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Published in: BMC Clinical Pathology 1/2013

Open Access 01-12-2013 | Case report

Segmental arterial mediolysis of left gastric artery: a case report and review of pathology

Authors: Azra Tabassum, Sanaz Sasani, Adeeb J Majid, Christopher Henderson, Neil D Merrett

Published in: BMC Clinical Pathology | Issue 1/2013

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Abstract

Background

Segmental arterial mediolysis (SAM) is a rare non inflammatory vascular disease that can present with massive haemorrhage, which may lead to death without prompt surgical intervention.

Case presentation

A 60 years old Aboriginal female presented with life threatening, spontaneous intra-abdominal bleeding requiring an emergency laparotomy. The source of bleeding was found to be ruptured left gastric artery. A total gastrectomy was performed as a damage control procedure. A staged Roux-en-Y oesophago-jejunostomy with Hunt Lawrence pouch reconstruction was undertaken thirty six hours later. Histopathological findings revealed evidence of non-inflammatory segmental vascular damage with microaneurysm, consistent with segmental arterial mediolysis.

Conclusion

Prompt resuscitation and surgical intervention can decrease the morbidity and mortality in this rare clinical entity.
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Literature
1.
go back to reference Inada K, Maeda M, Ikeda T: Segmental arterial mediolysis: unrecognized cases culled from cases of ruptured aneurysm of abdominal visceral arteries reported in the Japanese literature. Pathol Res Pract. 2007, 203 (11): 771-778. 10.1016/j.prp.2007.07.010.CrossRefPubMed Inada K, Maeda M, Ikeda T: Segmental arterial mediolysis: unrecognized cases culled from cases of ruptured aneurysm of abdominal visceral arteries reported in the Japanese literature. Pathol Res Pract. 2007, 203 (11): 771-778. 10.1016/j.prp.2007.07.010.CrossRefPubMed
2.
go back to reference Lie JT: Systemic, cerebral, and pulmonary segmental mediolytic arteriopathy: villainous masqueraders of vasculitis. Cardiovasc Pathol. 1996, 5: 305-314. 10.1016/S1054-8807(96)00071-3.CrossRefPubMed Lie JT: Systemic, cerebral, and pulmonary segmental mediolytic arteriopathy: villainous masqueraders of vasculitis. Cardiovasc Pathol. 1996, 5: 305-314. 10.1016/S1054-8807(96)00071-3.CrossRefPubMed
3.
go back to reference Gruenwald P: Necrosis in the coronary arteries of newborn infants. Am Heart J. 1949, 38 (6): 889-897. 10.1016/0002-8703(49)90889-3. illustCrossRefPubMed Gruenwald P: Necrosis in the coronary arteries of newborn infants. Am Heart J. 1949, 38 (6): 889-897. 10.1016/0002-8703(49)90889-3. illustCrossRefPubMed
4.
go back to reference Slavin RE: Segmental arterial mediolysis: course, sequelae, prognosis, and pathologic-radiologic correlation. Cardiovasc Pathol. 2009, 18 (6): 352-360. 10.1016/j.carpath.2008.09.001. Epub 2008 Nov 21CrossRefPubMed Slavin RE: Segmental arterial mediolysis: course, sequelae, prognosis, and pathologic-radiologic correlation. Cardiovasc Pathol. 2009, 18 (6): 352-360. 10.1016/j.carpath.2008.09.001. Epub 2008 Nov 21CrossRefPubMed
5.
go back to reference Müller AM, Kullmann HJ: Pulmonary segmental mediolytic arteriopathy. Pathologe. 2006, 27 (2): 152-158. 10.1007/s00292-006-0821-6. Article in GermanCrossRefPubMed Müller AM, Kullmann HJ: Pulmonary segmental mediolytic arteriopathy. Pathologe. 2006, 27 (2): 152-158. 10.1007/s00292-006-0821-6. Article in GermanCrossRefPubMed
6.
go back to reference Basso MC, Flores PC, de Azevedo MA, de Souza GL: Bilateral extensive cerebral infarction and mesenteric ischemia associated with segmental arterial mediolysis in two young women. Pathol Int. 2005, 55 (10): 632-638. 10.1111/j.1440-1827.2005.01881.x.CrossRefPubMed Basso MC, Flores PC, de Azevedo MA, de Souza GL: Bilateral extensive cerebral infarction and mesenteric ischemia associated with segmental arterial mediolysis in two young women. Pathol Int. 2005, 55 (10): 632-638. 10.1111/j.1440-1827.2005.01881.x.CrossRefPubMed
