Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Malaria Journal
Published in: Malaria Journal 1/2012

Open Access 01-12-2012 | Review

Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature

Authors: Marcus VG Lacerda, Maria PG Mourão, Márcia AA Alexandre, André M Siqueira, Belisa ML Magalhães, Flor E Martinez-Espinosa, Franklin S Santana Filho, Patrícia Brasil, Ana MRS Ventura, Mauro S Tada, Vanja SCD Couto, Antônio R Silva, Rita SU Silva, Maria GC Alecrim

Published in: Malaria Journal | Issue 1/2012

Login to get access

Abstract

The resurgence of the malaria eradication agenda and the increasing number of severe manifestation reports has contributed to a renewed interested in the Plasmodium vivax infection. It is the most geographically widespread parasite causing human malaria, with around 2.85 billion people living under risk of infection. The Brazilian Amazon region reports more than 50% of the malaria cases in Latin America and since 1990 there is a marked predominance of this species, responsible for 85% of cases in 2009. However, only a few complicated cases of P. vivax have been reported from this region. A systematic review of the Brazilian indexed and non-indexed literature on complicated cases of vivax malaria was performed including published articles, masters' dissertations, doctoral theses and national congresses' abstracts. The following information was retrieved: patient characteristics (demographic, presence of co-morbidities and, whenever possible, associated genetic disorders); description of each major clinical manifestation. As a result, 27 articles, 28 abstracts from scientific events' annals and 13 theses/dissertations were found, only after 1987. Most of the reported information was described in small case series and case reports of patients from all the Amazonian states, and also in travellers from Brazilian non-endemic areas. The more relevant clinical complications were anaemia, thrombocytopaenia, jaundice and acute respiratory distress syndrome, present in all age groups, in addition to other more rare clinical pictures. Complications in pregnant women were also reported. Acute and chronic co-morbidities were frequent, however death was occasional. Clinical atypical cases of malaria are more frequent than published in the indexed literature, probably due to a publication bias. In the Brazilian Amazon (considered to be a low to moderate intensity area of transmission), clinical data are in accordance with the recent findings of severity described in diverse P. vivax endemic areas (especially anaemia in Southeast Asia), however in this region both children and adults are affected. Finally, gaps of knowledge and areas for future research are opportunely pointed out.
Appendix
Available only for authorised users
Literature
1.
Mendis K, Sina BJ, Marchesini P, Carter R: The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg. 2001, 64: 97-106.PubMed
2.
Mendes C, Dias F, Figueiredo J, Mora VG, Cano J, de Sousa B, do Rosario VE, Benito A, Berzosa P, Arez AP: Duffy negative antigen is no longer a barrier to Plasmodium vivax-molecular evidences from the African West Coast (Angola and Equatorial Guinea). PLoS Negl Trop Dis. 2011, 5: e1192PubMedCentralPubMed
3.
Guerra CA, Howes RE, Patil AP, Gething PW, Van Boeckel TP, Temperley WH, Kabaria CW, Tatem AJ, Manh BH, Elyazar IR, Baird JK, Snow RW, Hay SI: The international limits and population at risk of Plasmodium vivax transmission in 2009. PLoS Negl Trop Dis. 2010, 4: e774PubMedCentralPubMed
4.
Mueller I, Galinski MR, Baird JK, Carlton JM, Kochar DK, Alonso PL, del Portillo HA: Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite. Lancet Infect Dis. 2009, 9: 555-566.PubMed
5.
Price RN, Tjitra E, Guerra CA, Yeung S, White NJ, Anstey NM: Vivax malaria: neglected and not benign. Am J Trop Med Hyg. 2007, 77: 79-87.PubMedCentralPubMed
6.
Lacerda MVG, Zackiewicz C, Alecrim WD, Alecrim MGC: The neglected Plasmodium vivax: are researchers from endemic areas really concerned about new treatment options?. Rev Soc Bras Med Trop. 2007, 40: 489-490.PubMed
7.
Kochar DK, Saxena V, Singh N, Kochar SK, Kumar SV, Das A: Plasmodium vivax malaria. Emerg Infect Dis. 2005, 11: 132-134.PubMedCentralPubMed
8.
Tjitra E, Anstey NM, Sugiarto P, Warikar N, Kenangalem E, Karyana M, Lampah DA, Price RN: Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia. PLoS Med. 2008, 5: e128PubMedCentralPubMed
9.
10.
11.
Austin SC, Stolley PD, Lasky T: The history of malariotherapy for neurosyphilis. Modern parallels. JAMA. 1992, 268: 516-519.PubMed
12.
Picot S: Is Plasmodium vivax still a paradigm for uncomplicated malaria?. Med Mal Infect. 2006, 36: 406-413.PubMed
13.
14.
Bassat Q, Alonso PL: Defying malaria: Fathoming severe Plasmodium vivax disease. Nat Med. 2011, 17: 48-49.PubMed
15.
16.
