Skip to main content
Top
Published in: BMC Musculoskeletal Disorders 1/2014

Open Access 01-12-2014 | Research article

Mono- versus polyaxial locking plates in distal femur fractures – a biomechanical comparison of the Non-Contact-Bridging- (NCB) and the PERILOC-plate

Authors: Bilal Farouk El-Zayat, Turgay Efe, Steffen Ruchholtz, Salim Khatib, Nina Timmesfeld, Antonio Krüger, Ralph Zettl

Published in: BMC Musculoskeletal Disorders | Issue 1/2014

Login to get access

Abstract

Background

The aim of this cadaveric study was to compare a polyaxial (NCB®, Zimmer) to a fixed-angle monoaxial locking plate (PERILOC®, Smith & Nephew) in comminuted fractures of the distal femur regarding stability of the construct. Up to date there is no published biomechanical data concerning polyaxial plating in cadaveric distal femurs.

Methods

Fourteen formalin fixed femora were scanned by dual-energy x-ray absorptiometry. As fracture model an unstable supracondylar comminuted fracture was simulated. Fractures were pairwise randomly fixed either with a mono- (group A) or a polyaxial (group B) distal femur plate. The samples were tested in a servohydraulic mechanical testing system starting with an axial loading of 200 N following an increase of 200 N in every step with 500 cycles in every sequence up to a maximum of 2 000 N. The end points were implant failure or relevant loss of reduction. Data records included for each specimen time, number of cycles, axial load and axial displacement. Statistical analysis was performed using the exact Wilcoxon signed rank test.

Results

The mean donor age at the time of death was 75 years. The bone mass density (BMD) of the femurs in both groups was comparable and showed no statistically significant differences. Five bones failed before reaching the maximum applied force of 2000 N. Distribution curves of all samples in both groups, showing the plastic deformation in relation to the axial force, showed no statistically significant differences.

