Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2014

Open Access 01-12-2014 | Research article

Population prevalence of ultrasound features of osteoarthritis in the hand, knee and hip at age 63 years: the Newcastle thousand families birth cohort

Authors: Ajay M Abraham, Mark S Pearce, Kay D Mann, Roger M Francis, Fraser Birrell

Published in: BMC Musculoskeletal Disorders | Issue 1/2014

Login to get access

Abstract

Background

Musculoskeletal ultrasound has been found to be more sensitive than radiographs in detecting osteophytes. Our objective was to measure the prevalence of features of osteoarthritis (OA), in the dominant hand, knees and hips using ultrasound, within the Newcastle Thousand Families birth cohort.

Methods

Participants were aged 61–63 (mean 63) years. Knee images were scored for presence of osteophytes and effusion. Hip images were scored for the presence of osteophytes and femoral head abnormality. The first carpometacarpal joint, metacarpophalangeal, proximal interphalangeal and distal interphalangeal joints of the index finger (dominant hand) were imaged for osteophytes.

Results

Among 311 participants, prevalence of osteophytes at the distal interphalangeal joint was 70% while it was 23%, 10% and 41% for index proximal interphalangeal and metacarpophalangeal and thumb base carpometacarpal joints respectively. Prevalence of knee osteophytes was 30%, hip OA was 41%. Prevalence of knee effusions was 24% (right) and 20% (left). Ultrasound evidence of generalised OA (48%) and isolated hand OA (31%) was common, compared to isolated hip or knee OA (5%) and both hip and knee OA (3%).