Saraiva MG, Amorim RD, Moura MA, Martinez-Espinosa FE, Barbosa MG: Urban expansion and spatial distribution of malaria in the municipality of Manaus, State of Amazonas. Rev Soc Bras Med Trop. 2009, 42: 515-522.PubMed
17.
Gonçalves MJF, Alecrim WD: Non-planed urbanization as a contributing factor for malaria incidence in Manaus-Amazonas, Brazil. Rev Salud Publica (Bogota). 2004, 6: 156-166.
18.
Oliveira-Ferreira J, Lacerda MV, Brasil P, Ladislau JL, Tauil PL, Daniel-Ribeiro CT: Malaria in Brazil: an overview. Malar J. 2010, 9: 115PubMedCentralPubMed
19.
Gama BE, Lacerda MV, Daniel-Ribeiro CT, Ferreira-da-Cruz MF: Chemoresistance of Plasmodium falciparum and Plasmodium vivax parasites in Brazil: consequences on disease morbidity and control. Mem Inst Oswaldo Cruz. 2011, 106 (Suppl 1): 159-166.PubMed
20.
Genton B, D'Acremont V, Rare L, Baea K, Reeder JC, Alpers MP, Muller I: Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea. PLoS Med. 2008, 5: e127PubMedCentralPubMed
21.
Maitland K, Williams TN, Bennett S, Newbold CI, Peto TE, Viji J, Timothy R, Clegg JB, Weatherall DJ, Bowden DK: The interaction between Plasmodium falciparum and P. vivax in children on Espiritu Santo island, Vanuatu. Trans R Soc Trop Med Hyg. 1996, 90: 614-620.PubMed
22.
Chagas C: Hematological studies of impaludism. MD Thesis. 1903, Manguinhos Institute
23.
Batista D: The paludisme in the Amazon: a contribution to epidemiology, protozoology and clinics, study about the billiary-hemoglobinuric fever. 1946, Rio de Janeiro: Imprensa Nacional
24.
Santos-Ciminera PD, Roberts DR, Alecrim MG, Costa MR, Quinnan GV: Malaria diagnosis and hospitalization trends, Brazil. Emerg Infect Dis. 2007, 13: 1597-1600.PubMedCentralPubMed
25.
Botelho C, Guedes Barbosa LS, Aquino JL, Silva MD, Meirelles SM, Jardim JR: Respiratory manifestations in Plasmodium falciparum and vivax malaria. Rev Inst Med Trop Sao Paulo. 1987, 29: 337-345.PubMed
26.
Moura EFA, Kawachi J, Mattos MNR, Cavalcante RS, Duarte AN: Neonatal malaria: report of a case. J Pediatr (Rio J). 1987, 62: 279-280.
27.
Severo V, Severo MMS, Behar PR, Dossin TJ: Laboratory profile of malarial patients. J Bras Med. 1994, 67: 141-154.
28.
Marques HH, Vallada MG, Sakane PT, Boulos M: Congenital malaria: case reports and brief review of literature. J Pediatr (Rio J). 1996, 72: 103-105.
29.
Siqueira-Batista R, Ramos AN, Pessanha BS, Sforza-de-Almeida MP, Potsch DF: Chloroquine and cardiac arrhythmia: case report. East Afr Med J. 1998, 75: 117-119.PubMed
30.
Ventura AMRS, Pinto AYN, Silva RSU, Calvosa VSP, Silva Filho MG, Souza JM: Plasmodium vivax malaria in children and adolescents - epidemiological, clinical and laboratory features. J Pediatr (Rio J). 1999, 75: 187-194.
31.
Pinheiro MCN, Branco E, Barata ACS, Dantas RTS, Fernandes WCS: Malaria during the pregnancy and low birth weight from endemic areas in the Amazon. Rev Para Med. 2002, 16: 25-28.
32.
Jarude R, Trindade R, Tavares-Neto J: Malaria in pregnant women of a public maternity of Rio Branco (Acre State, Brazil). Rev Bras Ginecol Obstet. 2003, 25: 149-154.
33.
Lacerda MV, Alexandre MA, Santos PD, Arcanjo AR, Alecrim WD, Alecrim MGC: Idiopathic thrombocytopenic purpura due to vivax malaria in the Brazilian Amazon. Acta Trop. 2004, 90: 187-190.PubMed
34.
Srinivas R, Agarwal R, Gupta D: Severe sepsis due to severe falciparum malaria and leptospirosis co-infection treated with activated protein C. Malar J. 2007, 6: 42PubMedCentralPubMed
35.
Melo AM, de Carvalho RA, Figueiredo JF, Vannucchi H, Jordao A, Rodrigues ML: Serum vitamin A levels in patients with ocular lesions attributable to non-complicated malaria in the Brazilian Amazon region. Trans R Soc Trop Med Hyg. 2004, 98: 485-488.PubMed
36.
Braga MD, Alcantara GC, Silva CN, Nascimento CG: Cerebral malaria in Ceara: a case report. Rev Soc Bras Med Trop. 2004, 37: 53-55.PubMed
37.
Lomar AV, Vidal JE, Lomar FP, Barbas CV, Matos GJ, Boulos M: Acute respiratory distress syndrome due to vivax malaria: case report and literature review. Braz J Infect Dis. 2005, 9: 425-430.PubMed
38.
Vermehren R, Cardoso AD, Bulbol WS, Franco M, Coelho K, Lorenzi F, Nunes V, Gonçalves J: Report of a case of acute renal failure in Plasmodium vivax malaria. J Bras Nefrol. 2005, 27:
39.
Curlin ME, Barat LM, Walsh DK, Granger DL: Noncardiogenic pulmonary edema during vivax malaria. Clin Infect Dis. 1999, 28: 1166-1167.PubMed
40.
Cabral PHO, Andrade SD, Alecrim WD, Alecrim MGC, Lacerda MVG: Malaria and sickle cell anemia: report of complications and clinical management of three patients in a highly endemic area for Plasmodium vivax malaria in the Brazilian Amazon. Case Rep Clin Pract Rev. 2006, 7: 220-223.
41.
Lacerda MVG, Oliveira SL, Alecrim MGC: Splenic hematoma in a patient with Plasmodium vivax malaria. Rev Soc Bras Med Trop. 2007, 40: 96-97.PubMed
42.
Santana MS, Rocha MA, Arcanjo AR, Sardinha JF, Alecrim WD, Alecrim MGC: Association of methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency in malaria patients treated with primaquine. Rev Soc Bras Med Trop. 2007, 40: 533-536.PubMed
