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BMC Women's Health
Published in: BMC Women's Health 1/2012

Open Access 01-12-2012 | Research article

Hypovitaminosis D and prevalent asymptomatic vertebral fractures in Moroccan postmenopausal women

Authors: Abdellah El Maghraoui, Zhor Ouzzif, Aziza Mounach, Asmaa Rezqi, Lahsen Achemlal, Ahmed Bezza, Saida Tellal, Mohamed Dehhaoui, Imad Ghozlani

Published in: BMC Women's Health | Issue 1/2012

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Abstract

Background

Hypovitaminosis D is associated to accentuated bone loss. However, association between osteoporotic vertebral fractures (VFs) and vitamin D status has not been clearly established.

Objective

To determine serum vitamin D status and to assess the association of vitamin D status with bone mineral density (BMD) and asymptomatic VFs prevalence using vertebral fracture assessment (VFA) in a cohort of Moroccan menopausal women.

Methods

from June to September 2010, 178 menopausal women 50 years old and over were enrolled in this cross-sectional study. The mean ± SD (range) age, weight, height and BMI were 58.8 ± 8.2 (50 to 79) years, 73.2 ± 13.8 (35 to 119) Kgs, 1.56 ± 0.06 (1.43 – 1.79) m and 29.8 ± 5.9 (17.5 – 49.8) kg/m2, respectively. VFA images and scans of the lumbar spine and proximal femur were obtained using a GE Healthcare Lunar Prodigy densitometer. VFs were defined using a combination of Genant semiquantitative approach and morphometry. Serum levels of 25-hydroxyvitamin D (25(OH)D) were measured.

Results

Among the 178 women, 45 (25.2%) had densitometric osteoporosis, and on VFA, VFs (grade 2 or 3) were detected in 20.2% while grade 1 were identified in 33.1%. The mean values of serum levels of 25(OH)D were 15.8 ± 11.6 ng/ml (range: 3.0 – 49.1) with 152 patients (85.3%) having levels <30 ng/ml (insufficiency) and 92 (51.6%) <10 ng/ml (deficiency). Stepwise regression analysis showed that presence of VFs was independently related to age, 25(OH)D and densitometric osteoporosis.

Conclusion

our study shows that advanced age, hypovitaminosis D and osteoporosis are independent risk factors for asymptomatic VFs in Moroccan postmenopausal women.
Appendix
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Metadata
Title
Hypovitaminosis D and prevalent asymptomatic vertebral fractures in Moroccan postmenopausal women
Authors
Abdellah El Maghraoui
Zhor Ouzzif
Aziza Mounach
Asmaa Rezqi
Lahsen Achemlal
Ahmed Bezza
Saida Tellal
Mohamed Dehhaoui
Imad Ghozlani
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Women's Health / Issue 1/2012
Electronic ISSN: 1472-6874
DOI
https://doi.org/10.1186/1472-6874-12-11

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