Malaria in infants aged less than six months - is it an area of unmet medical need?

go back to reference WHO: World malaria report. 2011, World Health Organization, Geneva WHO: World malaria report. 2011, World Health Organization, Geneva

go back to reference Macdonald G: The analysis of malaria parasite rates in infants. Trop Dis Bull. 1950, 47: 915-938.PubMed Macdonald G: The analysis of malaria parasite rates in infants. Trop Dis Bull. 1950, 47: 915-938.PubMed

go back to reference Foll CV: Application of malariometric data obtained from longitudinal studies on infants in northern Nigeria. Bull World Health Organ. 1968, 38: 255-265.PubMedCentralPubMed Foll CV: Application of malariometric data obtained from longitudinal studies on infants in northern Nigeria. Bull World Health Organ. 1968, 38: 255-265.PubMedCentralPubMed

go back to reference Thomson JG: Malaria in nyasaland: (section of tropical diseases and parasitology). Proc R Soc Med. 1935, 28: 391-404.PubMedCentralPubMed Thomson JG: Malaria in nyasaland: (section of tropical diseases and parasitology). Proc R Soc Med. 1935, 28: 391-404.PubMedCentralPubMed

go back to reference Brabin B: An analysis of malaria parasite rates in infants: 40 years after Macdonald. Trop Dis Bull. 1990, 87: 1-21. Brabin B: An analysis of malaria parasite rates in infants: 40 years after Macdonald. Trop Dis Bull. 1990, 87: 1-21.

go back to reference Biggar RJ, Collins WE, Campbell CC: The serological response to primary malaria infection in urban Ghanaian infants. AmJTrop Med Hyg. 1980, 29: 720-724. Biggar RJ, Collins WE, Campbell CC: The serological response to primary malaria infection in urban Ghanaian infants. AmJTrop Med Hyg. 1980, 29: 720-724.

go back to reference Sehgal VM, Siddjiqui WA, Alpers MP: A seroepidemiological study to evaluate the role of passive maternal immunity to malaria in infants. Trans R Soc Trop Med Hyg. 1989, 83 (Suppl): 105-106.CrossRefPubMed Sehgal VM, Siddjiqui WA, Alpers MP: A seroepidemiological study to evaluate the role of passive maternal immunity to malaria in infants. Trans R Soc Trop Med Hyg. 1989, 83 (Suppl): 105-106.CrossRefPubMed

go back to reference Fischer PR: Malaria and newborns. J Trop Pediatr. 2003, 49: 132-134. 10.1093/tropej/49.3.132.CrossRefPubMed Fischer PR: Malaria and newborns. J Trop Pediatr. 2003, 49: 132-134. 10.1093/tropej/49.3.132.CrossRefPubMed

go back to reference Afolabi BM, Salako LA, Mafe AG, Ovwigho UB, Rabiu KA, Sanyaolu NO, Ibrahim MM: Malaria in the first 6 months of life in urban African infants with anemia. AmJTrop Med Hyg. 2001, 65: 822-827. Afolabi BM, Salako LA, Mafe AG, Ovwigho UB, Rabiu KA, Sanyaolu NO, Ibrahim MM: Malaria in the first 6 months of life in urban African infants with anemia. AmJTrop Med Hyg. 2001, 65: 822-827.

go back to reference Riley EM, Wagner GE, Akanmori BD, Koram KA: Do maternally acquired antibodies protect infants from malaria infection?. Parasite Immunol. 2001, 23: 51-59. 10.1046/j.1365-3024.2001.00364.x.CrossRefPubMed Riley EM, Wagner GE, Akanmori BD, Koram KA: Do maternally acquired antibodies protect infants from malaria infection?. Parasite Immunol. 2001, 23: 51-59. 10.1046/j.1365-3024.2001.00364.x.CrossRefPubMed

go back to reference Riley EM, Wagner GE, Ofori MF, Wheeler JG, Akanmori BD, Tetteh K, McGuinness D, Bennett S, Nkrumah FK, Anders RF, Koram KA: Lack of association between maternal antibody and protection of African infants from malaria infection. Infect Immun. 2000, 68: 5856-5863. 10.1128/IAI.68.10.5856-5863.2000.PubMedCentralCrossRefPubMed Riley EM, Wagner GE, Ofori MF, Wheeler JG, Akanmori BD, Tetteh K, McGuinness D, Bennett S, Nkrumah FK, Anders RF, Koram KA: Lack of association between maternal antibody and protection of African infants from malaria infection. Infect Immun. 2000, 68: 5856-5863. 10.1128/IAI.68.10.5856-5863.2000.PubMedCentralCrossRefPubMed

go back to reference Doolan DL, Dobano C, Baird JK: Acquired immunity to malaria. Clin Microbiol Rev. 2009, 22: 13-36. 10.1128/CMR.00025-08. TablePubMedCentralCrossRefPubMed Doolan DL, Dobano C, Baird JK: Acquired immunity to malaria. Clin Microbiol Rev. 2009, 22: 13-36. 10.1128/CMR.00025-08. TablePubMedCentralCrossRefPubMed

go back to reference Kassim OO, Ako-Anai KA, Torimiro SE, Hollowell GP, Okoye VC, Martin SK: Inhibitory factors in breastmilk, maternal and infant sera against in vitro growth of Plasmodium falciparum malaria parasite. J Trop Pediatr. 2000, 46: 92-96. 10.1093/tropej/46.2.92.CrossRefPubMed Kassim OO, Ako-Anai KA, Torimiro SE, Hollowell GP, Okoye VC, Martin SK: Inhibitory factors in breastmilk, maternal and infant sera against in vitro growth of Plasmodium falciparum malaria parasite. J Trop Pediatr. 2000, 46: 92-96. 10.1093/tropej/46.2.92.CrossRefPubMed

