Skip to main content
Top
Published in: Malaria Journal 1/2014

Open Access 01-12-2014 | Case report

Mixed-species Plasmodium falciparum and Plasmodium ovale malaria in a paediatric returned traveller

Authors: Heather Senn, Nadia Alattas, Andrea K Boggild, Shaun K Morris

Published in: Malaria Journal | Issue 1/2014

Login to get access

Abstract

Malaria is a common and potentially fatal cause of febrile illness in returned travellers. Endemic areas for different malaria parasites overlap, but mixed species infections are rare. An adolescent male returned from a trip to Ghana in late summer 2013. He subsequently presented with blood smears positive for two species of malaria parasite, Plasmodium falciparum and Plasmodium ovale, on two isolated hospital visits within a six-week period. The epidemiology of mixed infections, likely pathophysiology of his presentation, and the implications for malaria testing and treatment in returned travellers are discussed.
Literature
1.
go back to reference Leder K, Torresi J, Libman MD, Cramer JP, Castelli F, Schlagenhauf P, Wilder-Smith A, Wilson ME, Keystone JS, Schwartz E, Barnett ED, Von Sonnenburg F, Brownstein JS, Cheng AC, Sotir MJ, Esposito DH, Freedman DO: GeoSentinel surveillance of illness in returned travelers, 2007–2011. Annals Int Med. 2013, 158: 456-468. 10.7326/0003-4819-158-6-201303190-00005.CrossRef Leder K, Torresi J, Libman MD, Cramer JP, Castelli F, Schlagenhauf P, Wilder-Smith A, Wilson ME, Keystone JS, Schwartz E, Barnett ED, Von Sonnenburg F, Brownstein JS, Cheng AC, Sotir MJ, Esposito DH, Freedman DO: GeoSentinel surveillance of illness in returned travelers, 2007–2011. Annals Int Med. 2013, 158: 456-468. 10.7326/0003-4819-158-6-201303190-00005.CrossRef
2.
go back to reference Leder K, Black J, Greenwood Z, Kain K, Schwartz E, Brown G, Torresi J: Malaria in travelers: a review of the GeoSentinel surveillance network. Clin Infect Dis. 2004, 39: 1104-1112. 10.1086/424510.CrossRefPubMed Leder K, Black J, Greenwood Z, Kain K, Schwartz E, Brown G, Torresi J: Malaria in travelers: a review of the GeoSentinel surveillance network. Clin Infect Dis. 2004, 39: 1104-1112. 10.1086/424510.CrossRefPubMed
3.
go back to reference Phuong M, Lau R, Ralevski F, Boggild AK: Sequence-based optimization of a quantitative real-time PCR assay for the detection of Plasmodium ovale and P. malariae. J Clin Microbiol. 2014, [Epub ahead of print] Phuong M, Lau R, Ralevski F, Boggild AK: Sequence-based optimization of a quantitative real-time PCR assay for the detection of Plasmodium ovale and P. malariae. J Clin Microbiol. 2014, [Epub ahead of print]
4.
go back to reference Paglia MG, Vairo F, Bevilacqua N, Ghirga P, Narciso P, Severini C, Nicastri E: Molecular diagnosis and species identification of imported malaria in returning travellers in Italy. Diagn Microbiol Infect Dis. 2012, 72: 175-180. 10.1016/j.diagmicrobio.2011.09.013.CrossRefPubMed Paglia MG, Vairo F, Bevilacqua N, Ghirga P, Narciso P, Severini C, Nicastri E: Molecular diagnosis and species identification of imported malaria in returning travellers in Italy. Diagn Microbiol Infect Dis. 2012, 72: 175-180. 10.1016/j.diagmicrobio.2011.09.013.CrossRefPubMed
5.
go back to reference Gneme A, Guelbeogo W, Riehle M, Tiono A, Diarra A, Kabre G, Sagnon N, Vernick K: Plasmodium species occurrence, temporal distribution and interaction in a child-aged population in rural Burkina Faso. Malar J. 2013, 12: 67-10.1186/1475-2875-12-67.PubMedCentralCrossRefPubMed Gneme A, Guelbeogo W, Riehle M, Tiono A, Diarra A, Kabre G, Sagnon N, Vernick K: Plasmodium species occurrence, temporal distribution and interaction in a child-aged population in rural Burkina Faso. Malar J. 2013, 12: 67-10.1186/1475-2875-12-67.PubMedCentralCrossRefPubMed
6.
go back to reference Faye FB, Konate L, Rogier C, Trape JF: Plasmodium ovale in a highly malaria endemic area of Senegal. Trans R Soc Trop Med Hyg. 1998, 92: 522-525. 10.1016/S0035-9203(98)90900-2.CrossRefPubMed Faye FB, Konate L, Rogier C, Trape JF: Plasmodium ovale in a highly malaria endemic area of Senegal. Trans R Soc Trop Med Hyg. 1998, 92: 522-525. 10.1016/S0035-9203(98)90900-2.CrossRefPubMed