Conclusion

This is the first study to assess prevalence of ultrasound features of OA in a population-based sample. The higher prevalence of hand/hip OA, when compared to previous radiographic studies, supports the hypothesis that ultrasound is more sensitive than radiography in detecting OA, particularly for osteophytes.
Appendix
Available only for authorised users
Literature
1.
Lawrence RC, Felson DT, Helmick CG: Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: part 2. Arthritis Rheum. 2008, 58: 26-35. 10.1002/art.23176.CrossRefPubMedPubMedCentral
2.
O’Reilly SC, Muir KR, Doherty M: Screening for pain in knee osteoarthritis: which question?. Ann Rheum Dis. 1996, 55: 931-933. 10.1136/ard.55.12.931.CrossRefPubMedPubMedCentral
3.
Bitton R: The economic burden of osteoarthritis. Am J Manag Care. 2009, 15: S230-S235.PubMed
4.
Moskowitz RW: The burden of osteoarthritis: clinical and quality-of-life issues. Am J Manag Care. 2009, 15: S223-S229.PubMed
5.
6.
Poole J, Sayer AA, Hardy R, Wadsworth M, Kuh D, Cooper C: Patterns of interphalangeal hand joint involvement of osteoarthritis among men and women: a British cohort study. Arthritis Rheum. 2003, 48: 3371-3376. 10.1002/art.11339.CrossRefPubMed
7.
Egger P, Cooper C, Hart DJ, Doyle DV, Coggon D, Spector TD: Patterns of joint involvement in osteoarthritis of the hand: the Chingford study. J Rheumatol. 1995, 22: 1509-1513.PubMed
8.
Hunter DJ, Zhang Y, Nevitt MC, Xu L, Niu J, Lui L-Y, Yu W, Aliabadi P, Felson DT: Chopstick arthropathy: the Beijing Osteoarthritis study. Arthritis Rheum. 2004, 50: 1495-1500. 10.1002/art.20145.CrossRefPubMed
9.
Wilder FV, Barrett JP, Farina EJ: Joint-specific prevalence of osteoarthritis of the hand. Osteoarthritis Cartilage. 2006, 14: 953-957. 10.1016/j.joca.2006.04.013.CrossRefPubMed
10.
Neame R, Zhang W, Deighton C, Doherty M, Doherty S, Lanyon P, Wright G: Distribution of radiographic osteoarthritis between the right and left hands, hips, and knees. Arthritis Rheum. 2004, 50: 1487-1494. 10.1002/art.20162.CrossRefPubMed
11.
Felson DT, Naimark A, Anderson JJ, Kazis L, Castelli W, Meenan RF: The prevalence of knee osteoarthritis in the elderly: the Framingham osteoarthritis study. Arthritis Rheum. 1987, 30: 914-918. 10.1002/art.1780300811.CrossRefPubMed
12.
Jordan JM, Helmick CG, Renner JB, Luta G, Dragomir AD, Woodard J, Fang F, Schwartz TA, Abbate LM, Callahan LF, Kalsbeek WD, Hochberg MC: Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston county osteoarthritis project. J Rheumatol. 2007, 34: 172-180.PubMed
13.
Dillon CF, Rasch EK, Gu Q, Hirsch R: Prevalence of knee osteoarthritis in the United States: arthritis data from the third national health and nutrition examination survey 1991–94. J Rheumatol. 2006, 33: 2271-2279.PubMed
14.
Van Saase JLCM, Romunde LKJV, Cats A, Vandenbroucke JP, Valkenburg HA: Epidemiology of osteoarthritis: Zoetermeer survey. Comparison of radiological osteoarthritis in a Dutch population with that in 10 other populations. Ann Rheum Dis. 1989, 48: 271-280. 10.1136/ard.48.4.271.CrossRefPubMedPubMedCentral
15.
Odding E, Valkenburg HA, Algra D, Vandenouweland FA, Grobbee DE, Hofman A: Associations of radiological osteoarthritis of the hip and knee with locomotor disability in the Rotterdam study. Ann Rheum Dis. 1998, 57: 203-208. 10.1136/ard.57.4.203.CrossRefPubMedPubMedCentral
16.
Jordan JM, Helmick CG, Renner JB, Luta G, Dragomir AD, Woodard J, Fang F, Schwartz TA, Nelson AE, Abbate LM, Callahan LF, Kalsbeek WD, Hochberg MC: Prevalence of hip symptoms and radiographic and symptomatic hip osteoarthritis in African-Americans and Caucasians: The Johnston County Osteoarthritis Project. J Rheumatol. 2009, 36: 809-815. 10.3899/jrheum.080677.CrossRefPubMedPubMedCentral
17.
Nevitt MC, Xu L, Zhang Y, Lui LY, Yu W, Lane NE, Qin M, Hochberg MC, Cummings SR, Felson DT: Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: the Beijing osteoarthritis study. Arthritis Rheum. 2002, 46: 1773-1779. 10.1002/art.10332.CrossRefPubMed
18.
Spector TD, Hochberg MC: Methodological problems in the epidemiological study of osteoarthritis. Ann Rheum Dis. 1994, 53: 143-146. 10.1136/ard.53.2.143.CrossRefPubMedPubMedCentral
19.