go back to reference Gitau GM, Eldred JM: Malaria in pregnancy: clinical, therapeutic and prophylactic considerations. Obstet Gynaecol. 2005, 7: 5-11. 10.1576/toag.7.1.005.27036.CrossRef Gitau GM, Eldred JM: Malaria in pregnancy: clinical, therapeutic and prophylactic considerations. Obstet Gynaecol. 2005, 7: 5-11. 10.1576/toag.7.1.005.27036.CrossRef

go back to reference Amaratunga C, Lopera-Mesa TM, Brittain NJ, Cholera R, Arie T, Fujioka H, Keefer JR, Fairhurst RM: A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria. PLoS One. 2011, 6: e14798-10.1371/journal.pone.0014798.PubMedCentralCrossRefPubMed Amaratunga C, Lopera-Mesa TM, Brittain NJ, Cholera R, Arie T, Fujioka H, Keefer JR, Fairhurst RM: A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria. PLoS One. 2011, 6: e14798-10.1371/journal.pone.0014798.PubMedCentralCrossRefPubMed

go back to reference Gwamaka M, Kurtis JD, Sorensen BE, Holte S, Morrison R, Mutabingwa TK, Fried M, Duffy PE: Iron deficiency protects against severe Plasmodium falciparum malaria and death in young children. Clin Infect Dis. 2012, 54: 1137-1144. 10.1093/cid/cis010.PubMedCentralCrossRefPubMed Gwamaka M, Kurtis JD, Sorensen BE, Holte S, Morrison R, Mutabingwa TK, Fried M, Duffy PE: Iron deficiency protects against severe Plasmodium falciparum malaria and death in young children. Clin Infect Dis. 2012, 54: 1137-1144. 10.1093/cid/cis010.PubMedCentralCrossRefPubMed

go back to reference Bardaji A, Sigauque B, Sanz S, Maixenchs M, Ordi J, Aponte JJ, Mabunda S, Alonso PL, Menéndez C: Impact of malaria at the end of pregnancy on infant mortality and morbidity. J Infect Dis. 2011, 203: 691-699. 10.1093/infdis/jiq049.PubMedCentralCrossRefPubMed Bardaji A, Sigauque B, Sanz S, Maixenchs M, Ordi J, Aponte JJ, Mabunda S, Alonso PL, Menéndez C: Impact of malaria at the end of pregnancy on infant mortality and morbidity. J Infect Dis. 2011, 203: 691-699. 10.1093/infdis/jiq049.PubMedCentralCrossRefPubMed

go back to reference Schwarz NG, Adegnika AA, Breitling LP, Gabor J, Agnandji ST, Newman RD, Lell B, Issifou S, Yazdanbakhsh M, Luty AJ, Kremsner PG, Grobusch MP: Placental malaria increases malaria risk in the first 30 months of life. Clin Infect Dis. 2008, 47: 1017-1025. 10.1086/591968.CrossRefPubMed Schwarz NG, Adegnika AA, Breitling LP, Gabor J, Agnandji ST, Newman RD, Lell B, Issifou S, Yazdanbakhsh M, Luty AJ, Kremsner PG, Grobusch MP: Placental malaria increases malaria risk in the first 30 months of life. Clin Infect Dis. 2008, 47: 1017-1025. 10.1086/591968.CrossRefPubMed

go back to reference Malhotra I, Dent A, Mungai P, Wamachi A, Ouma JH, Narum DL, Muchiri E, Tisch DJ, King CL: Can prenatal malaria exposure produce an immune tolerant phenotype? A prospective birth cohort study in Kenya. PLoS Med. 2009, 6: e1000116-10.1371/journal.pmed.1000116.PubMedCentralCrossRefPubMed Malhotra I, Dent A, Mungai P, Wamachi A, Ouma JH, Narum DL, Muchiri E, Tisch DJ, King CL: Can prenatal malaria exposure produce an immune tolerant phenotype? A prospective birth cohort study in Kenya. PLoS Med. 2009, 6: e1000116-10.1371/journal.pmed.1000116.PubMedCentralCrossRefPubMed

go back to reference Falade C, Mokuolu O, Okafor H, Orogade A, Falade A, Adedoyin O, Oguonu T, Aisha M, Hamer DH, Callahan MV: Epidemiology of congenital malaria in Nigeria: a multi-centre study. Trop Med Int Health. 2007, 12: 1279-1287. 10.1111/j.1365-3156.2007.01931.x.CrossRefPubMed Falade C, Mokuolu O, Okafor H, Orogade A, Falade A, Adedoyin O, Oguonu T, Aisha M, Hamer DH, Callahan MV: Epidemiology of congenital malaria in Nigeria: a multi-centre study. Trop Med Int Health. 2007, 12: 1279-1287. 10.1111/j.1365-3156.2007.01931.x.CrossRefPubMed

go back to reference Mukhtar M: The growing incidence of neonatal malaria–a situational review in developing countries. Niger J Med. 2007, 16: 25-30.PubMed Mukhtar M: The growing incidence of neonatal malaria–a situational review in developing countries. Niger J Med. 2007, 16: 25-30.PubMed

go back to reference Fischer PR, Nyirjesy P, Toko RM: Congenital malaria in twins. West J Med. 1995, 163: 395-396.PubMedCentralPubMed Fischer PR, Nyirjesy P, Toko RM: Congenital malaria in twins. West J Med. 1995, 163: 395-396.PubMedCentralPubMed

go back to reference Fischer PR: Congenital malaria: an African survey. Clin Pediatr (Phila). 1997, 36: 411-413. 10.1177/000992289703600706.CrossRef Fischer PR: Congenital malaria: an African survey. Clin Pediatr (Phila). 1997, 36: 411-413. 10.1177/000992289703600706.CrossRef