43.
Lacerda MV, Hipolito JR, Passos LN: Chronic Plasmodium vivax infection in a patient with splenomegaly and severe thrombocytopenia. Rev Soc Bras Med Trop. 2008, 41: 522-523.PubMed
44.
Ramos WM, Sardinha JF, Costa MR, Santana MS, Alecrim MG, Lacerda MV: Clinical aspects of hemolysis in patients with P. vivax malaria treated with primaquine, in the Brazilian Amazon. Braz J Infect Dis. 2010, 14: 410-412.
45.
Alexandre MA, Ferreira CO, Siqueira AM, Magalhaes BL, Mourao MPG, Lacerda MVG, Alecrim MGC: Severe Plasmodium vivax Malaria, Brazilian Amazon. Emerg Infect Dis. 2010, 16: 1611-1614.PubMedCentralPubMed
46.
Siqueira AM, Alexandre MA, Mourao MP, Santos VS, Nagahashi-Marie SK, Alecrim MG, Lacerda MV: Severe rhabdomyolysis caused by Plasmodium vivax malaria in the Brazilian Amazon. Am J Trop Med Hyg. 2010, 83: 271-273.PubMedCentralPubMed
47.
Melo GC, Reyes-Lecca RC, Vitor-Silva S, Monteiro WM, Martins M, Benzecry SG, Alecrim MG, Lacerda MV: Concurrent helminthic infection protects schoolchildren with Plasmodium vivax from anemia. PLoS ONE. 2010, 5: e11206PubMedCentralPubMed
48.
Andrade BB, Reis-Filho A, Souza-Neto SM, Clarencio J, Camargo LM, Barral A, Barral-Netto M: Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance. Malar J. 2010, 9: 13PubMedCentralPubMed
49.
Chagas EC, Nascimento CT, Santana Filho FS, Botto-Menezes CH, Martinez-Espinosa FE: Impact of malaria during pregnancy in the Amazon region. Rev Panam Salud Publica. 2009, 26: 203-208.PubMed
50.
Fragoso SC, Alexandre MA, Santos PJ, Mourao MP, Passos LN, Magalhaes BM, Siqueira AM, Lacerda MV: Hypovolaemic shock triggered by P. vivax infection in a patient with mild haemophilia A. Haemophilia. 2011, 17: 159-160.PubMed
51.
Ferreira ME, Gomes MD, Vieira JL: Methemoglobinemia in patients with Plasmodium vivax receiving oral therapy with primaquine. Rev Soc Bras Med Trop. 2011, 44: 113-115.PubMed
52.
Alecrim MGC, Silva VMQ, Melo MD, Araújo JR, Guerra MVF, Silva NB, Ferreira LCL, Silva EB, Alecrim WD: Splenic rupture in malarial patients from the Instituto de Medicina Tropical de Manaus [abstract]. Rev Soc Bras Med Trop. 1995, 28: 151
53.
Kalmar EMN, Cassetari V, Machado FR, Alencar F, Kirchgatter K, Boulos M, Tapajós R: Severe malaria in patient with Plasmodium vivax infection: a case report [abstract]. Rev Soc Bras Med Trop. 1998, 31: 56
54.
Sardinha YF, Nunes SB, Albuquerque SRL, Marques HO, Passos LNM: Hemolytic anemia due to secondary cryoagglutinins and P. vivax malaria: report of two cases [abstract]. Rev Soc Bras Med Trop. 1998, 31: 144
55.
Victoria MB, Victoria F, Coellho AHV, Santos LO, Alecrim MGC: Thrombocytopenic purpura in patient with Plasmodium vivax malaria: case report [abstract]. Rev Soc Bras Med Trop. 1998, 31: 55
56.
Zumpano JF, Queiroz JN, Rocha MOC: Spontaneous splenic rupture in vivax malaria [abstract]. Rev Soc Bras Med Trop. 1998, 31: 46
57.
Silva SL, Santana Filho FS, Arcanjo ARL, Alecrim WD, Alecrim MGC: Clinical and hematological profile of hospitalized patients with vivax malaria and thrombocytopenia in the Fundação de Medicina Tropical do Amazonas, from January 2007 to September 1999 [abstract]. Rev Soc Bras Med Trop. 2000, 33: 348
58.
Aragão PS, Alecrim MGC, Evangelista NMA, Tavares AM, Santana Filho FS, Alecrim WD: Clinical and laboratorial study on Plasmodium vivax malaria [abstract]. Rev Soc Bras Med Trop. 2001, 34: 341
59.
Evangelista NMA, Aragão DS, Tavares AM, Magalhães L, Alexandre MAA, Alecrim MGC, Alecrim WD: Neonatal malaria due to Plasmodium vivax in the Fundação de Medicina Tropical do Amazonas [abstract]. Rev Soc Bras Med Trop. 2002, 35: 344
60.
Moura ACL, Balbo BEP, Cancela ALE, Betti MH, Heneine RAD, Zumpano JF: Death due to P. vivax in a non-endemic area [abstract]. Rev Soc Bras Med Trop. 2002, 35: 369
61.
Park CHL, Ferreira CB, Bianchi CP, Fazio FS, Costa JC, Padilha ARS, Fonseca MO, Boulos M: Thrombocytopenia in patients with Plasmodium vivax malaria [abstract]. Rev Soc Bras Med Trop. 2002, 35: 370
62.
Viana GMC, Monteiro PS, Nascimento MDSB, Burarttini MN: Severe malaria due to P. vivax: case report [abstract]. Rev Soc Bras Med Trop. 2002, 35: 367
63.
Albuquerque BC, Couto BB, Moraes TC, Couto S: The relevance of clinical and laboratorial aspects in patients with Plasmodium vivax malaria hospitalized in the Fundação de Medicina Tropical do Amazonas, 2002 [abstract]. Rev Soc Bras Med Trop. 2003, 36: 280
64.
Lacerda MVG, Manso MRC, Ferreira LCL, Silva FM, Santos PJT, Alecrim WD, Alecrim MGC: Patient with vivax malaria and acute lung edema in the Brazilian Amazon: case report and literature review [abstract]. Rev Soc Bras Med Trop. 2003, 36: 281
65.
Silva IBA, Araújo JR, Cleonardo A, Ventura AM, Pinto AY, Linonati RMF, Silva Filho M, Valente MIA, Castro JAA, Souza JM: Severe vivax malaria and non-cardiogenic pulmonary edema [abstract]. Rev Soc Bras Med Trop. 2003, 36: 273
