Top

Published in:

Open Access 01-12-2012 | Original investigation

Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels

Authors: Rui-Xing Yin, Dong-Feng Wu, Lin Miao, Lynn Htet Htet Aung, Xiao-Li Cao, Ting-Ting Yan, Xing-Jiang Long, Wan-Ying Liu, Lin Zhang, Meng Li

Published in: Cardiovascular Diabetology | Issue 1/2012

Abstract

Background

Information about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on serum lipid profiles is still scarce. The present study was undertaken to detect ten SNPs and their interactions with overweight/obesity on serum lipid levels.

Methods

A total of 978 normal weight and 751 overweight/obese subjects of Bai Ku Yao were randomly selected from our previous stratified randomized cluster samples. Normal weight, overweight and obesity were defined as a body mass index (BMI) < 24, 24–28, and > 28 kg/m²; respectively. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein (Apo) A1 and ApoB levels were measured. Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low density lipoprotein receptor (LDL-R) Ava II, hepatic lipase gene (LIPC) -250G>A, endothelial lipase gene (LIPG) 584C>T, methylenetetrahydrofolate reductase (MTHFR) 677C>T, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP) rs3757354, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated receptor delta (PPARD) +294T>C, and Scavenger receptor class B type 1 (SCARB1) rs5888 was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing. The interactions were detected by factorial design covariance analysis.

Results

The genotypic and allelic frequencies of LIPC and PCSK9 were different between normal weight and overweight/obese subjects, the genotypic frequency of LIPG and allelic frequency of MYLIP were also different between normal weight and overweight/obese subjects (P < 0.05-0.001). The levels of TC, ApoA1 (ABCA-1); TC, LDL-C, ApoA1, ApoB and ApoA1/ApoB (LIPC); TG, HDL-C, and ApoA1 (LIPG); TC, HDL-C, LDL-C, ApoA1 and ApoB (MTHFR); HDL-C and ApoA1 (MYLIP) in normal weight subjects were different among the genotypes (P < 0.01-0.001). The levels of LDL-C, ApoB and ApoA1/ApoB (ABCA-1); HDL-C, ApoA1, ApoB and ApoA1/ApoB (LIPC); TC, HDL-C, ApoA1 and ApoB (LIPG); TC, TG, HDL-C, LDL-C, ApoA1 and ApoB (MTHFR); TC, TG and ApoB (MYLIP); TG (PCSK9); TG, ApoA1 and ApoB (PPARD); and TC, HDL-C, LDL-C, ApoA1 and ApoB (SCARB1) in overweight/obese subjects were different among the genotypes (P < 0.01-0.001). The SNPs of ABCA-1 (LDL-C and ApoA1/ApoB); LIPC (TC, LDL-C, ApoA1 and ApoB); LIPG (ApoB); MTHFR (TC, TG and LDL-C); MYLIP (TC and TG); PCSK9 (TG, HDL-C, ApoB and ApoA1/ApoB); PPARD (TG and ApoA1/ApoB); and SCARB1 (TG, ApoA1 and ApoB) interacted with overweight/obesity to influence serum lipid levels (P < 0.05-0.001).

Conclusions

The differences in serum lipid levels between normal weight and overweight/obese subjects might partly result from different genetic polymorphisms and the interactions between several SNPs and overweight/obesity.

Available only for authorised users

Shekelle RB, Shryock AM, Paul O, Lepper M, Stamler J, Liu S, Raynor WJ: Diet, serum cholesterol, and death from coronary heart disease. The Western Electric study. N Engl J Med. 1981, 304: 65-70.CrossRefPubMed

Austin MA: Plasma triglyceride as a risk factor for coronary heart disease. The epidemiologic evidence and beyond. Am J Epidemiol. 1989, 129: 249-259.PubMed

National Cholesterol Education Program (NCEP) Expert Panel on Detectionm, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III): Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002, 106: 3143-3421.