go back to reference Kamwendo DD, Dzinjalamala FK, Snounou G, Kanjala MC, Mhango CG, Molyneux ME, Rogerson SJ: Plasmodium falciparum: PCR detection and genotyping of isolates from peripheral, placental, and cord blood of pregnant Malawian women and their infants. Trans R Soc Trop Med Hyg. 2002, 96: 145-149. 10.1016/S0035-9203(02)90284-1.CrossRefPubMed Kamwendo DD, Dzinjalamala FK, Snounou G, Kanjala MC, Mhango CG, Molyneux ME, Rogerson SJ: Plasmodium falciparum: PCR detection and genotyping of isolates from peripheral, placental, and cord blood of pregnant Malawian women and their infants. Trans R Soc Trop Med Hyg. 2002, 96: 145-149. 10.1016/S0035-9203(02)90284-1.CrossRefPubMed

go back to reference Mwaniki MK, Talbert AW, Mturi FN, Berkley JA, Kager P, Marsh K, Newton CR: Congenital and neonatal malaria in a rural Kenyan district hospital: an eight-year analysis. Malar J. 2010, 9: 313-10.1186/1475-2875-9-313.PubMedCentralCrossRefPubMed Mwaniki MK, Talbert AW, Mturi FN, Berkley JA, Kager P, Marsh K, Newton CR: Congenital and neonatal malaria in a rural Kenyan district hospital: an eight-year analysis. Malar J. 2010, 9: 313-10.1186/1475-2875-9-313.PubMedCentralCrossRefPubMed

go back to reference Dicko-Traoré F, Syla M, Djimde AA, Diakité AA, Diawara M, Togo B, Togo P, Dara A, Dama S, Traoré K, Traoré S, Sissoko S, Poudiougo B, Sidibé T, Keita MM, Doumbo O: [Congenital and neonatal malaria in sub-sahara Africa, a scarce event?]. J Pediatr Pueric. 2011, 24: 57-61. Dicko-Traoré F, Syla M, Djimde AA, Diakité AA, Diawara M, Togo B, Togo P, Dara A, Dama S, Traoré K, Traoré S, Sissoko S, Poudiougo B, Sidibé T, Keita MM, Doumbo O: [Congenital and neonatal malaria in sub-sahara Africa, a scarce event?]. J Pediatr Pueric. 2011, 24: 57-61.

go back to reference Klein Klouwenberg PM, Oyakhirome S, Schwarz NG, Glaser B, Issifou S, Kiessling G, Klöpfer A, Kremsner PG, Längin M, Lassmann B, Necek M, Pötschke M, Ritz A, Grobusch MP: Malaria and asymptomatic parasitaemia in Gabonese infants under the age of 3 months. Acta Trop. 2005, 95: 81-85. 10.1016/j.actatropica.2005.05.003.CrossRefPubMed Klein Klouwenberg PM, Oyakhirome S, Schwarz NG, Glaser B, Issifou S, Kiessling G, Klöpfer A, Kremsner PG, Längin M, Lassmann B, Necek M, Pötschke M, Ritz A, Grobusch MP: Malaria and asymptomatic parasitaemia in Gabonese infants under the age of 3 months. Acta Trop. 2005, 95: 81-85. 10.1016/j.actatropica.2005.05.003.CrossRefPubMed

go back to reference Larru B, Molyneux E, ter Kuile FO, Taylor T, Molyneux M, Terlouw DJ: Malaria in infants below six months of age: retrospective surveillance of hospital admission records in Blantyre. Malawi. Malar J. 2009, 8: 310-10.1186/1475-2875-8-310.PubMedCentralCrossRefPubMed Larru B, Molyneux E, ter Kuile FO, Taylor T, Molyneux M, Terlouw DJ: Malaria in infants below six months of age: retrospective surveillance of hospital admission records in Blantyre. Malawi. Malar J. 2009, 8: 310-10.1186/1475-2875-8-310.PubMedCentralCrossRefPubMed

go back to reference Nankabirwa V, Tylleskar T, Nankunda J, Engebretsen IM, Sommerfelt H, Tumwine JK: Malaria parasitaemia among infants and its association with breastfeeding peer counselling and vitamin A supplementation: a secondary analysis of a cluster randomized trial. PLoS One. 2011, 6: e21862-10.1371/journal.pone.0021862.PubMedCentralCrossRefPubMed Nankabirwa V, Tylleskar T, Nankunda J, Engebretsen IM, Sommerfelt H, Tumwine JK: Malaria parasitaemia among infants and its association with breastfeeding peer counselling and vitamin A supplementation: a secondary analysis of a cluster randomized trial. PLoS One. 2011, 6: e21862-10.1371/journal.pone.0021862.PubMedCentralCrossRefPubMed

go back to reference Pedro R, Akech S, Fegan G, Maitland K: Changing trends in blood transfusion in children and neonates admitted in Kilifi District Hospital. Kenya. Malar J. 2010, 9: 307-10.1186/1475-2875-9-307.PubMedCentralCrossRefPubMed Pedro R, Akech S, Fegan G, Maitland K: Changing trends in blood transfusion in children and neonates admitted in Kilifi District Hospital. Kenya. Malar J. 2010, 9: 307-10.1186/1475-2875-9-307.PubMedCentralCrossRefPubMed

