Skip to main content
Top
Published in: Malaria Journal 1/2012

Open Access 01-12-2012 | Case report

Plasmodium vivax congenital malaria in an area of very low endemicity in Guatemala: implications for clinical and epidemiological surveillance in a malaria elimination context

Authors: María Eugenia Castellanos, Azucena Bardají, Michela Menegon, Alfredo Mayor, Meghna Desai, Carlo Severini, Clara Menéndez, Norma Padilla

Published in: Malaria Journal | Issue 1/2012

Login to get access

Abstract

This is a report of the first Plasmodium vivax congenital malaria case in Guatemala and the first case in Latin America with genotypical, histological and clinical characterization. The findings show that maternal P. vivax infection still occurs in areas that are in the pathway towards malaria elimination, and can be associated with detrimental health effects for the neonate. It also highlights the need in very low transmission areas of not only maintaining, but increasing awareness of the problem and developing surveillance strategies, based on population risk, to detect the infection especially in this vulnerable group of the population.
Appendix
Available only for authorised users
Literature
1.
go back to reference Poespoprodjo JR, Hasanuddin A, Fobia W, Sugiarto P, Kenangalem E, Lampah DA, Tjitra E, Price RN, Anstey NM: Severe congenital malaria acquired in utero. Am J Trop Med Hyg. 2010, 82: 563-565. 10.4269/ajtmh.2010.09-0744.PubMedCentralCrossRefPubMed Poespoprodjo JR, Hasanuddin A, Fobia W, Sugiarto P, Kenangalem E, Lampah DA, Tjitra E, Price RN, Anstey NM: Severe congenital malaria acquired in utero. Am J Trop Med Hyg. 2010, 82: 563-565. 10.4269/ajtmh.2010.09-0744.PubMedCentralCrossRefPubMed
2.
go back to reference Malhotra I, Mungai P, Muchiri E, Kwiek JJ, Meshnick SR, King CL: Umbilical cord-blood infections with Plasmodium falciparum malaria are acquired antenatally in Kenya. J Infect Dis. 2006, 194: 176-183. 10.1086/505150.CrossRefPubMed Malhotra I, Mungai P, Muchiri E, Kwiek JJ, Meshnick SR, King CL: Umbilical cord-blood infections with Plasmodium falciparum malaria are acquired antenatally in Kenya. J Infect Dis. 2006, 194: 176-183. 10.1086/505150.CrossRefPubMed
3.
go back to reference Menendez C, Mayor A: Congenital malaria: the least known consequence of malaria in pregnancy. Semin Fetal Neonatal Med. 2007, 12: 207-213. 10.1016/j.siny.2007.01.018.CrossRefPubMed Menendez C, Mayor A: Congenital malaria: the least known consequence of malaria in pregnancy. Semin Fetal Neonatal Med. 2007, 12: 207-213. 10.1016/j.siny.2007.01.018.CrossRefPubMed
4.
go back to reference Uneke CJ: Congenital malaria: an overview. Tanzan J Health Res. 2011, 13: 18-CrossRef Uneke CJ: Congenital malaria: an overview. Tanzan J Health Res. 2011, 13: 18-CrossRef
5.
go back to reference Mwaniki MK, Talbert AW, Mturi FN, Berkley JA, Kager P, Marsh K, Newton CR: Congenital and neonatal malaria in a rural Kenyan district hospital: an eight-year analysis. Malar J. 2010, 9: 313-10.1186/1475-2875-9-313.PubMedCentralCrossRefPubMed Mwaniki MK, Talbert AW, Mturi FN, Berkley JA, Kager P, Marsh K, Newton CR: Congenital and neonatal malaria in a rural Kenyan district hospital: an eight-year analysis. Malar J. 2010, 9: 313-10.1186/1475-2875-9-313.PubMedCentralCrossRefPubMed
6.