7.
go back to reference Slavin RE, Inada K: Segmental arterial mediolysis with accompanying venous angiopathy: a clinical pathologic review, report of 3 new cases, and comments on the role of endothelin-1 in its pathogenesis. Int J Surg Pathol. 2007, 15 (2): 121-134. 10.1177/1066896906297684.CrossRefPubMed Slavin RE, Inada K: Segmental arterial mediolysis with accompanying venous angiopathy: a clinical pathologic review, report of 3 new cases, and comments on the role of endothelin-1 in its pathogenesis. Int J Surg Pathol. 2007, 15 (2): 121-134. 10.1177/1066896906297684.CrossRefPubMed
8.
go back to reference Slavin RE, Cafferty L, Cartwright J: Segmental mediolytic arteritis. A clinicopathologic and ultrastructural study of two cases. Am J Surg Pathol. 1989, 13 (7): 558-568. 10.1097/00000478-198907000-00003.CrossRefPubMed Slavin RE, Cafferty L, Cartwright J: Segmental mediolytic arteritis. A clinicopathologic and ultrastructural study of two cases. Am J Surg Pathol. 1989, 13 (7): 558-568. 10.1097/00000478-198907000-00003.CrossRefPubMed
9.
go back to reference Filippone EJ, Foy A, Galanis T, Pokuah M, Newman E, Lallas CD, Gonsalves CF, Farber JL: Segmental arterial mediolysis: report of 2 cases and review of the literature. Am J Kidney Dis. 2011, 58 (6): 981-987. 10.1053/j.ajkd.2011.05.031. Epub 2011 Aug 26CrossRefPubMed Filippone EJ, Foy A, Galanis T, Pokuah M, Newman E, Lallas CD, Gonsalves CF, Farber JL: Segmental arterial mediolysis: report of 2 cases and review of the literature. Am J Kidney Dis. 2011, 58 (6): 981-987. 10.1053/j.ajkd.2011.05.031. Epub 2011 Aug 26CrossRefPubMed
10.
go back to reference Slavin RE, Saeki K, Bhagavan B, Maas AE: Segmental arterial mediolysis: a precursor to fibromuscular dysplasia?. Mod Pathol. 1995, 8 (3): 287-294.PubMed Slavin RE, Saeki K, Bhagavan B, Maas AE: Segmental arterial mediolysis: a precursor to fibromuscular dysplasia?. Mod Pathol. 1995, 8 (3): 287-294.PubMed
11.
12.
go back to reference Slavin RE, Yeager MJ: Segmental arterial mediolysis – an iatrogenic vascular disorder induced by ractopamine. Cardiovasc Pathol. 2012, 21: 334-338. 10.1016/j.carpath.2011.09.003.CrossRefPubMed Slavin RE, Yeager MJ: Segmental arterial mediolysis – an iatrogenic vascular disorder induced by ractopamine. Cardiovasc Pathol. 2012, 21: 334-338. 10.1016/j.carpath.2011.09.003.CrossRefPubMed
13.
go back to reference Rengstroff DS, Baker EL, Wack J, Yee LF: Intra-abdominal haemorrhage caused by segmental arterial mediolysis of the inferior mesenteric artery: report of a case. Dis Colon Rectum. 2004, 11 (47): 769-772.CrossRef Rengstroff DS, Baker EL, Wack J, Yee LF: Intra-abdominal haemorrhage caused by segmental arterial mediolysis of the inferior mesenteric artery: report of a case. Dis Colon Rectum. 2004, 11 (47): 769-772.CrossRef
14.
go back to reference Slavin RE, Gonzalez – Vitale JC: Segmental mediolytic arteritis; a clinical pathologic study. Lab Invest. 1976, 35: 23-29.PubMed Slavin RE, Gonzalez – Vitale JC: Segmental mediolytic arteritis; a clinical pathologic study. Lab Invest. 1976, 35: 23-29.PubMed
15.
go back to reference Nagashima Y, Taki A, Misugi K, et al.: Segmental mediolytic arteritis: a case report with review of the literature. Pathol Res Pract. 1998, 194: 643-647. 10.1016/S0344-0338(98)80101-5.CrossRefPubMed Nagashima Y, Taki A, Misugi K, et al.: Segmental mediolytic arteritis: a case report with review of the literature. Pathol Res Pract. 1998, 194: 643-647. 10.1016/S0344-0338(98)80101-5.CrossRefPubMed
16.
go back to reference Chan RJ, Goodman TA, Thomas A, Aretz TH, Lie JT: Segmental mediolytic arteriopathy of the splenic and hepatic arteries mimicking systemic necrotizing vasculitis. Arthritis Rheum. 1998, 41: 935-938. 10.1002/1529-0131(199805)41:5<935::AID-ART22>3.0.CO;2-N.CrossRefPubMed Chan RJ, Goodman TA, Thomas A, Aretz TH, Lie JT: Segmental mediolytic arteriopathy of the splenic and hepatic arteries mimicking systemic necrotizing vasculitis. Arthritis Rheum. 1998, 41: 935-938. 10.1002/1529-0131(199805)41:5<935::AID-ART22>3.0.CO;2-N.CrossRefPubMed