Hart DJ, Spector TD, Egger P, Coggon D, Cooper C: Defining osteoarthritis of the hand for epidemiological studies: the Chingford study. Ann Rheum Dis. 1994, 53: 220-223. 10.1136/ard.53.4.220.CrossRefPubMedPubMedCentral
20.
Spector TD, Hart DJ, Byrne J, Harris PA, Dacre JE, Doyle DV: Definition of osteoarthritis of the knee for epidemiological studies. Ann Rheum Dis. 1993, 52: 790-794. 10.1136/ard.52.11.790.CrossRefPubMedPubMedCentral
21.
Guermazi A, Eckstein F, Hellio Le Graverand-Gastineau M, Conaghan P, Burstein D, Keen H, Roemer F: Osteoarthritis: current role of imaging. Med Clin N Am. 2009, 93: 101-126. 10.1016/j.mcna.2008.08.003.CrossRefPubMed
22.
Möller I, Bong D, Naredo E, Filippucci E, Carrasco I, Moragues C, Iagnocco A: Ultrasound in the study and monitoring of osteoarthritis. Osteoarthritis Cartilage. 2008, 16 (Suppl 3): S4-7.CrossRefPubMed
23.
Meenagh G, Filippucci E, Iagnocco A, Delle Sedie A, Riente L, Bombardieri S, Valesini G, Grassi W: Ultrasound imaging for the rheumatologist VIII: ultrasound imaging in osteoarthritis. Clin Exp Rheumatol. 2007, 25: 172-175.PubMed
24.
Keen HI, Conaghan PG: Ultrasonography in osteoarthritis. Radiology Clinics of North America. 2009, 47: 581-594. 10.1016/j.rcl.2009.04.007.CrossRef
25.
Ayral X, Pickering EH, Woodworth TG, Mackillop N, Dougados M: Synovitis: a potential predictor of structural progression of medial tibiofemoral knee osteoarthritis - results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage. 2005, 13: 361-367. 10.1016/j.joca.2005.01.005.CrossRefPubMed
26.
Keen HI, Wakefield RJ, Grainger AJ, Hensor EM, Emery P, Conaghan PG: Can ultrasonography improve on radiographic assessment in osteoarthritis of the hands? a comparison between radiographic and ultrasonographic detected pathology. Ann Rheum Dis. 2008, 67: 1116-1120. 10.1136/ard.2007.079483.CrossRefPubMed
27.
Abraham AM, Goff I, Pearce MS, Francis RM, Birrell F: Reliability and validity of ultrasound imaging of features of knee osteoarthritis in the community. BMC Musculoskelet Disord. 2011, 12: 70-10.1186/1471-2474-12-70.CrossRefPubMedPubMedCentral
28.
Pearce MS, Unwin NC, Parker L, Craft AW: Cohort profile: the Newcastle thousand families study. Int J Epidemiol. 2009, 38: 932-937. 10.1093/ije/dyn184.CrossRefPubMed
29.
Backhaus M, Burmester G-R, Gerber T, Grassi W, Machold KP, Swen WA, Wakefield RJ, Manger B: Guidelines for musculoskeletal ultrasound in rheumatology. Ann Rheum Dis. 2001, 60: 641-649. 10.1136/ard.60.7.641.CrossRefPubMedPubMedCentral
30.
Wakefield RJ, Balint PV, Szkudlarek M, Filippucci E, Backhaus M, D’Agostino MA, Sanchez EN, Iagnocco A, Schmidt WA, Bruyn GA, Kane D, O’Connor PJ, Manger B, Joshua F, Koski J, Grassi W, Lassere MN, Swen N, Kainberger F, Klauser A, Ostergaard M, Brown AK, Machold KP, Conaghan PG: Musculoskeletal ultrasound including definitions for ultrasonographic pathology. J Rheumatol. 2005, 32: 2485-2487.PubMed
31.
Iagnocco A, Perricone C, Scirocco C, Ceccarelli F, Modesti M, Gattamelata A, Vavala C, Rutigliano IM, Musetescu A, Valesini G: The interobserver reliability of ultrasound in knee osteoarthritis. Rheumatol. 2012, 51: 2013-2019. 10.1093/rheumatology/kes161.CrossRef
32.
Mathiessen A, Haugen IK, Slatkowsky-Christensen B, Bøyesen P, Kvien TK, Hammer HB: Ultrasonographic assessment of osteophytes in 127 patients with hand osteoarthritis: exploring reliability and associations with MRI, radiographs and clinical joint findings. Ann Rheum Dis. 2013, 72: 51-56. 10.1136/annrheumdis-2011-201195.CrossRefPubMed
33.
Naredo E, Cabero F, Palop MJ, Collado P, Cruz A, Crespo M: Ultrasonographic findings in knee osteoarthritis: a comparative study with clinical and radiographic assessment. Osteoarthritis Cartilage. 2005, 13: 568-74. 10.1016/j.joca.2005.02.008.CrossRefPubMed
34.
D’Agostino MA, Conaghan P, Le Bars M, Baron G, Grassi W, Martin-Mola E, Wakefield R, Brasseur JL, So A, Backhaus M, Malaise M, Burmester G, Schmidely N, Ravaud P, Dougados M, Emery P: EULAR report on the use of ultrasonography in painful knee osteoarthritis: part 1: prevalence of inflammation in osteoarthritis. Ann Rheum Dis. 2005, 64: 1703-1709. 10.1136/ard.2005.037994.CrossRefPubMedPubMedCentral
35.