go back to reference Mosha Theobald CE, NDaJM: Prevalence of congenital malaria among neonates at Morogoro Regional Hospital, Morogoro, Tanzania. Tanzan J Health Res. 2010, 12: 10- Mosha Theobald CE, NDaJM: Prevalence of congenital malaria among neonates at Morogoro Regional Hospital, Morogoro, Tanzania. Tanzan J Health Res. 2010, 12: 10-
7.
go back to reference Osungbade KO, Oladunjoye OO: Prevention of congenital transmission of malaria in sub-saharan african countries: challenges and implications for health system strengthening. J Trop Med. 2012, 2012: 648456-PubMedCentralCrossRefPubMed Osungbade KO, Oladunjoye OO: Prevention of congenital transmission of malaria in sub-saharan african countries: challenges and implications for health system strengthening. J Trop Med. 2012, 2012: 648456-PubMedCentralCrossRefPubMed
8.
go back to reference Obiajunwa PO, Owa JA, Adeodu OO: Prevalence of congenital malaria in Ile-ife, Nigeria. J Trop Pediatr. 2005, 51: 219-222. 10.1093/tropej/fmi003.CrossRefPubMed Obiajunwa PO, Owa JA, Adeodu OO: Prevalence of congenital malaria in Ile-ife, Nigeria. J Trop Pediatr. 2005, 51: 219-222. 10.1093/tropej/fmi003.CrossRefPubMed
9.
go back to reference Campos IM, Uribe ML, Cuesta C, Franco-Gallego A, Carmona-Fonseca J, Maestre A: Diagnosis of gestational, congenital, and placental malaria in Colombia: comparison of the efficacy of microscopy, nested polymerase chain reaction, and histopathology. Am J Trop Med Hyg. 2011, 84: 929-935. 10.4269/ajtmh.2011.10-0507.PubMedCentralCrossRefPubMed Campos IM, Uribe ML, Cuesta C, Franco-Gallego A, Carmona-Fonseca J, Maestre A: Diagnosis of gestational, congenital, and placental malaria in Colombia: comparison of the efficacy of microscopy, nested polymerase chain reaction, and histopathology. Am J Trop Med Hyg. 2011, 84: 929-935. 10.4269/ajtmh.2011.10-0507.PubMedCentralCrossRefPubMed
10.
go back to reference Tobian AA, Mehlotra RK, Malhotra I, Wamachi A, Mungai P, Koech D, Ouma J, Zimmerman P, King CL: Frequent umbilical cord-blood and maternal-blood infections with Plasmodium falciparum, P. malariae, and P. ovale in Kenya. J Infect Dis. 2000, 182: 558-563. 10.1086/315729.CrossRefPubMed Tobian AA, Mehlotra RK, Malhotra I, Wamachi A, Mungai P, Koech D, Ouma J, Zimmerman P, King CL: Frequent umbilical cord-blood and maternal-blood infections with Plasmodium falciparum, P. malariae, and P. ovale in Kenya. J Infect Dis. 2000, 182: 558-563. 10.1086/315729.CrossRefPubMed
11.
go back to reference Kamwendo DD, Dzinjalamala FK, Snounou G, Kanjala MCC, Mhango CG, Molyneux ME, Rogerson SJ: Plasmodium falciparum: PCR detection and genotyping of isolates from peripheral, placenta), and cord blood of pregnant Malawian women and their infants. Trans R Soc Trop Med Hyg. 2002, 96: 145-149. 10.1016/S0035-9203(02)90284-1.CrossRefPubMed Kamwendo DD, Dzinjalamala FK, Snounou G, Kanjala MCC, Mhango CG, Molyneux ME, Rogerson SJ: Plasmodium falciparum: PCR detection and genotyping of isolates from peripheral, placenta), and cord blood of pregnant Malawian women and their infants. Trans R Soc Trop Med Hyg. 2002, 96: 145-149. 10.1016/S0035-9203(02)90284-1.CrossRefPubMed
12.
go back to reference Kassberger F, Birkenmaier A, Khattab A, Kremsner PG, Klinkert MQ: PCR typing of Plasmodium falciparum in matched peripheral, placental and umbilical cord blood. Parasitol Res. 2002, 88 (12): 1073-1079. 10.1007/s00436-002-0715-3.CrossRefPubMed Kassberger F, Birkenmaier A, Khattab A, Kremsner PG, Klinkert MQ: PCR typing of Plasmodium falciparum in matched peripheral, placental and umbilical cord blood. Parasitol Res. 2002, 88 (12): 1073-1079. 10.1007/s00436-002-0715-3.CrossRefPubMed