Kwiterovich PO, Coresh J, Smith HH, Bachorik PS, Derby CA, Pearson TA: Comparison of the plasma levels of apolipoproteins B and A-1, and other risk factors in men and women with premature coronary artery disease. Am J Cardiol. 1992, 69: 1015-1021.CrossRefPubMed

Hokanson JE, Austin MA: Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk. 1996, 3: 213-319.CrossRefPubMed

Stamler J, Daviglus ML, Garside DB, Dyer AR, Greenland P, Neaton JD: Relationship of baseline serum cholesterol levels in 3 large cohorts of younger men to long-term coronary, cardiovascular, and all-cause mortality and to longevity. JAMA. 2000, 284: 311-318.CrossRefPubMed

Ruixing Y, Qiming F, Dezhai Y, Shuquan L, Weixiong L, Shangling P, Hai W, Yongzhong Y, Feng H, Shuming Q: Comparison of demography, diet, lifestyle, and serum lipid levels between the Guangxi Bai Ku Yao and Han populations. J Lipid Res. 2007, 48: 2673-2681.CrossRefPubMed

Ruixing Y, Shangling P, Hong C, Hanjun Y, Hai W, Yuming C, Jinzhen W, Feng H, Meng L, Muyan L: Diet, alcohol consumption, and serum lipid levels of the middle-aged and elderly in the Guangxi Bai Ku Yao and Han populations. Alcohol. 2008, 42: 219-229.CrossRefPubMed

Ruixing Y, Dezhai Y, Shuquan L, Yuming C, Hanjun Y, Qiming F, Shangling P, Weixiong L, Jing T, Yiyang L: Hyperlipidaemia and its risk factors in the Guangxi Bai Ku Yao and Han populations. Public Health Nutr. 2009, 12: 816-824.CrossRefPubMed

10.

Ruixing Y, Yiyang L, Meng L, Kela L, Xingjiang L, Lin Z, Wanying L, Jinzhen W, Dezhai Y, Weixiong L: Interactions of the apolipoprotein C-III 3238C>G polymorphism and alcohol consumption on serum triglyceride levels. Lipids Health Dis. 2010, 9: 86.PubMedCentralPubMed

11.

Zhou Y, Yin R, Deng Y, Li Y, Wu J: Interactions between alcohol intake and the polymorphism of rs708272 on serum high-density lipoprotein cholesterol levels in the Guangxi Hei Yi Zhuang population. Alcohol. 2008, 42: 583-591.CrossRefPubMed

12.

Yin RX, Li YY, Liu WY, Zhang L, Wu JZ: Interactions of the apolipoprotein A5 gene polymorphisms and alcohol consumption on serum lipid levels. PLoS One. 2011, 6: e17954.PubMedCentralCrossRefPubMed

13.

Denke MA, Sempos CT, Grundy SM: Excess body weight: an under-recognized contributor to dyslipidemia in white American women. Arch Intern Med. 1994, 154: 401-410.CrossRefPubMed

14.

Zhou BF, Cooperative Meta-Analysis Group of the Working Group on Obesity in China: Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults–study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci. 2002, 15: 83-96.PubMed

15.

Kawada T: Body mass index is a good predictor of hypertension and hyperlipidemia in a rural Japanese population. Int J Obes Relat Metab Disord. 2002, 26: 725-729.CrossRefPubMed

16.

Denke MA: Connections between obesity and dyslipidaemia. Curr Opinion Lipidol. 2001, 12: 625-628.CrossRef

17.

Kopelman PG: Obesity as a medical problem. Nature. 2000, 404: 635-643.PubMed

18.

James PT: Obesity: the worldwide epidemic. Clin Dermatol. 2004, 22: 276-280.CrossRefPubMed

19.

Cheung CY, Tso AW, Cheung BM, Xu A, Ong KL, Fong CH, Wat NM, Janus ED, Sham PC, Lam KS: Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population. J Clin Endocrinol Metab. 2010, 95: 1395-1403.CrossRefPubMed

20.

Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM: Prevalence of overweight and obesity in the United States, 1999–2004. JAMA. 2006, 295: 1549-1555.CrossRefPubMed

21.

Flegal KM, Carroll MD, Ogden CL, Curtin LR: Prevalence and trends in obesity among U.S. adults, 1999–2008. JAMA. 2010, 303: 235-241.CrossRefPubMed

22.

Reynolds K, Gu D, Whelton PK, Wu X, Duan X, Mo J, He J, InterASIA Collaborative Group: Prevalence and risk factors of overweight and obesity in China. Obesity (Silver Spring). 2007, 15: 10-18.CrossRef

23.

Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, Ricketts SL, Bis JC, Aulchenko YS, Thorleifsson G, Feitosa MF, Chambers J, Orho-Melander M, Melander O, Johnson T, Li X, Guo X, Li M, Shin Cho Y, Jin Go M, Jin Kim Y: Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010, 466: 707-713.PubMedCentralCrossRefPubMed

24.

Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, Penninx BW, Janssens AC, Wilson JF, Spector T, Martin NG, Pedersen NL, Kyvik KO, Kaprio J, Hofman A, Freimer NB, Jarvelin MR, Gyllensten U, Campbell H, Rudan I, Johansson A, Marroni F, Hayward C, Vitart V, Jonasson I, Pattaro C, Wright A, Hastie N, Pichler I, Hicks AA: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet. 2009, 41: 47-55.PubMedCentralCrossRefPubMed

25.

Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T, Voight BF, Bonnycastle LL, Jackson AU, Crawford G, Surti A, Guiducci C, Burtt NP, Parish S, Clarke R, Zelenika D, Kubalanza KA, Morken MA, Scott LJ, Stringham HM, Galan P, Swift AJ, Kuusisto J, Bergman RN, Sundvall J, Laakso M: Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 2009, 41: 56-65.PubMedCentralCrossRefPubMed

26.

Dumitrescu L, Carty CL, Taylor K, Schumacher FR, Hindorff LA, Ambite JL, Anderson G, Best LG, Brown-Gentry K, Bůžková P, Carlson CS, Cochran B, Cole SA, Devereux RB, Duggan D, Eaton CB, Fornage M, Franceschini N, Haessler J, Howard BV, Johnson KC, Laston S, Kolonel LN, Lee ET, MacCluer JW, Manolio TA, Pendergrass SA, Quibrera M, Shohet RV, Wilkens LR: Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study. PLoS Genet. 2011, 7: e1002138.PubMedCentralCrossRefPubMed

27.

Cao XL, Yin RX, Wu DF, Miao L, Aung LH, Hu XJ, Li Q, Yan TT, Lin WX, Pan SL: Genetic variant of V825I in the ATP-binding cassette transporter A1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis. 2011, 10: 14.PubMedCentralCrossRefPubMed

28.

Wu DF, Yin RX, Aung LH, Hu XJ, Cao XL, Miao L, Li Q, Yan TT, Wu JZ, Pan SL: Polymorphism of rs1044925 in the acyl-CoA:cholesterol acyltransferase-1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis. 2010, 9: 139.PubMedCentralCrossRefPubMed

29.

Long XJ, Yin RX, Li KL, Liu WY, Zhang L, Cao XL, Miao L, Wu DF, Htet Aung LH, Hu XJ: Low density lipoprotein receptor gene Ava II polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis. 2011, 10: 34.PubMedCentralCrossRefPubMed

30.

Meng L, Ruixing Y, Yiyang L, Xingjiang L, Kela L, Wanying L, Lin Z, Weixiong L, Dezhai Y, Shangling P: Association of LIPC -250G>A polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis. 2010, 9: 28.PubMedCentralCrossRefPubMed

31.

Liu WY, Yin RX, Zhang L, Cao XL, Miao L, Wu DF, Aung LH, Hu XJ, Lin WX, Yang DZ: Association of the LIPG 584C>T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis. 2010, 9: 110.PubMedCentralCrossRefPubMed

32.

Zhang L, Yin RX, Liu WY, Miao L, Wu DF, Aung LH, Hu XJ, Cao XL, Wu JZ, Pan SL: Association of methylenetetrahydrofolate reductase C677T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis. 2010, 9: 123.PubMedCentralCrossRefPubMed

33.

Aung LH, Yin RX, Miao L, Hu XJ, Yan TT, Cao XL, Wu DF, Li Q, Pan SL, Wu JZ: The proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis. 2011, 10: 5.PubMedCentralCrossRefPubMed

34.

Miao L, Yin RX, Wu DF, Cao XL, Li Q, Hu XJ, Yan TT, Aung LH, Yang DZ, Lin WX: Peroxisome proliferator-activated receptor delta +294T>C polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis. 2010, 9: 145.PubMedCentralCrossRefPubMed

35.

Wu DF, Yin RX, Hu XJ, Aung LH, Cao XL, Miao L, Li Q, Yan TT, Wu JZ, Pan SL: Association of rs5888 SNP in the scavenger receptor class B type 1 gene and serum lipid levels. Lipids Health Dis. 2012, 11: 50.PubMedCentralCrossRefPubMed

36.

