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BMC Complementary Medicine and Therapies

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Open Access 01-12-2012 | Research article

Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain

Authors: Fariba Karimzadeh, Mahmoud Hosseini, Diana Mangeng, Hassan Alavi, Gholam Reza Hassanzadeh, Mohamad Bayat, Maryam Jafarian, Hadi Kazemi, Ali Gorji

Published in: BMC Complementary Medicine and Therapies | Issue 1/2012

Abstract

Background

Essential oil of Pimpinella anisum L. Apiaceae (anise oil) has been widely used in traditional Persian medicine to treat a variety of diseases, including some neurological disorders. This study was aimed to test the possible anti-seizure and anti-hypoxia effects of anise oil.

Methods

The effects of different concentrations of anise oil were tested on seizure attacks induced by pentylenetetrazol (PTZ) injection and neuronal hypoxia induced by oxygen withdrawal as well as on production of dark neurons and induction of long-term potentiation (LTP) in in vivo and in vitro experimental models of rat brain.

Results

Anise oil significantly prolonged the latency of seizure attacks and reduced the amplitude and duration of epileptiform burst discharges induced by injection of intraperitoneal PTZ. In addition, anise oil significantly inhibited production of dark neurons in different regions of the brain in epileptic rats. Anise oil also significantly enhanced the duration of the appearance of anoxic terminal negativity induced by oxygen withdrawal and inhibited induction of LTP in hippocampal slices.

Conclusions

Our data indicate the anticonvulsant and neuroprotective effects of anise oil, likely via inhibition of synaptic plasticity. Further evaluation of anise oil to use in the treatment of neurological disorders is suggested.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/12/76/prepub

Title: Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain
Authors: Fariba Karimzadeh
Mahmoud Hosseini
Diana Mangeng
Hassan Alavi
Gholam Reza Hassanzadeh
Mohamad Bayat
Maryam Jafarian
Hadi Kazemi
Ali Gorji
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: BMC Complementary Medicine and Therapies / Issue 1/2012
Electronic ISSN: 2662-7671
DOI: https://doi.org/10.1186/1472-6882-12-76

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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