13.
14.
go back to reference Poespoprodjo JR, Fobia W, Kenangalem E, Hasanuddin A, Sugiarto P, Tjitra E, Anstey NM, Price RN: Highly effective therapy for maternal malaria associated with a lower risk of vertical transmission. J Infect Dis. 2011, 204: 1613-1619. 10.1093/infdis/jir558.PubMedCentralCrossRefPubMed Poespoprodjo JR, Fobia W, Kenangalem E, Hasanuddin A, Sugiarto P, Tjitra E, Anstey NM, Price RN: Highly effective therapy for maternal malaria associated with a lower risk of vertical transmission. J Infect Dis. 2011, 204: 1613-1619. 10.1093/infdis/jir558.PubMedCentralCrossRefPubMed
15.
go back to reference Díaz RJFJ, Becerra JE, Pineda CE, Méndez C: Malaria Congénita. Rev Med Hondur. 1995, 63 (3): 3- Díaz RJFJ, Becerra JE, Pineda CE, Méndez C: Malaria Congénita. Rev Med Hondur. 1995, 63 (3): 3-
16.
go back to reference Pineros-Jimenez JG, Alvarez G, Tobon A, Arboleda M, Carrero S, Blair S: Congenital malaria in Uraba, Colombia. Malar J. 2011, 10: 239-10.1186/1475-2875-10-239.PubMedCentralCrossRefPubMed Pineros-Jimenez JG, Alvarez G, Tobon A, Arboleda M, Carrero S, Blair S: Congenital malaria in Uraba, Colombia. Malar J. 2011, 10: 239-10.1186/1475-2875-10-239.PubMedCentralCrossRefPubMed
17.
go back to reference Padilla N, Molina P, Juarez J, Brown D, Cordon-Rosales C: Potential malaria vectors in northern Guatemala (Vectores potenciales de malaria in la region norte de Guatemala). J Am Mosq Control Assoc. 1992, 8: 307-308. Padilla N, Molina P, Juarez J, Brown D, Cordon-Rosales C: Potential malaria vectors in northern Guatemala (Vectores potenciales de malaria in la region norte de Guatemala). J Am Mosq Control Assoc. 1992, 8: 307-308.
18.
go back to reference Ordi J, Ismail MR, Ventura PJ, Kahigwa E, Hirt R, Cardesa A, Alonso PL, Menendez C: Massive chronic intervillositis of the placenta associated with malaria infection. Am J Surg Pathol. 1998, 22: 1006-1011. 10.1097/00000478-199808000-00011.CrossRefPubMed Ordi J, Ismail MR, Ventura PJ, Kahigwa E, Hirt R, Cardesa A, Alonso PL, Menendez C: Massive chronic intervillositis of the placenta associated with malaria infection. Am J Surg Pathol. 1998, 22: 1006-1011. 10.1097/00000478-199808000-00011.CrossRefPubMed
19.
go back to reference Severini C, Menegon M, Di Luca M, Abdullaev I, Majori G, Razakov SA, Gradoni L: Risk of Plasmodium vivax malaria reintroduction in Uzbekistan: genetic characterization of parasites and status of potential malaria vectors in the Surkhandarya region. Trans R Soc Trop Med Hyg. 2004, 98: 585-592. 10.1016/j.trstmh.2004.01.003.CrossRefPubMed Severini C, Menegon M, Di Luca M, Abdullaev I, Majori G, Razakov SA, Gradoni L: Risk of Plasmodium vivax malaria reintroduction in Uzbekistan: genetic characterization of parasites and status of potential malaria vectors in the Surkhandarya region. Trans R Soc Trop Med Hyg. 2004, 98: 585-592. 10.1016/j.trstmh.2004.01.003.CrossRefPubMed
20.
go back to reference Veron V, Simon S, Carme B: Multiplex real-time PCR detection of P. falciparum, P. vivax and P. malariae in human blood samples. Exp Parasitol. 2009, 121: 346-351. 10.1016/j.exppara.2008.12.012.CrossRefPubMed Veron V, Simon S, Carme B: Multiplex real-time PCR detection of P. falciparum, P. vivax and P. malariae in human blood samples. Exp Parasitol. 2009, 121: 346-351. 10.1016/j.exppara.2008.12.012.CrossRefPubMed
