, Ohrt C, Harrington MA, Pillai D, Kain KC: Parasight F test compared with the polymerase chain reaction and microscopy for the diagnosis of Plasmodium falciparum malaria in travelers. Am J Trop Med Hyg. 1997, 56: 44-48.PubMed Humar A, Ohrt C, Harrington MA, Pillai D, Kain KC: Parasight F test compared with the polymerase chain reaction and microscopy for the diagnosis of Plasmodium falciparum malaria in travelers. Am J Trop Med Hyg. 1997, 56: 44-48.PubMed
24.
go back to reference Huong NM, Davis TM, Hewitt S, Huong NV, Uyen TT, Nhan DH, Cong le D: Comparison of three antigen detection methods for diagnosis and therapeutic monitoring of malaria: a field study from southern Vietnam. Trop Med Int Health. 2002, 7: 304-308. 10.1046/j.1365-3156.2002.00869.x.CrossRefPubMed Huong NM, Davis TM, Hewitt S, Huong NV, Uyen TT, Nhan DH, Cong le D: Comparison of three antigen detection methods for diagnosis and therapeutic monitoring of malaria: a field study from southern Vietnam. Trop Med Int Health. 2002, 7: 304-308. 10.1046/j.1365-3156.2002.00869.x.CrossRefPubMed
Metadata
Title
Use and limitations of malaria rapid diagnostic testing by community health workers in war-torn Democratic Republic of Congo
Authors
Michael Hawkes
Jean Paul Katsuva
Claude K Masumbuko
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2009
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-8-308

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