7.
go back to reference Menner N, Borchert M, Dieckmann S, Ignatius R, Mockenhaupt FP: Uncommon manifestation of a mixed-species malaria infection: cryptic falciparum malaria in a traveler with successfully treated tertian malaria. J Travel Med. 2012, 19: 133-135. 10.1111/j.1708-8305.2011.00595.x.CrossRefPubMed Menner N, Borchert M, Dieckmann S, Ignatius R, Mockenhaupt FP: Uncommon manifestation of a mixed-species malaria infection: cryptic falciparum malaria in a traveler with successfully treated tertian malaria. J Travel Med. 2012, 19: 133-135. 10.1111/j.1708-8305.2011.00595.x.CrossRefPubMed
8.
go back to reference Imwong M, Nakeesathit S, Day NPJ, White NJ: A review of mixed malaria species infections in anopheline mosquitoes. Malar J. 2011, 10: 253-10.1186/1475-2875-10-253.PubMedCentralCrossRefPubMed Imwong M, Nakeesathit S, Day NPJ, White NJ: A review of mixed malaria species infections in anopheline mosquitoes. Malar J. 2011, 10: 253-10.1186/1475-2875-10-253.PubMedCentralCrossRefPubMed
10.
go back to reference Bigaillon C, Fontan E, Cavallo JD, Hernandez E, Speigel A: Ineffectiveness of the Binax NOW malaria test for diagnosis of Plasmodium ovale malaria. J Clin Microbiol. 2005, 43: 1011-10.1128/JCM.43.2.1011.2005.PubMedCentralCrossRefPubMed Bigaillon C, Fontan E, Cavallo JD, Hernandez E, Speigel A: Ineffectiveness of the Binax NOW malaria test for diagnosis of Plasmodium ovale malaria. J Clin Microbiol. 2005, 43: 1011-10.1128/JCM.43.2.1011.2005.PubMedCentralCrossRefPubMed
11.
go back to reference Farcas GA, Zhong KJ, Lovegrove FE, Graham CM, Kain KC: Binax NOW ICT test versus polymerase chain reaction and microscopy for the detection of malaria in returned travelers. Am J Trop Med Hyg. 2003, 69: 589-592.PubMed Farcas GA, Zhong KJ, Lovegrove FE, Graham CM, Kain KC: Binax NOW ICT test versus polymerase chain reaction and microscopy for the detection of malaria in returned travelers. Am J Trop Med Hyg. 2003, 69: 589-592.PubMed
12.
go back to reference Kyabayinze DJ, Tibenderana JK, Odong GW, Rwakimari JB, Counihan H: Operational accuracy and comparative persistent antigenicity of HRP2 rapid diagnostic tests for Plasmodium falciparum malaria in a hyperendemic region of Uganda. Malar J. 2008, 7: 221-10.1186/1475-2875-7-221.PubMedCentralCrossRefPubMed Kyabayinze DJ, Tibenderana JK, Odong GW, Rwakimari JB, Counihan H: Operational accuracy and comparative persistent antigenicity of HRP2 rapid diagnostic tests for Plasmodium falciparum malaria in a hyperendemic region of Uganda. Malar J. 2008, 7: 221-10.1186/1475-2875-7-221.PubMedCentralCrossRefPubMed
13.
go back to reference Khairnar K, Martin D, Lau R, Ralevski F, Pillai DR: Multiplex real-time quantitative PCR, microscopy and rapid diagnostic immune-chromatographic tests for the detection of Plasmodium spp: performance, limit of detection analysis and quality assurance. Malar J. 2009, 8: 284-10.1186/1475-2875-8-284.PubMedCentralCrossRefPubMed Khairnar K, Martin D, Lau R, Ralevski F, Pillai DR: Multiplex real-time quantitative PCR, microscopy and rapid diagnostic immune-chromatographic tests for the detection of Plasmodium spp: performance, limit of detection analysis and quality assurance. Malar J. 2009, 8: 284-10.1186/1475-2875-8-284.PubMedCentralCrossRefPubMed
14.
go back to reference Zakeri S, Najafabadi ST, Zare A, Djadid ND: Detection of malaria parasites by nested PCR in south-eastern, Iran: evidence of highly mixed infections in Chahbahar district. Malar J. 2002, 1: 2-10.1186/1475-2875-1-2.PubMedCentralCrossRefPubMed Zakeri S, Najafabadi ST, Zare A, Djadid ND: Detection of malaria parasites by nested PCR in south-eastern, Iran: evidence of highly mixed infections in Chahbahar district. Malar J. 2002, 1: 2-10.1186/1475-2875-1-2.PubMedCentralCrossRefPubMed
15.