Conclusions

Operative stabilization of distal femur fractures can be successfully and equally well achieved using either a monoaxial or a polyaxial locking plate. Polyaxial screw fixation may have advantages if intramedullary implants are present.
Appendix
Available only for authorised users
Literature
1.
go back to reference Perren SM: Evolution of the internal fixation of long bone fractures. The scientific basis of biological internal fixation: choosing a new balance between stability and biology. J Bone Joint Surg Br. 2002, 84 (8): 1093-1110. 10.1302/0301-620X.84B8.13752.CrossRefPubMed Perren SM: Evolution of the internal fixation of long bone fractures. The scientific basis of biological internal fixation: choosing a new balance between stability and biology. J Bone Joint Surg Br. 2002, 84 (8): 1093-1110. 10.1302/0301-620X.84B8.13752.CrossRefPubMed
2.
go back to reference Lindahl H: Epidemiology of periprosthetic femur fracture around a total hip arthroplasty. Injury. 2007, 38 (6): 651-654. 10.1016/j.injury.2007.02.048.CrossRefPubMed Lindahl H: Epidemiology of periprosthetic femur fracture around a total hip arthroplasty. Injury. 2007, 38 (6): 651-654. 10.1016/j.injury.2007.02.048.CrossRefPubMed
3.
go back to reference Schandelmaier P, Gossling T, Partenheimer A, Krettek C: [Distal fractures of the femur]. Chirurg. 2002, 73 (12): 1221-1233. 10.1007/s00104-002-0583-5. quiz 1233-1224CrossRefPubMed Schandelmaier P, Gossling T, Partenheimer A, Krettek C: [Distal fractures of the femur]. Chirurg. 2002, 73 (12): 1221-1233. 10.1007/s00104-002-0583-5. quiz 1233-1224CrossRefPubMed
4.
go back to reference Smith TO, Hedges C, MacNair R, Schankat K, Wimhurst JA: The clinical and radiological outcomes of the LISS plate for distal femoral fractures: a systematic review. Injury. 2009, 40 (10): 1049-1063. 10.1016/j.injury.2009.01.005.CrossRefPubMed Smith TO, Hedges C, MacNair R, Schankat K, Wimhurst JA: The clinical and radiological outcomes of the LISS plate for distal femoral fractures: a systematic review. Injury. 2009, 40 (10): 1049-1063. 10.1016/j.injury.2009.01.005.CrossRefPubMed
5.
go back to reference Stover M: Distal femoral fractures: current treatment, results and problems. Injury. 2001, 32 (Suppl 3): SC3-SC13.CrossRefPubMed Stover M: Distal femoral fractures: current treatment, results and problems. Injury. 2001, 32 (Suppl 3): SC3-SC13.CrossRefPubMed
6.
go back to reference Butt MS, Krikler SJ, Ali MS: Displaced fractures of the distal femur in elderly patients. Operative versus non-operative treatment. J Bone Joint Surg Br. 1996, 78 (1): 110-114.PubMed Butt MS, Krikler SJ, Ali MS: Displaced fractures of the distal femur in elderly patients. Operative versus non-operative treatment. J Bone Joint Surg Br. 1996, 78 (1): 110-114.PubMed
7.
go back to reference Mont MA, Maar DC: Fractures of the ipsilateral femur after hip arthroplasty. A statistical analysis of outcome based on 487 patients. J Arthroplasty. 1994, 9 (5): 511-519. 10.1016/0883-5403(94)90098-1.CrossRefPubMed Mont MA, Maar DC: Fractures of the ipsilateral femur after hip arthroplasty. A statistical analysis of outcome based on 487 patients. J Arthroplasty. 1994, 9 (5): 511-519. 10.1016/0883-5403(94)90098-1.CrossRefPubMed
8.
go back to reference Buttaro MA, Farfalli G, Paredes Nunez M, Comba F, Piccaluga F: Locking compression plate fixation of Vancouver type-B1 periprosthetic femoral fractures. J Bone Joint Surg Am. 2007, 89 (9): 1964-1969. 10.2106/JBJS.F.01224.CrossRefPubMed Buttaro MA, Farfalli G, Paredes Nunez M, Comba F, Piccaluga F: Locking compression plate fixation of Vancouver type-B1 periprosthetic femoral fractures. J Bone Joint Surg Am. 2007, 89 (9): 1964-1969. 10.2106/JBJS.F.01224.CrossRefPubMed
9.