17.
go back to reference Inayama Y, Kitamura H, Tobe M, Kanisawa M: Segmental mediolytic arthritis; clinicopathologic study and three – dimensional analysis. Acta Pathol Jpn. 1992, 42: 201-209.PubMed Inayama Y, Kitamura H, Tobe M, Kanisawa M: Segmental mediolytic arthritis; clinicopathologic study and three – dimensional analysis. Acta Pathol Jpn. 1992, 42: 201-209.PubMed
18.
go back to reference Junoven T, Niemela O, Reinila A, Nissinen J, Kairaluoma MI: Spontaneous intraabdominal haemorrhage caused by segmental mediolytic arteritis in a patient with systemic lupus erythematosus: an underestimated entity of autoimmune origin?. Eur J Vasc Surg. 1994, 8: 96-100. 10.1016/S0950-821X(05)80128-8.CrossRef Junoven T, Niemela O, Reinila A, Nissinen J, Kairaluoma MI: Spontaneous intraabdominal haemorrhage caused by segmental mediolytic arteritis in a patient with systemic lupus erythematosus: an underestimated entity of autoimmune origin?. Eur J Vasc Surg. 1994, 8: 96-100. 10.1016/S0950-821X(05)80128-8.CrossRef
19.
go back to reference Kato T, Yamada Y, Akiyama M, et al.: Ruptured inferior mesenteric artery aneurysm due to segmental mediolytic arteritis. Cardiovasc Surg. 1996, 4: 644-646. 10.1016/0967-2109(95)00145-X.CrossRefPubMed Kato T, Yamada Y, Akiyama M, et al.: Ruptured inferior mesenteric artery aneurysm due to segmental mediolytic arteritis. Cardiovasc Surg. 1996, 4: 644-646. 10.1016/0967-2109(95)00145-X.CrossRefPubMed
20.
go back to reference Baker-LePain JC, Stone DH, Mattis AN, Nakamura MC, Fye KH: Clinical diagnosis of segmental arterial mediolysis: differentiation from vasculitis and other mimics. Arthritis Care Res (Hoboken). 2010, 62 (11): 1655-1660. 10.1002/acr.20294. doi:10.1002/acr.20294. Epub 2010 Jul 26CrossRef Baker-LePain JC, Stone DH, Mattis AN, Nakamura MC, Fye KH: Clinical diagnosis of segmental arterial mediolysis: differentiation from vasculitis and other mimics. Arthritis Care Res (Hoboken). 2010, 62 (11): 1655-1660. 10.1002/acr.20294. doi:10.1002/acr.20294. Epub 2010 Jul 26CrossRef
21.
go back to reference Gahide G, Servant S, Giroux MF: Vanishing renal artery disease: a segmental arterial mediolysis story. Kidney Int. 2011, 80 (9): 1002-10.1038/ki.2011.279. doi:10.1038/ki.2011.279CrossRefPubMed Gahide G, Servant S, Giroux MF: Vanishing renal artery disease: a segmental arterial mediolysis story. Kidney Int. 2011, 80 (9): 1002-10.1038/ki.2011.279. doi:10.1038/ki.2011.279CrossRefPubMed
22.
go back to reference Lie JT: Segmental mediolytic arteritis. Not an arteritis but a variant of arterial fibromuscular dysplasia. Arch Pathol Lab Med. 1992, 116 (3): 238-241.PubMed Lie JT: Segmental mediolytic arteritis. Not an arteritis but a variant of arterial fibromuscular dysplasia. Arch Pathol Lab Med. 1992, 116 (3): 238-241.PubMed
23.
go back to reference Yamada M, Ohno M, Itagaki T, Takaba T, Matsuyama T: Coexistence of cystic medial necrosis and segmental arterial mediolysis in a patient with aneurysms of the abdominal aorta and the iliac artery. J Vasc Surg. 2004, 39 (1): 246-249. 10.1016/j.jvs.2003.07.022.CrossRefPubMed Yamada M, Ohno M, Itagaki T, Takaba T, Matsuyama T: Coexistence of cystic medial necrosis and segmental arterial mediolysis in a patient with aneurysms of the abdominal aorta and the iliac artery. J Vasc Surg. 2004, 39 (1): 246-249. 10.1016/j.jvs.2003.07.022.CrossRefPubMed
Metadata
Title
Segmental arterial mediolysis of left gastric artery: a case report and review of pathology
Authors
Azra Tabassum
Sanaz Sasani
Adeeb J Majid
Christopher Henderson
Neil D Merrett
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Clinical Pathology / Issue 1/2013
Electronic ISSN: 1472-6890
DOI
https://doi.org/10.1186/1472-6890-13-26

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