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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2014

Open Access 01-12-2014 | Research article

Vitamin D concentrations and disease activity in Moroccan children with juvenile idiopathic arthritis

Authors: Ilham Bouaddi, Samira Rostom, Dalal El Badri, Asmae Hassani, Bouchra Chkirate, Redoine Abouqal, Bouchra Amine, Najia Hajjaj-Hassouni

Published in: BMC Musculoskeletal Disorders | Issue 1/2014

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Abstract

Background

In addition to its important metabolic activities, vitamin D also contributes to the regulation of the immune system. The aim of this study was to assess the relationship between hypovitaminosis D and disease activity in Moroccan children with juvenile idiopathic arthritis (JIA).

Methods

In this cross-sectional study, forty children with JIA were included, all having been diagnosed according to the classification criteria of International League of Associations for Rheumatology (ILAR). The children underwent anthropometric assessment and clinical evaluation. Disease activity was measured using the Disease Activity Score in 28 joints (DAS28) for polyarticular and oligoarticular JIA and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) for enthesitis-related arthritis. Serum 25-hydroxyvitamin [25(OH)D] D2 and D3 were measured using radioimmunoassay (RIA). Hypovitaminosis D was defined as serum 25(OH)D <30 ng/ml.

Results

The average age of participants was 11 years ± 4.23. Hypovitaminosis D was observed in 75% of patients. In univariate analyses, 25(OH)D levels were negatively associated with DAS28 for polyarticular and oligoarticular JIA. No significant relationship was found between 25(OH)D levels and BASDAI for juvenile spondylarthropathy. In multivariate linear regression analysis, no association persisted between 25(OH)D levels and DAS28.

Conclusions

Our study suggested that serum levels of vitamin D were low in Moroccan children with JIA disease. Future studies with a larger population are needed to confirm our results.
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Metadata
Title
Vitamin D concentrations and disease activity in Moroccan children with juvenile idiopathic arthritis
Authors
Ilham Bouaddi
Samira Rostom
Dalal El Badri
Asmae Hassani
Bouchra Chkirate
Redoine Abouqal
Bouchra Amine
Najia Hajjaj-Hassouni
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2014
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/1471-2474-15-115

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