go back to reference Kobbe P, Klemm R, Reilmann H, Hockertz TJ: Less invasive stabilisation system (LISS) for the treatment of periprosthetic femoral fractures: a 3-year follow-up. Injury. 2008, 39 (4): 472-479. 10.1016/j.injury.2007.10.034.CrossRefPubMed Kobbe P, Klemm R, Reilmann H, Hockertz TJ: Less invasive stabilisation system (LISS) for the treatment of periprosthetic femoral fractures: a 3-year follow-up. Injury. 2008, 39 (4): 472-479. 10.1016/j.injury.2007.10.034.CrossRefPubMed
10.
go back to reference O'Toole RV, Gobezie R, Hwang R, Chandler AR, Smith RM, Estok DM, Vrahas MS: Low complication rate of LISS for femur fractures adjacent to stable hip or knee arthroplasty. Clin Orthop Relat Res. 2006, 450: 203-210.CrossRefPubMed O'Toole RV, Gobezie R, Hwang R, Chandler AR, Smith RM, Estok DM, Vrahas MS: Low complication rate of LISS for femur fractures adjacent to stable hip or knee arthroplasty. Clin Orthop Relat Res. 2006, 450: 203-210.CrossRefPubMed
11.
go back to reference Wick M, Muller EJ, Kutscha-Lissberg F, Hopf F, Muhr G: [Periprosthetic supracondylar femoral fractures: LISS or retrograde intramedullary nailing? Problems with the use of minimally invasive technique]. Unfallchirurg. 2004, 107 (3): 181-188. 10.1007/s00113-003-0723-5.CrossRefPubMed Wick M, Muller EJ, Kutscha-Lissberg F, Hopf F, Muhr G: [Periprosthetic supracondylar femoral fractures: LISS or retrograde intramedullary nailing? Problems with the use of minimally invasive technique]. Unfallchirurg. 2004, 107 (3): 181-188. 10.1007/s00113-003-0723-5.CrossRefPubMed
12.
go back to reference Ruchholtz S, El-Zayat B, Kreslo D, Bucking B, Lewan U, Kruger A, Zettl R: Less invasive polyaxial locking plate fixation in periprosthetic and peri-implant fractures of the femur–a prospective study of 41 patients. Injury. 2013, 44 (2): 239-248. 10.1016/j.injury.2012.10.035.CrossRefPubMed Ruchholtz S, El-Zayat B, Kreslo D, Bucking B, Lewan U, Kruger A, Zettl R: Less invasive polyaxial locking plate fixation in periprosthetic and peri-implant fractures of the femur–a prospective study of 41 patients. Injury. 2013, 44 (2): 239-248. 10.1016/j.injury.2012.10.035.CrossRefPubMed
13.
go back to reference Kregor PJ, Stannard J, Zlowodzki M, Cole PA, Alonso J: Distal femoral fracture fixation utilizing the Less Invasive Stabilization System (L.I.S.S.): the technique and early results. Injury. 2001, 32 Suppl 3: SC32-SC47.CrossRefPubMed Kregor PJ, Stannard J, Zlowodzki M, Cole PA, Alonso J: Distal femoral fracture fixation utilizing the Less Invasive Stabilization System (L.I.S.S.): the technique and early results. Injury. 2001, 32 Suppl 3: SC32-SC47.CrossRefPubMed
14.
go back to reference Chakravarthy J, Bansal R, Cooper J: Locking plate osteosynthesis for Vancouver Type B1 and Type C periprosthetic fractures of femur: a report on 12 patients. Injury. 2007, 38 (6): 725-733. 10.1016/j.injury.2007.02.038.CrossRefPubMed Chakravarthy J, Bansal R, Cooper J: Locking plate osteosynthesis for Vancouver Type B1 and Type C periprosthetic fractures of femur: a report on 12 patients. Injury. 2007, 38 (6): 725-733. 10.1016/j.injury.2007.02.038.CrossRefPubMed
15.
go back to reference Hanschen M, Aschenbrenner IM, Fehske K, Kirchhoff S, Keil L, Holzapfel BM, Winkler S, Fuechtmeier B, Neugebauer R, Luehrs S, Liener U, Biberthaler P: Mono- versus polyaxial locking plates in distal femur fractures: a prospective randomized multicentre clinical trial. Int Orthop. 2014, 38 (4): 857-863. 10.1007/s00264-013-2210-0.CrossRefPubMed Hanschen M, Aschenbrenner IM, Fehske K, Kirchhoff S, Keil L, Holzapfel BM, Winkler S, Fuechtmeier B, Neugebauer R, Luehrs S, Liener U, Biberthaler P: Mono- versus polyaxial locking plates in distal femur fractures: a prospective randomized multicentre clinical trial. Int Orthop. 2014, 38 (4): 857-863. 10.1007/s00264-013-2210-0.CrossRefPubMed
16.