go back to reference Runsewe-Abiodun IT, Ogunfowora OB, Fetuga BM: Neonatal malaria in Nigeria–a 2 year review. BMC Pediatr. 2006, 6: 19-10.1186/1471-2431-6-19.PubMedCentralCrossRefPubMed Runsewe-Abiodun IT, Ogunfowora OB, Fetuga BM: Neonatal malaria in Nigeria–a 2 year review. BMC Pediatr. 2006, 6: 19-10.1186/1471-2431-6-19.PubMedCentralCrossRefPubMed

go back to reference van Eijk AM, Ayisi JG, ter Kuile FO, Slutsker L, Shi YP, Udhayakumar V, Otieno JA, Kager PA, Lal RB, Steketee RW, Nahlen BL: HIV, malaria, and infant anemia as risk factors for postneonatal infant mortality among HIV-seropositive women in Kisumu. Kenya. J Infect Dis. 2007, 196: 30-37. 10.1086/518441.CrossRefPubMed van Eijk AM, Ayisi JG, ter Kuile FO, Slutsker L, Shi YP, Udhayakumar V, Otieno JA, Kager PA, Lal RB, Steketee RW, Nahlen BL: HIV, malaria, and infant anemia as risk factors for postneonatal infant mortality among HIV-seropositive women in Kisumu. Kenya. J Infect Dis. 2007, 196: 30-37. 10.1086/518441.CrossRefPubMed

go back to reference Ojukwu JU, Ezeonu CT, Ogbu CN: Severe malaria in neonates masquerading as septicaemia. Nigerian J Paediatr. 2004, 31: 48-55. Ojukwu JU, Ezeonu CT, Ogbu CN: Severe malaria in neonates masquerading as septicaemia. Nigerian J Paediatr. 2004, 31: 48-55.

go back to reference Abdullah S, Adazu K, Masanja H, Diallo D, Hodgson A, Ilboudo-Sanogo E, Nhacolo A, Owusu-Agyei S, Thompson R, Smith T, Binka FN: Patterns of age-specific mortality in children in endemic areas of sub-Saharan Africa. AmJTrop Med Hyg. 2007, 77: 99-105.CrossRef Abdullah S, Adazu K, Masanja H, Diallo D, Hodgson A, Ilboudo-Sanogo E, Nhacolo A, Owusu-Agyei S, Thompson R, Smith T, Binka FN: Patterns of age-specific mortality in children in endemic areas of sub-Saharan Africa. AmJTrop Med Hyg. 2007, 77: 99-105.CrossRef

go back to reference Corkill JA, Brabin BJ, MacGregor DF, Alpers MP, Milner RD: Newborn splenic volumes vary under different malaria endemic conditions. Arch Dis Child. 1989, 64: 541-545. 10.1136/adc.64.4.541.PubMedCentralCrossRefPubMed Corkill JA, Brabin BJ, MacGregor DF, Alpers MP, Milner RD: Newborn splenic volumes vary under different malaria endemic conditions. Arch Dis Child. 1989, 64: 541-545. 10.1136/adc.64.4.541.PubMedCentralCrossRefPubMed

go back to reference Guinovart C, Bassat Q, Sigauque B, Aide P, Sacarlal J, Nhampossa T, Bardají A, Nhacolo A, Macete E, Mandomando I, Aponte JJ, Menéndez C, Alonso PL: Malaria in rural Mozambique. Part I: children attending the outpatient clinic. Malar J. 2008, 7: 36-10.1186/1475-2875-7-36.PubMedCentralCrossRefPubMed Guinovart C, Bassat Q, Sigauque B, Aide P, Sacarlal J, Nhampossa T, Bardají A, Nhacolo A, Macete E, Mandomando I, Aponte JJ, Menéndez C, Alonso PL: Malaria in rural Mozambique. Part I: children attending the outpatient clinic. Malar J. 2008, 7: 36-10.1186/1475-2875-7-36.PubMedCentralCrossRefPubMed

go back to reference Adja EA, Dick FA, N’guessan R: [Epidemiological study of the malaria at the neonatal period in the teaching hospital of Yopougon–Republic of Cote d’Ivoire] (in French). Mali Med. 2009, 24: 36-39.PubMed Adja EA, Dick FA, N’guessan R: [Epidemiological study of the malaria at the neonatal period in the teaching hospital of Yopougon–Republic of Cote d’Ivoire] (in French). Mali Med. 2009, 24: 36-39.PubMed

go back to reference Ekanem AD, Anah MU, Udo JJ: The prevalence of congenital malaria among neonates with suspected sepsis in Calabar. Nigeria. Trop Doct. 2008, 38: 73-76. 10.1258/td.2007.005274.CrossRefPubMed Ekanem AD, Anah MU, Udo JJ: The prevalence of congenital malaria among neonates with suspected sepsis in Calabar. Nigeria. Trop Doct. 2008, 38: 73-76. 10.1258/td.2007.005274.CrossRefPubMed

go back to reference Ibhanesebhor SE: Clinical characteristics of neonatal malaria. J Trop Pediatr. 1995, 41: 330-333. 10.1093/tropej/41.6.330.CrossRefPubMed Ibhanesebhor SE: Clinical characteristics of neonatal malaria. J Trop Pediatr. 1995, 41: 330-333. 10.1093/tropej/41.6.330.CrossRefPubMed

go back to reference Lesi FE, Mukhtar MY, Iroha EU, Egri-Okwaji MT: Clinical presentation of congenital malaria at the Lagos university teaching hospital. Niger J Clin Pract. 2010, 13: 134-138.PubMed Lesi FE, Mukhtar MY, Iroha EU, Egri-Okwaji MT: Clinical presentation of congenital malaria at the Lagos university teaching hospital. Niger J Clin Pract. 2010, 13: 134-138.PubMed

go back to reference Mosha TCE, Ntarukimana D, John M: Prevalence of congenital malaria among neonates at morogoro regional hospital, morogoro. Tanzania. Tanzania J Health Res. 2010, 12: 1-10. Mosha TCE, Ntarukimana D, John M: Prevalence of congenital malaria among neonates at morogoro regional hospital, morogoro. Tanzania. Tanzania J Health Res. 2010, 12: 1-10.