66.
Silva IBA, Carneiro MS, Araújo JR, von Mühler CA, Souza JM: Vivax malaria and vasculitis: case evolving with death [abstract]. Rev Soc Bras Med Trop. 2004, 37: 275
67.
Tavares AM, Tavares AM, Cavalcante CP: Splenic subcapsullary hematoma in patient with Plasmodium vivax malaria [abstract]. Rev Soc Bras Med Trop. 2004, 37: 270
68.
Penna J, Zumpano JF, Penna L, Rocha MOC: Case report: pulmonary manifestations of Plasmodium vivax malaria [abstract]. Rev Soc Bras Med Trop. 2005, 38: 379
69.
Mello GS, Mello Filho GB, Rodrigues DCH: Malarial coma due to Plasmodium vivax [abstract]. Rev Soc Bras Med Trop. 2006, 39: 106
70.
Menezes CHAB, Martinez-Espinosa FE, Ferreira LCL, Simplicio JL, Frota AC: Effects of malarial infection on the course of pregnancy and fetus in patients from the Fundação de Medicina Tropical do Amazonas [abstract]. Rev Soc Bras Med Trop. 2006, 39: 107
71.
Oliveira RSM, Santos VS, Lacerda MVG, Alecrim WD: Hemolysis associated to acute renal failure in an immunocompetent patient with G6PD deficiency and vivax malaria: case report with favourable evolution [abstract]. Rev Soc Bras Med Trop. 2006, 39: 109
72.
Bastos CJC, Mascarenhas-Batista AV, Freire M, Amorim F, Andrade M, Gomes E: Severe malaria due to Plasmodium vivax: case report [abstract]. Rev Soc Bras Med Trop. 2007, 40: 146
73.
Campos LRP, Mascheretti M, Brasil RA, Duarte MIS: Evaluation of splenic immune response in patient infected with Plasmodium vivax [abstract]. Rev Soc Bras Med Trop. 2007, 40: 141
74.
Gurgel RL, Coutinho LI, Su WCS, Lacerda MVG: Clinical manifestations of congenital vivax malaria in the Western Brazilian Amazon [abstract]. Rev Soc Bras Med Trop. 2007, 40: 147
75.
Borzacov LMP, Cardoso GA, Siqueira GD, Cardoso LAP, Barbieri AB, Fontes CJF: Acute psychosis induced by chloroquine during vivax malaria treatment [abstract]. Rev Soc Bras Med Trop. 2008, 41: 221
76.
Cardoso GA, Siqueira GD, Borzacov LMP, Tristão FR, Cardoso LAP, Fontes CJF: Leukemoid reaction caused by Plasmodium vivax: case report [abstract]. Rev Soc Bras Med Trop. 2008, 41: 221
77.
Ohnishi MDO, Ventura AM, Linonati RMF, Mendes MM, Apolinário JHD, Souza JM: The lung in vivax malaria: case report [abstract]. Rev Soc Bras Med Trop. 2008, 41: 215
78.
Menezes CHAB, Silva SCL, Farias LSR, Bacelar BRB, Bardaji A, Meghna D, Martinez-Espinosa FE: Prevalence of anemia and Plasmodium vivax infection in routine antenatal attention in a primary care center in the City of Manaus [abstract]. Rev Soc Bras Med Trop. 2010, 43: 215
79.
Ohnishi MDO, Linonati RMF, Silva AF, Santos SEB, Ventura AM, Souza JM: Pulmonary manifestations in patients infected with Plasmodium vivax and correlation with TNF-alfa and IL-12 polymorphisms [abstract]. Rev Soc Bras Med Trop. 2010, 43: 84
80.
Urbaez-Brito JD: Clinical and laboratorial characteristics of human malaria and hepatitis B virus association. Master Dissertation. 1995, University of Brasília, Tropical Medicine Department
81.
Alecrim MGC: Clinical aspects, resistance and parasitary polymorphism of Plasmodium vivax malaria in Manaus. PhD Thesis. 2000, University of Brasília, Tropical Medicine Department
82.
Neves JJO: Malaria in Pará: study of the clinical and laboratorial picture in infections caused by Plasmodium vivax. Master Dissertation. 2002, Federal University of Pará
83.
Marques HO: Hemostasis disturbances in patients with malaria. Master Dissertation. 2004, Federal University of São Paulo, Hematology Department
84.
Oliveira MS: Hematological characterization of children with vivax malaria diagnosed and treated in the Fundação de Medicina Tropical do Amazonas. Master Dissertation. 2004, University of the Amazonas State, Health Sciences School
85.
Silva IBA: Vivax malaria: clinical and laboratorial manifestations related to TNF-alpha. PhD Thesis. 2004, Federal University of Pará
86.
Raposo CCBS: Vivax malaria in Maranhão: epidemiological and clinical aspects. Master Dissertation. 2006, University of Brasília, Tropical Medicine Deprtment
87.
Pereira MSS: Study of malaria in pregnant and puerperal women in a public maternity in Manaus from 1999 to 2004. Master Dissertation. 2006, Federal University of Amazonas, Health Sciences School
88.
Guerreiro NSV: Clinical and epidemiological study of Plasmodium vivax malaria in the State of Amapá. Master Dissertation. 2006, Federal University of Pará
89.
Lacerda MVG: Clinical manifestations and pathogenesis of malarial thrombocytopenia. PhD Thesis. 2007, University of Brasília, Tropical Medicine Department
90.
Silva SBR: Evaluation of frequency and factors associated to thrombocytopenia caused by Plasmodium vivax. Master Dissertation. 2009, Federal University of Mato Grosso
91.
Fragoso SCP: Study of 17 cases of autopsies from patients with the diagnosis of vivax malaria in a reference center in the Brazilian Amazon. Master Dissertation. 2010, University of the Amazonas State, Health Sciences School