go back to reference El-Zayat BF, Zettl R, Efe T, Kruger A, Eisenberg F, Ruchholtz S: [Minimally invasive treatment of geriatric and osteoporotic femur fractures with polyaxial locking implants (NCB-DF (R)).]. Unfallchirurg. 2012, 115 (2): 134-144. 10.1007/s00113-010-1871-z.CrossRefPubMed El-Zayat BF, Zettl R, Efe T, Kruger A, Eisenberg F, Ruchholtz S: [Minimally invasive treatment of geriatric and osteoporotic femur fractures with polyaxial locking implants (NCB-DF (R)).]. Unfallchirurg. 2012, 115 (2): 134-144. 10.1007/s00113-010-1871-z.CrossRefPubMed
17.
go back to reference Erhardt JB, Grob K, Roderer G, Hoffmann A, Forster TN, Kuster MS: Treatment of periprosthetic femur fractures with the non-contact bridging plate: a new angular stable implant. Arch Orthop Trauma Surg. 2008, 128 (4): 409-416. 10.1007/s00402-007-0396-6.CrossRefPubMed Erhardt JB, Grob K, Roderer G, Hoffmann A, Forster TN, Kuster MS: Treatment of periprosthetic femur fractures with the non-contact bridging plate: a new angular stable implant. Arch Orthop Trauma Surg. 2008, 128 (4): 409-416. 10.1007/s00402-007-0396-6.CrossRefPubMed
18.
go back to reference Roderer G, Gebhard F, Erhardt J, Al-Agha S, AbouElsoud M, Kinzl L: [The Non-Contact Bridging Plate. A new fixed-angle device for the minimally-invasive treatment of fractures of the proximal humerus--technique and preliminary results]. Unfallchirurg. 2007, 110 (6): 505-512.CrossRefPubMed Roderer G, Gebhard F, Erhardt J, Al-Agha S, AbouElsoud M, Kinzl L: [The Non-Contact Bridging Plate. A new fixed-angle device for the minimally-invasive treatment of fractures of the proximal humerus--technique and preliminary results]. Unfallchirurg. 2007, 110 (6): 505-512.CrossRefPubMed
19.
go back to reference Heiney JP, Barnett MD, Vrabec GA, Schoenfeld AJ, Baji A, Njus GO: Distal femoral fixation: a biomechanical comparison of trigen retrograde intramedullary (i.m.) nail, dynamic condylar screw (DCS), and locking compression plate (LCP) condylar plate. J Trauma. 2009, 66 (2): 443-449. 10.1097/TA.0b013e31815edeb8.CrossRefPubMed Heiney JP, Barnett MD, Vrabec GA, Schoenfeld AJ, Baji A, Njus GO: Distal femoral fixation: a biomechanical comparison of trigen retrograde intramedullary (i.m.) nail, dynamic condylar screw (DCS), and locking compression plate (LCP) condylar plate. J Trauma. 2009, 66 (2): 443-449. 10.1097/TA.0b013e31815edeb8.CrossRefPubMed
20.
go back to reference Zlowodzki M, Williamson S, Zardiackas LD, Kregor PJ: Biomechanical evaluation of the less invasive stabilization system and the 95-degree angled blade plate for the internal fixation of distal femur Fractures in human cadaveric bones with high bone mineral density. J Trauma. 2006, 60 (4): 836-840. 10.1097/01.ta.0000208129.10022.f8.CrossRefPubMed Zlowodzki M, Williamson S, Zardiackas LD, Kregor PJ: Biomechanical evaluation of the less invasive stabilization system and the 95-degree angled blade plate for the internal fixation of distal femur Fractures in human cadaveric bones with high bone mineral density. J Trauma. 2006, 60 (4): 836-840. 10.1097/01.ta.0000208129.10022.f8.CrossRefPubMed
21.
go back to reference Wilkens KJ, Curtiss S, Lee MA: Polyaxial locking plate fixation in distal femur fractures: a biomechanical comparison. J Orthop Trauma. 2008, 22 (9): 624-628. 10.1097/BOT.0b013e31818896b3.CrossRefPubMed Wilkens KJ, Curtiss S, Lee MA: Polyaxial locking plate fixation in distal femur fractures: a biomechanical comparison. J Orthop Trauma. 2008, 22 (9): 624-628. 10.1097/BOT.0b013e31818896b3.CrossRefPubMed
22.
go back to reference Ritter MA, Thong AE, Keating EM, Faris PM, Meding JB, Berend ME, Pierson JL, Davis KE: The effect of femoral notching during total knee arthroplasty on the prevalence of postoperative femoral fractures and on clinical outcome. J Bone Joint Surg Am. 2005, 87 (11): 2411-2414. 10.2106/JBJS.D.02468.CrossRefPubMed Ritter MA, Thong AE, Keating EM, Faris PM, Meding JB, Berend ME, Pierson JL, Davis KE: The effect of femoral notching during total knee arthroplasty on the prevalence of postoperative femoral fractures and on clinical outcome. J Bone Joint Surg Am. 2005, 87 (11): 2411-2414. 10.2106/JBJS.D.02468.CrossRefPubMed