go back to reference Mukhtar MY, Lesi FE, Iroha EU, Egri-Okwaji MT, Mafe AG: Congenital malaria among inborn babies at a tertiary centre in Lagos. Nigeria. J Trop Pediatr. 2006, 52: 19-23. 10.1093/tropej/fmi044.CrossRefPubMed Mukhtar MY, Lesi FE, Iroha EU, Egri-Okwaji MT, Mafe AG: Congenital malaria among inborn babies at a tertiary centre in Lagos. Nigeria. J Trop Pediatr. 2006, 52: 19-23. 10.1093/tropej/fmi044.CrossRefPubMed

go back to reference Mwangoka GW, Kimera SI, Mboera LE: Congenital Plasmodium falciparum infection in neonates in Muheza District. Tanzania. Malar J. 2008, 7: 117-10.1186/1475-2875-7-117.PubMedCentralCrossRefPubMed Mwangoka GW, Kimera SI, Mboera LE: Congenital Plasmodium falciparum infection in neonates in Muheza District. Tanzania. Malar J. 2008, 7: 117-10.1186/1475-2875-7-117.PubMedCentralCrossRefPubMed

go back to reference Obiajunwa PO, Owa JA, Adeodu OO: Prevalence of congenital malaria in Ile-ife. Nigeria. J Trop Pediatr. 2005, 51: 219-222. 10.1093/tropej/fmi003.CrossRefPubMed Obiajunwa PO, Owa JA, Adeodu OO: Prevalence of congenital malaria in Ile-ife. Nigeria. J Trop Pediatr. 2005, 51: 219-222. 10.1093/tropej/fmi003.CrossRefPubMed

go back to reference Oduwole OA, Ejezie GC, Odey FA, Oringanje CM, Nwakanma D, Bello S, Oriero E, Okebe J, Alaribe AA, Etuk S, Meremikwu M: Congenital malaria in Calabar, Nigeria: the molecular perspective. AmJTrop Med Hyg. 2011, 84: 386-389. 10.4269/ajtmh.2011.10-0253.CrossRef Oduwole OA, Ejezie GC, Odey FA, Oringanje CM, Nwakanma D, Bello S, Oriero E, Okebe J, Alaribe AA, Etuk S, Meremikwu M: Congenital malaria in Calabar, Nigeria: the molecular perspective. AmJTrop Med Hyg. 2011, 84: 386-389. 10.4269/ajtmh.2011.10-0253.CrossRef

go back to reference Okafor UH, Oguonu T, Onah HE: Risk factors associated with congenital malaria in Enugu. South eastern Nigeria. J Obstet Gynaecol. 2006, 26: 612-616. 10.1080/09638280600902893.CrossRefPubMed Okafor UH, Oguonu T, Onah HE: Risk factors associated with congenital malaria in Enugu. South eastern Nigeria. J Obstet Gynaecol. 2006, 26: 612-616. 10.1080/09638280600902893.CrossRefPubMed

go back to reference Okechukwu AA, Olateju EK, Olutunde EO: Congenital malaria among newborns admitted for suspected neonatal sepsis in Abuja. Nigerian J Paediatr. 2011, 38: 82-89.CrossRef Okechukwu AA, Olateju EK, Olutunde EO: Congenital malaria among newborns admitted for suspected neonatal sepsis in Abuja. Nigerian J Paediatr. 2011, 38: 82-89.CrossRef

go back to reference Omalu IC, Mgbemena C, Mgbemena A, Ayanwale V, Olayemi IK, Lateef A, Chukwuemeka VI: Prevalence of congenital malaria in Minna, north central Nigeria. J Trop Med. 2012, 201 (2): 274142- Omalu IC, Mgbemena C, Mgbemena A, Ayanwale V, Olayemi IK, Lateef A, Chukwuemeka VI: Prevalence of congenital malaria in Minna, north central Nigeria. J Trop Med. 2012, 201 (2): 274142-

go back to reference Orogade AA, Falade CO, Okafor HU, Mokuolu OA, Mamman AI, Ogbonu TA, Ogunkunle OO, Ernest KS, Callahan MV, Hamer DH: Clinical and laboratory features of congenital malaria in Nigeria. J Pediatr Infect Dis. 2008, 3: 181-187. Orogade AA, Falade CO, Okafor HU, Mokuolu OA, Mamman AI, Ogbonu TA, Ogunkunle OO, Ernest KS, Callahan MV, Hamer DH: Clinical and laboratory features of congenital malaria in Nigeria. J Pediatr Infect Dis. 2008, 3: 181-187.

go back to reference Pineros-Jimenez JG, Alvarez G, Tobon A, Arboleda M, Carrero S, Blair S: Congenital malaria in Uraba. Colombia. Malar J. 2011, 10: 239-10.1186/1475-2875-10-239.PubMedCentralCrossRefPubMed Pineros-Jimenez JG, Alvarez G, Tobon A, Arboleda M, Carrero S, Blair S: Congenital malaria in Uraba. Colombia. Malar J. 2011, 10: 239-10.1186/1475-2875-10-239.PubMedCentralCrossRefPubMed

go back to reference Sule-Odu AO, Ogunledun A, Olatunji AO: Impact of asymptomatic maternal malaria parasitaemia at parturition on perinatal outcome. J Obstet Gynaecol. 2002, 22: 25-28. 10.1080/01443610120101664.CrossRefPubMed Sule-Odu AO, Ogunledun A, Olatunji AO: Impact of asymptomatic maternal malaria parasitaemia at parturition on perinatal outcome. J Obstet Gynaecol. 2002, 22: 25-28. 10.1080/01443610120101664.CrossRefPubMed

go back to reference Larkin GL, Thuma PE: Congenital malaria in a hyperendemic area. AmJTrop Med Hyg. 1991, 45: 587-592. Larkin GL, Thuma PE: Congenital malaria in a hyperendemic area. AmJTrop Med Hyg. 1991, 45: 587-592.

