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BMC Pulmonary Medicine
Published in: BMC Pulmonary Medicine 1/2013

Open Access 01-12-2013 | Case report

A case of synchronous bilateral lung cancers: EML4-ALK positive adenocarcinoma in the right lung and adenocarcinoma in situ (the former bronchioloalveolar carcinoma) in the left lung

Authors: Ikuo Matsuda, Kengo Takeuchi, Shinjiro Mizuguchi, Masahide Kaji, Kayo Ueda, Kazuhiro Teramura, Seiichi Hirota

Published in: BMC Pulmonary Medicine | Issue 1/2013

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Abstract

Background

Recently it has been revealed that lung adenocarcinomas with distinct gene mutations or fusions are associated with particular histopathological entities. For example, epidermal growth factor receptor (EGFR) gene mutations are often associated with well differentiated adenocarcinoma of the lung with bronchioloalveolar pattern. On the other hand, echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene in a subset of lung adenocarcinoma is related to mucinous cribriform histology.

Case presentation

Reported herein is a case of synchronous EML4-ALK positive lung adenocarcinoma and adenocarcinoma in situ in the bilateral lungs of a 55-year-old Japanese woman. The woman had EML4-ALK positive lung adenocarcinoma in the right lower lung while adenocarcinoma in situ in the left upper lung, which was EML4-ALK negative.

Conclusion

To our knowledge, this is the first report of synchronous, bilateral lung adenocarcinomas composed of EML4-ALK positive and negative ones.
Appendix
Available only for authorised users
Literature
1.
Travis WD, Brambilla E, Muller-Hermelink HK, Haris CC, World Health Organization: Classification of Tumours. Pathology & Genetics: tumours of the lung, pleura, thymus, and heart. 2004, Lyon: IARC Press
2.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE: International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 2011, 6: 244-285. 10.1097/JTO.0b013e318206a221.CrossRefPubMedPubMedCentral
3.
Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB: Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 2008, 455: 1069-1075. 10.1038/nature07423.CrossRefPubMedPubMedCentral
4.
Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H: Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007, 448: 561-566. 10.1038/nature05945.CrossRefPubMed
5.
Inamura K, Takeuchi K, Togashi Y, Nomura K, Ninomiya H, Okui M, Satoh Y, Okumura S, Nakagawa K, Soda M: EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. J Thorac Oncol. 2008, 3: 13-17. 10.1097/JTO.0b013e31815e8b60.CrossRefPubMed
6.
Inamura K, Takeuchi K, Togashi Y, Hatano S, Ninomiya H, Motoi N, Mun MY, Sakao Y, Okumura S, Nakagawa K: EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset. Mod Pathol. 2009, 22: 508-515. 10.1038/modpathol.2009.2.CrossRefPubMed
7.
Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, Asaka R, Hamanaka W, Ninomiya H, Uehara H: RET, ROS1 and ALK fusions in lung cancer. Nat Med. 2012, 18: 378-381. 10.1038/nm.2658.CrossRefPubMed
8.
Kohno T, Ichikawa H, Totoki Y, Yasuda K, Hiramoto M, Nammo T, Sakamoto H, Tsuta K, Furuta K, Shimada Y: KIF5B-RET fusions in lung adenocarcinoma. Nat Med. 2012, 18: 375-377. 10.1038/nm.2644.CrossRefPubMed
9.
Ju YS, Lee WC, Shin JY, Lee S, Bleazard T, Won JK, Kim YT, Kim JI, Kang JH, Seo JS: A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing. Genome Res. 2012, 22: 436-445. 10.1101/gr.133645.111.CrossRefPubMedPubMedCentral
10.
Paez JG, Jänne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ: EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004, 304: 1497-1500. 10.1126/science.1099314.CrossRefPubMed
11.
Nakata M, Sawada S, Yamashita M, Saeki H, Kurita A, Takashima S, Tanemoto K: Surgical treatments for multiple primary adenocarcinoma of the lung. Ann Thorac Surg. 2004, 78: 1194-1199. 10.1016/j.athoracsur.2004.03.102.CrossRefPubMed
12.
Graziano P, Cardillo G, Mancuso A, Paone G, Gasbarra R, De Marinis F, Leone A: Long-term disease-free survival of a patient with synchronous bilateral lung adenocarcinoma displaying different EGFR and C-MYC molecular characteristics. Chest. 2011, 140: 1354-1356. 10.1378/chest.10-2276.CrossRefPubMed
13.
Dohmoto K, Fujita J, Ohtsuki Y, Kotsuna N, Mitsunaka H, Kuwabara H, Takahara J: Synchronous four primary lung adenocarcinoma associated with multiple atypical adenomatous hyperplasia. Lung Cancer. 2000, 27: 125-130. 10.1016/S0169-5002(99)00094-X.CrossRefPubMed
14.
Suzuki K, Takahashi K, Yoshida J, Nishimura M, Yokose T, Nishiwaki Y, Nagai K: Synchronous double primary lung carcinomas associated with multiple atypical adenomatous hyperplasia. Lung Cancer. 1998, 19: 131-139. 10.1016/S0169-5002(97)00082-2.CrossRefPubMed
15.
Miller VA, Kris MG, Shah N, Patel J, Azzoli C, Gomez J, Krug LM, Pao W, Rizvi N, Pizzo B: Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer. J Clin Oncol. 2004, 22: 1103-1109. 10.1200/JCO.2004.08.158.CrossRefPubMed
16.
Yatabe Y, Kosaka T, Takahashi T, Mitsudomi T: EGFR mutation is specific for terminal respiratory unit type adenocarcinoma. Am J Surg Pathol. 2005, 29: 633-639. 10.1097/01.pas.0000157935.28066.35.CrossRefPubMed
17.
Yoshimoto K, Yoshida J, Ishii G, Nishimura M, Hishida T, Nagai K: Two lung adenocarcinomas in the same lobe: multiple primaries or intrapulmonary metastasis?. Ann Thorac Cardiovasc Surg. 2011, 17: 584-587. 10.5761/atcs.cr.10.01652.CrossRefPubMed
18.
Mitsudomi T, Yatabe Y: Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer. Cancer Sci. 2007, 98: 1817-1824. 10.1111/j.1349-7006.2007.00607.x.CrossRefPubMed
19.
Togashi Y, Soda M, Sakata S, Sugawara E, Hatano S, Asaka R, Nakajima T, Mano H, Takeuchi K: KLC1-ALK: a novel fusion in lung cancer identified using a formalin-fixed paraffin-embedded tissue only. PLoS One. 2012, 7: e31323-10.1371/journal.pone.0031323.CrossRefPubMedPubMedCentral
Metadata
Title
A case of synchronous bilateral lung cancers: EML4-ALK positive adenocarcinoma in the right lung and adenocarcinoma in situ (the former bronchioloalveolar carcinoma) in the left lung
Authors
Ikuo Matsuda
Kengo Takeuchi
Shinjiro Mizuguchi
Masahide Kaji
Kayo Ueda
Kazuhiro Teramura
Seiichi Hirota
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Pulmonary Medicine / Issue 1/2013
Electronic ISSN: 1471-2466
DOI
https://doi.org/10.1186/1471-2466-13-25

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