23.
go back to reference Bong MR, Egol KA, Koval KJ, Kummer FJ, Su ET, Iesaka K, Bayer J, Di Cesare PE: Comparison of the LISS and a retrograde-inserted supracondylar intramedullary nail for fixation of a periprosthetic distal femur fracture proximal to a total knee arthroplasty. J Arthroplasty. 2002, 17 (7): 876-881. 10.1054/arth.2002.34817.CrossRefPubMed Bong MR, Egol KA, Koval KJ, Kummer FJ, Su ET, Iesaka K, Bayer J, Di Cesare PE: Comparison of the LISS and a retrograde-inserted supracondylar intramedullary nail for fixation of a periprosthetic distal femur fracture proximal to a total knee arthroplasty. J Arthroplasty. 2002, 17 (7): 876-881. 10.1054/arth.2002.34817.CrossRefPubMed
24.
go back to reference Zlowodzki M, Williamson S, Cole PA, Zardiackas LD, Kregor PJ: Biomechanical evaluation of the less invasive stabilization system, angled blade plate, and retrograde intramedullary nail for the internal fixation of distal femur fractures. J Orthop Trauma. 2004, 18 (8): 494-502. 10.1097/00005131-200409000-00004.CrossRefPubMed Zlowodzki M, Williamson S, Cole PA, Zardiackas LD, Kregor PJ: Biomechanical evaluation of the less invasive stabilization system, angled blade plate, and retrograde intramedullary nail for the internal fixation of distal femur fractures. J Orthop Trauma. 2004, 18 (8): 494-502. 10.1097/00005131-200409000-00004.CrossRefPubMed
25.
go back to reference Krettek C, Schandelmaier P, Richter M, Tscherne H: [Distal femoral fractures]. Swiss Surg. 1998, 6: 263-278.PubMed Krettek C, Schandelmaier P, Richter M, Tscherne H: [Distal femoral fractures]. Swiss Surg. 1998, 6: 263-278.PubMed
26.
go back to reference Wong MK, Leung F, Chow SP: Treatment of distal femoral fractures in the elderly using a less-invasive plating technique. Int Orthop. 2005, 29 (2): 117-120. 10.1007/s00264-004-0609-3.CrossRefPubMedPubMedCentral Wong MK, Leung F, Chow SP: Treatment of distal femoral fractures in the elderly using a less-invasive plating technique. Int Orthop. 2005, 29 (2): 117-120. 10.1007/s00264-004-0609-3.CrossRefPubMedPubMedCentral
27.
28.
go back to reference Stoffel K, Dieter U, Stachowiak G, Gachter A, Kuster MS: Biomechanical testing of the LCP–how can stability in locked internal fixators be controlled?. Injury. 2003, 34 (Suppl 2): B11-B19.CrossRefPubMed Stoffel K, Dieter U, Stachowiak G, Gachter A, Kuster MS: Biomechanical testing of the LCP–how can stability in locked internal fixators be controlled?. Injury. 2003, 34 (Suppl 2): B11-B19.CrossRefPubMed
29.
go back to reference Fulkerson E, Tejwani N, Stuchin S, Egol K: Management of periprosthetic femur fractures with a first generation locking plate. Injury. 2007, 38 (8): 965-972. 10.1016/j.injury.2007.02.026.CrossRefPubMed Fulkerson E, Tejwani N, Stuchin S, Egol K: Management of periprosthetic femur fractures with a first generation locking plate. Injury. 2007, 38 (8): 965-972. 10.1016/j.injury.2007.02.026.CrossRefPubMed
30.
go back to reference Ehlinger M, Adam P, Abane L, Rahme M, Moor BK, Arlettaz Y, Bonnomet F: Treatment of periprosthetic femoral fractures of the knee. Knee Surg Sports Traumatol Arthrosc. 2011, 19 (9): 1473-1478. 10.1007/s00167-011-1480-6.CrossRefPubMed Ehlinger M, Adam P, Abane L, Rahme M, Moor BK, Arlettaz Y, Bonnomet F: Treatment of periprosthetic femoral fractures of the knee. Knee Surg Sports Traumatol Arthrosc. 2011, 19 (9): 1473-1478. 10.1007/s00167-011-1480-6.CrossRefPubMed
31.
go back to reference Wood GC, Naudie DR, McAuley J, McCalden RW: Locking compression plates for the treatment of periprosthetic femoral fractures around well-fixed total hip and knee implants. J Arthroplasty. 2011, 26 (6): 886-892. 10.1016/j.arth.2010.07.002.CrossRefPubMed Wood GC, Naudie DR, McAuley J, McCalden RW: Locking compression plates for the treatment of periprosthetic femoral fractures around well-fixed total hip and knee implants. J Arthroplasty. 2011, 26 (6): 886-892. 10.1016/j.arth.2010.07.002.CrossRefPubMed
