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Published in: Malaria Journal 1/2011

Open Access 01-12-2011 | Research

Monitoring fever treatment behaviour and equitable access to effective medicines in the context of initiatives to improve ACT access: baseline results and implications for programming in six African countries

Authors: Megan Littrell, Hellen Gatakaa, Illah Evance, Stephen Poyer, Julius Njogu, Tsione Solomon, Erik Munroe, Steven Chapman, Catherine Goodman, Kara Hanson, Cyprien Zinsou, Louis Akulayi, Jacky Raharinjatovo, Ekundayo Arogundade, Peter Buyungo, Felton Mpasela, Cherifatou Bello Adjibabi, Jean Angbalu Agbango, Benjamin Fanomezana Ramarosandratana, Babajide Coker, Denis Rubahika, Busiku Hamainza, Tanya Shewchuk, Desmond Chavasse, Kathryn A O'Connell

Published in: Malaria Journal | Issue 1/2011

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Abstract

Background

Access to artemisinin-based combination therapy (ACT) remains limited in high malaria-burden countries, and there are concerns that the poorest people are particularly disadvantaged. This paper presents new evidence on household treatment-seeking behaviour in six African countries. These data provide a baseline for monitoring interventions to increase ACT coverage, such as the Affordable Medicines Facility for malaria (AMFm).

Methods

Nationally representative household surveys were conducted in Benin, the Democratic Republic of Congo (DRC), Madagascar, Nigeria, Uganda and Zambia between 2008 and 2010. Caregivers responded to questions about management of recent fevers in children under five. Treatment indicators were tabulated across countries, and differences in case management provided by the public versus private sector were examined using chi-square tests. Logistic regression was used to test for association between socioeconomic status and 1) malaria blood testing, and 2) ACT treatment.

Results

Fever treatment with an ACT is low in Benin (10%), the DRC (5%), Madagascar (3%) and Nigeria (5%), but higher in Uganda (21%) and Zambia (21%). The wealthiest children are significantly more likely to receive ACT compared to the poorest children in Benin (OR = 2.68, 95% CI = 1.12-6.42); the DRC (OR = 2.18, 95% CI = 1.12-4.24); Madagascar (OR = 5.37, 95% CI = 1.58-18.24); and Nigeria (OR = 6.59, 95% CI = 2.73-15.89). Most caregivers seek treatment outside of the home, and private sector outlets are commonly the sole external source of treatment (except in Zambia). However, children treated in the public sector are significantly more likely to receive ACT treatment than those treated in the private sector (except in Madagascar). Nonetheless, levels of testing and ACT treatment in the public sector are low. Few caregivers name the national first-line drug as most effective for treating malaria in Madagascar (2%), the DRC (2%), Nigeria (4%) and Benin (10%). Awareness is higher in Zambia (49%) and Uganda (33%).