Keen HI, Lavie F, Wakefield RJ, D’Agostino MA, Hammer HB, Hensor E, Pendleton A, Kane D, Guerini H, Schueller-Weidekamm C, Kortekaas MC, Birrel F, Kloppenburg M, Stamm T, Watt I, Smolen JS, Maheu E, Dougados M, Conaghan PG: The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis. Ann Rheum Dis. 2008, 67: 651-655.CrossRefPubMed
36.
Qvistgaard E, Torp-Pedersen S, Christensen R, Bliddal H: Reproducibility and inter-reader agreement of a scoring system for ultrasound evaluation of hip osteoarthritis. Ann Rheum Dis. 2006, 65: 1613-1619. 10.1136/ard.2005.050690.CrossRefPubMedPubMedCentral
37.
Tepper S, Hochberg MC: Factors associated with hip osteoarthritis: data from the first national health and nutrition examination survey (NHANES 1). Am J Epidemiol. 1993, 137: 1081-1088.PubMed
38.
Rossignol M, Leclerc A, Allaert FA, Rozenberg S, Valat JP, Avouac B, Coste P, Litvak E, Hilliquin P: Primary osteoarthritis of hip, knee, and hand in relation to occupational exposure. Occup Environ Med. 2005, 62: 772-777. 10.1136/oem.2005.020057.CrossRefPubMedPubMedCentral
39.
Chaisson CE, Zhang Y, Sharma L, Felson DT: Higher grip strength increases the risk of incident radiographic osteoarthritis in proximal hand joints. Osteoarthritis Cartilage. 2000, 8: S29-S32.CrossRefPubMed
40.
Spector TD, Nandra D, Hart DJ, Doyle DV: Is hormone replacement therapy protective for hand and knee osteoarthritis in women?. Ann Rheum Dis. 1997, 56: 432-434. 10.1136/ard.56.7.432.CrossRefPubMedPubMedCentral
41.
Carman WJ, Sowers M, Hawthorne VM, Weissfeld LA: Obesity as a risk factor for osteoarthritis of the hand and wrist: a prospective study. Am J Epidemiol. 1994, 139: 119-129.PubMed
42.
Cooper C, Egger P, Coggon D, Hart DJ, Masud T, Cicuttini F, Doyle DV, Spector TD: Generalised Osteoarthritis in Women: Pattern of joint involvement and Approaches to Definition for Epidemiological Studies. J Rheumatol. 1996, 23: 1938-1942.PubMed
43.
Felson DT: The epidemiology of knee osteoarthritis: results from the Framingham osteoarthritis study. Semin Arthritis Rheum. 1990, 20 (Suppl 1): 42-50.CrossRefPubMed
44.
Srikanth VK, Fryer JL, Zhai G, Winzenberg TM, Hosner D, Jones G: A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis. Osteoarthritis Cartilage. 2005, 13: 769-781. 10.1016/j.joca.2005.04.014.CrossRefPubMed
45.
Spector TD, Hart DJ, Nandra D, Doyle DV, Mackillop N, Gallimore JR, Pepys MB: Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum. 1997, 40: 723-727. 10.1002/art.1780400419.CrossRefPubMed
46.
Kerkhof HJ, Meulenbelt I, Akune T, Arden NK, Aromaa A, Bierma-Zeinstra SM, Carr A, Cooper C, Dai J, Doherty M, Doherty SA, Felson D, Gonzalez A, Gordon A, Harilainen A, Hart DJ, Hauksson VB, Heliovaara M, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Jonsdottir I, Kawaguchi H, Kloppenburg M, Kujala UM, Lane NE, Leino-Arjas P, Lohmander LS, et al: Recommendations for standardisation and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. Osteoarthritis Cartilage. 2011, 19: 254-264. 10.1016/j.joca.2010.10.027.CrossRefPubMed
Metadata
Title
Population prevalence of ultrasound features of osteoarthritis in the hand, knee and hip at age 63 years: the Newcastle thousand families birth cohort
Authors
Ajay M Abraham
Mark S Pearce
Kay D Mann
Roger M Francis
Fraser Birrell
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2014
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/1471-2474-15-162

Other articles of this Issue 1/2014

BMC Musculoskeletal Disorders 1/2014 Go to the issue

Research article

Association between joint hypermobility, scoliosis, and cranial base anomalies in paediatric Osteogenesis imperfecta patients: a retrospective cross-sectional study

Research article

Activity levels and participation in physical activities by Korean patients following total knee arthroplasty

Research article

The active form of MMP-3 is a marker of synovial inflammation and cartilage turnover in inflammatory joint diseases

Research article

Does Low-intensity pulsed ultrasound treatment repair articular cartilage injury? A rabbit model study

Research article

Design modifications of high-flexion TKA do not improve short term clinical and radiographic outcomes

Research article

Analyses of outcomes of one-stage operation for treatment of late-diagnosed developmental dislocation of the hip: 864 hips followed for 3.2 to 8.9 years