32.
go back to reference Otto RJ, Moed BR, Bledsoe JG: Biomechanical comparison of polyaxial-type locking plates and a fixed-angle locking plate for internal fixation of distal femur fractures. J Orthop Trauma. 2009, 23 (9): 645-652. 10.1097/BOT.0b013e3181a567c8.CrossRefPubMed Otto RJ, Moed BR, Bledsoe JG: Biomechanical comparison of polyaxial-type locking plates and a fixed-angle locking plate for internal fixation of distal femur fractures. J Orthop Trauma. 2009, 23 (9): 645-652. 10.1097/BOT.0b013e3181a567c8.CrossRefPubMed
33.
go back to reference Fulkerson E, Egol KA, Kubiak EN, Liporace F, Kummer FJ, Koval KJ: Fixation of diaphyseal fractures with a segmental defect: a biomechanical comparison of locked and conventional plating techniques. J Trauma. 2006, 60 (4): 830-835. 10.1097/01.ta.0000195462.53525.0c.CrossRefPubMed Fulkerson E, Egol KA, Kubiak EN, Liporace F, Kummer FJ, Koval KJ: Fixation of diaphyseal fractures with a segmental defect: a biomechanical comparison of locked and conventional plating techniques. J Trauma. 2006, 60 (4): 830-835. 10.1097/01.ta.0000195462.53525.0c.CrossRefPubMed
34.
go back to reference Konstantinidis L, Hauschild O, Beckmann NA, Hirschmuller A, Sudkamp NP, Helwig P: Treatment of periprosthetic femoral fractures with two different minimal invasive angle-stable plates: biomechanical comparison studies on cadaveric bones. Injury. 2010, 41 (12): 1256-1261. 10.1016/j.injury.2010.05.007.CrossRefPubMed Konstantinidis L, Hauschild O, Beckmann NA, Hirschmuller A, Sudkamp NP, Helwig P: Treatment of periprosthetic femoral fractures with two different minimal invasive angle-stable plates: biomechanical comparison studies on cadaveric bones. Injury. 2010, 41 (12): 1256-1261. 10.1016/j.injury.2010.05.007.CrossRefPubMed
35.
go back to reference Wahnert D, Schroder R, Schulze M, Westerhoff P, Raschke M, Stange R: Biomechanical comparison of two angular stable plate constructions for periprosthetic femur fracture fixation. Int Orthop. 2014, 38 (1): 47-53. 10.1007/s00264-013-2113-0.CrossRefPubMed Wahnert D, Schroder R, Schulze M, Westerhoff P, Raschke M, Stange R: Biomechanical comparison of two angular stable plate constructions for periprosthetic femur fracture fixation. Int Orthop. 2014, 38 (1): 47-53. 10.1007/s00264-013-2113-0.CrossRefPubMed
36.
go back to reference Topp T, Muller T, Huss S, Kann PH, Weihe E, Ruchholtz S, Zettl RP: Embalmed and fresh frozen human bones in orthopedic cadaveric studies: which bone is authentic and feasible?. Acta Orthop. 2012, 83 (5): 543-547. 10.3109/17453674.2012.727079.CrossRefPubMedPubMedCentral Topp T, Muller T, Huss S, Kann PH, Weihe E, Ruchholtz S, Zettl RP: Embalmed and fresh frozen human bones in orthopedic cadaveric studies: which bone is authentic and feasible?. Acta Orthop. 2012, 83 (5): 543-547. 10.3109/17453674.2012.727079.CrossRefPubMedPubMedCentral
37.
go back to reference Zdero R, Walker R, Waddell JP, Schemitsch EH: Biomechanical evaluation of periprosthetic femoral fracture fixation. J Bone Joint Surg Am. 2008, 90 (5): 1068-1077. 10.2106/JBJS.F.01561.CrossRefPubMed Zdero R, Walker R, Waddell JP, Schemitsch EH: Biomechanical evaluation of periprosthetic femoral fracture fixation. J Bone Joint Surg Am. 2008, 90 (5): 1068-1077. 10.2106/JBJS.F.01561.CrossRefPubMed
Metadata
Title
Mono- versus polyaxial locking plates in distal femur fractures – a biomechanical comparison of the Non-Contact-Bridging- (NCB) and the PERILOC-plate
Authors
Bilal Farouk El-Zayat
Turgay Efe
Steffen Ruchholtz
Salim Khatib
Nina Timmesfeld
Antonio Krüger
Ralph Zettl
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2014
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/1471-2474-15-369

Other articles of this Issue 1/2014

BMC Musculoskeletal Disorders 1/2014 Go to the issue