Conclusions

Levels of effective fever treatment are low and inequitable in many contexts. The private sector is frequently accessed however case management practices are relatively poor in comparison with the public sector. Supporting interventions to inform caregiver demand for ACT and to improve provider behaviour in both the public and private sectors are needed to achieve maximum gains in the context of improved access to effective treatment.
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Literature
1.
go back to reference McCombie SC: Treatment seeking for malaria: a review of recent research. Soc Sci Med. 1996, 43: 933-945.CrossRefPubMed McCombie SC: Treatment seeking for malaria: a review of recent research. Soc Sci Med. 1996, 43: 933-945.CrossRefPubMed
2.
go back to reference McCombie SC: Self-treatment for malaria: the evidence and methodological issues. Health Policy Plan. 2002, 17: 333-344.CrossRefPubMed McCombie SC: Self-treatment for malaria: the evidence and methodological issues. Health Policy Plan. 2002, 17: 333-344.CrossRefPubMed
3.
go back to reference Williams HA, Jones COH: A critical review of behavioural issues related to malaria control in sub-Saharan Africa: what contributions have social scientists made?. Social Soc Sci Med. 2004, 59: 501-523.CrossRefPubMed Williams HA, Jones COH: A critical review of behavioural issues related to malaria control in sub-Saharan Africa: what contributions have social scientists made?. Social Soc Sci Med. 2004, 59: 501-523.CrossRefPubMed
4.
go back to reference WHO: World malaria report 2009. 2009, Geneva: WHO WHO: World malaria report 2009. 2009, Geneva: WHO
5.
go back to reference RBM: The global malaria action plan for a malaria free world. 2008, Geneva: RBM RBM: The global malaria action plan for a malaria free world. 2008, Geneva: RBM
6.
go back to reference O'Connell KA, Gatakaa H, Poyer S, Njogu J, Evance I, Munroe E, Solomon T, Goodman C, Hanson K, Zinsou C, Akulayi L, Raharinjatovo J, Arogundade E, Buyungo P, Mpasela F, Adjibabi CB, Agbango JA, Ramarosandratana BF, Coker B, Rubahika MD, Hamainza B, Chapman S, Shewchuk T, Chavasse D: Got ACTs? Availability, price, market share and provider knowledge of anti-malarial medicines in public and private sector outlets in six malaria-endemic countries. Malar J. O'Connell KA, Gatakaa H, Poyer S, Njogu J, Evance I, Munroe E, Solomon T, Goodman C, Hanson K, Zinsou C, Akulayi L, Raharinjatovo J, Arogundade E, Buyungo P, Mpasela F, Adjibabi CB, Agbango JA, Ramarosandratana BF, Coker B, Rubahika MD, Hamainza B, Chapman S, Shewchuk T, Chavasse D: Got ACTs? Availability, price, market share and provider knowledge of anti-malarial medicines in public and private sector outlets in six malaria-endemic countries. Malar J.
7.
go back to reference WHO: World malaria report 2010. 2010, Geneva: WHO WHO: World malaria report 2010. 2010, Geneva: WHO
10.
go back to reference Shewchuk T, O'Connell KA, Goodman C, Hanson K, Chapman S, Chavasse D: The ACTwatch project: methods to describe anti-malarial markets in seven countries. Malar J. Shewchuk T, O'Connell KA, Goodman C, Hanson K, Chapman S, Chavasse D: The ACTwatch project: methods to describe anti-malarial markets in seven countries. Malar J.
12.
go back to reference Rutstein SO, Johnson K: The DHS wealth index. DHS Comparative Reports No. 6. 2004, Calverton, MD: ORC Macro Rutstein SO, Johnson K: The DHS wealth index. DHS Comparative Reports No. 6. 2004, Calverton, MD: ORC Macro
13.
go back to reference Chizema-Kawesha E, Miller JM, Steketee RW, Mukonka VM, Mukuka C, Mohamed AD, Miti SK, Campbell CC: Scaling up malaria control in Zambia: progress and impact 2005-2008. Am J Trop Med Hyg. 2010, 83: 480-488.PubMedCentralCrossRefPubMed Chizema-Kawesha E, Miller JM, Steketee RW, Mukonka VM, Mukuka C, Mohamed AD, Miti SK, Campbell CC: Scaling up malaria control in Zambia: progress and impact 2005-2008. Am J Trop Med Hyg. 2010, 83: 480-488.PubMedCentralCrossRefPubMed