21.
go back to reference Karunaweera ND, Ferreira MU, Hartl DL, Wirth DF: Fourteen polymorphic microsatellite DNA markers for the human malaria parasite Plasmodium vivax. Molecular Ecology Notes. 2007, 7: 172-175.CrossRef Karunaweera ND, Ferreira MU, Hartl DL, Wirth DF: Fourteen polymorphic microsatellite DNA markers for the human malaria parasite Plasmodium vivax. Molecular Ecology Notes. 2007, 7: 172-175.CrossRef
22.
go back to reference Pineros-Jimenez JG, Arboleda M, Jaramillo JC, Blair S: [Report of five cases of severe neonatal Plasmodium vivax malaria in Uraba, Colombia]. Biomedica. 2008, 28: 471-479.CrossRefPubMed Pineros-Jimenez JG, Arboleda M, Jaramillo JC, Blair S: [Report of five cases of severe neonatal Plasmodium vivax malaria in Uraba, Colombia]. Biomedica. 2008, 28: 471-479.CrossRefPubMed
23.
go back to reference Orostegui-Pinilla D, Rodriguez-Morales AJ: Neonatal Plasmodium vivax malaria. Trop Biomed. 2011, 28: 339-342.PubMed Orostegui-Pinilla D, Rodriguez-Morales AJ: Neonatal Plasmodium vivax malaria. Trop Biomed. 2011, 28: 339-342.PubMed
24.
go back to reference Sotimehin SA, Runsewe-Abiodun TI, Oladapo OT, Njokanma OF, Olanrewaju DM: Possible risk factors for congenital malaria at a tertiary care hospital in Sagamu, Ogun State, South-West Nigeria. J Trop Pediatr. 2008, 54: 313-320. 10.1093/tropej/fmn016.CrossRefPubMed Sotimehin SA, Runsewe-Abiodun TI, Oladapo OT, Njokanma OF, Olanrewaju DM: Possible risk factors for congenital malaria at a tertiary care hospital in Sagamu, Ogun State, South-West Nigeria. J Trop Pediatr. 2008, 54: 313-320. 10.1093/tropej/fmn016.CrossRefPubMed
25.
go back to reference Mayor A, Bardaji A, Felger I, King CL, Cistero P, Dobano C, Stanisic DI, Siba P, Wahlgren M, Del Portillo H, Mueller I, Menéndez C, Ordi J, Rogerson S: Placental infection with Plasmodium vivax: a histopathological and molecular study. J Infect Dis. 2012, 206: 1904-1910. 10.1093/infdis/jis614.CrossRefPubMed Mayor A, Bardaji A, Felger I, King CL, Cistero P, Dobano C, Stanisic DI, Siba P, Wahlgren M, Del Portillo H, Mueller I, Menéndez C, Ordi J, Rogerson S: Placental infection with Plasmodium vivax: a histopathological and molecular study. J Infect Dis. 2012, 206: 1904-1910. 10.1093/infdis/jis614.CrossRefPubMed
26.
go back to reference MALera: A research agenda for malaria eradication: monitoring, evaluation, and surveillance. PLoS Med. 2011, 8: e1000400-CrossRef MALera: A research agenda for malaria eradication: monitoring, evaluation, and surveillance. PLoS Med. 2011, 8: e1000400-CrossRef
27.
go back to reference MALera: A research agenda for malaria eradication: diagnoses and diagnostics. PLoS Med. 2011, 8: e1000396-CrossRef MALera: A research agenda for malaria eradication: diagnoses and diagnostics. PLoS Med. 2011, 8: e1000396-CrossRef
Metadata
Title
Plasmodium vivax congenital malaria in an area of very low endemicity in Guatemala: implications for clinical and epidemiological surveillance in a malaria elimination context
Authors
María Eugenia Castellanos
Azucena Bardají
Michela Menegon
Alfredo Mayor
Meghna Desai
Carlo Severini
Clara Menéndez
Norma Padilla
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2012
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-11-411

Other articles of this Issue 1/2012

Malaria Journal 1/2012 Go to the issue