92.
Lança EFC: Children under 14 years with malaria admitted to Intensive Care Units in the Brazilian Amazon: a case-control study with Plasmodium vivax patients. Master Dissertation. 2011, University of the Amazonas State, Health Sciences School
93.
Karunaweera ND, Wijesekera SK, Wanasekera D, Mendis KN, Carter R: The paroxysm of Plasmodium vivax malaria. Trends Parasitol. 2003, 19: 188-193.PubMed
94.
Zimmerman PA, Mehlotra RK, Kasehagen LJ, Kazura JW: Why do we need to know more about mixed Plasmodium species infections in humans?. Trends Parasitol. 2004, 20: 440-447.PubMedCentralPubMed
95.
Quintero JP, Siqueira AM, Tobon A, Blair S, Moreno A, Arevalo-Herrera M, Lacerda MV, Valencia SH: Malaria-related anaemia: a Latin American perspective. Mem Inst Oswaldo Cruz. 2011, 106 (Suppl 1): 91-104.PubMed
96.
Caicedo O, Ramirez O, Mourao MP, Ziadec J, Perez P, Santos JB, Quinones F, Alecrim MG, Arevalo-Herrera M, Lacerda MV, Herrera S: Comparative hematologic analysis of uncomplicated malaria in uniquely different regions of unstable transmission in Brazil and Colombia. Am J Trop Med Hyg. 2009, 80: 146-151.PubMed
97.
Michon P, Cole-Tobian JL, Dabod E, Schoepflin S, Igu J, Susapu M, Tarongka N, Zimmerman PA, Reeder JC, Beeson JG, Schofield L, King CL, Mueller I: The risk of malarial infections and disease in Papua New Guinean children. Am J Trop Med Hyg. 2007, 76: 997-1008.PubMedCentralPubMed
98.
Rodriguez-Morales AJ, Sanchez E, Vargas M, Piccolo C, Colina R, Arria M: Anemia and thrombocytopenia in children with Plasmodium vivax malaria. J Trop Pediatr. 2006, 52: 49-51.PubMed
99.
Poespoprodjo JR, Fobia W, Kenangalem E, Lampah DA, Hasanuddin A, Warikar N, Sugiarto P, Tjitra E, Anstey NM, Price RN: Vivax malaria: a major cause of morbidity in early infancy. Clin Infect Dis. 2009
100.
Katsuragawa TH, Cunha RP, Souza DC, Gil LH, Cruz RB, Silva AA, Tada MS, Silva LHP: Malaria and hematological aspects among residents to be impacted by reservoirs for the Santo Antonio and Jirau Hydroelectric Power Stations, Rondonia State, Brazil. Cad Saude Publica. 2009, 25: 1486-1492.PubMed
101.
Ferreira MU, Silva-Nunes M, Bertolino CN, Malafronte RS, Muniz PT, Cardoso MA: Anemia and iron deficiency in school children, adolescents, and adults: a community-based study in rural Amazonia. Am J Public Health. 2007, 97: 237-239.PubMedCentralPubMed
102.
Cardoso MA, Ferreira MU, Camargo LM, Szarfarc SC: Anaemia, iron deficiency and malaria in a rural community in Brazilian Amazon. Eur J Clin Nutr. 1994, 48: 326-332.PubMed
103.
Wildig J, Michon P, Siba P, Mellombo M, Ura A, Mueller I, Cossart Y: Parvovirus B19 infection contributes to severe anemia in young children in Papua New Guinea. J Infect Dis. 2006, 194: 146-153.PubMed
104.
Kochar DK, Das A, Kochar A, Middha S, Acharya J, Tanwar GS, Gupta A, Pakalapati D, Garg S, Saxena V, Subudhi AK, Boopathi PA, Sirohi P, Kochar SK: Thrombocytopenia in Plasmodium falciparum, Plasmodium vivax and mixed infection malaria: A study from Bikaner (Northwestern India). Platelets. 2010, 21: 623-627.PubMed
105.
Lacerda MV, Mourao MP, Coelho HC, Santos JB: Thrombocytopenia in malaria: who cares?. Mem Inst Oswaldo Cruz. 2011, 106 (Suppl 1): 52-63.PubMed
106.
107.
Takaki K, Aoki T, Akeda H, Kajiwara T, Honda S, Maeda Y, Okada K, Sawae Y: A case of Plasmodium vivax malaria with findings of DIC (abstract). Kansenshogaku Zasshi. 1991, 65: 488-492.PubMed
108.
Lakhkar BB, Babu S, Shenoy V: DIC in vivax malaria. Indian Pediatr. 1996, 33: 971-972.PubMed
109.
Mourao MP, Lacerda MV, Macedo VO, Santos JB: Thrombocytopenia in patients with dengue virus infection in the Brazilian Amazon. Platelets. 2007, 18: 605-612.PubMed
110.
Santana VS, Lavezzo LC, Mondini A, Terzian AC, Bronzoni RV, Rossit AR, Machado RL, Rahal P, Nogueira MC, Nogueira ML: Concurrent Dengue and malaria in the Amazon region. Rev Soc Bras Med Trop. 2010, 43: 508-511.
111.
Charrel RN, Brouqui P, Foucault C, Lamballerie X: Concurrent dengue and malaria. Emerg Infect Dis. 2005, 11: 1153-1154.PubMedCentralPubMed
112.
WHO: Severe falciparum malaria. Trans R Soc Trop Med Hyg. 2000, 94 (Supp 1): S1-S90.
113.
Illamperuma C, Allen BL: Pulmonary edema due to Plasmodium vivax malaria in an American Missionary. Infection. 2007, 35: 374-376.PubMed
114.
Pukrittayakamee S, Chantra A, Vanijanonta S, White NJ: Pulmonary oedema in vivax malaria. Trans R Soc Trop Med Hyg. 1998, 92: 421-422.PubMed
115.
Tan LK, Yacoub S, Scott S, Bhagani S, Jacobs M: Acute lung injury and other serious complications of Plasmodium vivax malaria. Lancet Infect Dis. 2008, 8: 449-454.PubMed
116.
Anstey NM, Russell B, Yeo TW, Price RN: The pathophysiology of vivax malaria. Trends Parasitol. 2009, 25: 220-227.PubMed
117.
Menendez C, Romagosa C, Ismail MR, Carrilho C, Saute F, Osman N, Machungo F, Bardaji A, Quinto L, Mayor A, Naniche D, Dobano C, Alonso PL, Ordi J: An autopsy study of maternal mortality in Mozambique: the contribution of infectious diseases. PLoS Med. 2008, 5: e44PubMedCentralPubMed