14.
go back to reference Sipilanyambe N, Simon JL, Chanda P, Olumese P, Snow RW, Hamer DH: From chloroquine to artemether-lumafantrine: The process of drug policy change in Zambia. Malar J. 2008, 7: 25-32.PubMedCentralCrossRefPubMed Sipilanyambe N, Simon JL, Chanda P, Olumese P, Snow RW, Hamer DH: From chloroquine to artemether-lumafantrine: The process of drug policy change in Zambia. Malar J. 2008, 7: 25-32.PubMedCentralCrossRefPubMed
15.
go back to reference Steketee RW, Sipilanyambe N, Chimumbwa J, Banda JJ, Mohamed A, Miller J, Basu S, Miti SK, Campbell CC: National malaria control and scaling up for impact: The Zambian experience through 2006. Am J Trop Med Hyg. 2008, 79: 45-52.PubMed Steketee RW, Sipilanyambe N, Chimumbwa J, Banda JJ, Mohamed A, Miller J, Basu S, Miti SK, Campbell CC: National malaria control and scaling up for impact: The Zambian experience through 2006. Am J Trop Med Hyg. 2008, 79: 45-52.PubMed
16.
go back to reference Rutebemberwa E, Pariyo G, Peterson S, Tomson G, Kallander K: Utilization of public or private health care providers by febrile children after user fee removal in Uganda. Malar J. 2009, 8: 45-54.PubMedCentralCrossRefPubMed Rutebemberwa E, Pariyo G, Peterson S, Tomson G, Kallander K: Utilization of public or private health care providers by febrile children after user fee removal in Uganda. Malar J. 2009, 8: 45-54.PubMedCentralCrossRefPubMed
17.
go back to reference Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A, Dorsey G, Kamya MR, Rosenthal PJ: Malaria in Uganda: challenges to control on the long road to elimination I. Epidemiology and current control efforts. Acta Trop. Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A, Dorsey G, Kamya MR, Rosenthal PJ: Malaria in Uganda: challenges to control on the long road to elimination I. Epidemiology and current control efforts. Acta Trop.
18.
go back to reference Talisuna A, Grewal P, Rwakimai JB, Mukasa S, Jagoe G, Banerji J: Cost is killing patients: subsidising effective antimalarials. Lancet. 2009, 374: 1224-1225.CrossRefPubMed Talisuna A, Grewal P, Rwakimai JB, Mukasa S, Jagoe G, Banerji J: Cost is killing patients: subsidising effective antimalarials. Lancet. 2009, 374: 1224-1225.CrossRefPubMed
19.
go back to reference Countdown 2008 Equity Analysis Group: Mind the gap: equity and trends in coverage of maternal, newborn and child health services in 54 Countdown countries. Lancet. 2008, 371: 1259-1267.CrossRef Countdown 2008 Equity Analysis Group: Mind the gap: equity and trends in coverage of maternal, newborn and child health services in 54 Countdown countries. Lancet. 2008, 371: 1259-1267.CrossRef
21.
go back to reference Ndyomugyeny R, Magnussen P, Clark S: Malaria treatment-seeking behaviour and drug prescription practices in an area of low transmission in Uganda: implications for prevention and control. Trans R Soc Trop Med Hyg. 2007, 101: 209-215.CrossRef Ndyomugyeny R, Magnussen P, Clark S: Malaria treatment-seeking behaviour and drug prescription practices in an area of low transmission in Uganda: implications for prevention and control. Trans R Soc Trop Med Hyg. 2007, 101: 209-215.CrossRef
22.
go back to reference Osterholt DM, Rowe AK, Hamel MJ, Flanders WD, Mkandala C, Marum LH, Kaimila N: Predictors of treatment error for children with uncomplicated malaria seen as outpatients in Blantyre district, Malawi. Trop Med Int Health. 2006, 11: 1147-1156.CrossRefPubMed Osterholt DM, Rowe AK, Hamel MJ, Flanders WD, Mkandala C, Marum LH, Kaimila N: Predictors of treatment error for children with uncomplicated malaria seen as outpatients in Blantyre district, Malawi. Trop Med Int Health. 2006, 11: 1147-1156.CrossRefPubMed