go back to reference Akindele JA, Sowunmi A, Abohweyere AE: Congenital malaria in a hyperendemic area: a preliminary study. Ann Trop Paediatr. 1993, 13: 273-276.PubMed Akindele JA, Sowunmi A, Abohweyere AE: Congenital malaria in a hyperendemic area: a preliminary study. Ann Trop Paediatr. 1993, 13: 273-276.PubMed

go back to reference Wagner G, Koram K, McGuinness D, Bennett S, Nkrumah F, Riley E: High incidence of asymptomatic malara infections in a birth cohort of children less than one year of age in Ghana, detected by multicopy gene polymerase chain reaction. AmJTrop Med Hyg. 1998, 59: 115-123. Wagner G, Koram K, McGuinness D, Bennett S, Nkrumah F, Riley E: High incidence of asymptomatic malara infections in a birth cohort of children less than one year of age in Ghana, detected by multicopy gene polymerase chain reaction. AmJTrop Med Hyg. 1998, 59: 115-123.

go back to reference Carneiro I, Roca-Feltrer A, Griffin JT, Smith L, Tanner M, Schellenberg JA, Greenwood B, Schellenberg D: Age-patterns of malaria vary with severity, transmission intensity and seasonality in sub-Saharan Africa: a systematic review and pooled analysis. PLoS One. 2010, 5: e8988-10.1371/journal.pone.0008988.PubMedCentralCrossRefPubMed Carneiro I, Roca-Feltrer A, Griffin JT, Smith L, Tanner M, Schellenberg JA, Greenwood B, Schellenberg D: Age-patterns of malaria vary with severity, transmission intensity and seasonality in sub-Saharan Africa: a systematic review and pooled analysis. PLoS One. 2010, 5: e8988-10.1371/journal.pone.0008988.PubMedCentralCrossRefPubMed

go back to reference Hashemzadeh A, Heydarian F: Congenital malaria in a neonate. Arch Iranian Med. 2005, 8: 226-228. Hashemzadeh A, Heydarian F: Congenital malaria in a neonate. Arch Iranian Med. 2005, 8: 226-228.

go back to reference Hailegiorgis B, Girma S, Melaku Z, Teshi T, Demeke L, Gebresellasie S, Yadeta D, Tibesso G, Whitehurst N, Yamo E, Carter J, Reithinger R: Laboratory malaria diagnostic capacity in health facilities in five administrative zones of oromia regional state. Ethiopia. Trop Med Int Health. 2010, 15: 1449-1457. 10.1111/j.1365-3156.2010.02646.x.CrossRefPubMed Hailegiorgis B, Girma S, Melaku Z, Teshi T, Demeke L, Gebresellasie S, Yadeta D, Tibesso G, Whitehurst N, Yamo E, Carter J, Reithinger R: Laboratory malaria diagnostic capacity in health facilities in five administrative zones of oromia regional state. Ethiopia. Trop Med Int Health. 2010, 15: 1449-1457. 10.1111/j.1365-3156.2010.02646.x.CrossRefPubMed

go back to reference Ishengoma DR, Derua YA, Rwegoshora RT, Tenu F, Massaga JJ, Mboera LE, Magesa SM: The performance of health laboratories and the quality of malaria diagnosis in six districts of Tanzania. Ann Trop Med Parasitol. 2010, 104: 123-135. 10.1179/136485910X12607012373993.CrossRefPubMed Ishengoma DR, Derua YA, Rwegoshora RT, Tenu F, Massaga JJ, Mboera LE, Magesa SM: The performance of health laboratories and the quality of malaria diagnosis in six districts of Tanzania. Ann Trop Med Parasitol. 2010, 104: 123-135. 10.1179/136485910X12607012373993.CrossRefPubMed

go back to reference Uneke CJ: Congenital Plasmodium falciparum malaria in sub-Saharan Africa: a rarity or frequent occurrence?. Parasitol Res. 2007, 101: 835-842. 10.1007/s00436-007-0577-9.CrossRefPubMed Uneke CJ: Congenital Plasmodium falciparum malaria in sub-Saharan Africa: a rarity or frequent occurrence?. Parasitol Res. 2007, 101: 835-842. 10.1007/s00436-007-0577-9.CrossRefPubMed

go back to reference Lawn JE, Cousens S, Zupan J: 4 million neonatal deaths: when? Where? Why?. Lancet. 2005, 365: 891-900. 10.1016/S0140-6736(05)71048-5.CrossRefPubMed Lawn JE, Cousens S, Zupan J: 4 million neonatal deaths: when? Where? Why?. Lancet. 2005, 365: 891-900. 10.1016/S0140-6736(05)71048-5.CrossRefPubMed

go back to reference Sacarlal J, Nhacolo AQ, Sigauque B, Nhalungo DA, Abacassamo F, Sacoor CN, Aide P, Machevo S, Nhampossa T, Macete EV, Bassat Q, David C, Bardají A, Letang E, Saúte F, Aponte JJ, Thompson R, Alonso PL: A 10 year study of the cause of death in children under 15 years in Manhica. Mozambique. BMC Publ Health. 2009, 9: 67-10.1186/1471-2458-9-67.CrossRef Sacarlal J, Nhacolo AQ, Sigauque B, Nhalungo DA, Abacassamo F, Sacoor CN, Aide P, Machevo S, Nhampossa T, Macete EV, Bassat Q, David C, Bardají A, Letang E, Saúte F, Aponte JJ, Thompson R, Alonso PL: A 10 year study of the cause of death in children under 15 years in Manhica. Mozambique. BMC Publ Health. 2009, 9: 67-10.1186/1471-2458-9-67.CrossRef