go back to reference Gallien S, Taieb F, Schlemmer F, Lagrange-Xelot M, Atlan A, Sarfati C, Molina JM: Failure of atovaquone/proguanil to prevent Plasmodium ovale malaria in traveler returning from Cameroon. Travel Med Infect Dis. 2008, 6: 128-129. 10.1016/j.tmaid.2008.01.011.CrossRefPubMed Gallien S, Taieb F, Schlemmer F, Lagrange-Xelot M, Atlan A, Sarfati C, Molina JM: Failure of atovaquone/proguanil to prevent Plasmodium ovale malaria in traveler returning from Cameroon. Travel Med Infect Dis. 2008, 6: 128-129. 10.1016/j.tmaid.2008.01.011.CrossRefPubMed
16.
go back to reference Jimenez BC, Navarro M, Huerga H, Lopez-Roman E, Mendoza A, Lopez-Velez R: Tertian malaria (Plasmodium vivax and Plasmodium ovale) in two travelers despite atovaquone-proguanil prophylaxis. J Travel Med. 2006, 13: 373-375. 10.1111/j.1708-8305.2006.00073.x.CrossRefPubMed Jimenez BC, Navarro M, Huerga H, Lopez-Roman E, Mendoza A, Lopez-Velez R: Tertian malaria (Plasmodium vivax and Plasmodium ovale) in two travelers despite atovaquone-proguanil prophylaxis. J Travel Med. 2006, 13: 373-375. 10.1111/j.1708-8305.2006.00073.x.CrossRefPubMed
17.
go back to reference Mavrogordato A, Lever AM: A cluster of Plasmodium vivax malaria in an expedition group to Ethiopia: prophylactic efficacy of atovaquone/proguanil on liver stages of P. vivax. J Infect. 2012, 65: 269-274. 10.1016/j.jinf.2012.04.015.CrossRefPubMed Mavrogordato A, Lever AM: A cluster of Plasmodium vivax malaria in an expedition group to Ethiopia: prophylactic efficacy of atovaquone/proguanil on liver stages of P. vivax. J Infect. 2012, 65: 269-274. 10.1016/j.jinf.2012.04.015.CrossRefPubMed
18.
go back to reference Povinelli L, Monson TA, Fox BC, Parise ME, Morrisey JM, Vaidya AB: Plasmodium vivax malaria in spite of atovaquone/proguanil (Malarone) prophylaxis. J Travel Med. 2003, 2003 (10): 353-355. Povinelli L, Monson TA, Fox BC, Parise ME, Morrisey JM, Vaidya AB: Plasmodium vivax malaria in spite of atovaquone/proguanil (Malarone) prophylaxis. J Travel Med. 2003, 2003 (10): 353-355.
20.
go back to reference Davis TM, Singh B, Sheridan G: Parasitic procrastination: late-presenting ovale malaria and schistosomiasis. Med J Aust. 2001, 175: 146-148.PubMed Davis TM, Singh B, Sheridan G: Parasitic procrastination: late-presenting ovale malaria and schistosomiasis. Med J Aust. 2001, 175: 146-148.PubMed
21.
go back to reference Centers for Disease Control and Prevention: Late relapse of Plasmodium ovale malaria—Philadelphia, Pennsylvania, November 2004. MMWR Morb Mortal Wkly Rep. 2005, 54: 1231-1233. Centers for Disease Control and Prevention: Late relapse of Plasmodium ovale malaria—Philadelphia, Pennsylvania, November 2004. MMWR Morb Mortal Wkly Rep. 2005, 54: 1231-1233.
23.
24.
go back to reference Radloff PD, Philipps J, Hutchinson D, Kreusner PG: Atovaquone plus proguanil is an effective treatment for Plasmodium ovale and P. malariae malaria. Trans R Soc Trop Med Hyg. 1996, 90: 682-10.1016/S0035-9203(96)90435-6.CrossRefPubMed Radloff PD, Philipps J, Hutchinson D, Kreusner PG: Atovaquone plus proguanil is an effective treatment for Plasmodium ovale and P. malariae malaria. Trans R Soc Trop Med Hyg. 1996, 90: 682-10.1016/S0035-9203(96)90435-6.CrossRefPubMed
25.
go back to reference Kimura M, Koga M, Kikuchi T, Miura T, Maruyama H: Efficacy and safety of atovaquone-proguanil in treating imported malaria in Japan: the second report from the research group. Parasitol Int. 2012, 61: 466-469. 10.1016/j.parint.2012.03.004.CrossRefPubMed Kimura M, Koga M, Kikuchi T, Miura T, Maruyama H: Efficacy and safety of atovaquone-proguanil in treating imported malaria in Japan: the second report from the research group. Parasitol Int. 2012, 61: 466-469. 10.1016/j.parint.2012.03.004.CrossRefPubMed
Metadata
Title
Mixed-species Plasmodium falciparum and Plasmodium ovale malaria in a paediatric returned traveller
Authors
Heather Senn
Nadia Alattas
Andrea K Boggild
Shaun K Morris
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2014
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-13-78

Other articles of this Issue 1/2014

Malaria Journal 1/2014 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.