23.
go back to reference Zurovac D, Rowe AK: Quality of treatment for febrile illness among children at outpatient facilities in sub-Saharan Africa. Annals of Tropical Medicine & Parasitology. 2006, 4: 283-296.CrossRef Zurovac D, Rowe AK: Quality of treatment for febrile illness among children at outpatient facilities in sub-Saharan Africa. Annals of Tropical Medicine & Parasitology. 2006, 4: 283-296.CrossRef
24.
go back to reference Zurovac D, Ndhlovu M, Sipilanyambe N, Chanda P, Hamer DH, Simon JL, Snow RW: Paediatric malaria case-management with artemether-lumefantrine in Zambia: a repeat cross-sectional study. Malar J. 2007, 6: 31-PubMedCentralCrossRefPubMed Zurovac D, Ndhlovu M, Sipilanyambe N, Chanda P, Hamer DH, Simon JL, Snow RW: Paediatric malaria case-management with artemether-lumefantrine in Zambia: a repeat cross-sectional study. Malar J. 2007, 6: 31-PubMedCentralCrossRefPubMed
25.
go back to reference Smith LA, Jones C, Meek S, Webster J: Provider practice and user behaviour interventions to improve prompt and effective treatment of malaria: do we know what works?. Am J Trop Med Hyg. 2009, 80: 326-335.PubMed Smith LA, Jones C, Meek S, Webster J: Provider practice and user behaviour interventions to improve prompt and effective treatment of malaria: do we know what works?. Am J Trop Med Hyg. 2009, 80: 326-335.PubMed
26.
go back to reference Zurovac D, Tibenderana JK, Nankabirwa J, Ssekitooleko J, Njogu JN, Rwakimari JB, Meek S, Talisuna A, Snow RW: Malaria case-management under artemether-lumefantrine treatment policy in Uganda. Malar J. 2008, 7: 181-PubMedCentralCrossRefPubMed Zurovac D, Tibenderana JK, Nankabirwa J, Ssekitooleko J, Njogu JN, Rwakimari JB, Meek S, Talisuna A, Snow RW: Malaria case-management under artemether-lumefantrine treatment policy in Uganda. Malar J. 2008, 7: 181-PubMedCentralCrossRefPubMed
27.
go back to reference Wasunna B, Zurovac D, Goodman CA, Snow RW: Why don't health workers prescribe ACT? A qualitative study of factors affecting the prescription of artemether-lumefantrine. Malar J. 2008, 7: 29-PubMedCentralCrossRefPubMed Wasunna B, Zurovac D, Goodman CA, Snow RW: Why don't health workers prescribe ACT? A qualitative study of factors affecting the prescription of artemether-lumefantrine. Malar J. 2008, 7: 29-PubMedCentralCrossRefPubMed
28.
go back to reference Zurovac D, Ndhlovu M, Rowe AK, Hamer DH, Thea DM, Snow RW: Treatment of paediatric malaria during a period of drug transition to artemether-lumefantrine in Zambia: cross sectional study. BMJ. 2005, 331: 734-739.PubMedCentralCrossRefPubMed Zurovac D, Ndhlovu M, Rowe AK, Hamer DH, Thea DM, Snow RW: Treatment of paediatric malaria during a period of drug transition to artemether-lumefantrine in Zambia: cross sectional study. BMJ. 2005, 331: 734-739.PubMedCentralCrossRefPubMed
29.
go back to reference Wasunna B, Zurovac D, Bruce J, Jones C, Webster J, Snow RW: Health worker performance in the management of paediatric fevers following in-service training and exposure to job aids in Kenya. Malar J. 2010, 9: 261-PubMedCentralPubMed Wasunna B, Zurovac D, Bruce J, Jones C, Webster J, Snow RW: Health worker performance in the management of paediatric fevers following in-service training and exposure to job aids in Kenya. Malar J. 2010, 9: 261-PubMedCentralPubMed
30.
go back to reference Rowe AK, de Savigny D, Lanata CF, Victora CG: How can we achieve and maintain high-quality performance of health workers in low-resource settings?. Lancet. 2005, 366: 1026-1035.CrossRefPubMed Rowe AK, de Savigny D, Lanata CF, Victora CG: How can we achieve and maintain high-quality performance of health workers in low-resource settings?. Lancet. 2005, 366: 1026-1035.CrossRefPubMed
31.
go back to reference WHO: World malaria report 2008. 2008, Geneva: WHO WHO: World malaria report 2008. 2008, Geneva: WHO