118.
Kochar SK, Mahajan M, Gupta RP, Middha S, Acharya J, Kochar A, Das A, Kochar DK: Acute attack of AIP (acute intermittent porphyria) with severe vivax malaria associated with convulsions: a case report. J Vector Borne Dis. 2009, 46: 307-309.PubMed
119.
Lampah DA, Yeo TW, Hardianto SO, Tjitra E, Kenangalem E, Sugiarto P, Price RN, Anstey NM: Coma associated with microscopy-diagnosed plasmodium vivax: a prospective study in Papua, Indonesia. PLoS Negl Trop Dis. 2011, 5: e1032PubMedCentralPubMed
120.
Cavasini MT, Ribeiro WL, Kawamoto F, Ferreira MU: How prevalent is Plasmodium malariae in Rondonia, western Brazilian Amazon?. Rev Soc Bras Med Trop. 2000, 33: 489-492.PubMed
121.
Costa AP, Bressan CS, Pedro RS, Valls-de-Souza R, Silva S, Souza PR, Guaraldo L, Ferreira-da-Cruz MF, Daniel-Ribeiro CT, Brasil P: Delayed diagnosis of malaria in a dengue endemic area in the Brazilian extra-Amazon: recent experience of a malaria surveillance unit in state of Rio de Janeiro. Rev Soc Bras Med Trop. 2010, 43: 571-574.
122.
Kochar DK, Tanwar GS, Khatri PC, Kochar SK, Sengar GS, Gupta A, Kochar A, Middha S, Acharya J, Saxena V, Pakalapati D, Garg S, Das A: Clinical features of children hospitalized with malaria-a study from Bikaner, northwest India. Am J Trop Med Hyg. 2010, 83: 981-989.PubMedCentralPubMed
123.
Kochar DK, Das A, Kochar SK, Saxena V, Sirohi P, Garg S, Kochar A, Khatri MP, Gupta V: Severe Plasmodium vivax malaria: a report on serial cases from Bikaner in northwestern India. Am J Trop Med Hyg. 2009, 80: 194-198.PubMed
124.
Kochar DK, Singh P, Agarwal P, Kochar SK, Pokharna R, Sareen PK: Malarial hepatitis. J Assoc Physicians India. 2003, 51: 1069-1072.PubMed
125.
Khan FY, El-Hiday AH: Acute acalculous cholecystitis complicating an imported case of mixed malaria caused by Plasmodium falciparum and Plasmodium vivax. Int J Infect Dis. 2010, 14 (Suppl 3): e217-219.PubMed
126.
Kumar A, Katiyar GP: Mixed infection with Plasmodium vivax and Salmonella typhi in an infant. Indian Pediatr. 1995, 32: 243-244.PubMed
127.
Piyaphanee W, Issarachaikul R, Soontarach P, Silachamroon U: Concurrent salmonella bacteremia in P. vivax infection--a report of 2 cases at the Hospital for Tropical Diseases, Thailand. Southeast Asian J Trop Med Public Health. 2007, 38: 616-618.PubMed
128.
Fonseca JC: Natural history of chronic hepatitis B. Rev Soc Bras Med Trop. 2007, 40: 672-677.PubMed
129.
Lacerda MV, Mourao MP, Santos PJ, Alecrim MG: Algid malaria: a syndromic diagnosis. Rev Soc Bras Med Trop. 2009, 42: 79-81.PubMed
130.
Stoppacher R, Adams SP: Malaria deaths in the United States: case report and review of deaths, 1979-1998. J Forensic Sci. 2003, 48: 404-408.PubMed
131.
Bassat Q, Guinovart C, Sigauque B, Mandomando I, Aide P, Sacarlal J, Nhampossa T, Bardaji A, Morais L, Machevo S, Letang E, Macete E, Aponte JJ, Roca A, Menendez C, Alonso PL: Severe malaria and concomitant bacteraemia in children admitted to a rural Mozambican hospital. Trop Med Int Health. 2009, 14: 1011-1019.PubMed
132.
Song JY, Park CW, Jo YM, Kim JY, Kim JH, Yoon HJ, Kim CH, Lim CS, Cheong HJ, Kim WJ: Two cases of Plasmodium vivax malaria with the clinical picture resembling toxic shock. Am J Trop Med Hyg. 2007, 77: 609-611.PubMed
133.
Anstey NM, Handojo T, Pain MC, Kenangalem E, Tjitra E, Price RN, Maguire GP: Lung injury in vivax malaria: pathophysiological evidence for pulmonary vascular sequestration and posttreatment alveolar-capillary inflammation. J Infect Dis. 2007, 195: 589-596.PubMedCentralPubMed
134.
Carvalho BO, Lopes SC, Nogueira PA, Orlandi PP, Bargieri DY, Blanco YC, Mamoni R, Leite JA, Rodrigues MM, Soares IS, Oliveira TR, Wunderlich G, Lacerda MV, Del Portillo HA, Araujo MO, Russell B, Suwanarusk R, Snounou G, Renia L, Costa FT: On the Cytoadhesion of Plasmodium vivax-Infected Erythrocytes. J Infect Dis. 2010, 202: 638-647.PubMed
135.
Echeverri M, Tobon A, Alvarez G, Carmona J, Blair S: Clinical and laboratory findings of Plasmodium vivax malaria in Colombia, 2001. Rev Inst Med Trop São Paulo. 2003, 45: 29-34.PubMed
136.
Nosten F, McGready R, Simpson JA, Thwai KL, Balkan S, Cho T, Hkirijaroen L, Looareesuwan S, White NJ: Effects of Plasmodium vivax malaria in pregnancy. Lancet. 1999, 354: 546-549.PubMed
137.
Poespoprodjo JR, Fobia W, Kenangalem E, Lampah DA, Warikar N, Seal A, McGready R, Sugiarto P, Tjitra E, Anstey NM, Price RN: Adverse pregnancy outcomes in an area where multidrug-resistant Plasmodium vivax and Plasmodium falciparum infections are endemic. Clin Infect Dis. 2008, 46: 1374-1381.PubMedCentralPubMed
138.
Martinez-Espinosa FE, Daniel-Ribeiro CT, Alecrim WD: Malaria during pregnancy in a reference centre from the Brazilian Amazon: unexpected increase in the frequency of Plasmodium falciparum infections. Mem Inst Oswaldo Cruz. 2004, 99: 19-21.PubMed
139.
