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Malaria Journal
Published in: Malaria Journal 1/2011

Open Access 01-12-2011 | Commentary

Treatment of imported severe malaria with artesunate instead of quinine - more evidence needed?

Authors: Jakob P Cramer, Rogelio López-Vélez, Gerd D Burchard, Martin P Grobusch, Peter J de Vries

Published in: Malaria Journal | Issue 1/2011

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Abstract

Rapid and fast acting anti-malarials are essential to treat severe malaria. Quinine has been the only option for parenteral therapy until recently. While current evidence shows that intravenous artesunate is more effective than quinine in treating severe malaria in endemic countries, some questions remain regarding safety profiles and drug resistance. For imported severe malaria, additional unanswered questions are related to generalizability of the findings from endemic countries and to legal aspects, as there is no Good Manufacturing Practice-conform drug available yet. Here, the implications of existing evidence for the treatment of imported severe malaria are discussed.
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Metadata
Title
Treatment of imported severe malaria with artesunate instead of quinine - more evidence needed?
Authors
Jakob P Cramer
Rogelio López-Vélez
Gerd D Burchard
Martin P Grobusch
Peter J de Vries
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2011
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-10-256

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