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Open Access 01-12-2015 | Case report

Salvage surgery after chemotherapy with S-1 plus cisplatin for α-fetoprotein-producing gastric cancer with a portal vein tumor thrombus: a case report

Authors: Shigetomi Nakao, Bunzo Nakata, Masashige Tendo, Kenji Kuroda, Takeshi Hori, Mayumi Inaba, Kosei Hirakawa, Tetsuro Ishikawa

Published in: BMC Surgery | Issue 1/2015

Abstract

Background

Patient with α-Fetoprotein (AFP)-producing gastric cancer usually has a short survival time due to frequent hepatic and lymph node metastases. Gastric cancer with portal vein tumor thrombus (PVTT) is rare and has an extremely poor prognosis.

Case presentation

A 63-year-old man was found to have a huge Type 3 gastric cancer with a PVTT and a highly elevated serum AFP level. Chemotherapy with S-1 plus cisplatin was given to this patient with unresectable gastric cancer for 4 months. The serum AFP level decreased from 6,160 ng/mL to 60.7 ng/mL with chemotherapy. Since the PVTT disappeared after the chemotherapy, the patient underwent total gastrectomy. Histological findings of the primary tumor after chemotherapy showed poorly differentiated adenocarcinoma without hepatoid cells and viable tumor cells remaining in less than 1/3 of the neoplastic area of mucosa and one lymph node. The cancerous cells were immunohistochemically stained by anti-AFP antibody. The patient has survived for 48 month without recurrence.

Conclusions

AFP-producing gastric cancer with a PVTT has an extremely poor prognosis, but long-term survival was achieved for this dismal condition by salvage surgery after chemotherapy.

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The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2482/15/5/prepub

Title: Salvage surgery after chemotherapy with S-1 plus cisplatin for α-fetoprotein-producing gastric cancer with a portal vein tumor thrombus: a case report
Authors: Shigetomi Nakao
Bunzo Nakata
Masashige Tendo
Kenji Kuroda
Takeshi Hori
Mayumi Inaba
Kosei Hirakawa
Tetsuro Ishikawa
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Surgery / Issue 1/2015
Electronic ISSN: 1471-2482
DOI: https://doi.org/10.1186/1471-2482-15-5

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Springer Medicine

Salvage surgery after chemotherapy with S-1 plus cisplatin for α-fetoprotein-producing gastric cancer with a portal vein tumor thrombus: a case report

Abstract

Background

Case presentation

Conclusions

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Springer Medicine

Abstract

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