Zhou B: Effect of body mass index on all-cause mortality and incidence of cardiovas-cular diseases—report for meta-analysis of prospective studies open optimal cut-off points of body mass index in Chinese adults. Biomed Environ Sci. 2002, 15: 245-252.PubMed

37.

Jorgensen ME: Obesity and metabolic correlates among the Inuit and a general Danish population. Int J Circumpolar Health. 2004, 63: S77-S79.

38.

Taskinen MR: Type 2 diabetes as a lipid disorder. Curr Mol Med. 2005, 5: 297-308.CrossRefPubMed

39.

Houston MC, Basile J, Bestermann WH, Egan B, Lackland D, Hawkins RG, Moore MA, Reed J, Rogers P, Wise D, Ferrario CM: Addressing the global cardiovascular risk of hypertension, dyslipidemia, and insulin resistance in the southeastern United States. Am J Med Sci. 2005, 329: 276-291.CrossRefPubMed

40.

Pei D, Kuo SW, Wu DA, Lin TY, Hseih MC, Lee CH, Hsu WL, Chen SP, Sheu WH, Li JC: The relationships between insulin resistance and components of metabolic syndrome in Taiwanese Asians. Int J Clin Pract. 2005, 59: 1408-1416.CrossRefPubMed

41.

Zambon A, Deeb SS, Hokanson JE, Brown BG, Brunzell JD: Common variants in the promoter of the hepatic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 cholesterol. Arterioscler Thromb Vasc Biol. 1998, 18: 1723-1729.CrossRefPubMed

42.

Vega GL, Clark LT, Tang A, Marcovina S, Grundy SM, Cohen JC: Hepatic lipase activity is lower in African American men than in white American men: effects of 5′ flanking polymorphism in the hepatic lipase gene (LIPC). J Lipid Res. 1998, 39: 228-232.PubMed

43.

de Andrade FM, Silveira FR, Arsand M, Antunes AL, Torres MR, Zago AJ, Callegari-Jaques SM, Hutz MH: Association between -250G/A polymorphism of the hepatic lipase gene promoter and coronary artery disease and HDL-C levels in a Southern Brazilian population. Clin Genet. 2004, 65: 390-395.CrossRefPubMed

44.

Ko YL, Hsu LA, Hsu KH, Ko YH, Lee YS: The interactive effects of hepatic lipase gene promoter polymorphisms with sex and obesity on high-density-lipoprotein cholesterol levels in Taiwanese-Chinese. Atherosclerosis. 2004, 172: 135-142.CrossRefPubMed

45.

Huang CC, Fornage M, Lloyd-Jones DM, Wei GS, Boerwinkle E, Liu K: Longitudinal association of PCSK9 sequence variations with low-density lipoprotein cholesterol levels: the Coronary Artery Risk Development in Young Adults Study. Circ Cardiovasc Genet. 2009, 2: 354-361.PubMedCentralCrossRefPubMed

46.

Kotowski IK, Pertsemlidis A, Luke A, Cooper RS, Vega GL, Cohen JC, Hobbs HH: A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Hum Genet. 2006, 78: 410-422.PubMedCentralCrossRefPubMed

47.

Evans D, Beil FU: The E670G SNP in the PCSK9 gene is associated with polygenic hypercholesterolemia in men but not in women. BMC Med Genet. 2006, 7: 66.PubMedCentralCrossRefPubMed

48.

Chen SN, Ballantyne CM, Gotto AM, Tan Y, Willerson JT, Marian AJ: A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis. J Am Coll Cardiol. 2005, 45: 1611-1619.PubMedCentralCrossRefPubMed

49.

Hsu LA, Teng MS, Ko YL, Chang CJ, Wu S, Wang CL, Hu CF: The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan. Clin Chem Lab Med. 2009, 47: 154-158.CrossRefPubMed

50.

deLemos AS, Wolfe ML, Long CJ, Sivapackianathan R, Rader DJ: Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol. Circulation. 2002, 106: 1321-1326.CrossRefPubMed

51.

Ma K, Cilingiroglu M, Otvos JD, Ballantyne CM, Marian AJ, Chan L: Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci USA. 2003, 100: 2748-2753.PubMedCentralCrossRefPubMed

52.

Shimizu M, Kanazawa K, Hirata K, Ishida T, Hiraoka E, Matsuda Y, Iwai C, Miyamoto Y, Hashimoto M, Kajiya T, Akita H, Yokoyama M: Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels. Circ J. 2007, 71: 842-846.CrossRefPubMed

53.

