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Cancer Cell International
Published in: Cancer Cell International 1/2010

Open Access 01-12-2010 | Review

Wnt signal transduction pathway and apoptosis: a review

Author: Nives Pećina-Šlaus

Published in: Cancer Cell International | Issue 1/2010

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Abstract

The association between the wnt signaling pathway and apoptosis has become more firmly established in the recent scientific literature. Many reports indicate that the wnt signaling pathway regulates apoptosis through a variety of mechanisms.
The activity of wnt signaling according to specific cellular environment stimuli can either foster or restrain the processes of apoptosis. Wnt signaling regulates the early and late stages of apoptosis in both development and cellular injury in populations of neurons, endothelial cells, vascular smooth muscle cells and cardiomyocytes.
In this review I draw attention to genes and proteins of the wnt signaling pathway involved in apoptosis and describe some of their functional effects.
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Metadata
Title
Wnt signal transduction pathway and apoptosis: a review
Author
Nives Pećina-Šlaus
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2010
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/1475-2867-10-22

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