32.
go back to reference Abuya TO, Fegan G, Amin A, Akhwale WS, Noor AM, Snow RW, Marsh V: Evaluating different dimensions of programme effectiveness for private medicine retailer malaria control interventions in Kenya. PLoS One. 2010, 5: e8937-PubMedCentralCrossRefPubMed Abuya TO, Fegan G, Amin A, Akhwale WS, Noor AM, Snow RW, Marsh V: Evaluating different dimensions of programme effectiveness for private medicine retailer malaria control interventions in Kenya. PLoS One. 2010, 5: e8937-PubMedCentralCrossRefPubMed
34.
go back to reference Brugha R, Zwi A: Improving the quality of private sector delivery of public health services: Challenges and strategies. Health Policy Plan. 1998, 13: 107-120.CrossRefPubMed Brugha R, Zwi A: Improving the quality of private sector delivery of public health services: Challenges and strategies. Health Policy Plan. 1998, 13: 107-120.CrossRefPubMed
35.
go back to reference Goodman C, Kachur SP, Abdulla S, Mwangeni E, Nyoni J, Schellenberg JA, Mills A, Bloland P: Retail supply of malaria-related drugs in rural Tanzania: risks and opportunities. Trop Med Int Health. 2004, 9: 655-663.CrossRefPubMed Goodman C, Kachur SP, Abdulla S, Mwangeni E, Nyoni J, Schellenberg JA, Mills A, Bloland P: Retail supply of malaria-related drugs in rural Tanzania: risks and opportunities. Trop Med Int Health. 2004, 9: 655-663.CrossRefPubMed
36.
go back to reference Chuma J, Abuya T, Memusi D, Juma E, Akhwale W, Ntwiga J, Nyandigisi A, Tetteh G, Shretta R, Amin A: Reviewing the literature on access to prompt and effective malaria treatment in Kenya: implications for meeting the Abuja targets. Malar J. 2009, 8: 243-PubMedCentralCrossRefPubMed Chuma J, Abuya T, Memusi D, Juma E, Akhwale W, Ntwiga J, Nyandigisi A, Tetteh G, Shretta R, Amin A: Reviewing the literature on access to prompt and effective malaria treatment in Kenya: implications for meeting the Abuja targets. Malar J. 2009, 8: 243-PubMedCentralCrossRefPubMed
37.
go back to reference WHO: Guidelines for the treatment of malaria, Second edition 2010. 2010, Geneva: WHO WHO: Guidelines for the treatment of malaria, Second edition 2010. 2010, Geneva: WHO
38.
go back to reference PMI: Communication and social mobilization guidelines. 2008, Washington DC: PMI PMI: Communication and social mobilization guidelines. 2008, Washington DC: PMI
39.
go back to reference Sabot OJ, Mwita A, Cohen JM, Ipuge Y, Gordon M, Bishop D, Odhiambo M, Ward L, Goodman C: Piloting the global subsidy: The impact of subsidized artemisinin-based combination therapies distributed through private sector drug stops in rural Tanzania. PloS One. 2009, 4: e6857-PubMedCentralCrossRefPubMed Sabot OJ, Mwita A, Cohen JM, Ipuge Y, Gordon M, Bishop D, Odhiambo M, Ward L, Goodman C: Piloting the global subsidy: The impact of subsidized artemisinin-based combination therapies distributed through private sector drug stops in rural Tanzania. PloS One. 2009, 4: e6857-PubMedCentralCrossRefPubMed
Metadata
Title
Monitoring fever treatment behaviour and equitable access to effective medicines in the context of initiatives to improve ACT access: baseline results and implications for programming in six African countries
Authors
Megan Littrell
Hellen Gatakaa
Illah Evance
Stephen Poyer
Julius Njogu
Tsione Solomon
Erik Munroe
Steven Chapman
Catherine Goodman
Kara Hanson
Cyprien Zinsou
Louis Akulayi
Jacky Raharinjatovo
Ekundayo Arogundade
Peter Buyungo
Felton Mpasela
Cherifatou Bello Adjibabi
Jean Angbalu Agbango
Benjamin Fanomezana Ramarosandratana
Babajide Coker
Denis Rubahika
Busiku Hamainza
Tanya Shewchuk
Desmond Chavasse
Kathryn A O'Connell
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2011
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-10-327

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