Yamakawa-Kobayashi K, Yanagi H, Endo K, Arinami T, Hamaguchi H: Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children. Hum Genet. 2003, 113: 311-315.CrossRefPubMed

54.

Huang Y, Wu Y, Liu R, Fan P, Zhang J, Wang F, Luo X, Liu Y, Liu B, Bai H: Differential effect of ATP binding cassette transporter A1 R219K and cholesteryl ester transfer protein TaqIB genotypes on HDL-C levels in overweight/obese and non-obese Chinese subjects. Acta Cardiol. 2011, 66: 231-237.PubMed

55.

Acuña-Alonzo V, Flores-Dorantes T, Kruit JK, Villarreal-Molina T, Arellano-Campos O, Hünemeier T, Moreno-Estrada A, Ortiz-López MG, Villamil-Ramírez H, León-Mimila P, Villalobos-Comparan M, Jacobo-Albavera L, Ramírez-Jiménez S, Sikora M, Zhang LH, Pape TD, Granados-Silvestre Mde A, Montufar-Robles I, Tito-Alvarez AM, Zurita-Salinas C, Bustos-Arriaga J, Cedillo-Barrón L, Gómez-Trejo C, Barquera-Lozano R, Vieira-Filho JP, Granados J, Romero-Hidalgo S, Huertas-Vázquez A, González-Martín A, Gorostiza A: A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans. Hum Mol Genet. 2010, 19: 2877-2885.PubMedCentralCrossRefPubMed

56.

Kitjaroentham A, Hananantachai H, Tungtrongchitr A, Pooudong S, Tungtrongchitr R: R219K polymorphism of ATP binding cassette transporter A1 related with low HDL in overweight/obese Thai males. Arch Med Res. 2007, 38: 834-838.CrossRefPubMed

57.

Morris BJ, Zee RY, Robinson BG: Significant relationships of plasma lipids and body mass index with polymorphisms at the linked low-density-lipoprotein receptor gene and insulin receptor gene loci (19p13.2) in essential hypertensive patients. Clin Sci (Lond). 1994, 86: 583-592.CrossRef

58.

Zee RY, Schrader AP, Robinson BG, Griffiths LR, Morris BJ: Association of HincII RFLP of low density lipoprotein receptor gene with obesity in essential hypertensives. Clin Genet. 1995, 47: 118-121.CrossRefPubMed

59.

Griffiths LR, Nyholt DR, Curtain RP, Gaffney PT, Morris BJ: Cross-sectional study of a microsatellite marker in the low density lipoprotein receptor gene in obese normotensives. Clin Exp Pharmacol Physiol. 1995, 22: 496-498.CrossRefPubMed

60.

Rutherford S, Nyholt DR, Curtain RP, Quinlan SR, Gaffney PT, Morris BJ, Griffiths LR: Association of a low density lipoprotein receptor microsatellite variant with obesity. Int J Obes Relat Metab Disord. 1997, 21: 1032-1037.CrossRefPubMed

61.

Lunegova OS, Kerimkulova AS, Turdakmatov NB, Sovkhozova NA, Nabiev MP, Gotfrid II, Mirrakhimov AÉ, Aldasheva NM, Kheĭer E, Aldashev AA, Mirrakhimov ÉM: Association of C677T gene polymorphism of methylenetetrahydrofolate reductase with insulin resistance among Kirghizes. Kardiologiia. 2011, 51: 58-62.PubMed

62.

Frelut ML, Nicolas JP, Guilland JC, de Courcy GP: Methylenetetrahydrofolate reductase 677 C>T polymorphism: a link between birth weight and insulin resistance in obese adolescents. Int J Pediatr Obes. 2011, 6: e312-e317.CrossRefPubMed

63.

Burch LR, Donnelly LA, Doney AS, Brady J, Tommasi AM, Whitley AL, Goddard C, Morris AD, Hansen MK, Palmer CN: Peroxisome proliferator-activated receptor-delta genotype influences metabolic phenotype and may influence lipid response to statin therapy in humans: a genetics of diabetes audit and research Tayside study. J Clin Endocrinol Metab. 2010, 95: 1830-1837.CrossRefPubMed

64.