go back to reference Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE: Developmental pharmacology–drug disposition, action, and therapy in infants and children. N Engl J Med. 2003, 349: 1157-1167. 10.1056/NEJMra035092.CrossRefPubMed Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE: Developmental pharmacology–drug disposition, action, and therapy in infants and children. N Engl J Med. 2003, 349: 1157-1167. 10.1056/NEJMra035092.CrossRefPubMed

go back to reference WHO: Guidelines for the treatment of Malaria. 2010, World Health Organization, Geneva, Switzerland, Second WHO: Guidelines for the treatment of Malaria. 2010, World Health Organization, Geneva, Switzerland, Second

go back to reference Milsap RL, Jusko WJ: Pharmacokinetics in the infant. Environ Health Perspect. 1994, 102 (Suppl 11): 107-110. 10.1289/ehp.94102s11107.PubMedCentralCrossRefPubMed Milsap RL, Jusko WJ: Pharmacokinetics in the infant. Environ Health Perspect. 1994, 102 (Suppl 11): 107-110. 10.1289/ehp.94102s11107.PubMedCentralCrossRefPubMed

go back to reference Menendez C, Mayor A: Congenital malaria: the least known consequence of malaria in pregnancy. Semin Fetal Neonatal Med. 2007, 12: 207-213. 10.1016/j.siny.2007.01.018.CrossRefPubMed Menendez C, Mayor A: Congenital malaria: the least known consequence of malaria in pregnancy. Semin Fetal Neonatal Med. 2007, 12: 207-213. 10.1016/j.siny.2007.01.018.CrossRefPubMed

go back to reference Geerligs PD, Brabin BJ, Eggelte TA: Analysis of the effects of malaria chemoprophylaxis in children on haematological responses, morbidity and mortality. Bull World Health Organ. 2003, 81: 205-216.PubMedCentralPubMed Geerligs PD, Brabin BJ, Eggelte TA: Analysis of the effects of malaria chemoprophylaxis in children on haematological responses, morbidity and mortality. Bull World Health Organ. 2003, 81: 205-216.PubMedCentralPubMed

go back to reference McGregor IA, Gilles HM, Walters JH, Davies AH, Pearson FA: Effects of heavy and repeated malarial infections on Gambian infants and children; effects of erythrocytic parasitization. BMJ. 1956, 2: 686-692. 10.1136/bmj.2.4994.686.PubMedCentralCrossRefPubMed McGregor IA, Gilles HM, Walters JH, Davies AH, Pearson FA: Effects of heavy and repeated malarial infections on Gambian infants and children; effects of erythrocytic parasitization. BMJ. 1956, 2: 686-692. 10.1136/bmj.2.4994.686.PubMedCentralCrossRefPubMed

go back to reference Aponte JJ, Schellenberg D, Egan A, Breckenridge A, Carneiro I, Critchley J, Danquah I, Dodoo A, Kobbe R, Lell B, May J, Premji Z, Sanz S, Sevene E, Soulaymani-Becheikh R, Winstanley P, Adjei S, Anemana S, Chandramohan D, Issifou S, Mockenhaupt F, Owusu-Agyei S, Greenwood B, Grobusch MP, Kremsner PG, Macete E, Mshinda H, Newman RD, Slutsker L, Tanner M, Alonso P, Menendez C: Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials. Lancet. 2009, 374: 1533-1542. 10.1016/S0140-6736(09)61258-7.CrossRefPubMed Aponte JJ, Schellenberg D, Egan A, Breckenridge A, Carneiro I, Critchley J, Danquah I, Dodoo A, Kobbe R, Lell B, May J, Premji Z, Sanz S, Sevene E, Soulaymani-Becheikh R, Winstanley P, Adjei S, Anemana S, Chandramohan D, Issifou S, Mockenhaupt F, Owusu-Agyei S, Greenwood B, Grobusch MP, Kremsner PG, Macete E, Mshinda H, Newman RD, Slutsker L, Tanner M, Alonso P, Menendez C: Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials. Lancet. 2009, 374: 1533-1542. 10.1016/S0140-6736(09)61258-7.CrossRefPubMed

go back to reference WHO Global Malaria Programme: WHO Policy Recommendation: Seasonal Malaria Chemoprevention (SMC) for Plasmodium falciparum malaria control in highly seasonal transmission areas of the Sahel sub-region in Africa. 2012,http://www.who.int/malaria/publications/atoz/smc_policy_recommendation_en_032012.pdf, WHO Global Malaria Programme: WHO Policy Recommendation: Seasonal Malaria Chemoprevention (SMC) for Plasmodium falciparum malaria control in highly seasonal transmission areas of the Sahel sub-region in Africa. 2012,http://​www.​who.​int/​malaria/​publications/​atoz/​smc_​policy_​recommendation_​en_​032012.​pdf,

go back to reference Gosling RD, Okell L, Mosha J, Chandramohan D: The role of antimalarial treatment in the elimination of malaria. Clin Microbiol Infect. 2011, 17: 1617-1623. 10.1111/j.1469-0691.2011.03660.x.CrossRefPubMed Gosling RD, Okell L, Mosha J, Chandramohan D: The role of antimalarial treatment in the elimination of malaria. Clin Microbiol Infect. 2011, 17: 1617-1623. 10.1111/j.1469-0691.2011.03660.x.CrossRefPubMed

go back to reference The RTS,S Clinical Trials Partnership: A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. N Engl J Med. 2012, 10.1056/NEJMoa1208394. The RTS,S Clinical Trials Partnership: A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. N Engl J Med. 2012, 10.1056/NEJMoa1208394.