Poels PJ, Dolmans WM, Gabreels FJ: Rhabdomyolysis associated with malaria tertiana in a patient with myoadenylate deaminase deficiency. Trop Geogr Med. 1993, 45: 83-86.PubMed
140.
Hamel CT, Blum J, Harder F, Kocher T: Nonoperative treatment of splenic rupture in malaria tropica: review of literature and case report. Acta Trop. 2002, 82: 1-5.PubMed
141.
Lewallen S, Harding SP, Ajewole J, Schulenburg WE, Molyneux ME, Marsh K, Usen S, White NJ, Taylor TE: A review of the spectrum of clinical ocular fundus findings in P. falciparum malaria in African children with a proposed classification and grading system. Trans R Soc Trop Med Hyg. 1999, 93: 619-622.PubMed
142.
Lee JH, Chin HS, Chung MH, Moon YS: Retinal Hemorrhage in Plasmodium vivax Malaria. Am J Trop Med Hyg. 2010, 82: 219-222.PubMedCentralPubMed
143.
Vitor-Silva S, Reyes-Lecca RC, Pinheiro TR, Lacerda MV: Malaria is associated with poor school performance in an endemic area of the Brazilian Amazon. Malar J. 2009, 8: 230PubMedCentralPubMed
144.
Williams TN, Maitland K, Phelps L, Bennett S, Peto TE, Viji J, Timothy R, Clegg JB, Weatherall DJ, Bowden DK: Plasmodium vivax: a cause of malnutrition in young children. QJM. 1997, 90: 751-757.PubMed
145.
Pereira PC, Meira DA, Curi PR, Souza N, Burini RC: The malarial impact on the nutritional status of Amazonian adult subjects. Rev Inst Med Trop Sao Paulo. 1995, 37: 19-24.PubMed
146.
Ventura AM, Pinto AY, Silva RS, Calvosa VS, Silva Filho MG, Souza JM: Plasmodium vivax malaria in children and adolescents - epidemiological, clinical and laboratory features. J Pediatr (Rio J). 1999, 75: 187-194.
147.
Silamut K, White NJ: Relation of the stage of parasite development in the peripheral blood to prognosis in severe falciparum malaria. Trans R Soc Trop Med Hyg. 1993, 87: 436-443.PubMed
148.
Andrade BB, Reis-Filho A, Souza-Neto SM, Raffaele-Netto I, Camargo LM, Barral A, Barral-Netto M: Plasma superoxide dismutase-1 as a surrogate marker of vivax malaria severity. PLoS Negl Trop Dis. 2010, 4: e650PubMedCentralPubMed
149.
Santana MS, Lacerda MVG, Barbosa MGV, Alecrim WD, Alecrim MGC: Glucose-6-phosphate dehydrogenase deficiency in an endemic area for malaria in Manaus: a cross-sectional survey in the Brazilian Amazon. PLoS ONE. 2009, 4: e5259PubMedCentralPubMed
150.
Leslie T, Briceno M, Mayan I, Mohammed N, Klinkenberg E, Sibley CH, Whitty CJ, Rowland M: The impact of phenotypic and genotypic G6PD deficiency on risk of Plasmodium vivax infection: a case-control study amongst Afghan refugees in Pakistan. PLoS Med. 2010, 7: e1000283PubMedCentralPubMed
151.
Guindo A, Fairhurst RM, Doumbo OK, Wellems TE, Diallo DA: X-linked G6PD deficiency protects hemizygous males but not heterozygous females against severe malaria. PLoS Med. 2007, 4: e66PubMedCentralPubMed
152.
Cavasini CE, de Mattos LC, Couto AA, Couto VS, Gollino Y, Moretti LJ, Bonini-Domingos CR, Rossit AR, Castilho L, Machado RL: Duffy blood group gene polymorphisms among malaria vivax patients in four areas of the Brazilian Amazon region. Malar J. 2007, 6: 167PubMedCentralPubMed
153.
Cavasini CE, Mattos LC, Couto AA, Bonini-Domingos CR, Valencia SH, Neiras WC, Alves RT, Rossit AR, Castilho L, Machado RL: Plasmodium vivax infection among Duffy antigen-negative individuals from the Brazilian Amazon region: an exception?. Trans R Soc Trop Med Hyg. 2007, 101: 1042-1044.PubMed
154.
Albuquerque SR, Cavalcante F, de O, Sanguino EC, Tezza L, Chacon F, Castilho L, dos Santos MC: FY polymorphisms and vivax malaria in inhabitants of Amazonas State, Brazil. Parasitol Res. 2010, 106: 1049-1053.PubMed
155.
Costa FT, Lopes SC, Ferrer M, Leite JA, Martin-Jaular L, Bernabeu M, Nogueira PA, Mourao MP, Fernandez-Becerra C, Lacerda MV, Portillo HD: On cytoadhesion of Plasmodium vivax: raison d'etre?. Mem Inst Oswaldo Cruz. 2011, 106 (Suppl 1): 79-84.PubMed
156.
Campos FM, Franklin BS, Teixeira-Carvalho A, Filho AL, de Paula SC, Fontes CJ, Brito CF, Carvalho LH: Augmented plasma microparticles during acute Plasmodium vivax infection. Malar J. 2010, 9: 327PubMedCentralPubMed
157.
Andrade BB, Araujo-Santos T, Luz NF, Khouri R, Bozza MT, Camargo LM, Barral A, Borges VM, Barral-Netto M: Heme impairs prostaglandin E2 and TGF-beta production by human mononuclear cells via Cu/Zn superoxide dismutase: insight into the pathogenesis of severe malaria. J Immunol. 2010, 185: 1196-1204.PubMed
158.
Erel O, Vural H, Aksoy N, Aslan G, Ulukanligil M: Oxidative stress of platelets and thrombocytopenia in patients with vivax malaria. Clin Biochem. 2001, 34: 341-344.PubMed
159.
Araujo CF, Lacerda MV, Abdalla DS, Lima ES: The role of platelet and plasma markers of antioxidant status and oxidative stress in thrombocytopenia among patients with vivax malaria. Mem Inst Oswaldo Cruz. 2008, 103: 517-521.PubMed
160.
Grynberg P, Fernandes Fontes CJ, Martins Braga E: Association between particular polymorphic residues on apical membrane antigen 1 (AMA-1) and platelet levels in patients with vivax malaria. Clin Microbiol Infect. 2007