Yan ZC, Shen CY, Zhong J, Wang L, Ni YX, Nie H, Zhu ZM: PPARdelta + 294T/C gene polymorphism related to plasma lipid, obesity and left ventricular hypertrophy in subjects with metabolic syndrome. Zhonghua Xin Xue Guan Bing Za Zhi. 2005, 33: 529-533.PubMed

65.

Aberle J, Hopfer I, Beil FU, Seedorf U: Association of peroxisome proliferator-activated receptor delta +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha L162V. Int J Obes (Lond). 2006, 30: 1709-1713.CrossRef

66.

Talmud PJ, Berglund L, Hawe EM, Waterworth DM, Isasi CR, Deckelbaum RE, Starc T, Ginsberg HN, Humphries SE, Shea S: Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study. Pediatrics. 2001, 108: E50.CrossRefPubMed

67.

Nie L, Wang J, Clark LT, Tang A, Vega GL, Grundy SM, Cohen JC: Body mass index and hepatic lipase gene (LIPC) polymorphism jointly influence postheparin plasma hepatic lipase activity. J Lipid Res. 1998, 39: 1127-1130.PubMed

68.

Deeb SS, Zambon A, Carr MC, Ayyobi AF, Brunzell JD: Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender, and diet. J Lipid Res. 2003, 44: 1279-1286.CrossRefPubMed

69.

St-Pierre J, Miller-Felix I, Paradis ME, Bergeron J, Lamarche B, Després JP, Gaudet D, Vohl MC: Visceral obesity attenuates the effect of the hepatic lipase -514C>T polymorphism on plasma HDL-cholesterol levels in French-Canadian men. Mol Genet Metab. 2003, 78: 31-36.CrossRefPubMed

70.

Swarbrick MM, Chapman CM, McQuillan BM, Hung J, Thompson PL, Beilby JP: A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity. Eur J Endocrinol. 2001, 144: 277-282.CrossRefPubMed

71.

Schmid PM, Heid I, Buechler C, Steege A, Resch M, Birner C, Endemann DH, Riegger GA, Luchner A: Expression of fourteen novel obesity-related genes in zucker diabetic fatty rats. Cardiovasc Diabetol. 2012, 11: 48.PubMedCentralCrossRefPubMed

72.

Oktavianthi S, Trimarsanto H, Febinia CA, Suastika K, Saraswati MR, Dwipayana P, Arindrarto W, Sudoyo H, Malik SG: Uncoupling protein 2 gene polymorphisms are associated with obesity. Cardiovasc Diabetol. 2012, 11: 41.PubMedCentralCrossRefPubMed

73.

Opstad TB, Pettersen AÅ, Arnesen H, Seljeflot I: Circulating levels of IL-18 are significantly influenced by the IL-18 +183 A/G polymorphism in coronary artery disease patients with diabetes type 2 and the metabolic syndrome: an observational study. Cardiovasc Diabetol. 2011, 10: 110.PubMedCentralCrossRefPubMed

74.

Gragnoli C: Hypercholesterolemia and a candidate gene within the 12q24 locus. Cardiovasc Diabetol. 2011, 10: 38.PubMedCentralCrossRefPubMed

75.

Gragnoli C: Proteasome modulator 9 is linked to microvascular pathology of T2D. J Cell Physiol. 2012, cbt: 3116-3118.CrossRef

Title: Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels
Authors: Rui-Xing Yin
Dong-Feng Wu
Lin Miao
Lynn Htet Htet Aung
Xiao-Li Cao
Ting-Ting Yan
Xing-Jiang Long
Wan-Ying Liu
Lin Zhang
Meng Li
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Cardiovascular Diabetology / Issue 1/2012
Electronic ISSN: 1475-2840
DOI: https://doi.org/10.1186/1475-2840-11-123

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels

Abstract

Background

Methods

Results

Conclusions

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2012

Fatty acid-binding protein 4 impairs the insulin-dependent nitric oxide pathway in vascular endothelial cells

Regional evidence of modulation of cardiac adiponectin level in dilated cardiomyopathy: pilot study in a porcine animal model

Predictive value of advanced glycation end products for the development of post-infarction heart failure: a preliminary report

Personal attributes that influence the adequate management of hypertension and dyslipidemia in patients with type 2 diabetes. Results from the DIAB-CORE Cooperation

Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low

Fibrates are an essential part of modern anti-dyslipidemic arsenal: spotlight on atherogenic dyslipidemia and residual risk reduction

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page