go back to reference Daily JP: Malaria vaccine trials - beyond efficacy end points. N Engl J Med. 2012, 10.1056/NEJMe1213392. Daily JP: Malaria vaccine trials - beyond efficacy end points. N Engl J Med. 2012, 10.1056/NEJMe1213392.

go back to reference Agnandji ST, Lell B, Soulanoudjingar SS, Fernandes JF, Abossolo BP, Conzelmann C, Methogo BG, Doucka Y, Flamen A, Mordmüller B, Issifou S, Kremsner PG, Sacarlal J, Aide P, Lanaspa M, Aponte JJ, Nhamuave A, Quelhas D, Bassat Q, Mandjate S, Macete E, Alonso P, Abdulla S, Salim N, Juma O, Shomari M, Shubis K, Machera F, Hamad AS, Minja R, Mtoro A, Sykes A, Ahmed S, Urassa AM, Ali AM, Mwangoka G, Tanner M, Tinto H, D’Alessandro U, Sorgho H, Valea I, Tahita MC, Kaboré W, Ouédraogo S, Sandrine Y, Guiguemdé RT, Ouédraogo JB, Hamel MJ, Kariuki S, Odero C, Oneko M, Otieno K, Awino N, Omoto J, Williamson J, Muturi-Kioi V, Laserson KF, Slutsker L, Otieno W, Otieno L, Nekoye O, Gondi S, Otieno A, Ogutu B, Wasuna R, Owira V, Jones D, Onyango AA, Njuguna P, Chilengi R, Akoo P, Kerubo C, Gitaka J, Maingi C, Lang T, Olotu A, Tsofa B, Bejon P, Peshu N, Marsh K, Owusu-Agyei S, Asante KP, Osei-Kwakye K, Boahen O, Ayamba S, Kayan K, Owusu-Ofori R, Dosoo D, Asante I, Adjei G, Adjei G, Chandramohan D, Greenwood B, Lusingu J, Gesase S, Malabeja A, Abdul O, Kilavo H, Mahende C, Liheluka E, Lemnge M, Theander T, Drakeley C, Ansong D, Agbenyega T, Adjei S, Boateng HO, Rettig T, Bawa J, Sylverken J, Sambian D, Agyekum A, Owusu L, Martinson F, Hoffman I, Mvalo T, Kamthunzi P, Nkomo R, Msika A, Jumbe A, Chome N, Nyakuipa D, Chintedza J, Ballou WR, Bruls M, Cohen J, Guerra Y, Jongert E, Lapierre D, Leach A, Lievens M, Ofori-Anyinam O, Vekemans J, Carter T, Leboulleux D, Loucq C, Radford A, Savarese B, Schellenberg D, Sillman M, Vansadia P: RTS,S Clinical Trials Partnership: First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N Engl J Med. 2011, 365: 1863-1875.CrossRefPubMed Agnandji ST, Lell B, Soulanoudjingar SS, Fernandes JF, Abossolo BP, Conzelmann C, Methogo BG, Doucka Y, Flamen A, Mordmüller B, Issifou S, Kremsner PG, Sacarlal J, Aide P, Lanaspa M, Aponte JJ, Nhamuave A, Quelhas D, Bassat Q, Mandjate S, Macete E, Alonso P, Abdulla S, Salim N, Juma O, Shomari M, Shubis K, Machera F, Hamad AS, Minja R, Mtoro A, Sykes A, Ahmed S, Urassa AM, Ali AM, Mwangoka G, Tanner M, Tinto H, D’Alessandro U, Sorgho H, Valea I, Tahita MC, Kaboré W, Ouédraogo S, Sandrine Y, Guiguemdé RT, Ouédraogo JB, Hamel MJ, Kariuki S, Odero C, Oneko M, Otieno K, Awino N, Omoto J, Williamson J, Muturi-Kioi V, Laserson KF, Slutsker L, Otieno W, Otieno L, Nekoye O, Gondi S, Otieno A, Ogutu B, Wasuna R, Owira V, Jones D, Onyango AA, Njuguna P, Chilengi R, Akoo P, Kerubo C, Gitaka J, Maingi C, Lang T, Olotu A, Tsofa B, Bejon P, Peshu N, Marsh K, Owusu-Agyei S, Asante KP, Osei-Kwakye K, Boahen O, Ayamba S, Kayan K, Owusu-Ofori R, Dosoo D, Asante I, Adjei G, Adjei G, Chandramohan D, Greenwood B, Lusingu J, Gesase S, Malabeja A, Abdul O, Kilavo H, Mahende C, Liheluka E, Lemnge M, Theander T, Drakeley C, Ansong D, Agbenyega T, Adjei S, Boateng HO, Rettig T, Bawa J, Sylverken J, Sambian D, Agyekum A, Owusu L, Martinson F, Hoffman I, Mvalo T, Kamthunzi P, Nkomo R, Msika A, Jumbe A, Chome N, Nyakuipa D, Chintedza J, Ballou WR, Bruls M, Cohen J, Guerra Y, Jongert E, Lapierre D, Leach A, Lievens M, Ofori-Anyinam O, Vekemans J, Carter T, Leboulleux D, Loucq C, Radford A, Savarese B, Schellenberg D, Sillman M, Vansadia P: RTS,S Clinical Trials Partnership: First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N Engl J Med. 2011, 365: 1863-1875.CrossRefPubMed