161.
Fernandes AA, Carvalho LJ, Zanini GM, Ventura AM, Souza JM, Cotias PM, Silva-Filho IL, Daniel-Ribeiro CT: Similar cytokine responses and degrees of anemia in patients with Plasmodium falciparum and Plasmodium vivax infections in the Brazilian Amazon region. Clin Vaccine Immunol. 2008, 15: 650-658.PubMedCentralPubMed
162.
Wickramasinghe SN, Abdalla SH: Blood and bone marrow changes in malaria. Baillieres Best Pract Res Clin Haematol. 2000, 13: 277-299.PubMed
163.
Fernandez-Becerra C, Yamamoto MM, Vencio RZ, Lacerda M, Rosanas-Urgell A, Del Portillo HA: Plasmodium vivax and the importance of the subtelomeric multigene vir superfamily. Trends Parasitol. 2008, 25: 44-51.PubMed
164.
Santos-Ciminera PD, Alecrim MD, Roberts DR, Quinnan GV: Molecular epidemiology of Plasmodium vivax in the State of Amazonas, Brazil. Acta Trop. 2007
165.
Bussaratid V, Walsh DS, Wilairatana P, Krudsood S, Silachamroon U, Looareesuwan S: Frequency of pruritus in Plasmodium vivax malaria patients treated with chloroquine in Thailand. Trop Doct. 2000, 30: 211-214.PubMed
166.
Sahoo S, Kumar M, Sinha VK: Chloroquine-induced recurrent psychosis. Am J Ther. 2007, 14: 406-407.PubMed
167.
Katsuragawa TH, Gil LHS, Stabile RG, Pires MG, Bonini-Domingos CR: Incidence evaluation of Glucose-6-Phosphate Dehydrogenase and hematological profile in Rondônia. Rev Bras Hematol Hemoter. 2004, 26: 268-273.
168.
Silva MC, Santos EB, Costal EG, Filho MG, Guerreiro JF, Povoa MM: Clinical and laboratorial alterations in Plasmodium vivax malaria patients and glucose-6-phosphate dehydrogenase deficiency treated with primaquine at 0.50 mg/kg/day. Rev Soc Bras Med Trop. 2004, 37: 215-217.PubMed
169.
Walsh DS, Wilairatana P, Tang DB, Heppner DG, Brewer TG, Krudsood S, Silachamroon U, Phumratanaprapin W, Siriyanonda D, Looareesuwan S: Randomized trial of 3-dose regimens of tafenoquine (WR238605) versus low-dose primaquine for preventing Plasmodium vivax malaria relapse. Clin Infect Dis. 2004, 39: 1095-1103.PubMed
170.
Price RN, Douglas NM, Anstey NM: New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance. Curr Opin Infect Dis. 2009, 22: 430-435.PubMed
171.
Alecrim MG, Alecrim W, Macedo V: Plasmodium vivax resistance to chloroquine (R2) and mefloquine (R3) in Brazilian Amazon region. Rev Soc Bras Med Trop. 1999, 32: 67-68.PubMed
172.
Santana Filho FS, Arcanjo AR, Chehuan YM, Costa MR, Martinez-Espinosa FE, Vieira JL, Barbosa MG, Alecrim WD, Alecrim MG: Chloroquine-resistant Plasmodium vivax, Brazilian Amazon. Emerg Infect Dis. 2007, 13: 1125-1126.PubMedCentralPubMed
173.
Orjuela-Sanchez P, Santana Filho FS, Machado-Lima A, Chehuan YF, Costa MR, Alecrim MD, Del Portillo HA: Analysis of single-nucleotide polymorphisms in the crt-o and mdr1 genes of Plasmodium vivax among chloroquine resistant isolates from the Brazilian Amazon region. Antimicrob Agents Chemother. 2009
174.
Fernandez-Becerra C, Pinazo MJ, Gonzalez A, Alonso PL, Del Portillo HA, Gascon J: Increased expression levels of the pvcrt-o and pvmdr1 genes in a patient with severe Plasmodium vivax malaria. Malar J. 2009, 8: 55PubMedCentralPubMed
175.
Douglas NM, Anstey NM, Angus BJ, Nosten F, Price RN: Artemisinin combination therapy for vivax malaria. Lancet Infect Dis. 2010, 10: 405-416.PubMedCentralPubMed
176.
Pessoa SB: Parasitologia Médica. 1967, Rio de Janeiro: Guanabara-Koogan, 11
177.
Alves FP, Durlacher RR, Menezes MJ, Krieger H, Silva LH, Camargo EP: High prevalence of asymptomatic Plasmodium vivax and Plasmodium falciparum infections in native Amazonian populations. Am J Trop Med Hyg. 2002, 66: 641-648.PubMed
178.
Metadata
Title
Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature
Authors
Marcus VG Lacerda
Maria PG Mourão
Márcia AA Alexandre
André M Siqueira
Belisa ML Magalhães
Flor E Martinez-Espinosa
Franklin S Santana Filho
Patrícia Brasil
Ana MRS Ventura
Mauro S Tada
Vanja SCD Couto
Antônio R Silva
Rita SU Silva
Maria GC Alecrim
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2012
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-11-12

Other articles of this Issue 1/2012

Malaria Journal 1/2012 Go to the issue

Research

Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization

Research

Surveillance of the efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009

Research

Long-term storage limits PCR-based analyses of malaria parasites in archival dried blood spots

Review

The global pipeline of new medicines for the control and elimination of malaria

Research

Can universal insecticide-treated net campaigns achieve equity in coverage and use? the case of northern Nigeria

Research

Integrated vector management targeting Anopheles darlingi populations decreases malaria incidence in an unstable transmission area, in the rural Brazilian Amazon

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits